KEGG   PATHWAY: hsa00980Help
Entry
hsa00980                    Pathway                                

Name
Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Metabolism of xenobiotics by cytochrome P450
hsa00980

All organismsOrtholog table
Disease
H01075  
Peters anomaly
H01111  
Cortisone reductase deficiency (CRD)
H01203  
Primary congenital glaucoma (PCG)
Drug
D00707  
Fomepizole (JAN/USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
1543  
CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
1559  
CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1576  
CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.- 1.14.13.157 1.14.13.97 1.14.13.67 1.14.13.32]
1545  
CYP1B1; cytochrome P450 family 1 subfamily B member 1 [KO:K07410] [EC:1.14.14.1]
221357  
GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
2939  
GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
2941  
GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
119391  
GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
2948  
GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
2953  
GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
2952  
GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18]
2947  
GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
4257  
MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
4259  
MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
2950  
GSTP1; glutathione S-transferase pi 1 [KO:K00799] [EC:2.5.1.18]
2944  
GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
2949  
GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18]
4258  
MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
2938  
GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
2946  
GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18]
2940  
GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
9446  
GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
653689  
GSTT2B; glutathione S-transferase theta 2B (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
373156  
GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
27306  
HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:2.5.1.18 5.3.99.2]
2052  
EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
1555  
CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709] [EC:1.14.13.-]
6822  
SULT2A1; sulfotransferase family 2A member 1 [KO:K11822] [EC:2.8.2.14]
1544  
CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
1548  
CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.13.-]
1571  
CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.13.-]
1572  
CYP2F1; cytochrome P450 family 2 subfamily F member 1 [KO:K07416] [EC:1.14.14.1]
29785  
CYP2S1; cytochrome P450 family 2 subfamily S member 1 [KO:K07420] [EC:1.14.14.1]
1645  
AKR1C1; aldo-keto reductase family 1 member C1 [KO:K00212] [EC:1.3.1.20 1.1.1.357 1.1.1.149]
27294  
DHDH; dihydrodiol dehydrogenase [KO:K00078] [EC:1.1.1.179 1.3.1.20]
1553  
CYP2A13; cytochrome P450 family 2 subfamily A member 13 [KO:K17685] [EC:1.14.14.1]
1565  
CYP2D6; cytochrome P450 family 2 subfamily D member 6 [KO:K17712] [EC:1.14.14.1]
cytochrome P450 2D6-like [KO:K17712] [EC:1.14.14.1]
3290  
HSD11B1; hydroxysteroid 11-beta dehydrogenase 1 [KO:K15680] [EC:1.1.1.146]
873  
CBR1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.197 1.1.1.189 1.1.1.184]
874  
CBR3; carbonyl reductase 3 [KO:K00084] [EC:1.1.1.184]
10941  
UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  
UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  
UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  
UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  
UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  
UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  
UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  
UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  
UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  
UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  
UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  
UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  
UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  
UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  
UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  
UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  
UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  
UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  
UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
1577  
CYP3A5; cytochrome P450 family 3 subfamily A member 5 [KO:K17690] [EC:1.14.14.1]
8574  
AKR7A2; aldo-keto reductase family 7 member A2 [KO:K15303]
22977  
AKR7A3; aldo-keto reductase family 7 member A3 [KO:K15303]
221  
ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
222  
ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
220  
ALDH1A3; aldehyde dehydrogenase 1 family member A3 [KO:K00129] [EC:1.2.1.5]
218  
ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
124  
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  
ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  
ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  
ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  
ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  
ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.1 1.1.1.284]
130  
ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
Compound
C00745  
Nicotine
C00829  
Naphthalene
C02617  
1,4-Naphthoquinone
C03012  
Naphthalene-1,2-diol
C06205  
1,2-Dihydronaphthalene-1,2-diol
C06755  
Chloroacetic acid
C06790  
Trichloroethene
C06800  
Aflatoxin B1
C06899  
Chloral hydrate
C07490  
Trichloroethanol
C07535  
Benzo[a]pyrene
C11036  
Bromobenzene
C11088  
1,2-Dibromoethane
C11148  
TCE epoxide
C11149  
Dichloroacetate
C11150  
Trichloroacetate
C11278  
Aflatoxin B1exo-8,9-epoxide-GSH
C11713  
2-Naphthol
C11714  
1-Naphthol
C14039  
1,1-Dichloroethylene
C14040  
1-Nitronaphthalene
C14453  
4-Bromophenol
C14556  
9-Hydroxybenzo[a]pyrene
C14783  
1,2-Naphthoquinone
C14784  
1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  
1,4-Dihydroxynaphthalene
C14786  
(1R,2S)-Naphthalene 1,2-oxide
C14787  
(1S,2R)-Naphthalene 1,2-oxide
C14788  
1-Nitrosonaphthalene
C14789  
N-Hydroxy-1-aminonaphthalene
C14790  
1-Naphthylamine
C14791  
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  
(1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  
(1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  
(1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  
(1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  
1-Nitronaphthalene-5,6-oxide
C14801  
1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  
1-Nitronaphthalene-7,8-oxide
C14803  
1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  
1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  
1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  
1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  
Bromobenzene-3,4-oxide
C14840  
Bromobenzene-2,3-oxide
C14841  
2-Bromophenol
C14842  
Bromobenzene-2,3-dihydrodiol
C14843  
4-Bromocatechol
C14844  
Bromobenzene-3,4-dihydrodiol
C14845  
4-Bromophenol-2,3-epoxide
C14846  
4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  
3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  
2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  
Benzo[a]pyrene-9,10-oxide
C14850  
Benzo[a]pyrene-7,8-oxide
C14851  
Benzo[a]pyrene-4,5-oxide
C14852  
Benzo[a]pyrene-7,8-diol
C14853  
Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  
9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  
4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  
7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  
1,1-Dichloroethylene epoxide
C14858  
2,2-Dichloroacetaldehyde
C14859  
Chloroacetyl chloride
C14860  
2,2-Dichloro-1,1-ethanediol
C14861  
S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  
2-S-Glutathionyl acetate
C14863  
2-(S-Glutathionyl)acetyl glutathione
C14864  
S-(2-Chloroacetyl)glutathione
C14865  
2-(S-Glutathionyl)acetyl chloride
C14866  
Chloral
C14867  
Dichloroacetyl chloride
C14868  
S-(1,2-Dichlorovinyl)glutathione
C14869  
Trichloroethanol glucuronide
C14870  
2-Bromoacetaldehyde
C14871  
S-(Formylmethyl)glutathione
C14872  
Thiodiacetic acid
C14873  
Thiodiacetic acid sulfoxide
C14874  
Glutathione episulfonium ion
C14875  
S-(2-Hydroxyethyl)glutathione
C14876  
S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  
S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  
Aflatoxin M1
C19488  
7,12-Dimethylbenz[a]anthracene
C19489  
1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  
trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  
(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  
7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  
7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  
4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  
4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  
4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  
4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  
4-Oxo-1-(3-pyridyl)-1-butanone
C19568  
N-Nitrosomethanamine
C19569  
3-Succinoylpyridine
C19574  
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  
1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  
5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  
gamma-Hydroxy-3-pyridinebutanoate
C19580  
alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  
alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  
1-(3-Pyridinyl)-1,4-butanediol
C19585  
Aflatoxin Q1
C19586  
Aflatoxin B1-exo-8,9-epoxide
C19588  
Aflatoxin B1 diol
C19589  
Aflatoxin B1 dialdehyde
C19590  
6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  
1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  
alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  
Aflatoxin-M1-8,9-epoxide
C19595  
Aflatoxin B1-endo-8,9-epoxide
C19602  
4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  
7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  
NNAL-N-glucuronide
C19607  
trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
Reference
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
Reference
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
Reference
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
Reference
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
 

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