KEGG   PATHWAY: hsa04068Help
Entry
hsa04068                    Pathway                                

Name
FoxO signaling pathway - Homo sapiens (human)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
FoxO signaling pathway
hsa04068

All organismsOrtholog table
Module
PI3K-Akt signaling [PATH:hsa04068]
Disease
H01385  
Rienhoff syndrome
H01456  
Diabetic nephropathy
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
7040  
K13375 transforming growth factor beta-1 | (RefSeq) TGFB1; transforming growth factor beta 1 [KO:K13375]
7042  
K13376 transforming growth factor beta-2 | (RefSeq) TGFB2; transforming growth factor beta 2 [KO:K13376]
7043  
K13377 transforming growth factor beta-3 | (RefSeq) TGFB3; transforming growth factor beta 3 [KO:K13377]
7046  
K04674 TGF-beta receptor type-1 [EC:2.7.11.30] | (RefSeq) TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048  
K04388 TGF-beta receptor type-2 [EC:2.7.11.30] | (RefSeq) TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
4089  
K04501 mothers against decapentaplegic homolog 4 | (RefSeq) SMAD4; SMAD family member 4 [KO:K04501]
4087  
K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) SMAD2; SMAD family member 2 [KO:K04500]
4088  
K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) SMAD3; SMAD family member 3 [KO:K04500]
6794  
K07298 serine/threonine-protein kinase 11 | (RefSeq) STK11; serine/threonine kinase 11 [KO:K07298]
5562  
K07198 5'-AMP-activated protein kinase; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.11]
5563  
K07198 5'-AMP-activated protein kinase; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.11]
5564  
K07199 5'-AMP-activated protein kinase; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
5565  
K07199 5'-AMP-activated protein kinase; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
5571  
K07200 5'-AMP-activated protein kinase; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
53632  
K07200 5'-AMP-activated protein kinase; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
51422  
K07200 5'-AMP-activated protein kinase; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
51701  
K04468 nemo like kinase [EC:2.7.11.24] | (RefSeq) NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
6502  
K03875 F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2) | (RefSeq) SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [KO:K03875]
4193  
K06643 E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] | (RefSeq) MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
80854  
K11431 histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43] | (RefSeq) SETD7; SET domain containing lysine methyltransferase 7 [KO:K11431] [EC:2.1.1.43]
1387  
K04498 E1A/CREB-binding protein [EC:2.3.1.48] | (RefSeq) CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  
K04498 E1A/CREB-binding protein [EC:2.3.1.48] | (RefSeq) EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
23411  
K11411 NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-] | (RefSeq) SIRT1; sirtuin 1 [KO:K11411] [EC:3.5.1.-]
7874  
K11838 ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12] | (RefSeq) USP7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
6517  
K07191 MFS transporter; solute carrier family 2 member 4 [KO:K07191]
5599  
K04440 c-Jun N-terminal kinase [EC:2.7.11.24] | (RefSeq) MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  
K04440 c-Jun N-terminal kinase [EC:2.7.11.24] | (RefSeq) MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  
K04440 c-Jun N-terminal kinase [EC:2.7.11.24] | (RefSeq) MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
6789  
K04411 serine/threonine kinase 4 | (RefSeq) STK4; serine/threonine kinase 4 [KO:K04411]
3479  
K05459 insulin-like growth factor 1 | (RefSeq) IGF1; insulin like growth factor 1 [KO:K05459]
3480  
K05087 insulin-like growth factor 1 receptor [EC:2.7.10.1] | (RefSeq) IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
3630  
K04526 insulin | (RefSeq) INS; insulin [KO:K04526]
3643  
K04527 insulin receptor [EC:2.7.10.1] | (RefSeq) INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
3667  
K16172 insulin receptor substrate 1 | (RefSeq) IRS1; insulin receptor substrate 1 [KO:K16172]
8660  
K07187 insulin receptor substrate 2 | (RefSeq) IRS2; insulin receptor substrate 2 [KO:K07187]
8471  
K17446 insulin receptor substrate 4 | (RefSeq) IRS4; insulin receptor substrate 4 [KO:K17446]
5290  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
K00922 phosphatidylinositol-4; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5295  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
K02649 phosphoinositide-3-kinase; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5170  
K06276 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1] | (RefSeq) PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
1147  
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10] | (RefSeq) CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] | (RefSeq) IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
