KEGG   PATHWAY: hsa00760Help
Entry
hsa00760                    Pathway                                

Name
Nicotinate and nicotinamide metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Nicotinate and nicotinamide metabolism
hsa00760

All organismsOrtholog table
Disease
H00824  
Calcification of joints and arteries
H01002  
Generalized arterial calcification of infancy
H01394  
Cole disease
Drug
D04245  
Forodesine hydrochloride (JAN/USAN)
D06596  
Forodesine (USAN/INN)
D09678  
Teglarinad chloride (USAN/INN)
D10431  
Ulodesine (USAN)
D10432  
Ulodesine succinate (USAN)
Other DBs
BSID: 
UMBBD: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
23475  
QPRT; quinolinate phosphoribosyltransferase [KO:K00767] [EC:2.4.2.19]
nicotinate-nucleotide pyrophosphorylase [carboxylating]-like; K00767 nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] [KO:K00767] [EC:2.4.2.19]
93100  
NAPRT; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
4860  
PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
54981  
NMRK1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.173 2.7.1.22]
27231  
NMRK2; nicotinamide riboside kinase 2 [KO:K10524] [EC:2.7.1.173 2.7.1.22]
22978  
NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
84618  
NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
93034  
NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
30833  
NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
56953  
NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
51251  
NT5C3A; 5'-nucleotidase, cytosolic IIIA [KO:K01081] [EC:3.1.3.5]
115024  
NT5C3B; 5'-nucleotidase, cytosolic IIIB [KO:K01081] [EC:3.1.3.5]
NT5C1B-RDH14; NT5C1B-RDH14 readthrough [KO:K01081] [EC:3.1.3.5]
4907  
NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
349565  
NMNAT3; nicotinamide nucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.18 2.7.7.1]
64802  
NMNAT1; nicotinamide nucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.18 2.7.7.1]
23057  
NMNAT2; nicotinamide nucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.18 2.7.7.1]
5167  
ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
5169  
ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
83594  
NUDT12; nudix hydrolase 12 [KO:K03426] [EC:3.6.1.22]
55191  
NADSYN1; NAD synthetase 1 [KO:K01950] [EC:6.3.5.1]
10135  
NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
952  
CD38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]
683  
BST1; bone marrow stromal cell antigen 1 [KO:K18152] [EC:2.4.99.20 3.2.2.6]
65220  
NADK; NAD kinase [KO:K00858] [EC:2.7.1.23]
133686  
NADK2; NAD kinase 2, mitochondrial [KO:K00858] [EC:2.7.1.23]
23530  
NNT; nicotinamide nucleotide transhydrogenase [KO:K00323] [EC:1.6.1.2]
4837  
NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
316  
AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
Compound
C00003  
NAD+
C00006  
NADP+
C00022  
Pyruvate
C00042  
Succinate
C00049  
L-Aspartate
C00111  
Glycerone phosphate
C00122  
Fumarate
C00153  
Nicotinamide
C00163  
Propanoate
C00232  
Succinate semialdehyde
C00253  
Nicotinate
C00334  
4-Aminobutanoate
C00455  
Nicotinamide D-ribonucleotide
C00857  
Deamino-NAD+
C00922  
2,3-Dimethylmaleate
C01004  
N-Methylnicotinate
C01020  
6-Hydroxynicotinate
C01056  
(S)-6-Hydroxynicotine
C01059  
2,5-Dihydroxypyridine
C01185  
Nicotinate D-ribonucleotide
C01297  
6-Hydroxypseudooxynicotine
C01384  
Maleic acid
C01596  
Maleamate
C02295  
Methylitaconate
C02918  
1-Methylnicotinamide
C02930  
2-Methyleneglutarate
C03043  
(R)-6-Hydroxynicotine
C03056  
2,6-Dihydroxypyridine
C03150  
Nicotinamide-beta-riboside
C03458  
2,3,6-Trihydroxypyridine
C03652  
(2R,3S)-2,3-Dimethylmalate
C03722  
Quinolinate
C04226  
6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  
Nicotinurate
C05840  
Iminoaspartate
C05841  
Nicotinate D-ribonucleoside
C05842  
N1-Methyl-2-pyridone-5-carboxamide
C05843  
N1-Methyl-4-pyridone-5-carboxamide
C06178  
1-Methylpyrrolinium
C15523  
2,6-Dihydroxynicotinate
C15986  
2,6-Dihydroxypseudooxynicotine
C15987  
4-Methylaminobutyrate
C16150  
(R,S)-Nicotine
C16151  
2,6-Dihydroxy-N-methylmyosmine
C16152  
Blue pigment
C16159  
2-Formylglutarate
C16390  
(S)-2-(Hydroxymethyl)glutarate
C18232  
N-Formylmaleamic acid
C19567  
4-Oxo-1-(3-pyridyl)-1-butanone
C19569  
3-Succinoylpyridine
C19631  
6-Hydroxy-3-succinoylpyridine
C20361  
Pseudooxynicotine
C20381  
3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  
5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  
N-Methylmyosmine
Reference
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
Reference
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
Reference
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
KO pathway
 

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