KEGG   PATHWAY: hsa04060Help
Entry
hsa04060                    Pathway                                

Name
Cytokine-cytokine receptor interaction - Homo sapiens (human)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Cytokine-cytokine receptor interaction
hsa04060

All organismsOrtholog table
Disease
H00097  
Chemokine receptor defect
H00227  
Congenital amegakaryocytic thrombocytopenia (CAMT)
H00286  
Crohn's disease
H00344  
Leprosy
H00408  
Type I diabetes mellitus
H00609  
46,XY disorders of sex development (Other)
H00632  
Heterotaxy
H00651  
Ectodermal dysplasia
H00800  
Loeys-Dietz syndrome (LDS)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
H00821  
Macular degeneration
H00912  
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
H00935  
Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
H01023  
Juvenile polyposis syndrome
H01024  
Hereditary mixed polyposis syndrome
H01109  
Chronic mucocutaneous candidiasis (CMC)
H01122  
Pulmonary alveolar proteinosis (PAP)
H01217  
Primary localized cutaneous amyloidosis (PLCA)
H01227  
Inflammatory bowel disease (IBD)
H01466  
Ulcerative colitis (UC)
H01479  
Castleman disease
Drug
D00742  
Etanercept (USAN/INN)
D00745  
Interferon alfa-2a (USAN/INN)
D00746  
Interferon beta-1b (USAN/INN)
D00747  
Interferon gamma-1b (USAN/INN)
D00748  
Aldesleukin (USAN/INN)
D01441  
Imatinib mesylate (USAN)
D01977  
Gefitinib (JAN/USAN/INN)
D02596  
Tocilizumab (USAN/INN)
D02597  
Adalimumab (USAN/INN)
D02598  
Infliximab (USAN/INN)
D02691  
Somatropin (USP/INN)
D02743  
Celmoleukin (genetical recombination) (JP17)
D02744  
Interferon alfacon-1 (USAN/INN)
D02745  
Interferon alfa-2b (USAN)
D02747  
Peginterferon alfa-2a (USAN/INN)
D02748  
Peginterferon alfa-2b (genetical recombination) (JAN)
D02749  
Teceleukin (USAN)
D02934  
Anakinra (USAN/INN)
D03058  
Basiliximab (USAN/INN)
D03065  
Becaplermin (USAN/INN)
D03068  
Belimumab (USAN)
D03210  
Ancriviroc (USAN/INN)
D03218  
Axitinib (JAN/USAN)
D03231  
Epoetin alfa (USAN/INN)
D03232  
Epoetin beta (USAN/INN)
D03235  
Filgrastim (USAN/INN)
D03245  
Nartograstim (genetical recombination) (JP17)
D03247  
Lenograstim (USAN/INN)
D03304  
Interferon beta (JAN)
D03305  
Interferon alfa (NAMALWA) (JP17)
D03350  
Canertinib dihydrochloride (USAN)
D03357  
Interferon gamma-1a (genetical recombination) (JAN)
D03441  
Certolizumab pegol (USAN/INN)
D03455  
Cetuximab (USAN/INN)
D03639  
Daclizumab (USAN/INN)
D03645  
Daniplestim (USAN/INN)
D03651  
Darbepoetin alfa (USAN/INN)
D03658  
Dasatinib (INN)
D03682  
Denileukin diftitox (USAN/INN)
D03684  
Denosumab (USAN)
D03978  
Eltrombopag olamine (JAN/USAN)
D04023  
Erlotinib hydrochloride (JAN/USAN)
D04024  
Lapatinib ditosylate (USAN)
D04032  
Epoetin delta (USAN)
D04045  
Erlizumab (USAN/INN)
D04242  
Fontolizumab (USAN/INN)
D04358  
Golimumab (USAN/INN)
D04552  
Interferon alfa-n1 (USAN)
D04554  
Interferon beta-1a (USAN)
D04612  
Iratumumab (USAN)
D04690  
Lenercept (USAN/INN)
D04695  
Leridistim (USAN/INN)
D04696  
Lestaurtinib (USAN/INN)
D04858  
Mapatumumab (USAN/INN)
D04923  
Mepolizumab (USAN/INN)
D05014  
Metreleptin (USAN/INN)
D05029  
Midostaurin (USAN/INN)
D05036  
Milodistim (USAN/INN)
D05066  
Molgramostim (USAN/INN)
D05090  
Muplestim (USAN/INN)
D05146  
Nerelimomab (USAN/INN)
D05263  
Onercept (USAN/INN)
D05350  
Panitumumab (USAN/INN)
