KEGG PATHWAY: hsa04020

PATHWAY: hsa04020

Entry

hsa04020 Pathway

Name

Calcium signaling pathway - Homo sapiens (human)

Description

Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).

Class

Environmental Information Processing; Signal transduction

Pathway map

hsa04020

Calcium signaling pathway

Disease

H00608	46,XY disorders of sex development (Disorders in androgen synthesis or action)
H00627	Premature ovarian failure
H00699	Central core disease
H00715	Darier disease
H00728	Brugada syndrome (BRS)
H00746	Hypokalemic periodic paralysis (HypoPP)
H00749	Episodic ataxias
H00755	Acrokeratosis verruciformis
H00759	Waardenburg syndrome (WS)
H00775	Familial or sporadic hemiplegic migraine
H00787	Congenital stationary night blindness (CSNB)
H00801	Familial thoracic aortic aneurysm and dissection (TAAD)
H00823	ABCD syndrome
H00865	Lethal congenital contractural syndrome (LCCS)
H00910	Hirschsprung disease (HD)
H00937	Precocious puberty
H01019	Catecholaminergic polymorphic ventricular tachycardia
H01118	Progressive external ophthalmoplegia (PEO)
H01129	Brody myopathy
H01307	Nonsyndromic congenital nail disorder (NDNC)
H01310	Multi-minicore disease (MmD)