5728  
K01110 phosphatidylinositol-3; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
207  
K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
6446  
K13302 serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1] | (RefSeq) SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
10110  
K13303 serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1] | (RefSeq) SGK2; SGK2, serine/threonine kinase 2 [KO:K13303] [EC:2.7.11.1]
23678  
K13304 serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1] | (RefSeq) SGK3; serum/glucocorticoid regulated kinase family member 3 [KO:K13304] [EC:2.7.11.1]
K13304 serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1] | (RefSeq) C8orf44-SGK3; C8orf44-SGK3 readthrough [KO:K13304] [EC:2.7.11.1]
2308  
K07201 forkhead box protein O1 | (RefSeq) FOXO1; forkhead box O1 [KO:K07201]
2309  
K09408 forkhead box protein O3 | (RefSeq) FOXO3; forkhead box O3 [KO:K09408]
4303  
K12358 forkhead box protein O4 | (RefSeq) FOXO4; forkhead box O4 [KO:K12358]
K17847 forkhead box protein O6 | (RefSeq) FOXO6; forkhead box O6 [KO:K17847]
2911  
K04603 metabotropic glutamate receptor 1 | (RefSeq) GRM1; glutamate metabotropic receptor 1 [KO:K04603]
9456  
K15010 homer | (RefSeq) HOMER1; homer scaffolding protein 1 [KO:K15010]
9455  
K15010 homer | (RefSeq) HOMER2; homer scaffolding protein 2 [KO:K15010]
9454  
K15010 homer | (RefSeq) HOMER3; homer scaffolding protein 3 [KO:K15010]
116986  
K17848 Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K17848]
1454  
K08960 casein kinase 1; casein kinase 1 epsilon [KO:K08960] [EC:2.7.11.1]
K08960 casein kinase 1 [KO:K08960] [EC:2.7.11.1]
3569  
K05405 interleukin 6 | (RefSeq) IL6; interleukin 6 [KO:K05405]
3586  
K05443 interleukin 10 | (RefSeq) IL10; interleukin 10 [KO:K05443]
6774  
K04692 signal transducer and activator of transcription 3 | (RefSeq) STAT3; signal transducer and activator of transcription 3 [KO:K04692]
1950  
K04357 epidermal growth factor | (RefSeq) EGF; epidermal growth factor [KO:K04357]
1956  
K04361 epidermal growth factor receptor [EC:2.7.10.1] | (RefSeq) EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2885  
K04364 growth factor receptor-binding protein 2 | (RefSeq) GRB2; growth factor receptor bound protein 2 [KO:K04364]
6654  
K03099 son of sevenless | (RefSeq) SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  
K03099 son of sevenless | (RefSeq) SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  
K02833 GTPase HRas | (RefSeq) HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  
K07827 GTPase KRas | (RefSeq) KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  
K07828 GTPase NRas | (RefSeq) NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
673  
K04365 B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
369  
K08845 A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
5604  
K04368 mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] | (RefSeq) MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  
K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] | (RefSeq) MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  
K04371 mitogen-activated protein kinase 1/3 [EC:2.7.11.24] | (RefSeq) MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
K04371 mitogen-activated protein kinase 1/3 [EC:2.7.11.24] | (RefSeq) MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5600  
K04441 p38 MAP kinase [EC:2.7.11.24] | (RefSeq) MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  
K04441 p38 MAP kinase [EC:2.7.11.24] | (RefSeq) MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  
K04441 p38 MAP kinase [EC:2.7.11.24] | (RefSeq) MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  
K04441 p38 MAP kinase [EC:2.7.11.24] | (RefSeq) MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
1017  
K02206 cyclin-dependent kinase 2 [EC:2.7.11.22] | (RefSeq) CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
3276  
K11434 type I protein arginine methyltransferase [EC:2.1.1.319] | (RefSeq) PRMT1; protein arginine methyltransferase 1 [KO:K11434] [EC:2.1.1.319]
2290  
K09385 forkhead box protein G | (RefSeq) FOXG1; forkhead box G1 [KO:K09385]
891  
K05868 cyclin B | (RefSeq) CCNB1; cyclin B1 [KO:K05868]
9133  
K05868 cyclin B | (RefSeq) CCNB2; cyclin B2 [KO:K05868]
85417  
K05868 cyclin B | (RefSeq) CCNB3; cyclin B3 [KO:K05868]
595  
K04503 cyclin D1 | (RefSeq) CCND1; cyclin D1 [KO:K04503]
894  
K10151 cyclin D2 | (RefSeq) CCND2; cyclin D2 [KO:K10151]
901  
K10146 cyclin G2 | (RefSeq) CCNG2; cyclin G2 [KO:K10146]
1030  
K04685 cyclin-dependent kinase inhibitor 2B | (RefSeq) CDKN2B; cyclin dependent kinase inhibitor 2B [KO:K04685]
1032  
K06623 cyclin-dependent kinase inhibitor 2D | (RefSeq) CDKN2D; cyclin dependent kinase inhibitor 2D [KO:K06623]
1026  
K06625 cyclin-dependent kinase inhibitor 1A | (RefSeq) CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
1027  
K06624 cyclin-dependent kinase inhibitor 1B | (RefSeq) CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
5934  