D05380  
Pazopanib hydrochloride (JAN/USAN)
D05386  
Pegaptanib sodium (JAN/USAN)
D05389  
Pegnartograstim (USAN/INN)
D05393  
Pegsunercept (USAN)
D05394  
Pegvisomant (USAN/INN)
D05399  
Pelitinib (USAN/INN)
D05697  
Ranibizumab (USAN/INN)
D05712  
Regramostim (USAN/INN)
D05777  
Ruplizumab (USAN/INN)
D05803  
Sargramostim (USAN/INN)
D05819  
Semaxanib (USAN/INN)
D05884  
Somatrem (USAN)
D06005  
Tandutinib (USAN/INN)
D06071  
Teneliximab (USAN/INN)
D06193  
Toralizumab (USAN/INN)
D06272  
Sorafenib tosylate (USAN)
D06285  
Vatalanib (USAN/INN)
D06297  
Vicriviroc maleate (USAN)
D06402  
Sunitinib malate (JAN/USAN)
D06407  
Vandetanib (JAN/USAN/INN)
D06409  
Bevacizumab (genetical recombination) (JAN)
D06413  
Nilotinib hydrochloride hydrate (JAN)
D06414  
Dasatinib (USAN)
D06556  
Apilimod mesylate (USAN)
D06557  
Aplaviroc hydrochloride (USAN)
D06611  
Lexatumumab (USAN/INN)
D06635  
Rilonacept (USAN/INN)
D06670  
Maraviroc (JAN/INN)
D06678  
Motesanib
D06889  
Pegfilgrastim (genetical recombination) (JAN)
D07436  
Afelimomab (INN)
D07907  
Erlotinib (INN)
D08066  
Imatinib (INN)
D08108  
Lapatinib (INN)
D08503  
Toceranib (USAN)
D08524  
Sorafenib (USAN/INN)
D08544  
Toceranib phosphate (USAN)
D08552  
Sunitinib (INN)
D08805  
Interferon gamma-n1 (JAN)
D08844  
Albinterferon alfa-2b (USAN)
D08857  
Anrukinzumab (USAN)
D08866  
Baminercept (USAN/INN)
D08874  
Bevasiranib sodium (USAN)
D08877  
Briobacept (USAN)
D08878  
Brivanib alaninate (JAN/USAN/INN)
D08881  
Cediranib (USAN/INN)
D08883  
Cediranib maleate (JAN/USAN)
D08896  
Dacetuzumab (USAN)
D08907  
Dovitinib lactate (USAN)
D08942  
Lucatumumab (USAN)
D08947  
Motesanib diphosphate (USAN)
D08950  
Neratinib (INN/USAN)
D08953  
Nilotinib (USAN/INN)
D08971  
Plerixafor (JAN/USAN/INN)
D08984  
Reparixin (USAN/INN)
D08985  
Reslizumab (USAN)
D08990  
Romiplostim (USAN/INN)
D09024  
Totrombopag choline (USAN)
D09214  
Ustekinumab (USAN/INN)
D09315  
Canakinumab (USAN/INN)
D09329  
Conatumumab (USAN/INN)
D09332  
Denenicokin (USAN/INN)
D09371  
Ramucirumab (USAN)
D09574  
Aflibercept (USAN/INN)
D09587  
Brentuximab vedotin (USAN)
D09588  
Briakinumab (USAN/INN)
D09589  
Brivanib (USAN)
D09615  
Fezakinumab (USAN/INN)
D09618  
Foretinib (USAN/INN)
D09620  
Fresolimumab (USAN/INN)
D09633  
Lebrikizumab (USAN/INN)
D09635  
Linifanib (USAN/INN)
D09659  
Rilotumumab (USAN/INN)
D09662  
Rontalizumab (USAN/INN)
D09668  
Sifalimumab (USAN/INN)
D09669  
Siltuximab (USAN/INN)
D09670  
Sotatercept (USAN/INN)
D09683  
Tivozanib (USAN/INN)
D09704  
Atacicept (USAN/INN)
D09724  
Afatinib (USAN/INN)
D09733  
Afatinib dimaleate (USAN)
D09737  
Epoetin kappa (genetical recombination) (Epoetin alfa biosimilar 1) (JAN)
D09761  
Mogamulizumab (USAN)
D09864  
Amuvatinib (USAN/INN)
D09865  
Amuvatinib hydrochloride (USAN)
D09874  
Benralizumab (USAN/INN)
D09877  
Carlumab (USAN)
D09888  
Drozitumab (USAN/INN)
D09896  
Enavatuzumab (USAN/INN)
D09897  
Enokizumab (USAN/INN)
D09911  
Gevokizumab (USAN/INN)
D09919  
Lenvatinib (USAN/INN)
D09920  
Lenvatinib mesylate (USAN)
D09926  
Icrucumab (USAN/INN)
D09930  
Mavrilimumab (USAN/INN)
D09939  
Olaratumab (USAN/INN)
D09941  
Onartuzumab (USAN/INN)
D09944  
Ozoralizumab (USAN)
D09945  
Pegdinetanib (USAN/INN)
D09946  
Peginesatide (USAN/INN)
D09947  
Peginesatide acetate (JAN/USAN)
D09955  
Quizartinib (USAN/INN)