Drug

D00045	Adenosine (JAN/USP)
D00059	Levodopa (JP16/USP/INN)
D00076	Noradrenaline (JP16)
D00081	Dinoprost (JP16/USAN/INN)
D00089	Oxytocin (JP16/USP/INN)
D00095	Adrenaline (JP16)
D00101	Vasopressin (JP16/USP)
D00113	Atropine (USP)
D00124	Ephedrine (USP)
D00138	Scopolamine (INN)
D00147	Hyoscyamine (USP)
D00150	Angiotensin II (INN)
D00176	Protirelin (JP16/USAN/INN)
D00180	Alprostadil (JP16/USP/INN)
D00227	Aminophylline (USP/INN)
D00232	Methyloctatropine bromide (JAN)
D00234	Astemizole (JAN/USP/INN)
D00235	Atenolol (JP16/USP/INN)
D00255	Carvedilol (JAN/USAN/INN)
D00270	Chlorpromazine (USP/INN)
D00274	Cisapride (USAN/INN)
D00283	Clozapine (JAN/USP/INN)
D00291	Desmopressin (INN)
D00295	Cimetidine (JP16/USP/INN)
D00300	Diphenhydramine (JP16/INN)
D00304	Divalproex sodium (USP)
D00318	Famotidine (JP16/USP/INN)
D00319	Felodipine (JAN/USP/INN)
D00349	Isradipine (USP/INN)
D00356	Latanoprost (JAN/USAN/INN)
D00357	Losartan potassium (JP16/USAN)
D00364	Loratadine (JAN/USAN/INN)
D00366	Lypressin (USP/INN)
D00371	Theophylline (JP16)
D00374	Tiotixene (JAN)
D00378	Timolol (USAN)
D00397	Tropicamide (JP16/USP/INN)
D00399	Valproic acid (USP)
D00400	Valsartan (JP16/USAN/INN)
D00403	Levomepromazine (USAN/INN)
D00411	Zafirlukast (JAN/USAN/INN)
D00422	Ranitidine (USAN/INN)
D00426	Risperidone (JP16/USAN/INN)
D00432	Nadolol (JP16/USP/INN)
D00437	Nifedipine (JP16/USP/INN)
D00438	Nimodipine (USAN/INN)
D00440	Nizatidine (JP16/USP/INN)
D00454	Olanzapine (JAN/USAN/INN)
D00458	Quetiapine fumarate (JP16/USAN)
D00465	Oxybutynin (USAN/INN)
D00480	Promethazine hydrochloride (JP16/USP)
D00481	Propantheline bromide (JP16/USP/INN)
D00483	Propranolol hydrochloride (JP16/USP)
D00485	Pseudoephedrine hydrochloride (USP)
D00494	Promethazine (JAN/INN)
D00502	Pergolide mesilate (JAN)
D00507	Phenoxybenzamine hydrochloride (USP)
D00509	Phentolamine mesilate (JAN/INN)
D00511	Phenylephrine hydrochloride (JP16/USP)
D00513	Pindolol (JP16/USP/INN)
D00520	Dimenhydrinate (JP16/USP/INN)
D00521	Terfenadine (JAN/USAN/INN)
D00522	Candesartan (USAN/INN)
D00523	Irbesartan (JAN/USAN/INN)
D00524	Carbachol (JAN/USP/INN)
D00525	Pilocarpine (JAN/USP)
D00528	Anhydrous caffeine (JP16)
D00529	Montelukast sodium (JAN/USAN)
D00537	Topiramate (JAN/USAN/INN)
D00538	Zonisamide (JAN/USAN/INN)
D00539	Ethosuximide (JP16/USP/INN)
D00540	Glycopyrronium bromide (JAN/INN)
D00560	Pimozide (JP16/USP/INN)
D00561	Sertindole (USAN/INN)
D00563	Mirtazapine (JAN/USAN/INN)
D00597	Acebutolol hydrochloride (JP16/USP)
D00598	Betaxolol hydrochloride (JP16/USP)
D00599	Carteolol hydrochloride (JP16/USP)
D00600	Labetalol hydrochloride (JP16/USP)
D00601	Metoprolol tartrate (JP16/USP)
D00602	Penbutolol sulfate (JP16/USP)
D00603	Timolol maleate (JP16/USP)
D00607	Guanadrel sulfate (USP)
D00608	Doxazosin mesilate (JP16)
D00609	Prazosin hydrochloride (JP16/USP)
D00610	Terazosin hydrochloride hydrate (JAN)
D00611	Mecamylamine hydrochloride (USP)
D00613	Fenoldopam mesylate (USP)
D00615	Amlodipine besilate (JP16)
D00616	Diltiazem hydrochloride (JP16/USP)
D00617	Nicardipine hydrochloride (JP16/USAN)
D00618	Nisoldipine (JAN/USAN/INN)
D00619	Verapamil hydrochloride (JP16/USP)
D00626	Candesartan cilexetil (JP16/USAN)
D00627	Telmisartan (JAN/USAN/INN)
D00629	Nitrendipine (JP16/USAN/INN)
D00631	Bepridil hydrochloride hydrate (JAN)
D00632	Dobutamine hydrochloride (JP16/USP)
D00633	Dopamine hydrochloride (JP16/USP)
D00634	Bisoprolol fumarate (JP16/USP)
D00635	Metoprolol succinate (USP)
D00636	Amiodarone hydrochloride (JP16/USAN)
D00644	Esmolol hydrochloride (JAN/USAN)
D00646	Tolterodine (USAN/INN)
D00659	Azelastine hydrochloride (JP16/USAN)
D00661	Cevimeline hydrochloride hydrate (JAN)
D00662	Azatadine maleate (USP)
D00663	Brompheniramine maleate (USAN)
D00664	Cetirizine hydrochloride (JP16/USAN)
D00665	Chlorpheniramine maleate (JP16/USP)
D00666	Clemastine fumarate (JP16/USP)
D00668	d-Chlorpheniramine maleate (JP16)
D00669	Diphenhydramine hydrochloride (JP16/USP)
D00671	Fexofenadine hydrochloride (JP16/USAN)
D00672	Hydroxyzine hydrochloride (JP16/USP)
D00673	Ranitidine hydrochloride (JP16/USP)
D00679	Ergotamine tartrate (JP16/USP)
D00680	Methylergometrine maleate (JP16)
D00682	Carboprost tromethamine (USP)
D00683	Salbutamol sulfate (JP16)
D00684	Bitolterol mesilate (JAN)
D00685	Orciprenaline sulfate (JP16)
D00686	Pirbuterol acetate (USAN)
D00687	Salmeterol xinafoate (JAN/USAN)
D00688	Terbutaline sulfate (JP16/USP)
D00710	Sodium valproate (JP16)
D00711	Ketamine hydrochloride (JP16/USP)
D00715	Hyoscine methobromide (INN)
D00717	Dicyclomine hydrochloride (JAN/USP)
D00719	Hyoscyamine sulfate (USP)
D00720	Mepenzolate bromide (JP16/INN)
D00721	Methanthelinium bromide (INN)
D00722	Oxybutynin hydrochloride (JAN)
D00723	Tridihexethyl chloride (BAN)
D00726	Metoclopramide (JP16/INN)
D00740	Procaine hydrochloride (JP16/USP)
D00743	Naphazoline hydrochloride (JP16/USP)
D00756	Tetrahydrozoline nitrate (JAN)
D00757	Xylometazoline hydrochloride (USP)
D00774	Orphenadrine citrate (USP)
D00777	Amantadine hydrochloride (JP16/USP)
D00778	Benztropine mesilate (JAN)
D00779	Biperiden (JAN/USP/INN)
D00782	Procyclidine hydrochloride (USP)
D00787	Trihexyphenidyl hydrochloride (JP16/USP)
D00789	Chlorpromazine hydrochloride (JP16/USP)
D00819	Nefazodone hydrochloride (USAN)
D00820	Trazodone hydrochloride (JAN/USP)
D00848	Dextromethorphan hydrobromide hydrate (JP16)
D00996	Epinephrine hydrochloride (JAN)
D00997	Tolazoline hydrochloride (JAN/USP)
D00999	Acetylcholine chloride (JP16/USP/INN)
D01000	Bethanechol chloride (JP16/USP)
D01002	Cyclopentolate hydrochloride (JP16/USP)
D01003	Hexocyclium metilsulfate (INN)
D01004	Homatropine hydrobromide (JP16/USP)
D01005	Isopropamide iodide (JAN/USP/INN)
D01006	Oxyphencyclimine hydrochloride (JAN)
D01007	Propiverine hydrochloride (JP16)
D01017	Dipivefrin hydrochloride (JAN/USP)
D01019	Metaraminol bitartrate (JAN/USP)
D01020	Methoxamine hydrochloride (JAN)
D01021	Naphazoline nitrate (JP16)
D01022	Oxymetazoline hydrochloride (JAN/USP)
D01023	Tetrahydrozoline hydrochloride (JAN/USP)
D01024	Tamsulosin hydrochloride (JP16/USAN)
D01025	Levobunolol hydrochloride (JAN/USP)
D01026	Sotalol hydrochloride (JAN/USP)
D01044	Flupentixol (INN)
D01051	Spiperone (JAN/USAN)
D01077	Atropine methonitrate (JAN/INN)
D01096	Hydroxyzine pamoate (JP16/USP)
D01103	Trospium chloride (JAN/USAN/INN)
D01104	Barnidipine hydrochloride (JAN)
D01117	Mizolastine (JAN/INN)
D01118	Profenamine hydrochloride (JAN)
D01123	Seratrodast (JAN/USAN/INN)
D01128	Ramatroban (JAN/INN)
D01131	Lafutidine (JP16/INN)
D01143	Isothipendyl hydrochloride (JAN)