K16332 retinoblastoma-like protein 2 | (RefSeq) RBL2; RB transcriptional corepressor like 2 [KO:K16332]
5347  
K06631 polo-like kinase 1 [EC:2.7.11.21] | (RefSeq) PLK1; polo like kinase 1 [KO:K06631] [EC:2.7.11.21]
10769  
K08861 polo-like kinase 2 [EC:2.7.11.21] | (RefSeq) PLK2; polo like kinase 2 [KO:K08861] [EC:2.7.11.21]
1263  
K08862 polo-like kinase 3 [EC:2.7.11.21] | (RefSeq) PLK3; polo like kinase 3 [KO:K08862] [EC:2.7.11.21]
10733  
K08863 polo-like kinase 4 [EC:2.7.11.21] | (RefSeq) PLK4; polo like kinase 4 [KO:K08863] [EC:2.7.11.21]
1647  
K04402 growth arrest and DNA-damage-inducible protein | (RefSeq) GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
4616  
K04402 growth arrest and DNA-damage-inducible protein | (RefSeq) GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
10912  
K04402 growth arrest and DNA-damage-inducible protein | (RefSeq) GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
356  
K04389 tumor necrosis factor ligand superfamily member 6 | (RefSeq) FASLG; Fas ligand [KO:K04389]
10018  
K16341 Bcl-2-like protein 11 | (RefSeq) BCL2L11; BCL2 like 11 [KO:K16341]
8743  
K04721 tumor necrosis factor ligand superfamily member 10 | (RefSeq) TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
604  
K15618 B-cell lymphoma 6 protein | (RefSeq) BCL6; B-cell CLL/lymphoma 6 [KO:K15618]
664  
K15464 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | (RefSeq) BNIP3; BCL2 interacting protein 3 [KO:K15464]
9140  
K08336 ubiquitin-like protein ATG12 | (RefSeq) ATG12; autophagy related 12 [KO:K08336]
11337  
K08341 GABA(A) receptor-associated protein | (RefSeq) GABARAP; GABA type A receptor-associated protein [KO:K08341]
23710  
K08341 GABA(A) receptor-associated protein | (RefSeq) GABARAPL1; GABA type A receptor associated protein like 1 [KO:K08341]
11345  
K08341 GABA(A) receptor-associated protein | (RefSeq) GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341]
847  
K03781 catalase [EC:1.11.1.6] | (RefSeq) CAT; catalase [KO:K03781] [EC:1.11.1.6]
6648  
K04564 superoxide dismutase; superoxide dismutase 2, mitochondrial [KO:K04564] [EC:1.15.1.1]
472  
K04728 ataxia telangiectasia mutated family protein [EC:2.7.11.1] | (RefSeq) ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
5105  
K01596 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] | (RefSeq) PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
5106  
K01596 phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32] | (RefSeq) PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
2538  
K01084 glucose-6-phosphatase [EC:3.1.3.9] | (RefSeq) G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
57818  
K01084 glucose-6-phosphatase [EC:3.1.3.9] | (RefSeq) G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
92579  
K01084 glucose-6-phosphatase [EC:3.1.3.9] | (RefSeq) G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
3575  
K05072 interleukin 7 receptor | (RefSeq) IL7R; interleukin 7 receptor [KO:K05072]
10365  
K17845 krueppel-like factor 2 | (RefSeq) KLF2; Kruppel like factor 2 [KO:K17845]
1901  
K04288 sphingosine 1-phosphate receptor 1 | (RefSeq) S1PR1; sphingosine-1-phosphate receptor 1 [KO:K04288]
8698  
K04293 sphingosine 1-phosphate receptor 4 | (RefSeq) S1PR4; sphingosine-1-phosphate receptor 4 [KO:K04293]
5896  
K10628 V(D)J recombination-activating protein 1 [EC:2.3.2.27] | (RefSeq) RAG1; recombination activating 1 [KO:K10628] [EC:2.3.2.27]
5897  
K10988 recombination-activating protein 2 | (RefSeq) RAG2; recombination activating 2 [KO:K10988]
26260  
K10305 F-box protein 25/32 | (RefSeq) FBXO25; F-box protein 25 [KO:K10305]
114907  
K10305 F-box protein 25/32 | (RefSeq) FBXO32; F-box protein 32 [KO:K10305]
Compound
C00008  
ADP
C00020  
AMP
C00025  
L-Glutamate
C00031  
D-Glucose
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
Reference
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
Reference
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
Reference
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
Reference
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
Reference
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
Reference
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
Reference
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
Reference
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
Reference
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
Reference
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
Reference
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
Reference
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
Reference
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
Reference
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
Reference
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
Reference
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
Reference
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
Reference
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
KO pathway
 

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