D09956  
Quizartinib dihydrochloride (USAN)
D09967  
Secukinumab (USAN/INN)
D09979  
Tralokinumab (USAN/INN)
D09984  
Urelumab (USAN/INN)
D09998  
Epoetin beta pegol (genetical recombination) (JAN)
D10000  
Epoetin epsilon (genetical recombination) (JAN)
D10018  
Necitumumab (USAN/INN)
D10031  
Zalutumumab (USAN/INN)
D10061  
Brodalumab (USAN)
D10062  
Cabozantinib (USAN)
D10071  
Ixekizumab (USAN)
D10075  
Navarixin (USAN)
D10078  
Peginterferon lambda-1a (USAN)
D10080  
Sirukumab (USAN)
D10083  
Tabalumab (USAN)
D10102  
Crenolanib (USAN)
D10103  
Crenolanib besylate (USAN)
D10123  
Ficlatuzumab (USAN)
D10137  
Regorafenib hydrate (JAN)
D10138  
Regorafenib (USAN/INN)
D10161  
Sarilumab (USAN)
D10173  
Tivantinib (JAN/USAN/INN)
D10187  
Pateclizumab (USAN)
D10190  
Tivozanib hydrochloride (USAN)
D10224  
Golvatinib (USAN)
D10229  
Masitinib (INN)
D10242  
Lipegfilgrastim (USAN)
D10332  
Elubrixin (USAN)
D10341  
Vorsetuzumab mafodotin (USAN/INN)
D10342  
Vorsetuzumab (USAN/INN)
D10354  
Dupilumab (USAN)
D10378  
Vercirnon (USAN/INN)
D10379  
Vercirnon sodium (USAN)
D10387  
Danirixin (USAN/INN)
D10420  
Elubrixin tosylate (USAN)
D10465  
Golvatinib tartrate (USAN)
D10476  
Lusutrombopag (JAN/USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
2919  
CXCL1; C-X-C motif chemokine ligand 1 [KO:K05505]
2920  
CXCL2; C-X-C motif chemokine ligand 2 [KO:K05505]
2921  
CXCL3; C-X-C motif chemokine ligand 3 [KO:K05505]
6374  
CXCL5; C-X-C motif chemokine ligand 5 [KO:K05506]
6372  
CXCL6; C-X-C motif chemokine ligand 6 [KO:K05506]
5473  
PPBP; pro-platelet basic protein [KO:K10029]
3576  
CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
4283  
CXCL9; C-X-C motif chemokine ligand 9 [KO:K05416]
3627  
CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
6373  
CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672]
6387  
CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
10563  
CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032]
58191  
CXCL16; C-X-C motif chemokine ligand 16 [KO:K10035]
5196  
PF4; platelet factor 4 [KO:K05407]
5197  
PF4V1; platelet factor 4 variant 1 [KO:K05407]
9547  
CXCL14; C-X-C motif chemokine ligand 14 [KO:K10033]
6375  
XCL1; X-C motif chemokine ligand 1 [KO:K05507]
6846  
XCL2; X-C motif chemokine ligand 2 [KO:K05507]
6376  
CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508]
6346  
CCL1; C-C motif chemokine ligand 1 [KO:K05514]
6358  
CCL14; C-C motif chemokine ligand 14 [KO:K05514]
6360  
CCL16; C-C motif chemokine ligand 16 [KO:K05514]
6361  
CCL17; C-C motif chemokine ligand 17 [KO:K05514]
6362  
CCL18; C-C motif chemokine ligand 18 [KO:K05514]
6367  
CCL22; C-C motif chemokine ligand 22 [KO:K05514]
6369  
CCL24; C-C motif chemokine ligand 24 [KO:K05514]
10344  
CCL26; C-C motif chemokine ligand 26 [KO:K05514]
6364  
CCL20; C-C motif chemokine ligand 20 [KO:K14625]
6370  
CCL25; C-C motif chemokine ligand 25 [KO:K13072]
6363  
CCL19; C-C motif chemokine ligand 19 [KO:K05512]
6366  
CCL21; C-C motif chemokine ligand 21 [KO:K16062]
6347  
CCL2; C-C motif chemokine ligand 2 [KO:K14624]
6351  
CCL4; C-C motif chemokine ligand 4 [KO:K12964]
9560  
CCL4L2; C-C motif chemokine ligand 4 like 2 [KO:K12964]
388372  
CCL4L1; C-C motif chemokine ligand 4 like 1 [KO:K12964]
6348  
CCL3; C-C motif chemokine ligand 3 [KO:K05408]
6349  