D01145	Azelnidipine (JP16/INN)
D01148	Tolterodine tartrate (JAN/USAN)
D01163	Ergometrine maleate (JP16)
D01164	Aripiprazole (JAN/USAN/INN)
D01165	Piperidolate hydrochloride (JAN)
D01172	Diphenylpyraline hydrochloride (JAN)
D01173	Cilnidipine (JAN/INN)
D01174	Pheniramine maleate (JAN/USP)
D01175	Carpronium chloride (JAN/INN)
D01176	Blonanserin (JAN/INN)
D01182	Alprenolol hydrochloride (JP16/USAN)
D01192	Olopatadine hydrochloride (JAN/USAN)
D01193	Osutidine (JAN/INN)
D01201	Tiemonium iodide (JAN/INN)
D01204	Olmesartan medoxomil (JAN/USAN)
D01227	Bosentan hydrate (JAN)
D01231	Piroheptine hydrochloride (JAN)
D01236	Conivaptan hydrochloride (JAN/USAN)
D01242	Promethazine teoclate (JAN/INN)
D01263	Ritodrine hydrochloride (JP16/USP)
D01269	Solifenacin succinate (JAN/USAN/INN)
D01290	Nicergoline (JP16/USAN/INN)
D01295	Cinnarizine (JAN/USAN/INN)
D01297	Pirenzepine hydrochloride (USAN)
D01303	Flunarizine hydrochloride (JAN/USAN)
D01307	Midodrine hydrochloride (JAN/USAN)
D01315	Methylbenactyzium bromide (JP16/INN)
D01317	Meclizine hydrochloride (JAN/USP)
D01321	Zotepine (JAN/INN)
D01324	Mequitazine (JP16/INN)
D01332	Ketotifen fumarate (JP16/USAN)
D01333	Urapidil (JP16/INN)
D01336	Carbinoxamine maleate (JAN/USP)
D01343	Dimetindene maleate (JAN)
D01347	Tramazoline hydrochloride (JAN/USAN)
D01349	Pirbuterol hydrochloride (JAN/USAN)
D01352	Dinoprost tromethamine (JAN/USP)
D01358	Mianserin hydrochloride (JAN/USAN)
D01359	Etomidoline (JAN/INN)
D01360	Clenbuterol hydrochloride (JAN/USP)
D01362	Tulobuterol hydrochloride (JP16)
D01369	Bevantolol hydrochloride (JAN/USAN)
D01373	Formoterol fumarate (USAN)
D01377	Prifinium bromide (JAN/INN)
D01386	Ephedrine hydrochloride (JP16/USP)
D01390	dl-Isoprenaline hydrochloride (JAN)
D01405	Norfenefrine hydrochloride (JAN)
D01428	Fenoterol hydrobromide (JAN)
D01441	Imatinib mesilate (JAN)
D01444	Bunitrolol hydrochloride (JAN)
D01445	Ifenprodil tartrate (JP16)
D01451	Scopolamine butylbromide (JP16)
D01452	Isopropyl unoprostone (JAN)
D01453	Caffeine hydrate (JP16)
D01454	Bupranolol hydrochloride (JP16)
D01460	Homochlorcyclizine hydrochloride (JP16)
D01463	Diponium bromide (JAN/INN)
D01467	Roxatidine acetate hydrochloride (JP16/USAN)
D01469	Amosulalol hydrochloride (JP16)
D01471	Esatenolol (JAN/INN)
D01477	Opipramol hydrochloride (JAN/USAN)
D01478	Ebastine (JP16/USAN/INN)
D01482	Pipamperone hydrochloride (JAN)
D01491	Butropium bromide (JP16/INN)
D01500	Trimebutine maleate (JP16)
D01504	Bufetolol hydrochloride (JP16)
D01512	Befunolol hydrochloride (JAN)
D01520	Levomepromazine hydrochloride (JAN/USAN)
D01521	Pipethanate hydrochloride (JAN)
D01538	Valethamate bromide (JAN)
D01543	Nylidrin hydrochloride (JAN)
D01548	Mosapramine hydrochloride (JAN)
D01553	Manidipine hydrochloride (JP16)
D01562	Aranidipine (JAN/INN)
D01571	Moxisylyte hydrochloride (JAN)
D01573	Etilefrine hydrochloride (JP16)
D01589	Mabuterol hydrochloride (JAN)
D01592	Betahistine mesilate (JP16)
D01600	Diphenylpiperidinomethyldioxolan iodide (JAN)
D01604	Efonidipine hydrochloride ethanolate (JAN)
D01624	Sarpogrelate hydrochloride (JP16)
D01627	Diphenylpyraline teoclate (JAN)
D01635	Methoxyphenamine hydrochloride (JAN)
D01648	Hyoscyamine methylbromide (JAN)
D01652	Apafant (JAN/USAN/INN)
D01654	Bepotastine besilate (JAN)
D01674	Naftopidil (JAN/INN)
D01691	Nipradilol (JAN/INN)
D01692	Alfuzosin hydrochloride (JAN/USAN)
D01697	Colforsin daropate hydrochloride (JAN)
D01698	Dalcotidine (JAN/INN)
D01699	Darifenacin hydrobromide (JAN/USAN)
D01712	Theophylline sodium acetate (JAN)
D01713	Epinastine hydrochloride (JAN)
D01717	Levocabastine hydrochloride (JAN/USAN)
D01741	Celiprolol hydrochloride (JAN/USAN)
D01742	Clebopride malate (JP16)
D01748	Isoxsuprine hydrochloride (JP16/USP)
D01771	Proxyphylline (JAN/INN)
D01773	Oxatomide (JAN/USAN/INN)
D01782	Triprolidine hydrochloride hydrate (JAN)
D01794	Bopindolol malonate (JAN)
D01795	Tilisolol hydrochloride (JAN)
D01801	Thonzylamine hydrochloride (JAN/USAN)
D01806	Oxprenolol hydrochloride (JP16/USP)
D01815	Oxapium iodide (JP16/INN)
D01818	Proglumide (JP16/USAN/INN)
D01830	Arotinolol hydrochloride (JP16)
D01835	Clorprenaline hydrochloride (JAN/USAN)
D01847	Landiolol hydrochloride (JAN)
D01849	Lercanidipine hydrochloride (JAN/USAN)
D01858	Panazepide (JAN)
D01861	Pibutidine hydrochloride (JAN)
D01869	Ornoprostil (JAN/INN)
D01871	Metixene hydrochloride (JAN)
D01875	Tiquizium bromide (JAN/INN)
D01887	Bunazosin hydrochloride (JP16)
D01902	Dimetotiazine mesilate (JAN)
D01908	Nilvadipine (JP16/USAN/INN)
D01922	Pratosartan (JAN/INN)
D01925	Taltirelin hydrate (JP16)
D01929	Tiotropium bromide hydrate (JAN)
D01939	Ziprasidone hydrochloride hydrate (JAN)
D01946	Oxitropium bromide (JAN/INN)
D01952	L-Methylephedrine hydrochloride (JAN)
D01955	Aclatonium napadisilate (JAN)
D01958	Indenolol hydrochloride (JP16)
D01964	Travoprost (JAN/USAN/INN)
D01965	Silodosin (JAN/INN)
D01969	Gallopamil hydrochloride (JAN)
D01976	N-Methylscopolamine methylsulfate (JAN)
D01977	Gefitinib (JAN/USAN/INN)
D01978	Trimetoquinol hydrochloride
D01987	Pipethanate ethobromide (JAN)
D01994	Mosapride citrate hydrate (JP16)
D02004	Apomorphine hydrochloride hydrate (JAN)
D02007	Protirelin tartrate hydrate (JP16)
D02014	Angiotensin II (human type) (JAN)
D02017	Choline theophylline (JAN)
D02034	Setiptiline maleate (JAN)
D02045	Benidipine hydrochloride (JP16)
D02066	Isoprenaline sulfate (JAN)
D02069	Atropine sulfate (JP16/USP)
D02070	Homatropine methylbromide (USP)
D02071	Scopolamine hydrobromide hydrate (JP16)
D02073	Gemeprost (JAN/USAN/INN)
D02081	Metipranolol hydrochloride
D02082	Eprosartan mesylate (USAN)
D02090	Cyclizine lactate (BAN)
D02091	Tripelennamine hydrochloride (USP)
D02092	Cisapride (JAN)
D02093	Isoetharine hydrochloride (USP)
D02100	Ziprasidone mesylate (USAN)
D02102	Methadone hydrochloride (JAN/USP)
D02109	dl-Methylephedrine hydrochloride (JP16)
D02147	Albuterol (USP)
D02148	Phenindamine tartrate (USAN)
D02149	Epinephrine bitartrate (JAN/USP)
D02150	l-Isoprenaline hydrochloride (JP16)
D02151	Tulobuterol (JAN/INN)
D02200	Pilocarpine hydrochloride (JP16/USP)
D02202	Lobeline hydrochloride (JAN)
D02204	Hexamethonium bromide (JAN/INN)
D02211	Dihydroergotamine mesilate (JP16)
D02212	Ipratropium bromide hydrate (JP16)
D02213	Metoclopramide hydrochloride (JAN)
D02234	Cyproheptadine hydrochloride (JP16/USP)
D02235	Desmopressin acetate hydrate (JAN)
D02236	Flupentixol dihydrochloride (JAN)
D02245	Alimemazine tartrate (JP16)
D02246	Biperiden hydrochloride (JP16/USP)
D02247	Biperiden lactate (JAN/USP)
D02248	Levomepromazine maleate (JP16/USAN)
