KEGG   PATHWAY: hsa03018Help
Entry
hsa03018                    Pathway                                

Name
RNA degradation - Homo sapiens (human)
Description
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
RNA degradation
hsa03018

All organismsOrtholog table
Module
Exosome, archaea [PATH:hsa03018]
Exosome, eukaryotes [PATH:hsa03018]
Ski complex [PATH:hsa03018]
TRAMP complex [PATH:hsa03018]
Decapping complex [PATH:hsa03018]
Lsm 2-8 complex [PATH:hsa03018]
Lsm 1-7 complex [PATH:hsa03018]
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
28960  
DCPS; decapping enzyme, scavenger [KO:K12584] [EC:3.6.1.59]
51013  
EXOSC1; exosome component 1 [KO:K07573]
23404  
EXOSC2; exosome component 2 [KO:K03679]
51010  
EXOSC3; exosome component 3 [KO:K03681]
11340  
EXOSC8; exosome component 8 [KO:K12586]
118460  
EXOSC6; exosome component 6 [KO:K12587]
23016  
EXOSC7; exosome component 7 [KO:K12589]
54512  
EXOSC4; exosome component 4 [KO:K11600]
56915  
EXOSC5; exosome component 5 [KO:K12590]
5393  
EXOSC9; exosome component 9 [KO:K03678]
22894  
DIS3; DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [KO:K12585] [EC:3.1.13.-]
5394  
EXOSC10; exosome component 10 [KO:K12591] [EC:3.1.13.-]
10438  
C1D; C1D nuclear receptor corepressor [KO:K12592]
10200  
MPHOSPH6; M-phase phosphoprotein 6 [KO:K12593]
115752  
DIS3L; DIS3 like exosome 3'-5' exoribonuclease [KO:K18681] [EC:3.1.13.-]
11044  
PAPD7; PAP associated domain containing 7 [KO:K03514] [EC:2.7.7.19]
64282  
PAPD5; PAP associated domain containing 5 [KO:K03514] [EC:2.7.7.19]
84186  
ZCCHC7; zinc finger CCHC-type containing 7 [KO:K12597]
23517  
SKIV2L2; Ski2 like RNA helicase 2 [KO:K12598] [EC:3.6.4.13]
6499  
SKIV2L; Ski2 like RNA helicase [KO:K12599] [EC:3.6.4.-]
9652  
TTC37; tetratricopeptide repeat domain 37 [KO:K12600]
80349  
WDR61; WD repeat domain 61 [KO:K12602]
57472  
CNOT6; CCR4-NOT transcription complex subunit 6 [KO:K12603] [EC:3.1.13.4]
246175  
CNOT6L; CCR4-NOT transcription complex subunit 6 like [KO:K12603] [EC:3.1.13.4]
23019  
CNOT1; CCR4-NOT transcription complex subunit 1 [KO:K12604]
4848  
CNOT2; CCR4-NOT transcription complex subunit 2 [KO:K12605]
4849  
CNOT3; CCR4-NOT transcription complex subunit 3 [KO:K12580]
4850  
CNOT4; CCR4-NOT transcription complex subunit 4 [KO:K10643] [EC:2.3.2.27]
29883  
CNOT7; CCR4-NOT transcription complex subunit 7 [KO:K12581]
9337  
CNOT8; CCR4-NOT transcription complex subunit 8 [KO:K12581]
9125  
CNOT9; CCR4-NOT transcription complex subunit 9 [KO:K12606]
25904  
CNOT10; CCR4-NOT transcription complex subunit 10 [KO:K12607]
170506  
DHX36; DEAH-box helicase 36 [KO:K14442] [EC:3.6.4.13]
5073  
PARN; poly(A)-specific ribonuclease [KO:K01148] [EC:3.1.13.4]
10140  
TOB1; transducer of ERBB2, 1 [KO:K14443]
10766  
TOB2; transducer of ERBB2, 2 [KO:K14443]
10950  
BTG3; BTG anti-proliferation factor 3 [KO:K14443]
54766  
BTG4; BTG anti-proliferation factor 4 [KO:K14443]
694  
BTG1; BTG anti-proliferation factor 1 [KO:K14443]
7832  
BTG2; BTG anti-proliferation factor 2 [KO:K14443]
26986  
PABPC1; poly(A) binding protein cytoplasmic 1 [KO:K13126]
140886  
PABPC5; poly(A) binding protein cytoplasmic 5 [KO:K13126]
5042  
PABPC3; poly(A) binding protein cytoplasmic 3 [KO:K13126]
645974  
PABPC1L2B; poly(A) binding protein cytoplasmic 1 like 2B [KO:K13126]