CCL3L1; C-C motif chemokine ligand 3 like 1 [KO:K05408]
414062  
CCL3L3; C-C motif chemokine ligand 3 like 3 [KO:K05408]
6357  
CCL13; C-C motif chemokine ligand 13 [KO:K16595]
6354  
CCL7; C-C motif chemokine ligand 7 [KO:K05509]
6352  
CCL5; C-C motif chemokine ligand 5 [KO:K12499]
6359  
CCL15; C-C motif chemokine ligand 15 [KO:K05511]
6368  
CCL23; C-C motif chemokine ligand 23 [KO:K05511]
6355  
CCL8; C-C motif chemokine ligand 8 [KO:K16596]
6356  
CCL11; C-C motif chemokine ligand 11 [KO:K16597]
56477  
CCL28; C-C motif chemokine ligand 28 [KO:K05513]
10850  
CCL27; C-C motif chemokine ligand 27 [KO:K16598]
3569  
IL6; interleukin 6 [KO:K05405]
3589  
IL11; interleukin 11 [KO:K05417]
5008  
OSM; oncostatin M [KO:K05418]
3976  
LIF; leukemia inhibitory factor [KO:K05419]
1270  
CNTF; ciliary neurotrophic factor [KO:K05420]
23529  
CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
1489  
CTF1; cardiotrophin 1 [KO:K05422]
1440  
CSF3; colony stimulating factor 3 [KO:K05423]
3952  
LEP; leptin [KO:K05424]
3565  
IL4; interleukin 4 [KO:K05430]
3596  
IL13; interleukin 13 [KO:K05435]
3592  
IL12A; interleukin 12A [KO:K05406]
3593  
IL12B; interleukin 12B [KO:K05425]
51561  
IL23A; interleukin 23 subunit alpha [KO:K05426]
1437  
CSF2; colony stimulating factor 2 [KO:K05427]
3562  
IL3; interleukin 3 [KO:K04736]
3567  
IL5; interleukin 5 [KO:K05428]
3558  
IL2; interleukin 2 [KO:K05429]
3574  
IL7; interleukin 7 [KO:K05431]
3578  
IL9; interleukin 9 [KO:K05432]
3600  
IL15; interleukin 15 [KO:K05433]
59067  
IL21; interleukin 21 [KO:K05434]
85480  
TSLP; thymic stromal lymphopoietin [KO:K05436]
2056  
EPO; erythropoietin [KO:K05437]
2688  
GH1; growth hormone 1 [KO:K05438]
2689  
GH2; growth hormone 2 [KO:K05438]
5617  
PRL; prolactin [KO:K05439]
7066  
THPO; thrombopoietin [KO:K06854]
56034  
PDGFC; platelet derived growth factor C [KO:K05450]
5154  
PDGFA; platelet derived growth factor subunit A [KO:K04359]
5155  
PDGFB; platelet derived growth factor subunit B [KO:K17386]
7422  
VEGFA; vascular endothelial growth factor A [KO:K05448]
7423  
VEGFB; vascular endothelial growth factor B [KO:K16858]
7424  
VEGFC; vascular endothelial growth factor C [KO:K05449]
2277  
FIGF; c-fos induced growth factor (vascular endothelial growth factor D) [KO:K05449]
3082  
HGF; hepatocyte growth factor [KO:K05460]
1950  
EGF; epidermal growth factor [KO:K04357]
1435  
CSF1; colony stimulating factor 1 [KO:K05453]
4254  
KITLG; KIT ligand [KO:K05461]
2323  
FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
3439  
IFNA1; interferon, alpha 1 [KO:K05414]
3440  
IFNA2; interferon, alpha 2 [KO:K05414]
3441  
IFNA4; interferon, alpha 4 [KO:K05414]
3442  
IFNA5; interferon alpha 5 [KO:K05414]
3443  
IFNA6; interferon alpha 6 [KO:K05414]
3444  
IFNA7; interferon, alpha 7 [KO:K05414]
3445  
IFNA8; interferon alpha 8 [KO:K05414]
3446  
IFNA10; interferon, alpha 10 [KO:K05414]
3447  
IFNA13; interferon, alpha 13 [KO:K05414]
3448  
IFNA14; interferon alpha 14 [KO:K05414]
3449  
IFNA16; interferon, alpha 16 [KO:K05414]
3451  
IFNA17; interferon, alpha 17 [KO:K05414]
3452  
IFNA21; interferon, alpha 21 [KO:K05414]
3456  
IFNB1; interferon beta 1 [KO:K05415]
3467  
IFNW1; interferon, omega 1 [KO:K05440]
56832  
IFNK; interferon kappa [KO:K05441]
338376  
IFNE; interferon, epsilon [KO:K05442]
3458  
IFNG; interferon, gamma [KO:K04687]
