KEGG PATHWAY: hsa03410

PATHWAY: hsa03410

Entry

hsa03410 Pathway

Name

Base excision repair - Homo sapiens (human)

Description

Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.

Class

Genetic Information Processing; Replication and repair

Pathway map

hsa03410

Base excision repair

Module

hsa_M00262	DNA polymerase delta complex [PATH:hsa03410]
hsa_M00296	BER complex [PATH:hsa03410]

Disease

H01025	Familial adenomatous polyposis
H02014	Ataxia-telangiectasia-like syndrome

Other DBs

BSID:

83043

GO:

0006284 0006285 0006286 0006287 0006288

Organism

Homo sapiens (human) [GN:hsa]

Gene

4968	OGG1; 8-oxoguanine DNA glycosylase [KO:K03660] [EC:4.2.99.18 3.2.2.-]
4913	NTHL1; nth like DNA glycosylase 1 [KO:K10773] [EC:4.2.99.18]
79661	NEIL1; nei like DNA glycosylase 1 [KO:K10567] [EC:4.2.99.18 3.2.2.-]
252969	NEIL2; nei like DNA glycosylase 2 [KO:K10568] [EC:4.2.99.18 3.2.2.-]
55247	NEIL3; nei like DNA glycosylase 3 [KO:K10569]
7374	UNG; uracil DNA glycosylase [KO:K03648] [EC:3.2.2.27]
23583	SMUG1; single-strand-selective monofunctional uracil-DNA glycosylase 1 [KO:K10800] [EC:3.2.2.-]
4595	MUTYH; mutY DNA glycosylase [KO:K03575] [EC:3.2.2.31]
4350	MPG; N-methylpurine DNA glycosylase [KO:K03652] [EC:3.2.2.21]
8930	MBD4; methyl-CpG binding domain 4, DNA glycosylase [KO:K10801] [EC:3.2.2.-]
6996	TDG; thymine DNA glycosylase [KO:K20813] [EC:3.2.2.29]
328	APEX1; apurinic/apyrimidinic endodeoxyribonuclease 1 [KO:K10771] [EC:4.2.99.18]
27301	APEX2; apurinic/apyrimidinic endodeoxyribonuclease 2 [KO:K10772] [EC:4.2.99.18]
5423	POLB; DNA polymerase beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
27343	POLL; DNA polymerase lambda [KO:K03512] [EC:4.2.99.- 2.7.7.7]
3146	HMGB1; high mobility group box 1 [KO:K10802]
7515	XRCC1; X-ray repair cross complementing 1 [KO:K10803]
5111	PCNA; proliferating cell nuclear antigen [KO:K04802]
5424	POLD1; DNA polymerase delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
5425	POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
10714	POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
57804	POLD4; DNA polymerase delta 4, accessory subunit [KO:K03505]
5426	POLE; DNA polymerase epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
5427	POLE2; DNA polymerase epsilon 2, accessory subunit [KO:K02325] [EC:2.7.7.7]
54107	POLE3; DNA polymerase epsilon 3, accessory subunit [KO:K02326] [EC:2.7.7.7]
56655	POLE4; DNA polymerase epsilon 4, accessory subunit [KO:K03506] [EC:2.7.7.7]
3978	LIG1; DNA ligase 1 [KO:K10747] [EC:6.5.1.7 6.5.1.6 6.5.1.1]
3980	LIG3; DNA ligase 3 [KO:K10776] [EC:6.5.1.1]
10038	PARP2; poly(ADP-ribose) polymerase 2 [KO:K10798] [EC:2.4.2.30]
142	PARP1; poly(ADP-ribose) polymerase 1 [KO:K10798] [EC:2.4.2.30]
10039	PARP3; poly(ADP-ribose) polymerase family member 3 [KO:K10798] [EC:2.4.2.30]
143	PARP4; poly(ADP-ribose) polymerase family member 4 [KO:K10798] [EC:2.4.2.30]
2237	FEN1; flap structure-specific endonuclease 1 [KO:K04799] [EC:3.-.-.-]

Reference

PMID:17893748

Authors

Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.

Title

Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.

Journal

Acta Biochim Pol 54:413-34 (2007)

Reference

PMID:17337257

Authors

Almeida KH, Sobol RW.

Title

A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.

Journal

DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009

Reference

PMID:21665970

Authors

Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S

Title

Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.

Journal

J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11

Reference

PMID:11436317

Authors

Ikeda S, Seki S.

Title

[Base excision repair: DNA glycosylase and AP endonuclease] Japanese

Journal

Tanpakushitsu Kakusan Koso 46:916-23 (2001)

KO pathway

ko03410

All links

Pathway (1)   
   BioSystems (1)   
Disease (2)   
   KEGG DISEASE (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG GENES (33)   
All databases (37)   

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