D02249	Emedastine difumarate (JP16/USP)
D02274	Dantrolene sodium hydrate (JP16)
D02281	Levalbuterol hydrochloride (USAN)
D02327	Doxylamine succinate (USP)
D02338	Acebutolol (USAN/INN)
D02342	Bisoprolol (JAN/USAN/INN)
D02343	Carboprost (USAN/INN)
D02347	Dantrolene (USAN/INN)
D02349	Dipivefrin (USAN)
D02356	Verapamil (USAN/INN)
D02358	Metoprolol (USAN/INN)
D02359	Ritodrine (USAN/INN)
D02363	Ketanserin (USAN/INN)
D02364	Lobeline (INN)
D02372	Perospirone hydrochloride hydrate (JAN)
D02374	Metipranolol (USAN/INN)
D02384	Verlukast (USAN/INN)
D02389	Primidolol (USAN/INN)
D02396	Hexoprenaline sulfate (USAN)
D02404	Procaterol hydrochloride (USAN)
D02410	Selfotel (USAN/INN)
D02417	Flutropium bromide (JAN)
D02419	Diphenhydramine salicylate (JAN)
D02535	Timepidium bromide hydrate (JP16)
D02537	Dronedarone (INN)
D02577	Flibanserin (USAN/INN)
D02578	Agomelatine (INN)
D02588	Montirelin (INN)
D02590	Israpafant (JAN/INN)
D02599	Orphenadrine hydrochloride
D02612	Thiothixene hydrochloride (USP)
D02613	Clopenthixol (USAN)
D02614	Denopamine (JAN/INN)
D02622	Pipamperone (USAN/INN)
D02630	Penfluridol (USAN/INN)
D02641	Butaclamol hydrochloride (USAN)
D02656	Fananserin (USAN/INN)
D02666	Iloperidone (USAN/INN)
D02676	Oxiperomide (USAN/INN)
D02692	Human menopausal gonadotrophin (JP16)
D02693	Devazepide (USAN/INN)
D02702	Talibegron hydrochloride (USAN)
D02705	Alprostadil alfadex (JP16)
D02710	Tarazepide (INN)
D02719	Rosaprostol (INN)
D02722	Limaprost (INN)
D02724	Bimatoprost (JAN/USAN/INN)
D02730	Tegaserod maleate (USAN)
D02732	Pranlukast hydrate (JAN)
D02739	Ablukast (USAN/INN)
D02741	Ablukast sodium (USAN)
D02750	Aceclidine (USAN/INN)
D02760	Acrivastine (USAN/INN)
D02765	Adaprolol maleate (USAN)
D02767	Adatanserin hydrochloride (USAN)
D02775	Adrogolide hydrochloride (USAN)
D02780	Acamprosate calcium (JAN/USAN)
D02834	Alprenoxime hydrochloride (USAN)
D02836	Altanserin tartrate (USAN)
D02846	Cinalukast (USAN/INN)
D02848	Pobilukast edamine (USAN)
D02849	Ritolukast (USAN/INN)
D02850	Sulukast (USAN/INN)
D02851	Tomelukast (USAN/INN)
D02860	Limaprost alfadex (JP16)
D02876	Alvameline maleate (USAN)
D02893	Amesergide (USAN/INN)
D02901	Amidephrine mesylate (USAN)
D02910	Amiodarone (USAN/INN)
D02914	Amlodipine maleate (USAN)
D02939	Angiotensin amide (USAN)
D02950	Antazoline phosphate (USP)
D02968	Aprepitant (JAN/USAN/INN)
D02973	Aptiganel hydrochloride (USAN)
D02976	Arbutamine hydrochloride (USAN)
D02981	Arformoterol tartrate (USAN)
D02983	Argipressin tannate (USAN)
D02995	Asenapine maleate (USAN)
D03008	Atosiban (USAN/INN)
D03009	Atrasentan hydrochloride (USAN)
D03011	Atropine oxide hydrochloride (USAN)
D03065	Becaplermin (USAN/INN)
D03087	Benzetimide hydrochloride (USAN)
D03102	Betahistine hydrochloride (USP)
D03120	Binodenoson (USAN/INN)
D03166	Bromodiphenhydramine hydrochloride (USP)
D03170	Bucindolol hydrochloride (USAN)
D03177	Bunolol hydrochloride (USAN)
D03195	Butopamine (USAN/INN)
D03198	Butoxamine hydrochloride (USAN)
D03212	Apadenoson (USAN)
D03218	Axitinib (JAN/USAN)
D03221	Befetupitant (USAN/INN)
D03264	Mazaticol hydrochloride hydrate (JAN)
D03274	Chlorpromazine hibenzate (JAN)
D03276	Profenamine hibenzate (JAN)
D03285	Diphenhydramine tannate (JP16)
D03290	Promethazine methylenedisalicylate (JAN)
D03334	Gonadotrophin, chorionic (JAN)
D03350	Canertinib dihydrochloride (USAN)
D03360	Diphenhydramine laurylsulfate (JAN)
D03399	Carboprost methyl (USAN)
D03402	Carbuterol hydrochloride (USAN)
D03415	Carvedilol phosphate hydrate (JAN)
D03449	Cetamolol hydrochloride (USAN)
D03455	Cetuximab (genetical recombination) (JAN)
D03475	Chlorpheniramine polistirex (USAN)
D03478	Choriogonadotropin alfa (USAN/INN)
D03490	Cicloprolol hydrochloride (USAN)
D03494	Ciladopa hydrochloride (USAN)
D03502	Cimaterol (USAN/INN)
D03503	Cimetidine hydrochloride (USP)
D03506	Cinanserin hydrochloride (USAN)
D03534	Clebopride (USAN)
D03535	Clemastine (USAN)
D03556	Zuclopenthixol (INN)
D03587	Colterol mesylate (USAN)
D03621	Cyclizine (INN)
D03622	Cyclizine hydrochloride (USP)
D03642	Daltroban (USAN/INN)
D03648	Dapiprazole hydrochloride (USAN)
D03654	Darifenacin (USAN/INN)
D03655	Darodipine (USAN/INN)
D03658	Dasatinib (INN)
D03677	Deltibant (USAN/INN)
D03679	Delucemine hydrochloride (USAN)
D03693	Desloratadine (USAN/INN)
D03704	Dexbrompheniramine maleate (USAN)
D03711	Dexetimide (USAN/INN)
D03729	Dexpropranolol hydrochloride (USAN)
D03742	Dextromethorphan (USP)
D03744	Dextromethorphan polistirex (USAN)
D03746	Dextrorphan hydrochloride (USAN)
D03759	Diacetolol hydrochloride (USAN)
D03814	Atropine methylbromide (JAN)
D03830	Diltiazem malate (USAN)
D03854	Diphenhydramine citrate (USP)
D03878	Dizocilpine maleate (USAN)
D03879	Dobutamine (USP/INN)
D03880	Dobutamine lactobionate (USAN)
D03881	Dobutamine tartrate (USP)
D03889	Donetidine (USAN)
D03891	Dopexamine (USAN/INN)
D03914	Dronedarone hydrochloride (USAN)
D03937	Ecopipam hydrochloride (USAN)
D03953	Edonentan (USAN)
D04018	Ephedrine sulfate (USP)
D04023	Erlotinib hydrochloride (JAN/USAN)
D04024	Lapatinib tosilate hydrate (JAN)
D04025	Mubritinib (USAN/INN)
D04034	Chlorpromazine phenolphthalinate (JAN)
D04040	Eprosartan (USAN/INN)
D04057	Esoxybutynin chloride (USAN)
D04074	Etalocib (USAN)
D04087	Ethybenztropine (USAN)
D04098	Etintidine hydrochloride (USAN)
D04116	Eucatropine hydrochloride (USP XXXII)
D04126	Saralasin acetate (USAN)
D04137	Felypressin (USAN/INN)
D04155	Fenobam (USAN)
D04157	Fenoterol (USAN/INN)
D04184	Fiduxosin hydrochloride (USAN)
D04190	Flestolol sulfate (USAN)
D04226	Flupirtine maleate (USAN)
D04243	Forasartan (USAN/INN)
D04308	Gavestinel (USAN/INN)
D04320	Glemanserin (USAN/INN)
D04479	Hyoscyamine hydrobromide (USP)
D04488	Ibopamine (USAN/INN)
D04492	Icatibant acetate (USAN)
D04494	Icotidine (USAN)
D04500	Ifetroban (USAN/INN)
D04501	Ifetroban sodium (USAN)
D04517	Impromidine hydrochloride (USAN)
D04531	Indoramin (USAN/INN)
D04532	Indoramin hydrochloride (USAN)
D04625	Isoetharine (USP)
D04626	Isoetharine mesylate (USP)
D04641	Istradefylline (JAN/USAN/INN)
D04657	Lacidipine (USAN/INN)
D04680	Lavoltidine succinate (USAN)
D04701	Levalbuterol sulfate (USAN)
D04703	Levalbuterol tartrate (USAN)
D04708	Levdobutamine lactobionate (USAN)
D04710	Levobetaxolol hydrochloride (USAN)
D04724	Lexipafant (USAN/INN)
D04728	Licostinel (USAN/INN)
D04788	Lubazodone hydrochloride (USAN)
D04794	Lupitidine hydrochloride (USAN)
D04820	Lurasidone hydrochloride (JAN/USAN)
D04824	Lutropin alfa (USAN/INN)
D04860	Maropitant citrate (USAN)
D04888	Medroxalol (USAN/INN)
D04889	Medroxalol hydrochloride (USAN)
