KEGG   PATHWAY: hsa04145Help
Entry
hsa04145                    Pathway                                

Name
Phagosome - Homo sapiens (human)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
hsa04145

All organismsOrtholog table
Module
Sec61 complex [PATH:hsa04145]
Disease
H00265  
Hereditary sensory and autonomic neuropathy (HSAN)
H00751  
Asphyxiating thoracic dystrophy
H00821  
Macular degeneration
H00838  
Congenital fibrosis of the extraocular muscles (CFEOM)
H00856  
Distal hereditary motor neuropathies (dHMN)
H00957  
Fleck corneal dystrophy (FCD)
H00984  
Bare lymphocyte syndrome (BLS) type1
H01108  
CD36 deficiency
H01109  
Chronic mucocutaneous candidiasis (CMC)
H01240  
Immune thrombocytopenia (ITP)
H01255  
Juvenile-onset dystonia
Drug
D10028  
Valategrast hydrochloride (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
9341  
VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
23673  
STX12; syntaxin 12 [KO:K13813]
8417  
STX7; syntaxin 7 [KO:K08488]
60  
ACTB; actin, beta [KO:K05692]
71  
ACTG1; actin, gamma 1 [KO:K05692]
11151  
CORO1A; coronin, actin binding protein, 1A [KO:K13882]
53407  
STX18; syntaxin 18 [KO:K08492]
9554  
SEC22B; SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) [KO:K08517]
3105  
HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  
HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  
HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  
HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  
HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  
HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3108  
HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  
HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  
HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  
HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  
HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
5868  
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869  
RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878  
RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
8411  
EEA1; early endosome antigen 1 [KO:K12478]
5289  
PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
7037  
TFRC; transferrin receptor [KO:K06503]
9146  
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
523  
ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A [KO:K02145] [EC:3.6.3.14]
525  
ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 [KO:K02147]
526  
ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [KO:K02147]
245973  
ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [KO:K02148]
528  
ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [KO:K02148]
51382  
ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D [KO:K02149]
90423  
ATP6V1E2; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 [KO:K02150]
529  
ATP6V1E1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 [KO:K02150]
9296  
ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F [KO:K02151]
9550  
ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 [KO:K02152]
127124  
ATP6V1G3; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 [KO:K02152]
534  
ATP6V1G2; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 [KO:K02152]
8992  
ATP6V0E1; ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 [KO:K02153]
155066  
ATP6V0E2; ATPase, H+ transporting V0 subunit e2 [KO:K02153]
10312  
TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 [KO:K02154]
23545  
ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154]
50617  
ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4 [KO:K02154]
535  
ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154]
9114  
ATP6V0D1; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 [KO:K02146]
245972  
ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 [KO:K02146]
51606  
ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [KO:K02144]
527  
ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c [KO:K02155]
533  
ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [KO:K03661]
537  
ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1 [KO:K03662]
7879  
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
338382  
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
83547  
RILP; Rab interacting lysosomal protein [KO:K13883]
1778  
DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
79659  
DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
1780  
DYNC1I1; dynein, cytoplasmic 1, intermediate chain 1 [KO:K10415]
1781  
DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
1783  
DYNC1LI2; dynein, cytoplasmic 1, light intermediate chain 2 [KO:K10416]
51143  
DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
10376  
TUBA1B; tubulin, alpha 1b [KO:K07374]
7277  
TUBA4A; tubulin, alpha 4a [KO:K07374]
7278  
TUBA3C; tubulin, alpha 3c [KO:K07374]
7846  
TUBA1A; tubulin, alpha 1a [KO:K07374]
84790  
TUBA1C; tubulin, alpha 1c [KO:K07374]