3586  
IL10; interleukin 10 [KO:K05443]
29949  
IL19; interleukin 19 [KO:K05444]
50604  
IL20; interleukin 20 [KO:K05444]
11009  
IL24; interleukin 24 [KO:K05444]
50616  
IL22; interleukin 22 [KO:K05445]
282616  
IFNL2; interferon, lambda 2 [KO:K05447]
282617  
IFNL3; interferon, lambda 3 [KO:K05447]
282618  
IFNL1; interferon, lambda 1 [KO:K05447]
55801  
IL26; interleukin 26 [KO:K05446]
9966  
TNFSF15; tumor necrosis factor superfamily member 15 [KO:K05478]
8743  
TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
8600  
TNFSF11; tumor necrosis factor superfamily member 11 [KO:K05473]
8742  
TNFSF12; tumor necrosis factor superfamily member 12 [KO:K05474]
7124  
TNF; tumor necrosis factor [KO:K03156]
4049  
LTA; lymphotoxin alpha [KO:K05468]
4050  
LTB; lymphotoxin beta [KO:K03157]
8740  
TNFSF14; tumor necrosis factor superfamily member 14 [KO:K05477]
356  
FASLG; Fas ligand [KO:K04389]
959  
CD40LG; CD40 ligand [KO:K03161]
970  
CD70; CD70 molecule [KO:K05470]
944  
TNFSF8; tumor necrosis factor superfamily member 8 [KO:K05471]
8744  
TNFSF9; tumor necrosis factor superfamily member 9 [KO:K05472]
7292  
TNFSF4; tumor necrosis factor superfamily member 4 [KO:K05469]
8995  
TNFSF18; tumor necrosis factor superfamily member 18 [KO:K05479]
8741  
TNFSF13; tumor necrosis factor superfamily member 13 [KO:K05475]
10673  
TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476]
1896  
EDA; ectodysplasin A [KO:K05480]
7040  
TGFB1; transforming growth factor beta 1 [KO:K13375]
7042  
TGFB2; transforming growth factor beta 2 [KO:K13376]
7043  
TGFB3; transforming growth factor beta 3 [KO:K13377]
3624  
INHBA; inhibin beta A [KO:K04667]
3625  
INHBB; inhibin beta B [KO:K04667]
3626  
INHBC; inhibin beta C [KO:K04667]
83729  
INHBE; inhibin beta E [KO:K04667]
268  
AMH; anti-Mullerian hormone [KO:K04665]
650  
BMP2; bone morphogenetic protein 2 [KO:K04662]
655  
BMP7; bone morphogenetic protein 7 [KO:K16621]
8200  
GDF5; growth differentiation factor 5 [KO:K04664]
3605  
IL17A; interleukin 17A [KO:K05489]
27190  
IL17B; interleukin 17B [KO:K05490]
64806  
IL25; interleukin 25 [KO:K05493]
3552  
IL1A; interleukin 1 alpha [KO:K04383]
3553  
IL1B; interleukin 1 beta [KO:K04519]
3606  
IL18; interleukin 18 [KO:K05482]
3579  
CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
3577  
CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175]
2833  
CXCR3; C-X-C motif chemokine receptor 3 [KO:K04188]
7852  
CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
643  
CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190]
10663  
CXCR6; C-X-C motif chemokine receptor 6 [KO:K04191]
57007  
ACKR3; atypical chemokine receptor 3 [KO:K04304]
2829  
XCR1; X-C motif chemokine receptor 1 [KO:K04193]
1524  
CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192]
1237  
CCR8; C-C motif chemokine receptor 8 [KO:K04183]
1235  
CCR6; C-C motif chemokine receptor 6 [KO:K04181]
10803  
CCR9; C-C motif chemokine receptor 9 [KO:K04184]
1233  
CCR4; C-C motif chemokine receptor 4 [KO:K04179]
1236  
CCR7; C-C motif chemokine receptor 7 [KO:K04182]
729230  
CCR2; C-C motif chemokine receptor 2 [KO:K04177]
1234  
CCR5; C-C motif chemokine receptor 5 (gene/pseudogene) [KO:K04180]
1230  
CCR1; C-C motif chemokine receptor 1 [KO:K04176]
1232  
CCR3; C-C motif chemokine receptor 3 [KO:K04178]