D04905	Memantine hydrochloride (JAN/USAN)
D04954	Metaproterenol polistirex (USAN)
D04970	Methacholine chloride (USAN/INN)
D05004	Metiamide (USAN/INN)
D05008	Metoclopramide hydrochloride (USAN)
D05011	Metoprolol fumarate (USP)
D05015	Metrenperone (USAN/INN)
D05024	Mibefradil dihydrochloride (USAN)
D05029	Midostaurin (USAN/INN)
D05035	Milameline hydrochloride (USAN)
D05037	Trimetoquinol hydrochloride hydrate (JP16)
D05085	Moxilubant maleate (USAN)
D05107	Nafronyl oxalate (USAN)
D05127	Nebivolol (USAN/INN)
D05145	Neramexane mesylate (USAN)
D05196	Noberastine (USAN/INN)
D05206	Norepinephrine bitartrate (USP)
D05246	Olmesartan (USAN/INN)
D05258	Serum gonadotrophin (JP16)
D05276	Pirenzepine hydrochloride hydrate (JP16)
D05277	Formoterol fumarate hydrate (JP16)
D05306	Oxmetidine hydrochloride (USAN)
D05307	Oxmetidine mesylate (USAN)
D05339	Paliperidone (JAN/USAN/INN)
D05340	Paliperidone palmitate (JAN/USAN)
D05345	Pamatolol sulfate (USAN)
D05350	Panitumumab (genetical recombination) (JAN)
D05366	Procaterol hydrochloride hydrate (JP16)
D05380	Pazopanib hydrochloride (JAN/USAN)
D05395	Pelanserin hydrochloride (USAN)
D05399	Pelitinib (USAN/INN)
D05429	Aminophylline hydrate (JP16)
D05442	Perhexiline maleate (USAN)
D05446	Pertuzumab (genetical recombination) (JAN)
D05447	Perzinfotel (USAN/INN)
D05453	Phencyclidine hydrochloride (USAN)
D05471	Piboserod hydrochloride (USAN)
D05476	Picumeterol fumarate (USAN)
D05478	Pilocarpine nitrate (USP)
D05523	Pizotyline (USAN)
D05587	Practolol (USAN)
D05606	Prenalterol hydrochloride (USAN)
D05648	Pseudoephedrine polistirex (USAN)
D05649	Pseudoephedrine sulfate (USP)
D05660	Pyrilamine maleate (USP)
D05691	Ractopamine hydrochloride (USAN)
D05699	Ranitidine bismuth citrate (USAN)
D05711	Regadenoson (USAN/INN)
D05714	Remacemide hydrochloride (USAN)
D05718	Reproterol hydrochloride (USAN)
D05727	Ridogrel (USAN/INN)
D05730	Rimiterol hydrobromide (USAN)
D05738	Ritanserin (USAN/INN)
D05742	Rocastine hydrochloride (USAN)
D05779	Sabcomeline hydrochloride (USAN)
D05792	Salmeterol (USAN/INN)
D05832	Sibenadet hydrochloride (USAN)
D05879	Solabegron hydrochloride (USAN)
D05902	Soterenol hydrochloride (USAN)
D05939	Sufotidine (USAN/INN)
D05941	Sulamserod hydrochloride (USAN)
D05970	Sulotroban (USAN/INN)
D05996	Talnetant hydrochloride (USAN)
D06000	Talsaclidine fumarate (USAN)
D06005	Tandutinib (USAN/INN)
D06015	Tazomeline citrate (USAN)
D06021	Tecastemizole (USAN/INN)
D06056	Tegaserod (USAN/INN)
D06063	Temelastine (USAN/INN)
D06103	Theophylline (USP)
D06104	Theophylline sodium glycinate (USP)
D06120	Thyrotropin alfa (genetical recombination) (JAN)
D06140	Ticolubant (USAN/INN)
D06146	Tiletamine hydrochloride (USP)
D06157	Tiotidine (USAN/INN)
D06234	Trimazosin hydrochloride (USAN)
D06246	Tripelennamine citrate
D06253	Tropanserin hydrochloride (USAN)
D06272	Sorafenib tosilate (JAN)
D06273	Imidafenacin (JAN/INN)
D06274	Tafluprost (JAN/USAN/INN)
D06280	Vapiprost hydrochloride (JAN/USAN)
D06285	Vatalanib (USAN/INN)
D06293	Vestipitant mesylate (USAN)
D06317	Vofopitant dihydrochloride (USAN)
D06328	Xamoterol (USAN)
D06329	Xamoterol fumarate (USAN)
D06330	Xanomeline (USAN)
D06331	Xanomeline tartrate (USAN)
D06353	Zacopride hydrochloride (USAN)
D06355	Zaltidine hydrochloride (USAN)
D06374	Zinterol hydrochloride (USAN)
D06394	Dabuzalgron hydrochloride (USAN)
D06396	Renzapride (INN)
D06402	Sunitinib malate (JAN/USAN)
D06407	Vandetanib (JAN/USAN/INN)
D06413	Nilotinib hydrochloride hydrate (JAN)
D06414	Dasatinib hydrate (JAN)
D06457	Chorionic gonadotrophin (JP16)
D06459	Purified human menopausal gonadotrophin (JAN)
D06477	Serum gonadotrophin for injection (JP16)
D06552	Alcaftadine (USAN/INN)
D06574	Casopitant mesylate (USAN)
D06597	Fosaprepitant meglumine (JAN)
D06613	Lorcaserin hydrochloride (USAN)
D06622	Nebivolol hydrochloride (USAN)
D06623	Olanzapine pamoate (USAN)
D06632	Pruvanserin (USAN/INN)
D06633	Pruvanserin hydrochloride (USAN)
D06646	Epanolol (USAN/INN)
D06659	Tipelukast (USAN)
D06672	Terlipressin (USAN/INN)
D06678	Motesanib
D07058	Acamprosate (INN)
D07072	Niperotidine (INN)
D07076	Camylofin (INN)
D07077	Ambrisentan (JAN/INN)
D07099	Cimetropium bromide (INN)
D07124	Alfuzosin (INN)
D07125	Alimemazine (INN)
D07140	Picotamide (BAN)
D07148	Oxedrine (BAN)
D07156	Alprenolol (INN)
D07171	Sitaxentan (USAN/INN)
D07181	Mepindolol (INN)
D07182	Tertatolol (INN)
D07183	Cloranolol (INN)
D07184	Talinolol (INN)
D07185	Fendiline (INN)
D07197	Bamipine (INN)
D07198	Chlorphenoxamine (INN)
D07218	Metergoline (INN)
D07226	Fesoterodine (INN)
D07227	Ornipressin (INN)
D07228	Demoxytocin (INN)
D07229	Carbetocin (INN/BAN)
D07283	Esketamine (INN)
D07349	Choline alfoscerate (INN)
D07377	Bambuterol (INN)
D07398	Chlorphenamine (INN)
D07402	Levocetirizine (USAN/INN)
D07406	Pimethixene (INN)
D07407	Rupatadine (INN)
D07441	Amantadine (INN)
D07450	Amlodipine (INN)
D07451	Amosulalol (INN)
D07458	Antazoline (INN)
D07459	Antazoline hydrochloride
D07460	Apomorphine (BAN)
D07463	Arformoterol (INN)
D07465	Arotinolol (INN)
D07475	Atosiban acetate
D07477	Atropine oxide (INN)
D07482	Azatadine (INN)
D07483	Azelastine (INN)
D07489	Bambuterol hydrochloride
D07492	Bamipine dihydrochloride
D07493	Bamipine lactate
D07494	Barnidipine (INN)
D07509	Benidipine (INN)
D07511	Benzatropine (INN)
D07513	Benzetimide (INN)
D07520	Bepridil (INN)
D07522	Betahistine (INN)
D07526	Betaxolol (INN)
D07534	Bitolterol (INN)
D07537	Bopindolol (INN)
D07538	Bosentan (INN)
D07543	Brompheniramine (INN)
D07550	Bunazosin (INN)
D07551	Buphenine (INN)
D07590	Bupranolol (INN)
D07603	Caffeine citrate (USP)
D07608	Carazolol (INN)
D07617	Carbinoxamine (INN)
D07624	Carteolol (INN)
D07660	Celiprolol (INN)
D07662	Cetirizine (INN)
D07667	Cevimeline (INN)
D07682	Clazosentan sodium (JAN)
D07684	Chlorphenoxamine hydrochloride
D07713	Clenbuterol (INN)
D07734	Cinnarizine dihydrochloride
D07741	Zibotentan (JAN/USAN/INN)
D07748	Conivaptan (INN)
D07759	Cyclopentolate (INN)
D07765	Cyproheptadine (INN)
D07803	Dexchlorpheniramine (INN)
D07804	Dexetimide hydrochloride
D07820	Dicycloverine (INN)
D07837	Dihydroergotamine (INN)
D07838	Dihydroergotamine tartrate
D07845	Diltiazem (INN)
D07853	Dimetindene (INN)
D07854	Dimetotiazine (INN)
D07860	Dioxopromethazine hydrochloride
D07862	Diphenylpyraline (INN)
D07870	Dopamine (INN)
D07874	Doxazosin (INN)
D07878	Doxylamine (INN)
D07886	Efonidipine (INN)
D07890	Emedastine (INN)
D07900	Epinastine (INN)
D07905	Ergometrine (INN)
D07906	Ergotamine (INN)
D07907	Erlotinib (INN)
D07916	Esmolol (INN)
D07931	Etilefrine (INN)
D07951	Fentonium bromide (INN)
D07958	Fexofenadine (INN)