51807  
TUBA8; tubulin, alpha 8 [KO:K07374]
112714  
TUBA3E; tubulin, alpha 3e [KO:K07374]
113457  
TUBA3D; tubulin, alpha 3d [KO:K07374]
79861  
TUBAL3; tubulin, alpha-like 3 [KO:K07374]
84617  
TUBB6; tubulin, beta 6 class V [KO:K07375]
203068  
TUBB; tubulin, beta class I [KO:K07375]
81027  
TUBB1; tubulin, beta 1 class VI [KO:K07375]
7280  
TUBB2A; tubulin, beta 2A class IIa [KO:K07375]
10381  
TUBB3; tubulin, beta 3 class III [KO:K07375]
10382  
TUBB4A; tubulin, beta 4A class IVa [KO:K07375]
347688  
TUBB8; tubulin, beta 8 class VIII [KO:K07375]
347733  
TUBB2B; tubulin, beta 2B class IIb [KO:K07375]
10383  
TUBB4B; tubulin, beta 4B class IVb [KO:K07375]
3916  
LAMP1; lysosomal-associated membrane protein 1 [KO:K06528]
3920  
LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
200576  
PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
4074  
M6PR; mannose-6-phosphate receptor (cation dependent) [KO:K10089]
4842  
NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
4353  
MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
1514  
CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
1520  
CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
29927  
SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
55176  
SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
10952  
SEC61B; Sec61 beta subunit [KO:K09481]
23480  
SEC61G; Sec61 gamma subunit [KO:K07342]
6890  
TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05653]
6891  
TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654]
811  
CALR; calreticulin [KO:K08057]
821  
CANX; calnexin [KO:K08054]
2204  
FCAR; Fc fragment of IgA, receptor for [KO:K06513]
2209  
FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64) [KO:K06498]
2212  
FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32) [KO:K06472]
2213  
FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32) [KO:K12560]
9103  
FCGR2C; Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) [KO:K16824]
2214  
FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [KO:K06463]
2215  
FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b) [KO:K06463]
715  
C1R; complement component 1, r subcomponent [KO:K01330] [EC:3.4.21.41]
3684  
ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) [KO:K06461]
3689  
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
718  
C3; complement component 3 [KO:K03990]
78989  
COLEC11; collectin sub-family member 11 [KO:K10066]
81035  
COLEC12; collectin sub-family member 12 [KO:K10062]
4153  
MBL2; mannose-binding lectin (protein C) 2, soluble [KO:K03991]
653509  
SFTPA1; surfactant protein A1 [KO:K10067]
729238  
SFTPA2; surfactant protein A2 [KO:K10067]
6441  
SFTPD; surfactant protein D [KO:K10068]
3685  
ITGAV; integrin, alpha V [KO:K06487]
3673  
ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [KO:K06481]
3678  
ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [KO:K06484]
3688  
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
3690  
ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [KO:K06493]
3693  
ITGB5; integrin, beta 5 [KO:K06588]
7057  
THBS1; thrombospondin 1 [KO:K16857]
1311  
COMP; cartilage oligomeric matrix protein [KO:K04659]
7058  
THBS2; thrombospondin 2 [KO:K04659]
7059  
THBS3; thrombospondin 3 [KO:K04659]
7060  
THBS4; thrombospondin 4 [KO:K04659]
7097  
TLR2; toll-like receptor 2 [KO:K10159]
10333  
TLR6; toll-like receptor 6 [KO:K10169]
7099  
TLR4; toll-like receptor 4 [KO:K10160]
929  
CD14; CD14 molecule [KO:K04391]
22925  
PLA2R1; phospholipase A2 receptor 1, 180kDa [KO:K06560]
4360  
MRC1; mannose receptor, C type 1 [KO:K06560]
9902  
MRC2; mannose receptor, C type 2 [KO:K06560]
macrophage mannose receptor 1-like; K06560 mannose receptor, C type [KO:K06560]
10332  
CLEC4M; C-type lectin domain family 4, member M [KO:K06563]
30835  
CD209; CD209 molecule [KO:K06563]
64581  
CLEC7A; C-type lectin domain family 7, member A [KO:K10074]
4481  
MSR1; macrophage scavenger receptor 1 [KO:K06558]
8685  
MARCO; macrophage receptor with collagenous structure [KO:K13884]
4973  
OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
949  
SCARB1; scavenger receptor class B, member 1 [KO:K13885]
948  
CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
1535  
CYBA; cytochrome b-245, alpha polypeptide [KO:K08009]
50508  
NOX3; NADPH oxidase 3 [KO:K08008]
27035  
NOX1; NADPH oxidase 1 [KO:K08008]
1536  
CYBB; cytochrome b-245, beta polypeptide [KO:K08008]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
653361  
NCF1; neutrophil cytosolic factor 1 [KO:K08011]
4688  
NCF2; neutrophil cytosolic factor 2 [KO:K08010]
4689  
NCF4; neutrophil cytosolic factor 4, 40kDa [KO:K08012]
Compound
C00007  
Oxygen
C00027  
Hydrogen peroxide
C00533  
Nitric oxide
C00704  
O2.-
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 

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