KEGG   PATHWAY: hsa00640Help
Entry
hsa00640                    Pathway                                

Name
Propanoate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
hsa00640  Propanoate metabolism
hsa00640

Ortholog table
Module
hsa_M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA [PATH:hsa00640]
hsa_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:hsa00640]
Disease
H00174  Methylmalonic aciduria (MMA)
H00175  Propionic acidemia
H01283  Malonyl-CoA decarboxylase deficiency
Drug
D00535  Vigabatrin (JAN/USAN/INN)
Other DBs
BSID: 83004
GO: 0019541
Organism
Homo sapiens (human) [GN:hsa]
Gene
84532  ACSS1; acyl-CoA synthetase short chain family member 1 [KO:K01895] [EC:6.2.1.1]
55902  ACSS2; acyl-CoA synthetase short chain family member 2 [KO:K01895] [EC:6.2.1.1]
79611  ACSS3; acyl-CoA synthetase short chain family member 3 [KO:K01908] [EC:6.2.1.17]
593  BCKDHA; branched chain keto acid dehydrogenase E1, alpha polypeptide [KO:K00166] [EC:1.2.4.4]
594  BCKDHB; branched chain keto acid dehydrogenase E1 subunit beta [KO:K00167] [EC:1.2.4.4]
1629  DBT; dihydrolipoamide branched chain transacylase E2 [KO:K09699] [EC:2.3.1.168]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
34  ACADM; acyl-CoA dehydrogenase medium chain [KO:K00249] [EC:1.3.8.7]
3030  HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:1.1.1.211 4.2.1.17]
1962  EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
1892  ECHS1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]
26275  HIBCH; 3-hydroxyisobutyryl-CoA hydrolase [KO:K05605] [EC:3.1.2.4]
31  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:2.1.3.15 6.3.4.14 6.4.1.2]
32  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:2.1.3.15 6.3.4.14 6.4.1.2]
23417  MLYCD; malonyl-CoA decarboxylase [KO:K01578] [EC:4.1.1.9]
18  ABAT; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.22 2.6.1.19]
5095  PCCA; propionyl-CoA carboxylase alpha subunit [KO:K01965] [EC:6.4.1.3]
5096  PCCB; propionyl-CoA carboxylase beta subunit [KO:K01966] [EC:2.1.3.15 6.4.1.3]
55862  ECHDC1; ethylmalonyl-CoA decarboxylase 1 [KO:K18426] [EC:4.1.1.41 4.1.1.94]
84693  MCEE; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
4594  MUT; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
8802  SUCLG1; succinate-CoA ligase alpha subunit [KO:K01899] [EC:6.2.1.5 6.2.1.4]
8801  SUCLG2; succinate-CoA ligase GDP-forming beta subunit [KO:K01900] [EC:6.2.1.5 6.2.1.4]
8803  SUCLA2; succinate-CoA ligase ADP-forming beta subunit [KO:K01900] [EC:6.2.1.5 6.2.1.4]
4329  ALDH6A1; aldehyde dehydrogenase 6 family member A1 [KO:K00140] [EC:1.2.1.27 1.2.1.18]
160287  LDHAL6A; lactate dehydrogenase A like 6A [KO:K00016] [EC:1.1.1.27]
92483  LDHAL6B; lactate dehydrogenase A like 6B [KO:K00016] [EC:1.1.1.27]
3939  LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
3945  LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
3948  LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
Compound
C00024  Acetyl-CoA
C00033  Acetate
C00042  Succinate
C00068  Thiamin diphosphate
C00083  Malonyl-CoA
C00091  Succinyl-CoA
C00099  beta-Alanine
C00100  Propanoyl-CoA
C00109  2-Oxobutanoate
C00111  Glycerone phosphate
C00132  Methanol
C00163  Propanoate
C00164  Acetoacetate
C00186  (S)-Lactate
C00207  Acetone
C00222  3-Oxopropanoate
C00332  Acetoacetyl-CoA
C00424  (S)-Lactaldehyde
C00479  Propanal
C00546  Methylglyoxal
C00583  Propane-1,2-diol
C00683  (S)-Methylmalonyl-CoA
C00804  Propynoate
C00827  Lactoyl-CoA
C00894  Propenoyl-CoA
C01013  3-Hydroxypropanoate
C01213  (R)-Methylmalonyl-CoA
C01845  Propan-2-ol
C02170  Methylmalonate
C02225  2-Methylcitrate
C02335  beta-Alanyl-CoA
C02876  Propanoyl phosphate
C04225  (Z)-But-2-ene-1,2,3-tricarboxylate
C04593  (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate
C05235  Hydroxyacetone
C05668  3-Hydroxypropionyl-CoA
C05979  Propane-1-ol
C05983  Propionyladenylate
C05984  2-Hydroxybutanoic acid
C05989  3-Oxopropionyl-CoA
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C17530  Methyl acetate
C20783  Propane
C21017  2-(alpha-Hydroxypropyl)thiamine diphosphate
C21018  Enzyme N6-(S-propyldihydrolipoyl)lysine
C21250  2-Methyl-trans-aconitate
KO pathway
ko00640   

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