D07971	Flunarizine (INN)
D07976	Flupentixol decanoate
D07978	Flupirtine (INN)
D07979	Flupirtine D-gluconate
D07990	Formoterol (INN)
D08009	Gallopamil (INN)
D08039	Hexoprenaline (INN)
D08040	Histamine (DCF)
D08041	Homochlorcyclizine (INN)
D08054	Hydroxyzine (INN)
D08057	Ibopamine hydrochloride
D08064	Ifenprodil (INN)
D08066	Imatinib (INN)
D08067	Azilsartan medoxomil (USAN)
D08074	Penbutolol (INN)
D08078	Indenolol (INN)
D08090	Isoprenaline (INN)
D08091	Isothipendyl (INN)
D08092	Isoxsuprine (INN)
D08093	Isoxsuprine lactate
D08098	Ketamine (INN)
D08099	Ketanserin tartrate
D08100	Ketobemidone (INN)
D08101	Ketobemidone hydrochloride
D08105	Ketotifen (INN)
D08106	Labetalol (INN)
D08108	Lapatinib (INN)
D08111	Lercanidipine (INN)
D08115	Levobunolol (INN)
D08117	Levocabastine (INN)
D08118	Levocetirizine hydrochloride (JAN/USAN)
D08121	Levomethadone (INN)
D08122	Levomethadone hydrochloride
D08124	Levosalbutamol (INN)
D08138	Lobeline sulfate
D08146	Losartan (INN)
D08155	Manidipine (INN)
D08157	Mazaticol (INN)
D08163	Meclozine (BAN)
D08174	Memantine (INN)
D08183	Mepyramine (INN)
D08184	Mepyramine theophyllineacetate
D08192	Metaraminol (INN)
D08195	Methadone (BAN)
D08201	Methoxamine (BAN)
D08206	Methylephedrine (BAN)
D08207	Methylergometrine (INN)
D08209	Metixene (INN)
D08212	Trimazosin (INN)
D08216	Mianserin (INN)
D08217	Mibefradil (INN)
D08220	Midodrine (INN)
D08229	Montelukast (INN)
D08235	Mosapramine (INN)
D08236	Mosapride (INN)
D08239	Moxisylyte (INN)
D08244	Naftidrofuryl (INN)
D08253	Naphazoline (INN)
D08257	Nefazodone (INN)
D08270	Nicardipine (INN)
D08271	Nicergoline tartrate
D08284	Norepinephrine hydrochoride
D08286	Norfenefrine (INN)
D08293	Olopatadine (INN)
D08297	Opipramol (INN)
D08300	Orciprenaline (INN)
D08305	Orphenadrine (INN)
D08308	Oxedrine tartrate
D08309	Oxedrine hydrochloride
D08318	Oxprenolol (INN)
D08322	Oxymetazoline (INN)
D08325	Oxyphencyclimine (INN)
D08339	Pergolide (INN)
D08353	Phenindamine (INN)
D08355	Pheniramine (INN)
D08358	Phenoxybenzamine (INN)
D08362	Phentolamine (INN)
D08365	Phenylephrine (INN)
D08366	Phenylephrine tartrate
D08376	Pilocarpine borate
D08382	Piperidolate (INN)
D08384	Pipethanate (INN)
D08387	Pirbuterol (INN)
D08389	Pirenzepine (INN)
D08395	Piroheptine (INN)
D08397	Pizotifen malate
D08408	Pranlukast (INN)
D08411	Prazosin (INN)
D08424	Procaterol (INN)
D08425	Procyclidine (INN)
D08426	Profenamine (INN)
D08432	Promethazine maleate
D08441	Propiverine (INN)
D08443	Propranolol (INN)
D08449	Pseudoephedrine (INN)
D08456	Quetiapine (INN)
D08474	Reproterol (INN)
D08494	Roxatidine (INN)
D08495	Roxatidine acetate (BAN)
D08497	Rupatadine fumarate
D08503	Toceranib (USAN)
D08508	Sarpogrelate (INN)
D08511	Setiptiline (INN)
D08517	Sitaxentan sodium (USAN)
D08522	Solifenacin (INN)
D08524	Sorafenib (USAN/INN)
D08525	Sotalol (INN)
D08544	Toceranib phosphate (USAN)
D08552	Sunitinib (INN)
D08560	Tamsulosin (INN)
D08569	Terazosin (INN)
D08570	Terbutaline (INN)
D08571	Terlipressin acetate (JAN)
D08572	Tertatolol hydrochloride
D08578	Tetryzoline (INN)
D08587	Thonzylamine (INN)
D08591	Tiaprost (INN)
D08595	Tiemonium methylsulfate
D08596	Tiletamine (INN)
D08598	Tilisolol (INN)
D08600	Timolol (INN)
D08614	Tolazoline (INN)
D08624	Tramazoline (INN)
D08626	Trazodone (INN)
D08629	Tretoquinol (INN)
D08638	Trihexyphenidyl (INN)
D08639	Trimebutine (INN)
D08645	Tripelennamine (INN)
D08648	Triprolidine (INN)
D08660	Ulobetasol (INN)
D08661	Unoprostone (INN)
D08662	Urapidil hydrochloride
D08667	Calcium valproate
D08684	Xylometazoline (INN)
D08687	Ziprasidone (INN)
D08691	Zuclopenthixol acetate
D08692	Zuclopenthixol decanoate
D08693	Zuclopenthixol dihydrochloride
D08768	Promethazine hibenzate
D08837	Aclidinium bromide (USAN/INN)
D08850	Amibegron (USAN/INN)
D08851	Amibegron hydrochloride (USAN)
D08864	Azilsartan (JAN/USAN/INN)
D08865	Azilsartan kamedoxomil (USAN)
D08892	Clevidipine (USAN/INN)
D08923	Fesoterodine fumarate (JAN/USP)
D08937	Labradimil (INN/USAN)
D08945	Milveterol hydrochloride (USAN)
D08947	Motesanib phosphate (JAN)
D08950	Neratinib (INN/USAN)
D08953	Nilotinib (USAN/INN)
D08966	Phenylephrine bitartrate (USP)
D08969	Pimavanserin tartrate (USAN)
D08986	Retosiban (USAN)
D08988	Rolapitant hydrochloride (USAN)
D09003	Sonedenoson (USAN)
D09205	Prucalopride (USAN/INN)
D09318	Indacaterol (USAN/INN)
D09319	Indacaterol maleate (JAN/USAN)
D09344	Fasobegron (INN)
D09378	Serlopitant (USAN)
D09402	Darotropium bromide (USAN/INN)
D09535	Mirabegron (USAN/JAN)
D09570	Bilastine (INN)
D09645	Nelotanserin (USAN/INN)
D09650	Orvepitant (USAN/INN)
D09651	Orvepitant maleate (USAN)
D09689	Varlitinib (USAN/INN)
D09690	Varlitinib tosylate (USAN)
D09693	Velusetrag (USAN/INN)
D09694	Velusetrag hydrochloride (USAN)
D09696	Vilanterol (USAN)
D09697	Vilanterol trifenatate (JAN/USAN)
D09705	Bepotastine (USAN/INN)
D09717	Preladenant (USAN/INN)
D09724	Afatinib (USAN/INN)
D09732	Ritobegron ethyl hydrochloride (JAN)
D09733	Afatinib maleate (JAN)
D09752	Carpronium chloride hydrate (JAN)
D09765	Vorapaxar (USAN/INN)
D09766	Vorapaxar sulfate (JAN/USAN)
D09774	Imitrodast sodium (JAN)
D09784	Garomefrine hydrochloride (JAN)
D09789	Kirenidipine hydrochloride (JAN)
D09794	Norepinephrine hydrochloride (JAN)
D09797	Cargutocin (INN/JAN)
D09808	Carbinoxamine diphenyldisulfonate (JAN)
D09819	Chlorpromazine tannate (JAN)
D09820	Vasopressin tannate (JAN)
D09842	dl-Methylephedrine saccharinate (JAN)
D09845	Montirelin hydrate (JAN)
D09866	Atopaxar (USAN)
D09867	Atopaxar hydrobromide (USAN)
D09883	Dacomitinib (USAN/INN)
D09919	Lenvatinib (USAN/INN)
D09920	Lenvatinib mesilate (JAN)
D09933	Naronapride (USAN/INN)
D09934	Naronapride dihydrochloride (USAN)
D09939	Olaratumab (USAN/INN)
D09976	Temanogrel (USAN/INN)
D09977	Temanogrel hydrochloride (USAN)
D09980	Trastuzumab emtansine (genetical recombination) (JAN)
D09991	Vipadenant (USAN/INN)
D10006	Eplivanserin (USAN/INN)
D10018	Necitumumab (USAN/INN)
D10020	Olodaterol hydrochloride (JAN/USAN)
D10031	Zalutumumab (USAN/INN)
D10062	Cabozantinib (USAN)
D10099	Cerlapirdine (USAN)
D10100	Cerlapirdine hydrochloride (USAN)
D10102	Crenolanib (USAN)
D10103	Crenolanib besylate (USAN)
D10117	Epelsiban (USAN)
D10118	Epelsiban besylate (USAN)
D10135	Macitentan (USAN)
D10137	Regorafenib hydrate (JAN)
D10138	Regorafenib (USAN/INN)
D10145	Olodaterol (USAN/INN)
D10152	Prucalopride succinate (USAN)
D10174	Tozadenant (USAN)
D10180	Umeclidinium (USAN)
D10181	Umeclidinium bromide (JAN/USAN)
D10184	Vortioxetine (USAN)
D10185	Vortioxetine hydrobromide (USAN)
D10219	abediterol (USAN/INN)
D10220	Abediterol napadisylate (USAN)

