KEGG PATHWAY: hsa04145

PATHWAY: hsa04145

Entry

hsa04145 Pathway

Name

Phagosome - Homo sapiens (human)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

hsa04145

Phagosome

Module

hsa_M00401

Sec61 complex [PATH:hsa04145]

Disease

H00751	Asphyxiating thoracic dystrophy
H00821	Macular degeneration
H00838	Congenital fibrosis of the extraocular muscles (CFEOM)
H00856	Distal hereditary motor neuropathies (dHMN)
H00957	Fleck corneal dystrophy (FCD)
H00984	Bare lymphocyte syndrome (BLS) type1
H01108	CD36 deficiency
H01109	Chronic mucocutaneous candidiasis (CMC)
H01240	Immune thrombocytopenia (ITP)
H01255	Juvenile-onset dystonia

Drug

D10028

Valategrast hydrochloride (USAN)

Other DBs

BSID:

153910

GO:

0045335

Organism

Homo sapiens (human) [GN:hsa]

Gene

9341	VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
23673	STX12; syntaxin 12 [KO:K13813]
8417	STX7; syntaxin 7 [KO:K08488]
60	ACTB; actin, beta [KO:K05692]
71	ACTG1; actin, gamma 1 [KO:K05692]
11151	CORO1A; coronin, actin binding protein, 1A [KO:K13882]
53407	STX18; syntaxin 18 [KO:K08492]
9554	SEC22B; SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) [KO:K08517]
3105	HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106	HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107	HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134	HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135	HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133	HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3108	HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109	HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111	HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112	HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113	HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115	HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117	HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118	HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119	HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122	HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123	HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125	HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126	HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127	HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
100507709	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100507714	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100509457	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
101060835	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
5868	RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869	RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878	RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
8411	EEA1; early endosome antigen 1 [KO:K12478]
5289	PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
7037	TFRC; transferrin receptor (p90, CD71) [KO:K06503]
9146	HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
523	ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A [KO:K02145] [EC:3.6.3.14]
525	ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 [KO:K02147] [EC:3.6.3.14]
526	ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [KO:K02147] [EC:3.6.3.14]
245973	ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [KO:K02148] [EC:3.6.3.14]
528	ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [KO:K02148] [EC:3.6.3.14]
51382	ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D [KO:K02149] [EC:3.6.3.14]
90423	ATP6V1E2; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 [KO:K02150] [EC:3.6.3.14]
529	ATP6V1E1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 [KO:K02150] [EC:3.6.3.14]
9296	ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F [KO:K02151] [EC:3.6.3.14]
9550	ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 [KO:K02152] [EC:3.6.3.14]
127124	ATP6V1G3; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 [KO:K02152] [EC:3.6.3.14]
534	ATP6V1G2; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 [KO:K02152] [EC:3.6.3.14]
8992	ATP6V0E1; ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 [KO:K02153] [EC:3.6.3.14]
155066	ATP6V0E2; ATPase, H+ transporting V0 subunit e2 [KO:K02153] [EC:3.6.3.14]
10312	TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 [KO:K02154] [EC:3.6.3.14]
23545	ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154] [EC:3.6.3.14]
50617	ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4 [KO:K02154] [EC:3.6.3.14]
535	ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154] [EC:3.6.3.14]
9114	ATP6V0D1; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 [KO:K02146] [EC:3.6.3.14]
245972	ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 [KO:K02146] [EC:3.6.3.14]
51606	ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [KO:K02144] [EC:3.6.3.14]
527	ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c [KO:K02155] [EC:3.6.3.14]
533	ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [KO:K03661] [EC:3.6.3.14]
537	ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1 [KO:K03662] [EC:3.6.3.14]
7879	RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
338382	RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
83547	RILP; Rab interacting lysosomal protein [KO:K13883]
1778	DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
79659	DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
