KEGG   PATHWAY: hsa00982Help
Entry
hsa00982                    Pathway                                

Name
Drug metabolism - cytochrome P450 - Homo sapiens (human)
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Drug metabolism - cytochrome P450
hsa00982

All organismsOrtholog table
Disease
H01171  
Poor drug metabolism (PM)
H01205  
Coumarin resistance
H01234  
Trimethylaminuria (TMAU)
Drug
D00505  
Phenelzine sulfate (USP)
D00707  
Fomepizole (JAN/USAN/INN)
D00785  
Selegiline hydrochloride (JAN/USP)
D00826  
Tranylcypromine sulfate (USP XXI)
D01097  
Lazabemide hydrochloride (JAN/USAN)
D01304  
Amezinium metilsulfate (JAN)
D01888  
Safrazine hydrochloride (JAN)
D02559  
Toloxatone (INN)
D02560  
Brofaromine (INN)
D02561  
Moclobemide (USAN/INN)
D02562  
Rasagiline mesylate (USAN)
D02563  
Befloxatone (INN)
D02564  
Pargyline hydrochloride (USAN)
D02579  
Iproniazid (INN)
D02580  
Isocarboxazid (INN)
D02581  
Cimoxatone (INN)
D03239  
Ladostigil tartrate (USAN)
D03248  
Clorgiline (INN)
D03409  
Caroxazone (USAN/INN)
D03731  
Selegiline (USAN/INN)
D03733  
Mofegiline hydrochloride (USAN)
D04092  
Etryptamine acetate (USAN)
D04681  
Lazabemide (USAN/INN)
D05033  
Milacemide hydrochloride (USAN)
D07337  
Nialamide (INN)
D07338  
Iproclozide (INN)
D08085  
Iproniazid phosphate
D08349  
Phenelzine (BAN)
D08392  
Pirlindole (INN)
D08393  
Pirlindole hydrochloride
D08453  
Pargyline (INN)
D08469  
Rasagiline (USAN/INN)
D08625  
Tranylcypromine (INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
1565  
CYP2D6; cytochrome P450 family 2 subfamily D member 6 [KO:K17712] [EC:1.14.14.1]
1559  
CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1576  
CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.- 1.14.13.157 1.14.13.97 1.14.13.67 1.14.13.32]
2326  
FMO1; flavin containing monooxygenase 1 [KO:K00485] [EC:1.14.13.8]
2327  
FMO2; flavin containing monooxygenase 2 [KO:K00485] [EC:1.14.13.8]
2330  
FMO5; flavin containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8]
2328  
FMO3; flavin containing monooxygenase 3 [KO:K00485] [EC:1.14.13.8]
2329  
FMO4; flavin containing monooxygenase 4 [KO:K00485] [EC:1.14.13.8]
1557  
CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17721] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1555  
CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709] [EC:1.14.13.-]
1577  
CYP3A5; cytochrome P450 family 3 subfamily A member 5 [KO:K17690] [EC:1.14.14.1]
221357  
GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
2939  
GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
2941  
GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
119391  
GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
2948  
GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
2953  
GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
2952  
GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18]
2947  
GSTM3; glutathione S-transferase mu 3 (brain) [KO:K00799] [EC:2.5.1.18]
4257  
MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
4259  
MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
2950  
GSTP1; glutathione S-transferase pi 1 [KO:K00799] [EC:2.5.1.18]
2944  
GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
2949  
GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18]
4258  
MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
2938  
GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
2946  
GSTM2; glutathione S-transferase mu 2 (muscle) [KO:K00799] [EC:2.5.1.18]
2940  
GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
9446  
GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
653689  
GSTT2B; glutathione S-transferase theta 2B (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
373156  
GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
27306  
HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:2.5.1.18 5.3.99.2]
124  
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  
ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  
ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  
ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  
ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  
ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.1 1.1.1.284]
130  
ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
221  
ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
222  
ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
220  
ALDH1A3; aldehyde dehydrogenase 1 family member A3 [KO:K00129] [EC:1.2.1.5]
218  
ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
4129  
MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  
MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
