KEGG   PATHWAY: hsa00630Help
Entry
hsa00630                    Pathway                                

Name
Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glyoxylate and dicarboxylate metabolism
hsa00630

All organismsOrtholog table
Module
Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:hsa00630]
Disease
H00117  
Primary hyperoxaluria (HP)
H00174  
Methylmalonic aciduria (MMA)
Organism
Homo sapiens (human) [GN:hsa]
Gene
4190  
MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]
4191  
MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
1431  
CS; citrate synthase [KO:K01647] [EC:2.3.3.1]
50  
ACO2; aconitase 2 [KO:K01681] [EC:4.2.1.3]
48  
ACO1; aconitase 1 [KO:K01681] [EC:4.2.1.3]
39  
ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  
ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
84693  
MCEE; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
5095  
PCCA; propionyl-CoA carboxylase alpha subunit [KO:K01965] [EC:6.4.1.3]
5096  
PCCB; propionyl-CoA carboxylase beta subunit [KO:K01966] [EC:6.4.1.3]
4594  
MUT; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
51179  
HAO2; hydroxyacid oxidase 2 [KO:K11517] [EC:1.1.3.15]
54363  
HAO1; hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
847  
CAT; catalase [KO:K03781] [EC:1.11.1.6]
9380  
GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.81 1.1.1.79]
283871  
PGP; phosphoglycolate phosphatase [KO:K19269] [EC:3.1.3.48 3.1.3.18]
189  
AGXT; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.51 2.6.1.45 2.6.1.44]
2752  
GLUL; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
6472  
SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
6470  
SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
2731  
GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
275  
AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
1738  
DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
2653  
GCSH; glycine cleavage system protein H [KO:K02437]
81888  
HYI; hydroxypyruvate isomerase (putative) [KO:K01816] [EC:5.3.1.22]
132158  
GLYCTK; glycerate kinase [KO:K15788] [EC:2.7.1.31]
112817  
HOGA1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
125061  
AFMID; arylformamidase [KO:K01432] [EC:3.5.1.9]
Compound
C00007  
Oxygen
C00011  
CO2
C00014  
Ammonia
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00025  
L-Glutamate
C00026  
2-Oxoglutarate
C00027  
Hydrogen peroxide
C00036  
Oxaloacetate
C00037  
Glycine
C00042  
Succinate
C00048  
Glyoxylate
C00058  
Formate
C00064  
L-Glutamine
C00065  
L-Serine
C00091  
Succinyl-CoA
C00100  
Propanoyl-CoA
C00136  
Butanoyl-CoA
C00149  
(S)-Malate
C00158  
Citrate
C00160  
Glycolate
C00168  
Hydroxypyruvate
C00197  
3-Phospho-D-glycerate
C00209  
Oxalate
C00258  
D-Glycerate
C00266  
Glycolaldehyde
C00311  
Isocitrate
C00313  
Oxalyl-CoA
C00332  
Acetoacetyl-CoA
C00417  
cis-Aconitate
C00552  
meso-Tartaric acid
C00683  
(S)-Methylmalonyl-CoA
C00798  
Formyl-CoA
C00877  
Crotonoyl-CoA
C00888  
Pentanoyl-CoA
C00898  
(R,R)-Tartaric acid
C00975  
Dihydroxyfumarate
C00988  
2-Phosphoglycolate
C01127  
4-Hydroxy-2-oxoglutarate
C01146  
2-Hydroxy-3-oxopropanoate
C01182  
D-Ribulose 1,5-bisphosphate
C01213  
(R)-Methylmalonyl-CoA
C01380  
Ethylene glycol
C01732  
Mesaconate
C01989  
3-Ethylmalate
C01990  
3-Oxalomalate
C02123  
3-Propylmalate
C02405  
Formyl phosphate
C03217  
2-Hydroxy-3-oxoadipate
C03459  
2-Hydroxy-3-oxosuccinate
C03548  
trans-2,3-Epoxysuccinate
C03561  
(R)-3-Hydroxybutanoyl-CoA
C03618  
L-threo-3-Methylaspartate
C04348  
L-Malyl-CoA
C06027  
L-erythro-3-Methylmalyl-CoA
C06028  
2-Methylfumaryl-CoA
C06049  
N-Formylderivatives
C18026  
(2S)-Ethylmalonyl-CoA
C18324  
(2S)-Methylsuccinyl-CoA
C20238  
(2R)-Ethylmalonyl-CoA
Reference
PMID:10978349 (EC5.3.1.22)
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta -hydroxyacid dehydrogenases in Escherichia coli and Haemophilusinfluenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
Reference
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
Reference
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play  distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
Reference
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
KO pathway
 

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