KEGG   PATHWAY: hsa03450Help
Entry
hsa03450                    Pathway                                

Name
Non-homologous end-joining - Homo sapiens (human)
Description
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Non-homologous end-joining
hsa03450

All organismsOrtholog table
Module
DNA-PK complex [PATH:hsa03450]
Disease
H00848  
Ataxia with ocular apraxia (AOA)
H00924  
Severe combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation
H01344  
Nijmegen Breakage Syndrome
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
2547  
XRCC6; X-ray repair complementing defective repair in Chinese hamster cells 6 [KO:K10884]
7520  
XRCC5; X-ray repair complementing defective repair in Chinese hamster cells 5 [KO:K10885]
64421  
DCLRE1C; DNA cross-link repair 1C [KO:K10887] [EC:3.1.-.-]
5591  
PRKDC; protein kinase, DNA-activated, catalytic polypeptide [KO:K06642] [EC:2.7.11.1]
27343  
POLL; polymerase (DNA) lambda [KO:K03512] [EC:4.2.99.- 2.7.7.7]
27434  
POLM; polymerase (DNA) mu [KO:K03513] [EC:2.7.7.7]
1791  
DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
3981  
LIG4; DNA ligase 4 [KO:K10777] [EC:6.5.1.1]
7518  
XRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4 [KO:K10886]
79840  
NHEJ1; non-homologous end joining factor 1 [KO:K10980]
10111  
RAD50; RAD50 double strand break repair protein [KO:K10866] [EC:3.6.-.-]
4361  
MRE11A; MRE11 homolog A, double strand break repair nuclease [KO:K10865]
2237  
FEN1; flap structure-specific endonuclease 1 [KO:K04799] [EC:3.-.-.-]
Reference
  Authors
Gennery AR.
  Title
Primary immunodeficiency syndromes associated with defective DNA double-strand break repair.
  Journal
Br Med Bull 77-78:71-85 (2006)
Reference
  Authors
Zhang Y, Hefferin ML, Chen L, Shim EY, Tseng HM, Kwon Y, Sung P, Lee SE, Tomkinson AE.
  Title
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination.
  Journal
Nat Struct Mol Biol 14:639-46 (2007)
Reference
  Authors
Wyman C, Kanaar R.
  Title
DNA double-strand break repair: all's well that ends well.
  Journal
Annu Rev Genet 40:363-83 (2006)
Reference
  Authors
Weller GR, Brandt VL, Roth DB.
  Title
Doing more with less in bacterial DNA repair.
  Journal
Nat Struct Mol Biol 11:1158-9 (2004)
Reference
  Authors
Weller GR, Kysela B, Roy R, Tonkin LM, Scanlan E, Della M, Devine SK, Day JP, Wilkinson A, d'Adda di Fagagna F, Devine KM, Bowater RP, Jeggo PA, Jackson SP, Doherty AJ.
  Title
Identification of a DNA nonhomologous end-joining complex in bacteria.
  Journal
Science 297:1686-9 (2002)
Reference
  Authors
Pitcher RS, Brissett NC, Doherty AJ.
  Title
Nonhomologous end-joining in bacteria: a microbial perspective.
  Journal
Annu Rev Microbiol 61:259-82 (2007)
KO pathway
 

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