KEGG   PATHWAY: hsa03460Help
Entry
hsa03460                    Pathway                                

Name
Fanconi anemia pathway - Homo sapiens (human)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
hsa03460  Fanconi anemia pathway
hsa03460

Ortholog table
Module
hsa_M00293  DNA polymerase zeta complex [PATH:hsa03460]
hsa_M00295  BRCA1-associated genome surveillance complex (BASC) [PATH:hsa03460]
hsa_M00413  FA core complex [PATH:hsa03460]
hsa_M00414  Bloom's syndrome complex [PATH:hsa03460]
Disease
H00238  Fanconi anemia
H00992  Seckel syndrome
H01346  Bloom syndrome
Other DBs
BSID: 377262
GO: 0043240
Organism
Homo sapiens (human) [GN:hsa]
Gene
84126  ATRIP; ATR interacting protein [KO:K10905]
545  ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
57697  FANCM; Fanconi anemia complementation group M [KO:K10896]
91442  FAAP24; Fanconi anemia core complex associated protein 24 [KO:K10898]
378708  CENPS; centromere protein S [KO:K11511]
100526739  CENPS-CORT; CENPS-CORT readthrough [KO:K11511]
201254  CENPX; centromere protein X [KO:K15360]
9894  TELO2; telomere maintenance 2 [KO:K11137]
3280  HES1; hes family bHLH transcription factor 1 [KO:K06054]
80233  FAAP100; Fanconi anemia core complex associated protein 100 [KO:K10993]
2175  FANCA; Fanconi anemia complementation group A [KO:K10888]
2187  FANCB; Fanconi anemia complementation group B [KO:K10889]
2176  FANCC; Fanconi anemia complementation group C [KO:K10890]
2178  FANCE; Fanconi anemia complementation group E [KO:K10892]
2188  FANCF; Fanconi anemia complementation group F [KO:K10893]
2189  FANCG; Fanconi anemia complementation group G [KO:K10894]
55120  FANCL; Fanconi anemia complementation group L [KO:K10606] [EC:2.3.2.27]
57599  WDR48; WD repeat domain 48 [KO:K15361]
7398  USP1; ubiquitin specific peptidase 1 [KO:K11832] [EC:3.4.19.12]
29089  UBE2T; ubiquitin conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
55215  FANCI; Fanconi anemia complementation group I [KO:K10895]
2177  FANCD2; Fanconi anemia complementation group D2 [KO:K10891]
675  BRCA2; BRCA2, DNA repair associated [KO:K08775]
79728  PALB2; partner and localizer of BRCA2 [KO:K10897]
5889  RAD51C; RAD51 paralog C [KO:K10870]
5888  RAD51; RAD51 recombinase [KO:K04482]
672  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
83990  BRIP1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:3.6.4.12]
22909  FAN1; FANCD2 and FANCI associated nuclease 1 [KO:K15363] [EC:3.1.4.1 3.1.21.-]
4292  MLH1; mutL homolog 1 [KO:K08734]
5395  PMS2; PMS1 homolog 2, mismatch repair system component [KO:K10858]
51455  REV1; REV1, DNA directed polymerase [KO:K03515] [EC:2.7.7.-]
5980  REV3L; REV3 like, DNA directed polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
5429  POLH; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
11201  POLI; DNA polymerase iota [KO:K03510] [EC:2.7.7.7]
51426  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
353497  POLN; DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
80010  RMI1; RecQ mediated genome instability 1 [KO:K10990]
116028  RMI2; RecQ mediated genome instability 2 [KO:K15365]
7156  TOP3A; DNA topoisomerase III alpha [KO:K03165] [EC:5.99.1.2]
8940  TOP3B; DNA topoisomerase III beta [KO:K03165] [EC:5.99.1.2]
641  BLM; Bloom syndrome RecQ like helicase [KO:K10901] [EC:3.6.4.12]
6117  RPA1; replication protein A1 [KO:K07466]
6118  RPA2; replication protein A2 [KO:K10739]
6119  RPA3; replication protein A3 [KO:K10740]
29935  RPA4; replication protein A4 [KO:K10741]
80198  MUS81; MUS81 structure-specific endonuclease subunit [KO:K08991] [EC:3.1.22.-]
146956  EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
197342  EME2; essential meiotic structure-specific endonuclease subunit 2 [KO:K10883]
2072  ERCC4; ERCC excision repair 4, endonuclease catalytic subunit [KO:K10848] [EC:3.1.-.-]
2067  ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit [KO:K10849]
548593  SLX1A; SLX1 homolog A, structure-specific endonuclease subunit [KO:K15078] [EC:3.6.1.-]
79008  SLX1B; SLX1 homolog B, structure-specific endonuclease subunit [KO:K15078] [EC:3.6.1.-]
105369236  structure-specific endonuclease subunit SLX1 [KO:K15078] [EC:3.6.1.-]
84464  SLX4; SLX4 structure-specific endonuclease subunit [KO:K10484]
Reference
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
KO pathway
ko03460   

DBGET integrated database retrieval system