KEGG   PATHWAY: hsa03060Help
Entry
hsa03060                    Pathway                                

Name
Protein export - Homo sapiens (human)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein export
hsa03060

All organismsOrtholog table
Module
Sec61 complex [PATH:hsa03060]
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
5018  
OXA1L; OXA1L, mitochondrial inner membrane protein [KO:K03217]
6729  
SRP54; signal recognition particle 54 [KO:K03106] [EC:3.6.5.4]
29927  
SEC61A1; Sec61 translocon alpha 1 subunit [KO:K10956]
55176  
SEC61A2; Sec61 translocon alpha 2 subunit [KO:K10956]
10952  
SEC61B; Sec61 translocon beta subunit [KO:K09481]
23480  
SEC61G; Sec61 translocon gamma subunit [KO:K07342]
7095  
SEC62; SEC62 homolog, preprotein translocation factor [KO:K12275]
11231  
SEC63; SEC63 homolog, protein translocation regulator [KO:K09540]
3309  
HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490]
6726  
SRP9; signal recognition particle 9 [KO:K03109]
6727  
SRP14; signal recognition particle 14 [KO:K03104]
6731  
SRP72; signal recognition particle 72 [KO:K03108]
6730  
SRP68; signal recognition particle 68 [KO:K03107]
6728  
SRP19; signal recognition particle 19 [KO:K03105]
6734  
SRPRA; SRP receptor alpha subunit [KO:K13431]
58477  
SRPRB; SRP receptor beta subunit [KO:K12272]
28972  
SPCS1; signal peptidase complex subunit 1 [KO:K12946] [EC:3.4.-.-]
9789  
SPCS2; signal peptidase complex subunit 2 [KO:K12947] [EC:3.4.-.-]
60559  
SPCS3; signal peptidase complex subunit 3 [KO:K12948] [EC:3.4.-.-]
90701  
SEC11C; SEC11 homolog C, signal peptidase complex subunit [KO:K13280] [EC:3.4.-.-]
23478  
SEC11A; SEC11 homolog A, signal peptidase complex subunit [KO:K13280] [EC:3.4.-.-]
196294  
IMMP1L; inner mitochondrial membrane peptidase subunit 1 [KO:K09647] [EC:3.4.21.-]
83943  
IMMP2L; inner mitochondrial membrane peptidase subunit 2 [KO:K09648] [EC:3.4.21.-]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
KO pathway
 

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