KEGG   PATHWAY: hsa03013Help
Entry
hsa03013                    Pathway                                

Name
RNA transport - Homo sapiens (human)
Description
RNA transport from the nucleus to the cytoplasm is  fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
RNA transport
hsa03013

All organismsOrtholog table
Module
Cap binding complex [PATH:hsa03013]
THC complex [PATH:hsa03013]
TREX complex [PATH:hsa03013]
Survival motor neuron (SMN) complex [PATH:hsa03013]
Nuclear pore complex [PATH:hsa03013]
eIF4F complex [PATH:hsa03013]
Exon junction complex (EJC) [PATH:hsa03013]
Disease
H00455  
Spinal muscular atrophy (SMA)
H00465  
Fragile X Syndrome
H00869  
Leukoencephalopathy with vanishing white matter
H01177  
Infantile bilateral striatal necrosis (IBSN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
10940  
POP1; POP1 homolog, ribonuclease P/MRP subunit [KO:K01164] [EC:3.1.26.5]
10557  
RPP38; ribonuclease P/MRP subunit p38 [KO:K14523] [EC:3.1.26.5]
10775  
POP4; POP4 homolog, ribonuclease P/MRP subunit [KO:K03538] [EC:3.1.26.5]
51367  
POP5; POP5 homolog, ribonuclease P/MRP subunit [KO:K03537] [EC:3.1.26.5]
138716  
RPP25L; ribonuclease P/MRP subunit p25 like [KO:K14525] [EC:3.1.26.5]
54913  
RPP25; ribonuclease P/MRP subunit p25 [KO:K14525] [EC:3.1.26.5]
10248  
POP7; POP7 homolog, ribonuclease P/MRP subunit [KO:K14527] [EC:3.1.26.5]
11102  
RPP14; ribonuclease P/MRP subunit p14 [KO:K14529] [EC:3.1.26.5]
10556  
RPP30; ribonuclease P/MRP subunit p30 [KO:K03539] [EC:3.1.26.5]
79897  
RPP21; ribonuclease P/MRP subunit p21 [KO:K03540] [EC:3.1.26.5]
10799  
RPP40; ribonuclease P/MRP subunit p40 [KO:K14530] [EC:3.1.26.5]
60528  
ELAC2; elaC ribonuclease Z 2 [KO:K00784] [EC:3.1.26.11]
55520  
ELAC1; elaC ribonuclease Z 1 [KO:K00784] [EC:3.1.26.11]
51095  
TRNT1; tRNA nucleotidyl transferase 1 [KO:K00974] [EC:3.1.4.- 3.1.3.- 2.7.7.72]
5901  
RAN; RAN, member RAS oncogene family [KO:K07936]
11260  
XPOT; exportin for tRNA [KO:K14288]
57510  
XPO5; exportin 5 [KO:K14289]
1915  
EEF1A1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]
1917  
EEF1A2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231]
7514  
XPO1; exportin 1 [KO:K14290]
51808  
PHAX; phosphorylated adaptor for RNA export [KO:K14291]
4686  
NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
22916  
NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
1207  
CLNS1A; chloride nucleotide-sensitive channel 1A [KO:K05019]
10419  
PRMT5; protein arginine methyltransferase 5 [KO:K02516] [EC:2.1.1.320]
96764  
TGS1; trimethylguanosine synthase 1 [KO:K14292] [EC:2.1.1.-]
3837  
KPNB1; karyopherin subunit beta 1 [KO:K14293]
10073  
SNUPN; snurportin 1 [KO:K13151]
51068  
NMD3; NMD3 ribosome export adaptor [KO:K07562]
84305  
PYM1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
7175  
TPR; translocated promoter region, nuclear basket protein [KO:K09291]
10762  
NUP50; nucleoporin 50 [KO:K14295]
9972  
NUP153; nucleoporin 153 [KO:K14296]
59343  
SENP2; SUMO1/sentrin/SMT3 specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
4928  
NUP98; nucleoporin 98 [KO:K14297]
8480  
RAE1; ribonucleic acid export 1 [KO:K14298]
6396  
SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
81929  
SEH1L; SEH1 like nucleoporin [KO:K14299]
55746  
NUP133; nucleoporin 133 [KO:K14300]
57122  
NUP107; nucleoporin 107 [KO:K14301]
79023  
NUP37; nucleoporin 37 [KO:K14302]
23279  
NUP160; nucleoporin 160 [KO:K14303]
79902  
NUP85; nucleoporin 85 [KO:K14304]
348995  
NUP43; nucleoporin 43 [KO:K14305]
23636  
NUP62; nucleoporin 62 [KO:K14306]
9818  
NUP58; nucleoporin 58 [KO:K14307]
53371  
NUP54; nucleoporin 54 [KO:K14308]
9688  
NUP93; nucleoporin 93 [KO:K14309]
23165  
NUP205; nucleoporin 205 [KO:K14310]
23511  
NUP188; nucleoporin 188 [KO:K14311]
9631  
NUP155; nucleoporin 155 [KO:K14312]
129401  
NUP35; nucleoporin 35 [KO:K14313]
23225  
NUP210; nucleoporin 210 [KO:K14314]
91181  
NUP210L; nucleoporin 210 like [KO:K14314]
55706  
NDC1; NDC1 transmembrane nucleoporin [KO:K14315]
POM121C; POM121 transmembrane nucleoporin C [KO:K14316]
9883  
POM121; POM121 transmembrane nucleoporin [KO:K14316]
94026  
POM121L2; POM121 transmembrane nucleoporin like 2 [KO:K14316]
8021  
NUP214; nucleoporin 214 [KO:K14317]
4927  
NUP88; nucleoporin 88 [KO:K14318]