2826  
CCR10; C-C motif chemokine receptor 10 [KO:K04185]
3570  
IL6R; interleukin 6 receptor [KO:K05055]
3572  
IL6ST; interleukin 6 signal transducer [KO:K05060]
3590  
IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
3977  
LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
9180  
OSMR; oncostatin M receptor [KO:K05057]
1271  
CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
1441  
CSF3R; colony stimulating factor 3 receptor [KO:K05061]
3953  
LEPR; leptin receptor [KO:K05062]
3566  
IL4R; interleukin 4 receptor [KO:K05071]
3597  
IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
3594  
IL12RB1; interleukin 12 receptor subunit beta 1 [KO:K05063]
3595  
IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
149233  
IL23R; interleukin 23 receptor [KO:K05065]
1438  
CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
1439  
CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
3563  
IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
3568  
IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
3559  
IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3560  
IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
3561  
IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
3575  
IL7R; interleukin 7 receptor [KO:K05072]
3581  
IL9R; interleukin 9 receptor [KO:K05073]
3601  
IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
50615  
IL21R; interleukin 21 receptor [KO:K05075]
64109  
CRLF2; cytokine receptor-like factor 2 [KO:K05078]
2057  
EPOR; erythropoietin receptor [KO:K05079]
2690  
GHR; growth hormone receptor [KO:K05080]
5618  
PRLR; prolactin receptor [KO:K05081]
4352  
MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
5156  
PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
5159  
PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
2321  
FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
3791  
KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
2324  
FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
4233  
MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
1956  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
1436  
CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
3815  
KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
2322  
FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
3454  
IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
3455  
IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
3459  
IFNGR1; interferon gamma receptor 1 [KO:K05132]
3460  
IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
3587  
IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
3588  
IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
53832  
IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
53833  
IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
58985  
IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
116379  
IL22RA2; interleukin 22 receptor subunit alpha 2 [KO:K05139]
163702  
IFNLR1; interferon lambda receptor 1 [KO:K05140]
8797  
TNFRSF10A; tumor necrosis factor receptor superfamily member 10a [KO:K04722]
8795  
TNFRSF10B; tumor necrosis factor receptor superfamily member 10b [KO:K04722]
8794  
TNFRSF10C; tumor necrosis factor receptor superfamily member 10c [KO:K04722]
8793  
TNFRSF10D; tumor necrosis factor receptor superfamily member 10d [KO:K04722]
4982  
