KEGG   PATHWAY: hsa00603Help
Entry
hsa00603                    Pathway                                

Name
Glycosphingolipid biosynthesis - globo and isoglobo series - Homo sapiens (human)
Class
Metabolism; Glycan biosynthesis and metabolism
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Glycosphingolipid biosynthesis - globo and isoglobo series
hsa00603

All organismsOrtholog table
Module
Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer [PATH:hsa00603]
Disease
H00124  
GM2 gangliosidoses
H00125  
Fabry disease
H00146  
Alpha-N-acetylgalactosaminidase deficiency
H00422  
Glycoproteinoses
Organism
Homo sapiens (human) [GN:hsa]
Gene
127550  
A3GALT2; alpha 1,3-galactosyltransferase 2 [KO:K20736] [EC:2.4.1.87]
8706  
B3GALNT1; beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) [KO:K00719] [EC:2.4.1.79]
26301  
GBGT1; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [KO:K00722] [EC:2.4.1.88]
53947  
A4GALT; alpha 1,4-galactosyltransferase [KO:K01988] [EC:2.4.1.228]
2717  
GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
10317  
B3GALT5; beta-1,3-galactosyltransferase 5 [KO:K03877] [EC:2.4.1.-]
3073  
HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
3074  
HEXB; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
4668  
NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
2523  
FUT1; fucosyltransferase 1 (H blood group) [KO:K00718] [EC:2.4.1.69]
2524  
FUT2; fucosyltransferase 2 [KO:K00718] [EC:2.4.1.69]
6482  
ST3GAL1; ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [KO:K00780] [EC:2.4.99.4]
6483  
ST3GAL2; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.99.4]
6489  
ST8SIA1; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [KO:K03371] [EC:2.4.99.8]
10690  
FUT9; fucosyltransferase 9 [KO:K03663] [EC:2.4.1.152]
Compound
G00092  
Lactosylceramide
G00093  
Globotriaosylceramide
G00094  
Globoside
G00095  
Forssman antigen, IV3GalNAca-Gb4Cer
G00096  
IV3GalNAcb-Gb4Cer
G00097  
Galactosylgloboside
G00098  
Monosialylgalactosylgloboside
G00099  
Globo-H
G00100  
V3(NeuAc)2-Gb5Cer
G00101  
 
G00102  
 
G00103  
 
G00104  
 
G00105  
GalGb3Cer
G00106  
 
G00107  
 
G00181  
Disialosylglobopentaosylceramide
G00392  
iGb4-Cer
G00403  
iGb3-Cer
G02977  
 
Reference
  Authors
Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T.
  Title
Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
  Journal
J Biol Chem 278:26474-9 (2003)
Reference
  Authors
Zhou D, Henion TR, Jungalwala FB, Berger EG, Hennet T.
  Title
The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase.
  Journal
J Biol Chem 275:22631-4 (2000)
Reference
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  Journal
J Biol Chem 275:15152-6 (2000)
Reference
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU.
  Title
Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipidsynthesis, predicts a family of alpha 1, 4-glycosyltransferases conservedin plants, insects, and mammals.
  Journal
J Biol Chem 275:25315-21 (2000)
Reference
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU
  Title
Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.
  Journal
J Biol Chem 275:25308-14 (2000)
KO pathway
 

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