Other DBs

BSID:

83050

GO:

0019722

Organism

Homo sapiens (human) [GN:hsa]

Gene

6546	SLC8A1; solute carrier family 8 (sodium/calcium exchanger), member 1 [KO:K05849]
6543	SLC8A2; solute carrier family 8 (sodium/calcium exchanger), member 2 [KO:K05849]
6547	SLC8A3; solute carrier family 8 (sodium/calcium exchanger), member 3 [KO:K05849]
490	ATP2B1; ATPase, Ca++ transporting, plasma membrane 1 [KO:K05850] [EC:3.6.3.8]
492	ATP2B3; ATPase, Ca++ transporting, plasma membrane 3 [KO:K05850] [EC:3.6.3.8]
493	ATP2B4; ATPase, Ca++ transporting, plasma membrane 4 [KO:K05850] [EC:3.6.3.8]
491	ATP2B2; ATPase, Ca++ transporting, plasma membrane 2 [KO:K05850] [EC:3.6.3.8]
1128	CHRM1; cholinergic receptor, muscarinic 1 [KO:K04129]
1131	CHRM3; cholinergic receptor, muscarinic 3 [KO:K04131]
1133	CHRM5; cholinergic receptor, muscarinic 5 [KO:K04133]
135	ADORA2A; adenosine A2a receptor [KO:K04266]
136	ADORA2B; adenosine A2b receptor [KO:K04267]
153	ADRB1; adrenoceptor beta 1 [KO:K04141]
154	ADRB2; adrenoceptor beta 2, surface [KO:K04142]
155	ADRB3; adrenoceptor beta 3 [KO:K04143]
1812	DRD1; dopamine receptor D1 [KO:K04144]
1816	DRD5; dopamine receptor D5 [KO:K05840]
3274	HRH2; histamine receptor H2 [KO:K04150]
3360	HTR4; 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled [KO:K04160]
3361	HTR5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled [KO:K04161]
3362	HTR6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled [KO:K04162]
3363	HTR7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [KO:K04163]
2778	GNAS; GNAS complex locus [KO:K04632]
2774	GNAL; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type [KO:K04633]
107	ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
108	ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
109	ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883	ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
113	ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114	ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
115	ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566	PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567	PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568	PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613	PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
5350	PLN; phospholamban [KO:K05852]
487	ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [KO:K05853] [EC:3.6.3.8]
489	ATP2A3; ATPase, Ca++ transporting, ubiquitous [KO:K05853] [EC:3.6.3.8]
488	ATP2A2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853] [EC:3.6.3.8]
6786	STIM1; stromal interaction molecule 1 [KO:K16059]
57620	STIM2; stromal interaction molecule 2 [KO:K16059]
84876	ORAI1; ORAI calcium release-activated calcium modulator 1 [KO:K16056]
80228	ORAI2; ORAI calcium release-activated calcium modulator 2 [KO:K16057]
93129	ORAI3; ORAI calcium release-activated calcium modulator 3 [KO:K16058]
775	CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
776	CACNA1D; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
778	CACNA1F; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
779	CACNA1S; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
773	CACNA1A; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
774	CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
777	CACNA1E; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852]
8913	CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit [KO:K04854]
8912	CACNA1H; calcium channel, voltage-dependent, T type, alpha 1H subunit [KO:K04855]
8911	CACNA1I; calcium channel, voltage-dependent, T type, alpha 1I subunit [KO:K04856]
1139	CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal) [KO:K04809]
5023	P2RX1; purinergic receptor P2X, ligand-gated ion channel, 1 [KO:K05215]
22953	P2RX2; purinergic receptor P2X, ligand-gated ion channel, 2 [KO:K05216]
5024	P2RX3; purinergic receptor P2X, ligand-gated ion channel, 3 [KO:K05217]
5025	P2RX4; purinergic receptor P2X, ligand-gated ion channel, 4 [KO:K05218]
5026	P2RX5; purinergic receptor P2X, ligand-gated ion channel, 5 [KO:K05219]
5027	P2RX7; purinergic receptor P2X, ligand-gated ion channel, 7 [KO:K05220]
9127	P2RX6; purinergic receptor P2X, ligand-gated ion channel, 6 [KO:K05221]
2902	GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 [KO:K05208]
2903	GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A [KO:K05209]
2905	GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C [KO:K05211]
2906	GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D [KO:K05212]
6261	RYR1; ryanodine receptor 1 (skeletal) [KO:K04961]
6262	RYR2; ryanodine receptor 2 (cardiac) [KO:K04962]
6263	RYR3; ryanodine receptor 3 [KO:K04963]
10800	CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
57105	CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
1129	CHRM2; cholinergic receptor, muscarinic 2 [KO:K04130]
148	ADRA1A; adrenoceptor alpha 1A [KO:K04135]
147	ADRA1B; adrenoceptor alpha 1B [KO:K04136]
146	ADRA1D; adrenoceptor alpha 1D [KO:K04137]
185	AGTR1; angiotensin II receptor, type 1 [KO:K04166]
1909	EDNRA; endothelin receptor type A [KO:K04197]
1910	EDNRB; endothelin receptor type B [KO:K04198]
2149	F2R; coagulation factor II (thrombin) receptor [KO:K03914]
2911	GRM1; glutamate receptor, metabotropic 1 [KO:K04603]
2915	GRM5; glutamate receptor, metabotropic 5 [KO:K04604]
2925	GRPR; gastrin-releasing peptide receptor [KO:K04169]
3269	HRH1; histamine receptor H1 [KO:K04149]
3356	HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled [KO:K04157]
3357	HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [KO:K04157]
3358	HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [KO:K04157]
3973	LHCGR; luteinizing hormone/choriogonadotropin receptor [KO:K04248]
4923	NTSR1; neurotensin receptor 1 (high affinity) [KO:K04211]
5021	OXTR; oxytocin receptor [KO:K04229]
552	AVPR1A; arginine vasopressin receptor 1A [KO:K04226]
553	AVPR1B; arginine vasopressin receptor 1B [KO:K04227]
56413	LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
5724	PTAFR; platelet-activating factor receptor [KO:K04279]
5731	PTGER1; prostaglandin E receptor 1 (subtype EP1), 42kDa [KO:K04258]
5733	PTGER3; prostaglandin E receptor 3 (subtype EP3) [KO:K04260]
5737	PTGFR; prostaglandin F receptor (FP) [KO:K04262]
623	BDKRB1; bradykinin receptor B1 [KO:K03915]
624	BDKRB2; bradykinin receptor B2 [KO:K03916]
6869	TACR1; tachykinin receptor 1 [KO:K04222]
6865	TACR2; tachykinin receptor 2 [KO:K04223]
6870	TACR3; tachykinin receptor 3 [KO:K04224]
6915	TBXA2R; thromboxane A2 receptor [KO:K04264]
7201	TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
886	CCKAR; cholecystokinin A receptor [KO:K04194]
887	CCKBR; cholecystokinin B receptor [KO:K04195]
1956	EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2064	ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [KO:K05083] [EC:2.7.10.1]
2065	ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [KO:K05084] [EC:2.7.10.1]
2066	ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [KO:K05085] [EC:2.7.10.1]
5156	PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
5159	PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
2776	GNAQ; guanine nucleotide binding protein (G protein), q polypeptide [KO:K04634]
2767	GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) [KO:K04635]
9630	GNA14; guanine nucleotide binding protein (G protein), alpha 14 [KO:K04636]
2769	GNA15; guanine nucleotide binding protein (G protein), alpha 15 (Gq class) [KO:K04637]
5333	PLCD1; phospholipase C, delta 1 [KO:K05857] [EC:3.1.4.11]
113026	PLCD3; phospholipase C, delta 3 [KO:K05857] [EC:3.1.4.11]
84812	PLCD4; phospholipase C, delta 4 [KO:K05857] [EC:3.1.4.11]
23236	PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330	PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331	PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332	PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
5335	PLCG1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
5336	PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
51196	PLCE1; phospholipase C, epsilon 1 [KO:K05860] [EC:3.1.4.11]
89869	PLCZ1; phospholipase C, zeta 1 [KO:K05861] [EC:3.1.4.11]
3708	ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
3709	ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
3710	ITPR3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
952	CD38; CD38 molecule [KO:K01242] [EC:3.2.2.5]
683	BST1; bone marrow stromal cell antigen 1 [KO:K01242] [EC:3.2.2.5]
8877	SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
56848	SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
7416	VDAC1; voltage-dependent anion channel 1 [KO:K05862]
7417	VDAC2; voltage-dependent anion channel 2 [KO:K15040]
7419	VDAC3; voltage-dependent anion channel 3 [KO:K15041]
291	SLC25A4; solute carrier family 25 (mitochondrial carrier [KO:K05863]
292	SLC25A5; solute carrier family 25 (mitochondrial carrier [KO:K05863]
293	SLC25A6; solute carrier family 25 (mitochondrial carrier [KO:K05863]
83447	SLC25A31; solute carrier family 25 (mitochondrial carrier [KO:K05863]
10105	PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
7134	TNNC1; troponin C type 1 (slow) [KO:K05865]
7125	TNNC2; troponin C type 2 (fast) [KO:K12042]
810	CALML3; calmodulin-like 3 [KO:K02183]
805	CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808	CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801	CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688	CALML6; calmodulin-like 6 [KO:K02183]
51806	CALML5; calmodulin-like 5 [KO:K02183]
5260	PHKG1; phosphorylase kinase, gamma 1 (muscle) [KO:K00871] [EC:2.7.11.19]
5261	PHKG2; phosphorylase kinase, gamma 2 (testis) [KO:K00871] [EC:2.7.11.19]
5257	PHKB; phosphorylase kinase, beta [KO:K07190]
5256	PHKA2; phosphorylase kinase, alpha 2 (liver) [KO:K07190]
5255	PHKA1; phosphorylase kinase, alpha 1 (muscle) [KO:K07190]
4638	MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
85366	MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
91807	MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
340156	MYLK4; myosin light chain kinase family, member 4 [KO:K00907] [EC:2.7.11.18]
815	CAMK2A; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
817	CAMK2D; calcium/calmodulin-dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
816	CAMK2B; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
818	CAMK2G; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
814	CAMK4; calcium/calmodulin-dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
5530	PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
5532	PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
5533	PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
5534	PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
5535	PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
11261	CHP1; calcineurin-like EF-hand protein 1 [KO:K06268]
63928	CHP2; calcineurin-like EF-hand protein 2 [KO:K06268]
4842	NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
4843	NOS2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
4846	NOS3; nitric oxide synthase 3 (endothelial cell) [KO:K13242] [EC:1.14.13.39]
5136	PDE1A; phosphodiesterase 1A, calmodulin-dependent [KO:K13755] [EC:3.1.4.17]
5153	PDE1B; phosphodiesterase 1B, calmodulin-dependent [KO:K13755] [EC:3.1.4.17]
5137	PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa [KO:K13755] [EC:3.1.4.17]
2185	PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
3707	ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
3706	ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
80271	ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
5578	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]