TNFRSF11B; tumor necrosis factor receptor superfamily member 11b [KO:K05148]
8792  
TNFRSF11A; tumor necrosis factor receptor superfamily member 11a [KO:K05147]
8718  
TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
51330  
TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
27242  
TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
4804  
NGFR; nerve growth factor receptor [KO:K02583]
7133  
TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
7132  
TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
4055  
LTBR; lymphotoxin beta receptor [KO:K03159]
8764  
TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
8771  
TNFRSF6B; tumor necrosis factor receptor superfamily member 6b [KO:K05143]
355  
FAS; Fas cell surface death receptor [KO:K04390]
958  
CD40; CD40 molecule [KO:K03160]
939  
CD27; CD27 molecule [KO:K05144]
943  
TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
3604  
TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
7293  
TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
8784  
TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
608  
TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
23495  
TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
115650  
TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
10913  
EDAR; ectodysplasin A receptor [KO:K05162]
60401  
EDA2R; ectodysplasin A2 receptor [KO:K05163]
55504  
TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
84957  
RELT; RELT tumor necrosis factor receptor [KO:K05156]
7048  
TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
7046  
TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
92  
ACVR2A; activin A receptor type 2A [KO:K04670] [EC:2.7.11.30]
93  
ACVR2B; activin A receptor type 2B [KO:K13596] [EC:2.7.11.30]
90  
ACVR1; activin A receptor type 1 [KO:K04675] [EC:2.7.11.30]
91  
ACVR1B; activin A receptor type 1B [KO:K13567] [EC:2.7.11.30]
269  
AMHR2; anti-Mullerian hormone receptor type 2 [KO:K04672] [EC:2.7.11.30]
659  
BMPR2; bone morphogenetic protein receptor type 2 [KO:K04671] [EC:2.7.11.30]
657  
BMPR1A; bone morphogenetic protein receptor type 1A [KO:K04673] [EC:2.7.11.30]
658  
BMPR1B; bone morphogenetic protein receptor type 1B [KO:K13578] [EC:2.7.11.30]
23765  
IL17RA; interleukin 17 receptor A [KO:K05164]
55540  
IL17RB; interleukin 17 receptor B [KO:K05165]
3554  
IL1R1; interleukin 1 receptor type 1 [KO:K04386]
3556  
IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
7850  
IL1R2; interleukin 1 receptor type 2 [KO:K04387]
8809  
IL18R1; interleukin 18 receptor 1 [KO:K05173]
8807  
IL18RAP; interleukin 18 receptor accessory protein [KO:K05174]
80301  
PLEKHO2; pleckstrin homology domain containing O2
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Mol Cell Biol 15:3479-86 (1995)
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TGF-beta signal transduction.
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Annu Rev Biochem 67:753-91 (1998)
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Nat Rev Mol Cell Biol 1:169-78 (2000)
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Interleukin-17 family and IL-17 receptors.
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Cytokine Growth Factor Rev 14:155-74 (2003)
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KO pathway
 

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