KEGG   PATHWAY: hsa00670Help
Entry
hsa00670                    Pathway                                

Name
One carbon pool by folate - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
One carbon pool by folate
hsa00670

All organismsOrtholog table
Module
C1-unit interconversion, eukaryotes [PATH:hsa00670]
Disease
H00183  
Homocystinuria
H00262  
Spina bifida
H00966  
AICA-ribosiduria
H01197  
Dihydrofolate reductase (DHFR) deficiency
H01262  
Formiminotransferase deficiency
H01285  
Methylcobalamin deficiency type G (cblG)
Drug
D00142  
Methotrexate (JP17/USP/INN)
D00584  
Fluorouracil (JP17/USP/INN)
D01064  
Raltitrexed (JAN/USAN/INN)
D01223  
Capecitabine (JAN/USAN/INN)
D01244  
Tegafur (JP17/USAN/INN)
D01309  
Doxifluridine (JP17/INN)
D01784  
Carmofur (JP17/INN)
D02115  
Methotrexate sodium
D03828  
Pemetrexed disodium (USAN)
D03942  
Edatrexate (USAN/INN)
D04197  
Floxuridine (USP/INN)
D04964  
Metesind glucuronate (USAN)
D05400  
Pelitrexol (USAN/INN)
D05589  
Pralatrexate (JAN/USAN/INN)
D06238  
Trimetrexate (USAN/INN)
D06239  
Trimetrexate glucuronate (USAN)
D06503  
Pemetrexed sodium hydrate (JAN)
D07472  
Pemetrexed (INN)
D07974  
Fluorouracil sodium salt
Organism
Homo sapiens (human) [GN:hsa]
Gene
1719  
DHFR; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
200895  
DHFR2; dihydrofolate reductase 2 [KO:K00287] [EC:1.5.1.3]
25902  
MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like [KO:K13402] [EC:6.3.4.3]
4522  
MTHFD1; methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [KO:K00288] [EC:6.3.4.3 3.5.4.9 1.5.1.5]
10797  
MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [KO:K13403] [EC:3.5.4.9 1.5.1.15]
441024  
MTHFD2L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like [KO:K13403] [EC:3.5.4.9 1.5.1.15]
6472  
SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
6470  
SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
2618  
GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.3.1 2.1.2.2 6.3.4.13]
471  
ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:3.5.4.10 2.1.2.3]
10841  
FTCD; formimidoyltransferase cyclodeaminase [KO:K13990] [EC:4.3.1.4 2.1.2.5]
123263  
MTFMT; mitochondrial methionyl-tRNA formyltransferase [KO:K00604] [EC:2.1.2.9]
275  
AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
4548  
MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
7298  
TYMS; thymidylate synthetase [KO:K00560] [EC:2.1.1.45]
10840  
ALDH1L1; aldehyde dehydrogenase 1 family member L1 [KO:K00289] [EC:1.5.1.6]
160428  
ALDH1L2; aldehyde dehydrogenase 1 family member L2 [KO:K00289] [EC:1.5.1.6]
4524  
MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) [KO:K00297] [EC:1.5.1.20]
10588  
MTHFS; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) [KO:K01934] [EC:6.3.3.2]
ST20-MTHFS; ST20-MTHFS readthrough [KO:K01934] [EC:6.3.3.2]
Compound
C00101  
Tetrahydrofolate
C00143  
5,10-Methylenetetrahydrofolate
C00234  
10-Formyltetrahydrofolate
C00415  
Dihydrofolate
C00440  
5-Methyltetrahydrofolate
C00445  
5,10-Methenyltetrahydrofolate
C00504  
Folate
C00664  
5-Formiminotetrahydrofolate
C03479  
Folinic acid
KO pathway
 

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