1780	DYNC1I1; dynein, cytoplasmic 1, intermediate chain 1 [KO:K10415]
1781	DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
1783	DYNC1LI2; dynein, cytoplasmic 1, light intermediate chain 2 [KO:K10416]
51143	DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
10376	TUBA1B; tubulin, alpha 1b [KO:K07374]
7277	TUBA4A; tubulin, alpha 4a [KO:K07374]
7278	TUBA3C; tubulin, alpha 3c [KO:K07374]
7846	TUBA1A; tubulin, alpha 1a [KO:K07374]
84790	TUBA1C; tubulin, alpha 1c [KO:K07374]
51807	TUBA8; tubulin, alpha 8 [KO:K07374]
112714	TUBA3E; tubulin, alpha 3e [KO:K07374]
113457	TUBA3D; tubulin, alpha 3d [KO:K07374]
79861	TUBAL3; tubulin, alpha-like 3 [KO:K07374]
84617	TUBB6; tubulin, beta 6 class V [KO:K07375]
203068	TUBB; tubulin, beta class I [KO:K07375]
81027	TUBB1; tubulin, beta 1 class VI [KO:K07375]
7280	TUBB2A; tubulin, beta 2A class IIa [KO:K07375]
10381	TUBB3; tubulin, beta 3 class III [KO:K07375]
10382	TUBB4A; tubulin, beta 4A class IVa [KO:K07375]
347688	TUBB8; tubulin, beta 8 class VIII [KO:K07375]
347733	TUBB2B; tubulin, beta 2B class IIb [KO:K07375]
10383	TUBB4B; tubulin, beta 4B class IVb [KO:K07375]
3916	LAMP1; lysosomal-associated membrane protein 1 [KO:K06528]
3920	LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
200576	PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
4074	M6PR; mannose-6-phosphate receptor (cation dependent) [KO:K10089]
4842	NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
4353	MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
1514	CTSL1; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
1520	CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
29927	SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
55176	SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
10952	SEC61B; Sec61 beta subunit [KO:K09481]
23480	SEC61G; Sec61 gamma subunit [KO:K07342]
6890	TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05653]
6891	TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654]
811	CALR; calreticulin [KO:K08057]
821	CANX; calnexin [KO:K08054]
2204	FCAR; Fc fragment of IgA, receptor for [KO:K06513]
2209	FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64) [KO:K06498]
2212	FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32) [KO:K06472]
2213	FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32) [KO:K12560]
9103	FCGR2C; Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) [KO:K16824]
2214	FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [KO:K06463]
2215	FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b) [KO:K06463]
715	C1R; complement component 1, r subcomponent [KO:K01330] [EC:3.4.21.41]
3684	ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) [KO:K06461]
3689	ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
718	C3; complement component 3 [KO:K03990]
78989	COLEC11; collectin sub-family member 11 [KO:K10066]
81035	COLEC12; collectin sub-family member 12 [KO:K10062]
4153	MBL2; mannose-binding lectin (protein C) 2, soluble [KO:K03991]
653509	SFTPA1; surfactant protein A1 [KO:K10067]
729238	SFTPA2; surfactant protein A2 [KO:K10067]
6441	SFTPD; surfactant protein D [KO:K10068]
3685	ITGAV; integrin, alpha V [KO:K06487]
3673	ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [KO:K06481]
3678	ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [KO:K06484]
3688	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
3690	ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [KO:K06493]
3693	ITGB5; integrin, beta 5 [KO:K06588]
7057	THBS1; thrombospondin 1 [KO:K16857]
1311	COMP; cartilage oligomeric matrix protein [KO:K04659]
7058	THBS2; thrombospondin 2 [KO:K04659]
7059	THBS3; thrombospondin 3 [KO:K04659]
7060	THBS4; thrombospondin 4 [KO:K04659]
7097	TLR2; toll-like receptor 2 [KO:K10159]
10333	TLR6; toll-like receptor 6 [KO:K10169]
7099	TLR4; toll-like receptor 4 [KO:K10160]
929	CD14; CD14 molecule [KO:K04391]
22925	PLA2R1; phospholipase A2 receptor 1, 180kDa [KO:K06560]
4360	MRC1; mannose receptor, C type 1 [KO:K06560]
9902	MRC2; mannose receptor, C type 2 [KO:K06560]
10332	CLEC4M; C-type lectin domain family 4, member M [KO:K06563]
30835	CD209; CD209 molecule [KO:K06563]
64581	CLEC7A; C-type lectin domain family 7, member A [KO:K10074]
4481	MSR1; macrophage scavenger receptor 1 [KO:K06558]
8685	MARCO; macrophage receptor with collagenous structure [KO:K13884]
4973	OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
949	SCARB1; scavenger receptor class B, member 1 [KO:K13885]
948	CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
1535	CYBA; cytochrome b-245, alpha polypeptide [KO:K08009]
50508	NOX3; NADPH oxidase 3 [KO:K08008]
27035	NOX1; NADPH oxidase 1 [KO:K08008]
1536	CYBB; cytochrome b-245, beta polypeptide [KO:K08008]
5879	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
653361	NCF1; neutrophil cytosolic factor 1 [KO:K08011]
4688	NCF2; neutrophil cytosolic factor 2 [KO:K08010]
4689	NCF4; neutrophil cytosolic factor 4, 40kDa [KO:K08012]

Compound

C00007	Oxygen
C00027	Hydrogen peroxide
C00533	Nitric oxide
C00704	O2.-
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)

KO pathway

ko04145

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Disease (10)   
   KEGG DISEASE (10)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (157)   
   KEGG GENES (157)   
All databases (172)   

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