KEGG   PATHWAY: hsa00591Help
Entry
hsa00591                    Pathway                                

Name
Linoleic acid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Linoleic acid metabolism
hsa00591

All organismsOrtholog table
Disease
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
Organism
Homo sapiens (human) [GN:hsa]
Gene
8399  
PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
26279  
PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
30814  
PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
50487  
PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
64600  
PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
81579  
PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
84647  
PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
5319  
PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
5322  
PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
5320  
PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
391013  
PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
123745  
PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
8681  
JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
8605  
PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
255189  
PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
8398  
PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
151056  
PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.5 3.1.1.4]
11145  
PLA2G16; phospholipase A2 group XVI [KO:K16817] [EC:3.1.1.4 3.1.1.32]
246  
ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
1544  
CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
1558  
CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
1559  
CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1557  
CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17721] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1573  
CYP2J2; cytochrome P450 family 2 subfamily J member 2 [KO:K07418] [EC:1.14.14.1]
1571  
CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.13.-]
1576  
CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.- 1.14.13.157 1.14.13.97 1.14.13.67 1.14.13.32]
Compound
C00157  
Phosphatidylcholine
C00219  
Arachidonate
C01595  
Linoleate
C03242  
(8Z,11Z,14Z)-Icosatrienoic acid
C04056  
9-cis,11-trans-Octadecadienoate
C04717  
(9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  
(6Z,9Z,12Z)-Octadecatrienoic acid
C07289  
Crepenynate
C07338  
(9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  
(7S,8S)-DiHODE
C14762  
13(S)-HODE
C14765  
13-OxoODE
C14766  
9-OxoODE
C14767  
9(S)-HODE
C14825  
9(10)-EpOME
C14826  
12(13)-EpOME
C14827  
9(S)-HPODE
C14828  
9,10-DHOME
C14829  
12,13-DHOME
C14831  
8(R)-HPODE
C14832  
12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  
9,12,13-TriHOME
C14834  
9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  
9,10,13-TriHOME
C14836  
9,10-12,13-Diepoxyoctadecanoate
C14837  
9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  
(8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  
5S,8R-DiHODE
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
KO pathway
 

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