80336  
PABPC1L; poly(A) binding protein cytoplasmic 1 like [KO:K13126]
340529  
PABPC1L2A; poly(A) binding protein cytoplasmic 1 like 2A [KO:K13126]
8761  
PABPC4; poly(A) binding protein cytoplasmic 4 [KO:K13126]
132430  
PABPC4L; poly(A) binding protein cytoplasmic 4 like [KO:K13126]
9924  
PAN2; PAN2 poly(A) specific ribonuclease subunit [KO:K12571] [EC:3.1.13.4]
255967  
PAN3; PAN3 poly(A) specific ribonuclease subunit [KO:K12572]
55802  
DCP1A; decapping mRNA 1A [KO:K12610] [EC:3.-.-.-]
196513  
DCP1B; decapping mRNA 1B [KO:K12611] [EC:3.-.-.-]
167227  
DCP2; decapping mRNA 2 [KO:K12613] [EC:3.6.1.62]
1656  
DDX6; DEAD-box helicase 6 [KO:K12614] [EC:3.6.4.13]
80153  
EDC3; enhancer of mRNA decapping 3 [KO:K12615]
23644  
EDC4; enhancer of mRNA decapping 4 [KO:K12616]
219988  
PATL1; PAT1 homolog 1, processing body mRNA decay factor [KO:K12617]
54464  
XRN1; 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
22803  
XRN2; 5'-3' exoribonuclease 2 [KO:K12619] [EC:3.1.13.-]
131870  
NUDT16; nudix hydrolase 16 [KO:K16855] [EC:3.6.1.64 3.6.1.62]
27257  
LSM1; LSM1 homolog, mRNA degradation associated [KO:K12620]
57819  
LSM2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12621]
27258  
LSM3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12622]
25804  
LSM4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12623]
23658  
LSM5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12624]
11157  
LSM6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12625]
51690  
LSM7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12626]
51691  
LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
2027  
ENO3; enolase 3 [KO:K01689] [EC:4.2.1.11]
2026  
ENO2; enolase 2 [KO:K01689] [EC:4.2.1.11]
2023  
ENO1; enolase 1 [KO:K01689] [EC:4.2.1.11]
87178  
PNPT1; polyribonucleotide nucleotidyltransferase 1 [KO:K00962] [EC:2.7.7.8]
5213  
PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
5214  
PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
5211  
PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
3313  
HSPA9; heat shock protein family A (Hsp70) member 9 [KO:K04043]
3329  
HSPD1; heat shock protein family D (Hsp60) member 1 [KO:K04077]
Reference
  Authors
Houseley J, Tollervey D
  Title
The many pathways of RNA degradation.
  Journal
Cell 136:763-76 (2009)
Reference
  Authors
Buttner K, Wenig K, Hopfner KP
  Title
The exosome: a macromolecular cage for controlled RNA degradation.
  Journal
Mol Microbiol 61:1372-9 (2006)
Reference
  Authors
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
  Title
Cell and molecular biology of the exosome: how to make or break an RNA.
  Journal
Int Rev Cytol 251:159-208 (2006)
Reference
  Authors
Hartung S, Hopfner KP
  Title
The exosome, plugged.
  Journal
EMBO Rep 8:456-7 (2007)
Reference
  Authors
Carpousis AJ
  Title
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
  Journal
Annu Rev Microbiol 61:71-87 (2007)
Reference
  Authors
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
  Title
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
  Journal
Trends Biochem Sci 31:359-65 (2006)
Reference
  Authors
Condon C
  Title
Maturation and degradation of RNA in bacteria.
  Journal
Curr Opin Microbiol 10:271-8 (2007)
KO pathway
 

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