Compound

C00002	ATP
C00004	NADH
C00076	Calcium cation
C00165	Diacylglycerol
C00575	3',5'-Cyclic AMP
C01245	D-myo-Inositol 1,4,5-trisphosphate
C01330	Sodium cation
C06124	Sphingosine 1-phosphate
C13050	Cyclic ADP-ribose
C13051	Nicotinic acid adenine dinucleotide phosphate

Reference

PMID:12838335

Authors

Berridge MJ, Bootman MD, Roderick HL.

Title

Calcium signalling: dynamics, homeostasis and remodelling.

Journal

Nat Rev Mol Cell Biol 4:517-29 (2003)

Reference

PMID:11413485

Authors

Berridge MJ, Lipp P, Bootman MD.

Title

The versatility and universality of calcium signalling.

Journal

Nat Rev Mol Cell Biol 1:11-21 (2000)

Reference

PMID:15111104

Authors

Wang MC, Dolphin A, Kitmitto A.

Title

L-type voltage-gated calcium channels: understanding function through structure.

Journal

FEBS Lett 564:245-50 (2004)

Reference

PMID:11299192

Authors

Ferrier GR, Howlett SE.

Title

Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.

Journal

Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)

Reference

PMID:11698232

Authors

Keef KD, Hume JR, Zhong J.

Title

Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.

Journal

Am J Physiol Cell Physiol 281:C1743-56 (2001)

Reference

PMID:8125957

Authors

Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.

Title

Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.

Journal

J Biol Chem 269:7390-6 (1994)

Reference

PMID:15000521

Authors

Yunker AM.

Title

Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.

Journal

J Bioenerg Biomembr 35:577-98 (2003)

Reference

PMID:9149541

Authors

Yakel JL.

Title

Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.

Journal

Trends Pharmacol Sci 18:124-34 (1997)

Reference

PMID:10997573

Authors

Fukunaga K, Miyamoto E.

Title

A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.

Journal

Neurosci Res 38:3-17 (2000)

Reference

PMID:9235901

Authors

Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.

Title

Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.

Journal

J Biol Chem 272:19125-32 (1997)

Reference

PMID:7861177

Authors

Furuichi T, Mikoshiba K.

Title

Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.

Journal

J Neurochem 64:953-60 (1995)

Reference

PMID:14572802

Authors

Bruce JI, Straub SV, Yule DI.

Title

Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.

Journal

Cell Calcium 34:431-44 (2003)

Reference

PMID:10331643

Authors

Lee HC, Munshi C, Graeff R.

Title

Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.

Journal

Mol Cell Biochem 193:89-98 (1999)

Reference

PMID:11080247

Authors

Crompton M.

Title

Mitochondrial intermembrane junctional complexes and their role in cell death.

Journal

J Physiol 529 Pt 1:11-21 (2000)

Reference

PMID:10508738

Authors

Grewal SS, York RD, Stork PJ.

Title

Extracellular-signal-regulated kinase signalling in neurons.

Journal

Curr Opin Neurobiol 9:544-53 (1999)

Reference

PMID:12972622

Authors

Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.

Title

Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.

Journal

Mol Cell Biol 23:7068-81 (2003)

Reference

PMID:14517314

Authors

Hutchins JR, Dikovskaya D, Clarke PR.

Title

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.

Journal

Mol Biol Cell 14:4003-14 (2003)

Reference

PMID:21338471

Authors

Tornquist K

Title

Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.

Journal

Acta Physiol (Oxf) 204:151-7 (2012)

Reference

PMID:22129055

Authors

Feske S

Title

Immunodeficiency due to defects in store-operated calcium entry.

Journal

Ann N Y Acad Sci 1238:74-90 (2011)

Reference

PMID:22002090

Authors

Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC

Title

STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.

Journal

Braz J Med Biol Res 44:1080-7 (2011)

Reference

PMID:19172794

Authors

Baba Y, Kurosaki T

Title

[Regulation of store-operated calcium entry by STIM1].

Journal

Seikagaku 80:1123-8 (2008)

KO pathway

ko04020

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