KEGG   PATHWAY: hsa00603Help
Entry
hsa00603                    Pathway                                

Name
Glycosphingolipid biosynthesis - globo series - Homo sapiens (human)
Class
Metabolism; Glycan biosynthesis and metabolism
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Glycosphingolipid biosynthesis - globo series
hsa00603

All organismsOrtholog table
Module
Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer [PATH:hsa00603]
Disease
H00124  
GM2 gangliosidoses
H00125  
Fabry disease
H00146  
Alpha-N-acetylgalactosaminidase deficiency
H00422  
Glycoproteinoses
Organism
Homo sapiens (human) [GN:hsa]
Gene
53947  
A4GALT; alpha 1,4-galactosyltransferase [KO:K01988] [EC:2.4.1.228]
2717  
GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
8706  
B3GALNT1; beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) [KO:K00719] [EC:2.4.1.79]
3073  
HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
3074  
HEXB; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
10317  
B3GALT5; Beta-1,3-galactosyltransferase 5 [KO:K03877] [EC:2.4.1.-]
26301  
GBGT1; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [KO:K00722] [EC:2.4.1.88]
4668  
NAGA; N-acetylgalactosaminidase, alpha- [KO:K01204] [EC:3.2.1.49]
2523  
FUT1; fucosyltransferase 1 (H blood group) [KO:K00718] [EC:2.4.1.69]
2524  
FUT2; fucosyltransferase 2 [KO:K00718] [EC:2.4.1.69]
6482  
ST3GAL1; ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [KO:K00780] [EC:2.4.99.4]
6483  
ST3GAL2; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.99.4]
6489  
ST8SIA1; ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1 [KO:K03371] [EC:2.4.99.8]
10690  
FUT9; fucosyltransferase 9 (alpha (1,3) fucosyltransferase) [KO:K03663] [EC:2.4.1.152]
Compound
G00092  
Lactosylceramide
G00093  
Globotriaosylceramide
G00094  
Globoside
G00095  
Forssman antigen, IV3GalNAca-Gb4Cer
G00096  
IV3GalNAcb-Gb4Cer
G00097  
Galactosylgloboside
G00098  
Monosialylgalactosylgloboside
G00099  
Globo-H
G00100  
V3(NeuAc)2-Gb5Cer
G00101  
 
G00102  
 
G00103  
 
G00104  
 
G00105  
GalGb3Cer
G00106  
 
G00107  
 
G00181  
Disialosylglobopentaosylceramide
Reference
  Authors
Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T.
  Title
Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
  Journal
J Biol Chem 278:26474-9 (2003)
Reference
  Authors
Zhou D, Henion TR, Jungalwala FB, Berger EG, Hennet T.
  Title
The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase.
  Journal
J Biol Chem 275:22631-4 (2000)
Reference
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, aglycosyltransferase that initiates the synthesis of globo seriesglycosphingolipids.
  Journal
J Biol Chem 275:15152-6 (2000)
Reference
  Authors
Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU.
  Title
Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipidsynthesis, predicts a family of alpha 1, 4-glycosyltransferases conservedin plants, insects, and mammals.
  Journal
J Biol Chem 275:25315-21 (2000)
KO pathway
 

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