KEGG   PATHWAY: hsa00830Help
Entry
hsa00830                    Pathway                                

Name
Retinol metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Retinol metabolism
hsa00830

All organismsOrtholog table
Disease
H00527  
Retinitis pigmentosa (RP)
H00825  
Familial flecked retina syndrome
H00837  
Leber congenital amaurosis (LCR)
H01266  
Hypercarotenemia and vitamin A deficiency
Drug
D00707  
Fomepizole (JAN/USAN/INN)
D09385  
Talarozole (USAN/INN)
D10657  
Pradigastat sodium (USAN)
D10664  
Pradigastat (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
53630  
BCO1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]
124  
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  
ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  
ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  
ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  
ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  
ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.1 1.1.1.284]
130  
ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
9249  
DHRS3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
10901  
DHRS4; dehydrogenase/reductase 4 [KO:K11147] [EC:1.1.-.-]
728635  
DHRS4L1; dehydrogenase/reductase 4 like 1 [KO:K11147] [EC:1.1.-.-]
317749  
DHRS4L2; dehydrogenase/reductase 4 like 2 [KO:K11148] [EC:1.1.-.-]
10170  
DHRS9; dehydrogenase/reductase 9 [KO:K11149] [EC:1.1.-.-]
50700  
RDH8; retinol dehydrogenase 8 (all-trans) [KO:K11150] [EC:1.1.1.-]
157506  
RDH10; retinol dehydrogenase 10 (all-trans) [KO:K11151] [EC:1.1.1.-]
51109  
RDH11; retinol dehydrogenase 11 (all-trans/9-cis/11-cis) [KO:K11152] [EC:1.1.1.300]
145226  
RDH12; retinol dehydrogenase 12 (all-trans/9-cis/11-cis) [KO:K11153] [EC:1.1.1.300]
8608  
RDH16; retinol dehydrogenase 16 (all-trans) [KO:K11154] [EC:1.1.1.-]
195814  
SDR16C5; short chain dehydrogenase/reductase family 16C, member 5 [KO:K15734] [EC:1.1.1.105]
8630  
HSD17B6; hydroxysteroid 17-beta dehydrogenase 6 [KO:K13369] [EC:1.1.1.239 1.1.1.105 1.1.1.62]
9227  
LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) [KO:K00678] [EC:2.3.1.135]
8694  
DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.76 2.3.1.75 2.3.1.20]
158835  
AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.76 2.3.1.75]
8228  
PNPLA4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]
6121  
RPE65; RPE65, retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64]
5959  
RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
316  
AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
8854  
ALDH1A2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]
216  
ALDH1A1; aldehyde dehydrogenase 1 family member A1 [KO:K07249] [EC:1.2.1.36]
1592  
CYP26A1; cytochrome P450 family 26 subfamily A member 1 [KO:K07437]
56603  
CYP26B1; cytochrome P450 family 26 subfamily B member 1 [KO:K12664]
340665  
CYP26C1; cytochrome P450 family 26 subfamily C member 1 [KO:K12665]
1543  
CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
1544  
CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
1548  
CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.13.-]
1555  
CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709] [EC:1.14.13.-]
1558  
CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
1559  
CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1562  
CYP2C18; cytochrome P450 family 2 subfamily C member 18 [KO:K17720] [EC:1.14.14.1]
29785  
CYP2S1; cytochrome P450 family 2 subfamily S member 1 [KO:K07420] [EC:1.14.14.1]
1576  
CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.- 1.14.13.157 1.14.13.97 1.14.13.67 1.14.13.32]
1577  
CYP3A5; cytochrome P450 family 3 subfamily A member 5 [KO:K17690] [EC:1.14.14.1]
1551  
CYP3A7; cytochrome P450 family 3 subfamily A member 7 [KO:K17691] [EC:1.14.14.1]
CYP3A7-CYP3A51P; CYP3A7-CYP3A51P readthrough [KO:K17691] [EC:1.14.14.1]
1579  
CYP4A11; cytochrome P450 family 4 subfamily A member 11 [KO:K17687] [EC:1.14.15.3]
10941  
UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  
UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  
UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  
UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  
UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  
UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  
UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  
UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  
UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  
UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  
UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  
UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  
UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  
UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  
UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  
UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  
UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  
UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  
UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
54884  
RETSAT; retinol saturase [KO:K09516] [EC:1.3.99.23]
Compound
C00376  
Retinal
C00473  
Retinol
C00777  
Retinoate
C00778  
Rhodopsin
C00899  
11-cis-Retinol
C02075  
Retinyl ester
C02094  
beta-Carotene
C02110  
11-cis-Retinal
C02588  
Retinyl palmitate
C03455  
11-cis-Retinyl palmitate
C05914  
Bathorhodopsin
C05915  
Lumirhodopsin
C05916  
Metarhodopsin
C05917  
Iodopsin
C11061  
all-trans-Retinoyl-beta-glucuronide
C15492  
all-trans-13,14-Dihydroretinol
C15493  
9-cis-Retinoic acid
C16677  
all-trans-4-Hydroxyretinoic acid
C16678  
all-trans-4-Oxoretinoic acid
C16679  
all-trans-18-Hydroxyretinoic acid
C16680  
all-trans-5,6-Epoxyretinoic acid
C16681  
9-cis-Retinal
C16682  
9-cis-Retinol
C16683  
4-Oxoretinol
Reference
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
Reference
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
Reference
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
Reference
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
Reference
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
KO pathway
 

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