5903  
RANBP2; RAN binding protein 2 [KO:K12172]
285190  
RGPD4; RANBP2-like and GRIP domain containing 4 [KO:K12172]
400966  
RGPD1; RANBP2-like and GRIP domain containing 1 [KO:K12172]
653489  
RGPD3; RANBP2-like and GRIP domain containing 3 [KO:K12172]
727851  
RGPD8; RANBP2-like and GRIP domain containing 8 [KO:K12172]
729857  
RGPD2; RANBP2-like and GRIP domain containing 2 [KO:K12172]
84220  
RGPD5; RANBP2-like and GRIP domain containing 5 [KO:K12172]
5905  
RANGAP1; Ran GTPase activating protein 1 [KO:K14319]
7329  
UBE2I; ubiquitin conjugating enzyme E2 I [KO:K10577]
6612  
SUMO3; small ubiquitin-like modifier 3 [KO:K12160]
6613  
SUMO2; small ubiquitin-like modifier 2 [KO:K12160]
7341  
SUMO1; small ubiquitin-like modifier 1 [KO:K12160]
387082  
SUMO4; small ubiquitin-like modifier 4 [KO:K12160]
8086  
AAAS; aladin WD repeat nucleoporin [KO:K14320]
11097  
NUPL2; nucleoporin like 2 [KO:K14321]
6606  
SMN1; survival of motor neuron 1, telomeric [KO:K13129]
6607  
SMN2; survival of motor neuron 2, centromeric [KO:K13129]
8487  
GEMIN2; gem nuclear organelle associated protein 2 [KO:K13130]
11218  
DDX20; DEAD-box helicase 20 [KO:K13131] [EC:3.6.4.13]
50628  
GEMIN4; gem nuclear organelle associated protein 4 [KO:K13132]
25929  
GEMIN5; gem nuclear organelle associated protein 5 [KO:K13133]
79833  
GEMIN6; gem nuclear organelle associated protein 6 [KO:K13134]
79760  
GEMIN7; gem nuclear organelle associated protein 7 [KO:K13135]
54960  
GEMIN8; gem nuclear organelle associated protein 8 [KO:K13136]
11171  
STRAP; serine/threonine kinase receptor associated protein [KO:K13137]
8669  
EIF3J; eukaryotic translation initiation factor 3 subunit J [KO:K03245]
8668  
EIF3I; eukaryotic translation initiation factor 3 subunit I [KO:K03246]
8667  
EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
8666  
EIF3G; eukaryotic translation initiation factor 3 subunit G [KO:K03248]
8665  
EIF3F; eukaryotic translation initiation factor 3 subunit F [KO:K03249]
3646  
EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
8664  
EIF3D; eukaryotic translation initiation factor 3 subunit D [KO:K03251]
8663  
EIF3C; eukaryotic translation initiation factor 3 subunit C [KO:K03252]
728689  
EIF3CL; eukaryotic translation initiation factor 3 subunit C-like [KO:K03252]
8662  
EIF3B; eukaryotic translation initiation factor 3 subunit B [KO:K03253]
8661  
EIF3A; eukaryotic translation initiation factor 3 subunit A [KO:K03254]
9086  
EIF1AY; eukaryotic translation initiation factor 1A, Y-linked [KO:K03236]
1964  
EIF1AX; eukaryotic translation initiation factor 1A, X-linked [KO:K03236]
10289  
EIF1B; eukaryotic translation initiation factor 1B [KO:K03113]
10209  
EIF1; eukaryotic translation initiation factor 1 [KO:K03113]
1983  
EIF5; eukaryotic translation initiation factor 5 [KO:K03262]
1965  
EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
8894  
EIF2S2; eukaryotic translation initiation factor 2 subunit beta [KO:K03238]
1968  
EIF2S3; eukaryotic translation initiation factor 2 subunit gamma [KO:K03242]
1967  
EIF2B1; eukaryotic translation initiation factor 2B subunit alpha [KO:K03239]
8892  
EIF2B2; eukaryotic translation initiation factor 2B subunit beta [KO:K03754]
8890  
EIF2B4; eukaryotic translation initiation factor 2B subunit delta [KO:K03680]
8891  
EIF2B3; eukaryotic translation initiation factor 2B subunit gamma [KO:K03241]
8893  
EIF2B5; eukaryotic translation initiation factor 2B subunit epsilon [KO:K03240]
9669  
EIF5B; eukaryotic translation initiation factor 5B [KO:K03243]
8672  
EIF4G3; eukaryotic translation initiation factor 4 gamma 3 [KO:K03260]
1981  
EIF4G1; eukaryotic translation initiation factor 4 gamma 1 [KO:K03260]
1982  
EIF4G2; eukaryotic translation initiation factor 4 gamma 2 [KO:K03260]
1977  
EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
9470  
EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
253314  
EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
1973  
EIF4A1; eukaryotic translation initiation factor 4A1 [KO:K03257]
1974  
EIF4A2; eukaryotic translation initiation factor 4A2 [KO:K03257]
1975  
EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
26986  
PABPC1; poly(A) binding protein cytoplasmic 1 [KO:K13126]
140886  
