KEGG   PATHWAY: hsa00790Help
Entry
hsa00790                    Pathway                                

Name
Folate biosynthesis - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Folate biosynthesis
hsa00790

All organismsOrtholog table
Disease
H00167  
Phenylketonuria (PKU)
H00213  
Hypophosphatasia
H00831  
Primary dystonia
H01197  
Dihydrofolate reductase (DHFR) deficiency
Drug
D00142  
Methotrexate (JP16/USP/INN)
D02115  
Methotrexate sodium
D03942  
Edatrexate (USAN/INN)
D05589  
Pralatrexate (USAN/INN)
D06238  
Trimetrexate (USAN/INN)
D06239  
Trimetrexate glucuronate (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
2643  
GCH1; GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
249  
ALPL; alkaline phosphatase, liver/bone/kidney [KO:K01077] [EC:3.1.3.1]
248  
ALPI; alkaline phosphatase, intestinal [KO:K01077] [EC:3.1.3.1]
250  
ALPP; alkaline phosphatase, placental [KO:K01077] [EC:3.1.3.1]
251  
ALPPL2; alkaline phosphatase, placental-like 2 [KO:K01077] [EC:3.1.3.1]
1719  
DHFR; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
200895  
DHFRL1; dihydrofolate reductase-like 1 [KO:K00287] [EC:1.5.1.3]
2356  
FPGS; folylpolyglutamate synthase [KO:K01930] [EC:6.3.2.17]
8836  
GGH; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) [KO:K01307] [EC:3.4.19.9]
5805  
PTS; 6-pyruvoyltetrahydropterin synthase [KO:K01737] [EC:4.1.2.50 4.2.3.12]
6697  
SPR; sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) [KO:K00072] [EC:1.1.1.153]
5860  
QDPR; quinoid dihydropteridine reductase [KO:K00357] [EC:1.5.1.34]
4337  
MOCS1; molybdenum cofactor synthesis 1 [KO:K03639] [EC:4.1.99.18]
4338  
MOCS2; molybdenum cofactor synthesis 2 [KO:K03635] [EC:2.8.1.12]
Compound
C00044  
GTP
C00101  
Tetrahydrofolate
C00251  
Chorismate
C00266  
Glycolaldehyde
C00268  
Dihydrobiopterin
C00272  
Tetrahydrobiopterin
C00415  
Dihydrofolate
C00504  
Folate
C00568  
4-Aminobenzoate
C00921  
Dihydropteroate
C01217  
5,6,7,8-Tetrahydromethanopterin
C01300  
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
C03541  
THF-polyglutamate
C03684  
6-Pyruvoyltetrahydropterin
C04244  
6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  
2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine
C04874  
2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
C04895  
7,8-Dihydroneopterin 3'-triphosphate
C05922  
Formamidopyrimidine nucleoside triphosphate
C05923  
2,5-Diaminopyrimidine nucleoside triphosphate
C05924  
Molybdopterin
C05925  
Dihydroneopterin phosphate
C05926  
Neopterin
C05927  
7,8-Dihydromethanopterin
C06148  
2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06149  
6-(3'-Triphosphoryl-1'-methylglyceryl)-7-methyl-7,8-dihydrobiopterin
C09332  
THF-L-glutamate
C11355  
4-Amino-4-deoxychorismate
C15996  
7-Cyano-7-carbaguanine
C16675  
7-Aminomethyl-7-carbaguanine
C18239  
Precursor Z
C18802  
Tetrahydrosarcinapterin
C20239  
6-Carboxy-5,6,7,8-tetrahydropterin
C20248  
7-Carboxy-7-carbaguanine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
KO pathway
 

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