KEGG   PATHWAY: hsa01040Help
Entry
hsa01040                    Pathway                                

Name
Biosynthesis of unsaturated fatty acids - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Biosynthesis of unsaturated fatty acids
hsa01040

All organismsOrtholog table
Disease
H00407  
Peroxisomal beta-oxidation enzyme deficiency
Organism
Homo sapiens (human) [GN:hsa]
Gene
79071  
ELOVL6; ELOVL fatty acid elongase 6 [KO:K10203] [EC:2.3.1.199]
51144  
HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12 [KO:K10251] [EC:1.1.1.330 1.1.1.62]
201562  
HACD2; 3-hydroxyacyl-CoA dehydratase 2 [KO:K10703] [EC:4.2.1.134]
9200  
HACD1; 3-hydroxyacyl-CoA dehydratase 1 [KO:K10703] [EC:4.2.1.134]
401494  
HACD4; 3-hydroxyacyl-CoA dehydratase 4 [KO:K10703] [EC:4.2.1.134]
51495  
HACD3; 3-hydroxyacyl-CoA dehydratase 3 [KO:K10703] [EC:4.2.1.134]
9524  
TECR; trans-2,3-enoyl-CoA reductase [KO:K10258] [EC:1.3.1.93]
55825  
PECR; peroxisomal trans-2-enoyl-CoA reductase [KO:K07753] [EC:1.3.1.38]
6319  
SCD; stearoyl-CoA desaturase (delta-9-desaturase) [KO:K00507] [EC:1.14.19.1]
79966  
SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
9415  
FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
60481  
ELOVL5; ELOVL fatty acid elongase 5 [KO:K10244] [EC:2.3.1.199]
3992  
FADS1; fatty acid desaturase 1 [KO:K10224] [EC:1.14.19.44]
54898  
ELOVL2; ELOVL fatty acid elongase 2 [KO:K10205] [EC:2.3.1.199]
8310  
ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
51  
ACOX1; acyl-CoA oxidase 1, palmitoyl [KO:K00232] [EC:1.3.3.6]
3030  
HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:1.1.1.211 4.2.1.17]
30  
ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
122970  
ACOT4; acyl-CoA thioesterase 4 [KO:K01068] [EC:3.1.2.2]
10965  
ACOT2; acyl-CoA thioesterase 2 [KO:K01068] [EC:3.1.2.2]
641371  
ACOT1; acyl-CoA thioesterase 1 [KO:K01068] [EC:3.1.2.2]
11332  
ACOT7; acyl-CoA thioesterase 7 [KO:K17360] [EC:3.1.2.2]
570  
BAAT; bile acid-CoA:amino acid N-acyltransferase [KO:K00659] [EC:3.1.2.2 2.3.1.65]
Compound
C00154  
Palmitoyl-CoA
C00219  
Arachidonate
C00249  
Hexadecanoic acid
C00412  
Stearoyl-CoA
C00510  
Oleoyl-CoA
C00712  
(9Z)-Octadecenoic acid
C01203  
Oleoyl-[acyl-carrier protein]
C01530  
Octadecanoic acid
C01595  
Linoleate
C02041  
Eicosanoyl-CoA
C02050  
Linoleoyl-CoA
C02249  
Arachidonyl-CoA
C03035  
gamma-Linolenoyl-CoA
C03242  
(8Z,11Z,14Z)-Icosatrienoic acid
C03595  
8,11,14-Eicosatrienoyl-CoA
C04088  
Octadecanoyl-[acyl-carrier protein]
C05764  
Hexadecanoyl-[acp]
C06425  
Icosanoic acid
C06426  
(6Z,9Z,12Z)-Octadecatrienoic acid
C06427  
(9Z,12Z,15Z)-Octadecatrienoic acid
C06428  
(5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid
C06429  
(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid
C08281  
Docosanoic acid
C08316  
Erucic acid
C08320  
Tetracosanoic acid
C08323  
(15Z)-Tetracosenoic acid
C16160  
Linoleoyl-[acyl-carrier protein]
C16161  
alpha-Linolenoyl-ACP
C16162  
(9Z,12Z,15Z)-Octadecatrienoyl-CoA
C16163  
(6Z,9Z,12Z,15Z)-Octadecatetraenoyl-CoA
C16164  
(8Z,11Z,14Z,17Z)-Icosatetraenoyl-CoA
C16165  
(5Z,8Z,11Z,14Z,17Z)-Icosapentaenoyl-CoA
C16166  
(7Z,10Z,13Z,16Z,19Z)-Docosapentaenoyl-CoA
C16167  
(9Z,12Z,15Z,18Z,21Z)-Tetracosapentaenoyl-CoA
C16168  
(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA
C16169  
(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoyl-CoA
C16170  
(7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA
C16171  
(9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA
C16172  
(6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA
C16173  
(4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA
C16179  
(11Z,14Z,17Z)-Icosatrienoyl-CoA
C16180  
(11Z,14Z)-Icosadienoyl-CoA
C16513  
(7Z,10Z,13Z,16Z,19Z)-Docosa-7,10,13,16,19-pentaenoic acid
C16522  
Icosatrienoic acid
C16525  
Icosadienoic acid
C16526  
Icosenoic acid
C16527  
7,10,13,16-Docosatetraenoic acid
C16528  
Docosanoyl-CoA
C16529  
Tetracosanoyl-CoA
C16530  
Icosenoyl-CoA
C16531  
Docosenoyl-CoA
C16532  
Tetracosenoyl-CoA
C16533  
13,16-Docosadienoic acid
C16645  
(13Z,16Z)-Docosadi-13,16-enoyl-CoA
Reference
  Authors
Jakobsson A, Westerberg R, Jacobsson A.
  Title
Fatty acid elongases in mammals: their regulation and roles in metabolism.
  Journal
Prog Lipid Res 45:237-49 (2006)
Reference
  Authors
Moon YA, Horton JD.
  Title
Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.
  Journal
J Biol Chem 278:7335-43 (2003)
Reference
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM.
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
Reference
  Authors
Su HM, Moser AB, Moser HW, Watkins PA.
  Title
Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis.
  Journal
J Biol Chem 276:38115-20 (2001)
Reference
  Authors
Huyghe S, Mannaerts GP, Baes M, Van Veldhoven PP.
  Title
Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model.
  Journal
Biochim Biophys Acta 1761:973-94 (2006)
Reference
  Authors
Denic V, Weissman JS
  Title
A molecular caliper mechanism for determining very long-chain fatty acid length.
  Journal
Cell 130:663-77 (2007)
KO pathway
 

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