KEGG   PATHWAY: hsa00760Help
Entry
hsa00760                    Pathway                                

Name
Nicotinate and nicotinamide metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
hsa00760  Nicotinate and nicotinamide metabolism
hsa00760

Ortholog table
Disease
H00824  Calcification of joints and arteries
H01002  Generalized arterial calcification of infancy
H01394  Cole disease
H01929  2,4-Dienoyl-CoA reductase deficiency
Drug
D04245  Forodesine hydrochloride (JAN/USAN)
D06596  Forodesine (USAN/INN)
D09678  Teglarinad chloride (USAN/INN)
D10431  Ulodesine (USAN)
D10432  Ulodesine succinate (USAN)
Other DBs
BSID: 83014
UMBBD: nic
GO: 0006769
Organism
Homo sapiens (human) [GN:hsa]
Gene
554235  ASPDH; aspartate dehydrogenase domain containing [KO:K06989] [EC:1.4.1.21]
23475  QPRT; quinolinate phosphoribosyltransferase [KO:K00767] [EC:2.4.2.19]
93100  NAPRT; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
4860  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
54981  NMRK1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.173 2.7.1.22]
27231  NMRK2; nicotinamide riboside kinase 2 [KO:K10524] [EC:2.7.1.173 2.7.1.22]
22978  NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
84618  NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
93034  NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
30833  NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
56953  NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
51251  NT5C3A; 5'-nucleotidase, cytosolic IIIA [KO:K01081] [EC:3.1.3.5]
115024  NT5C3B; 5'-nucleotidase, cytosolic IIIB [KO:K01081] [EC:3.1.3.5]
100526794  NT5C1B-RDH14; NT5C1B-RDH14 readthrough [KO:K01081] [EC:3.1.3.5]
4907  NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
349565  NMNAT3; nicotinamide nucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.18 2.7.7.1]
64802  NMNAT1; nicotinamide nucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.18 2.7.7.1]
23057  NMNAT2; nicotinamide nucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.18 2.7.7.1]
5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
83594  NUDT12; nudix hydrolase 12 [KO:K03426] [EC:3.6.1.22]
55191  NADSYN1; NAD synthetase 1 [KO:K01950] [EC:6.3.5.1]
10135  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
952  CD38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]
683  BST1; bone marrow stromal cell antigen 1 [KO:K18152] [EC:2.4.99.20 3.2.2.6]
65220  NADK; NAD kinase [KO:K00858] [EC:2.7.1.23]
133686  NADK2; NAD kinase 2, mitochondrial [KO:K00858] [EC:2.7.1.23]
23530  NNT; nicotinamide nucleotide transhydrogenase [KO:K00323] [EC:1.6.1.2]
4837  NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01004  N-Methylnicotinate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16150  (R,S)-Nicotine
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
KO pathway
ko00760   

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