PABPC5; poly(A) binding protein cytoplasmic 5 [KO:K13126]
5042  
PABPC3; poly(A) binding protein cytoplasmic 3 [KO:K13126]
645974  
PABPC1L2B; poly(A) binding protein cytoplasmic 1 like 2B [KO:K13126]
80336  
PABPC1L; poly(A) binding protein cytoplasmic 1 like [KO:K13126]
340529  
PABPC1L2A; poly(A) binding protein cytoplasmic 1 like 2A [KO:K13126]
8761  
PABPC4; poly(A) binding protein cytoplasmic 4 [KO:K13126]
132430  
PABPC4L; poly(A) binding protein cytoplasmic 4 like [KO:K13126]
10605  
PAIP1; poly(A) binding protein interacting protein 1 [KO:K14322]
1978  
EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
1979  
EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2 [KO:K18644]
8637  
EIF4EBP3; eukaryotic translation initiation factor 4E binding protein 3 [KO:K18645]
10460  
TACC3; transforming acidic coiled-coil containing protein 3 [KO:K14283]
23191  
CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
26999  
CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
2332  
FMR1; fragile X mental retardation 1 [KO:K15516]
8087  
FXR1; FMR1 autosomal homolog 1 [KO:K15516]
9513  
FXR2; FMR1 autosomal homolog 2 [KO:K15516]
9939  
RBM8A; RNA binding motif protein 8A [KO:K12876]
4116  
MAGOH; mago homolog, exon junction complex core component [KO:K12877]
55110  
MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
22794  
CASC3; cancer susceptibility candidate 3 [KO:K14323]
9775  
EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:3.6.4.13]
10284  
SAP18; Sin3A associated protein 18 [KO:K14324]
5411  
PNN; pinin, desmosome associated protein [KO:K13114]
22985  
ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
10921  
RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
10189  
ALYREF; Aly/REF export factor [KO:K12881]
7919  
DDX39B; DEAD-box helicase 39B [KO:K12812] [EC:3.6.4.13]
9984  
THOC1; THO complex 1 [KO:K12878]
57187  
THOC2; THO complex 2 [KO:K12879]
8563  
THOC5; THO complex 5 [KO:K13174]
79228  
THOC6; THO complex 6 [KO:K13175]
80145  
THOC7; THO complex 7 [KO:K13176]
84321  
THOC3; THO complex 3 [KO:K12880]
10250  
SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
10482  
NXF1; nuclear RNA export factor 1 [KO:K14284]
56001  
NXF2; nuclear RNA export factor 2 [KO:K14284]
728343  
NXF2B; nuclear RNA export factor 2B [KO:K14284]
55998  
NXF5; nuclear RNA export factor 5 [KO:K14284]
56000  
NXF3; nuclear RNA export factor 3 [KO:K14284]
29107  
NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
55916  
NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
5976  
UPF1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:3.6.4.-]
26019  
UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
65109  
UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
65110  
UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
26827  
RNU6-1; RNA, U6 small nuclear 1 [KO:K14280]
780851  
SNORD3A; small nucleolar RNA, C/D box 3A [KO:K14483]
780853  
SNORD3C; small nucleolar RNA, C/D box 3C [KO:K14483]
780852  
SNORD3B-2; small nucleolar RNA, C/D box 3B-2 [KO:K14483]
26851  
SNORD3B-1; small nucleolar RNA, C/D box 3B-1 [KO:K14483]
 
Compound
C00035  
GDP
C00044  
GTP
C01647  
tRNA(Met)
Reference
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
Reference
  Authors
Suzuki T, Izumi H, Ohno M
  Title
Cajal body surveillance of U snRNA export complex assembly.
  Journal
J Cell Biol 190:603-12 (2010)
Reference
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
Reference
  Authors
Pellizzoni L
  Title
Chaperoning ribonucleoprotein biogenesis in health and disease.
  Journal
EMBO Rep 8:340-5 (2007)
Reference
  Authors
Gingras AC, Raught B, Sonenberg N
  Title
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
  Journal
Annu Rev Biochem 68:913-63 (1999)
Reference
  Authors
Asano K, Clayton J, Shalev A, Hinnebusch AG
  Title
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
  Journal
Genes Dev 14:2534-46 (2000)
Reference
PMID:9548260
  Authors
Craig AW, Haghighat A, Yu AT, Sonenberg N
  Title
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
  Journal
Nature 392:520-3 (1998)
Reference
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
Reference
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
KO pathway
 

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