KEGG   PATHWAY: hsa04070Help
Entry
hsa04070                    Pathway                                

Name
Phosphatidylinositol signaling system - Homo sapiens (human)
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Phosphatidylinositol signaling system
hsa04070

All organismsOrtholog table
Disease
H00530  
Joubert syndrome
H00692  
Lowe syndrome
H00694  
Dent disease
H00700  
Centronuclear myopathy
H00865  
Lethal congenital contractural syndrome (LCCS)
H00957  
Fleck corneal dystrophy (FCD)
H01195  
VACTERL/VATER association
H01307  
Nonsyndromic congenital nail disorder (NDNC)
Organism
Homo sapiens (human) [GN:hsa]
Gene
5297  
PI4KA; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
5298  
PI4KB; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
55361  
PI4K2A; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
55300  
PI4K2B; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
23396  
PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
8394  
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
8395  
PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
8867  
SYNJ1; synaptojanin 1 [KO:K01099] [EC:3.1.3.36]
8871  
SYNJ2; synaptojanin 2 [KO:K01099] [EC:3.1.3.36]
4952  
OCRL; oculocerebrorenal syndrome of Lowe [KO:K01099] [EC:3.1.3.36]
56623  
INPP5E; inositol polyphosphate-5-phosphatase E [KO:K01099] [EC:3.1.3.36]
3633  
INPP5B; inositol polyphosphate-5-phosphatase B [KO:K01099] [EC:3.1.3.36]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5295  
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5728  
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
3635  
INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
3636  
INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
3631  
INPP4A; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
8821  
INPP4B; inositol polyphosphate-4-phosphatase type II B [KO:K01109] [EC:3.1.3.66]
200576  
PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
4534  
MTM1; myotubularin 1 [KO:K01108] [EC:3.1.3.95 3.1.3.64]
8776  
MTMR1; myotubularin related protein 1 [KO:K18081] [EC:3.1.3.95 3.1.3.64]
8898  
MTMR2; myotubularin related protein 2 [KO:K18081] [EC:3.1.3.95 3.1.3.64]
8897  
MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
9110  
MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
55613  
MTMR8; myotubularin related protein 8 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
9107  
MTMR6; myotubularin related protein 6 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
9108  
MTMR7; myotubularin related protein 7 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
64419  
MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.95 3.1.3.64]
79837  
PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [KO:K00920] [EC:2.7.1.149]
5305  
PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
8396  
PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
90809  
TMEM55B; transmembrane protein 55B [KO:K13084] [EC:3.1.3.78]
55529  
TMEM55A; transmembrane protein 55A [KO:K13084] [EC:3.1.3.78]
5289  
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
5288  
PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
5286  
PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
5287  
PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
23236  
PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
5330  
PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
5332  
PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
5333  
PLCD1; phospholipase C delta 1 [KO:K05857] [EC:3.1.4.11]
113026  
PLCD3; phospholipase C delta 3 [KO:K05857] [EC:3.1.4.11]
84812  
PLCD4; phospholipase C delta 4 [KO:K05857] [EC:3.1.4.11]
51196  
PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
5335  
PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  
PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
89869  
PLCZ1; phospholipase C zeta 1 [KO:K05861] [EC:3.1.4.11]
253430  
IPMK; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.151 2.7.1.140]
3707  
ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
3706  
ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
80271  
ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
51763  
INPP5K; inositol polyphosphate-5-phosphatase K [KO:K01106] [EC:3.1.3.56]
27124  
INPP5J; inositol polyphosphate-5-phosphatase J [KO:K01106] [EC:3.1.3.56]
3632  
INPP5A; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
3705  
ITPK1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.134 2.7.1.159]
64768  
IPPK; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
9807  
IP6K1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
51447  
IP6K2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
117283  
IP6K3; inositol hexakisphosphate kinase 3 [KO:K07756] [EC:2.7.4.21]
9677  
PPIP5K1; diphosphoinositol pentakisphosphate kinase 1 [KO:K13024] [EC:2.7.4.24]
23262  
PPIP5K2; diphosphoinositol pentakisphosphate kinase 2 [KO:K13024] [EC:2.7.4.24]
3628  
INPP1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
3613  
IMPA2; inositol(myo)-1(or 4)-monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
3612  
IMPA1; inositol(myo)-1(or 4)-monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
54928  
IMPAD1; inositol monophosphatase domain containing 1 [KO:K15759] [EC:3.1.3.7 3.1.3.25]
8525  
DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
8527  
DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
9162  
DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
1606  
DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
8526  
DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
1607  
DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
160851  
DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
1608  
DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
1609  
DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
139189  
DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
1040  
CDS1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
8760  
CDS2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
10423  
CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
3708  
ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
3709  
ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
3710  
ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
5578  
PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
810  
CALML3; calmodulin like 3 [KO:K02183]
805  
CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808  
CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801  
CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688  
CALML6; calmodulin like 6 [KO:K02183]
51806  
CALML5; calmodulin like 5 [KO:K02183]
Compound
C00076  
Calcium cation
C00137  
myo-Inositol
C00269  
CDP-diacylglycerol
C00416  
Phosphatidate
C00641  
1,2-Diacyl-sn-glycerol
C01177  
Inositol 1-phosphate
C01194  
1-Phosphatidyl-D-myo-inositol
C01204  
Phytic acid
C01220  
1D-myo-Inositol 1,4-bisphosphate
C01243  
1D-myo-Inositol 1,3,4-trisphosphate
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01272  
1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  
1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  
1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  
myo-Inositol 4-phosphate
C04006  
1D-myo-Inositol 3-phosphate
C04062  
D-myo-Inositol 1,3-bisphosphate
C04063  
D-myo-Inositol 3,4-bisphosphate
C04477  
1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C11174  
1-Diphosinositol pentakisphosphate
C11526  
5-PP-InsP5
C11554  
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  
1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  
1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  
1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  
1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
Reference
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
KO pathway
 

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