KEGG   PATHWAY: hsa00740Help
Entry
hsa00740                    Pathway                                

Name
Riboflavin metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
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Pathway map
Riboflavin metabolism
hsa00740

All organismsOrtholog table
Disease
H01002  
Generalized arterial calcification of infancy
H01113  
Acid phosphatase deficiency
H01394  
Cole disease
Drug
D00073  
Hydroquinone (USP)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
55312  
RFK; riboflavin kinase [KO:K00861] [EC:2.7.1.26]
54  
ACP5; acid phosphatase 5, tartrate resistant [KO:K14379] [EC:3.1.3.2]
52  
ACP1; acid phosphatase 1, soluble [KO:K14394] [EC:3.1.3.48 3.1.3.2]
53  
ACP2; acid phosphatase 2, lysosomal [KO:K14410] [EC:3.1.3.2]
80308  
FLAD1; flavin adenine dinucleotide synthetase 1 [KO:K00953] [EC:2.7.7.2]
5167  
ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
5169  
ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
645  
BLVRB; biliverdin reductase B [KO:K05901] [EC:1.5.1.30 1.3.1.24]
Compound
C00016  
FAD
C00044  
GTP
C00061  
FMN
C00199  
D-Ribulose 5-phosphate
C00255  
Riboflavin
C00474  
Ribitol
C01007  
Reduced riboflavin
C01268  
5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  
2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  
FADH2
C01727  
Lumichrome
C01847  
Reduced FMN
C03114  
Dimethylbenzimidazole
C04332  
6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  
5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  
5-Amino-6-(1-D-ribitylamino)uracil
C05995  
7-Hydroxy-6-methyl-8-ribityllumazine
C15556  
L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  
2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  
2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
Reference
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
KO pathway
 

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