316  
AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
10941  
UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  
UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  
UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  
UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  
UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  
UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  
UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  
UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  
UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  
UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  
UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  
UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  
UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  
UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  
UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  
UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  
UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  
UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  
UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
1544  
CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
1571  
CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.13.-]
1558  
CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
1548  
CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.13.-]
Compound
C01471  
Acrolein
C01516  
Morphine
C05011  
Hydroxytamoxifen
C06174  
Codeine
C06754  
Chloroacetaldehyde
C06868  
Carbamazepine
C07047  
Ifosfamide
C07073  
Lidocaine
C07108  
Tamoxifen
C07163  
Methadone
C07185  
Valproic acid
C07492  
Oxcarbazepine
C07493  
10-Hydroxycarbazepine
C07495  
Dihydroxycarbazepine
C07496  
Carbamazepine-10,11-epoxide
C07501  
Felbamate
C07572  
Citalopram
C07643  
4-Hydroxycyclophosphamide
C07644  
4-Ketocyclophosphamide
C07645  
Aldophosphamide
C07646  
Carboxyphosphamide
C07647  
Phosphoramide mustard
C07888  
Cyclophosphamide
C08012  
Levomethadyl acetate
C11004  
2,6-Dimethylaniline
C11583  
4-Glutathionyl cyclophosphamide
C11785  
Normorphine
C16544  
alpha-Hydroxytamoxifen
C16545  
Tamoxifen N-oxide
C16546  
N-Desmethyltamoxifen
C16547  
Endoxifen
C16548  
N,N-Didesmethyltamoxifen
C16549  
alpha-Hydroxy-N-desmethyltamoxifen
C16550  
Dechloroethylcyclophosphamide
C16551  
Alcophosphamide
C16552  
Nornitrogen mustard
C16553  
4-Hydroxyifosfamide
C16554  
4-Ketoifosfamide
C16555  
2-Dechloroethylifosfamide
C16556  
Aldoifosfamide
C16557  
Carboxyifosfamide
C16558  
Alcoifosfamide
C16559  
Isophosphamide mustard
C16560  
3-Hydroxylidocaine
C16561  
Monoethylglycinexylidide
C16569  
Glycinexylidide
C16570  
4-Hydroxy-2,6-dimethylaniline
C16571  
2-Amino-3-methylbenzoate
C16572  
3-Hydroxymonoethylglycinexylidide
C16576  
Norcodeine
C16577  
Codeine-6-glucuronide
C16578  
Morphine-6-glucuronide
C16582  
2-Hydroxyfelbamate
C16584  
p-Hydroxyfelbamate
C16586  
2-Phenyl-1,3-propanediol monocarbamate
C16587  
3-Carbamoyl-2-phenylpropionaldehyde
C16591  
3-Carbamoyl-2-phenylpropionic acid
C16592  
Atropaldehyde
C16595  
4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  
5-Phenyl-1,3-oxazinane-2,4-dione
C16601  
2-Hydroxycarbamazepine
C16602  
3-Hydroxycarbamazepine
C16603  
2,3-Dihydroxycarbamazepine
C16604  
2-Hydroxyiminostilbene
C16605  
2H-Dibenz[b,f]azepin-2-one
C16606  
Carbamazepine-o-quinone
C16607  
Citalopram N-oxide
C16608  
Demethylcitalopram
C16609  
Didemethylcitalopram
C16610  
Citalopram propionic acid
C16612  
Citalopram aldehyde
C16643  
Morphine-3-glucuronide
C16648  
2-n-Propyl-4-pentenoic acid
C16649  
4-Hydroxyvalproic acid
C16650  
5-Hydroxyvalproic acid
C16651  
3-Hydroxyvalproic acid
C16652  
3-Oxovalproic acid
C16653  
2-n-Propyl-2-pentenoic acid
C16654  
2-n-Propyl-3-pentenoic acid
C16655  
2-n-Propyl-4-oxopentanoic acid
C16656  
2-Propyl-2,4-pentadienoic acid
C16657  
2-Propylsuccinic acid
C16658  
2-Propylglutaric acid
C16659  
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  
2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  
L-alpha-Acetyl-N-normethadol
C16662  
L-alpha-Acetyl-N,N-dinormethadol
D00195  
Codeine (USP)
D00252  
Carbamazepine (JP17/USP/INN)
D00343  
Ifosfamide (JAN/USP/INN)
D00358  
Lidocaine (JP17/USP/INN)
D00399  
Valproic acid (USP)
D00533  
Oxcarbazepine (JAN/USAN/INN)
D00536  
Felbamate (USAN/INN)
D04716  
Levomethadyl acetate (USAN)
D07704  
Citalopram (USP/INN)
D07760  
Cyclophosphamide (INN)
D08195  
Methadone (BAN)
D08233  
Morphine (BAN)
D08559  
Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
 

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