KEGG PATHWAY: hsa04150

PATHWAY: hsa04150

Entry

hsa04150 Pathway

Name

mTOR signaling pathway - Homo sapiens (human)

Class

Environmental Information Processing; Signal transduction

Pathway map

hsa04150

mTOR signaling pathway

Disease

H00539	PTEN hamartoma tumor syndrome (PHTS)
H00666	Peutz-Jeghers syndrome
H00896	Lymphangioleiomyomatosis (LAM)
H00915	Tuberous sclerosis complex (TSC)
H01112	Polyhydramnios, megalencephaly, and symptomatic epilepsy
H01251	Focal cortical dysplasia of Taylor

Drug

D00595	Buformin (USAN/INN)
D00753	Sirolimus (USAN/INN)
D00944	Metformin hydrochloride (JP16/USP)
D02206	Buformin hydrochloride (JP16)
D02714	Everolimus (JAN/USAN/INN)
D03647	Dapiclermin (USAN/INN)
D04966	Metformin (USAN/INN)
D05393	Pegsunercept (USAN)
D06068	Temsirolimus (JAN/USAN/INN)
D06272	Sorafenib tosilate (JAN)
D06409	Bevacizumab (genetical recombination) (JAN)
D08351	Phenformin (BAN)
D08352	Phenformin hydrochloride
D08524	Sorafenib (USAN/INN)
D08900	Ridaforolimus (JAN/USAN)
D10076	Olcorolimus (USAN)

Organism

Homo sapiens (human) [GN:hsa]

Gene

3630	INS; insulin [KO:K04526]
3479	IGF1; insulin-like growth factor 1 (somatomedin C) [KO:K05459]
3667	IRS1; insulin receptor substrate 1 [KO:K16172]
5295	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503	PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294	PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5728	PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
5170	PDPK1; 3-phosphoinositide dependent protein kinase-1 [KO:K06276] [EC:2.7.11.1]
207	AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
84335	AKT1S1; AKT1 substrate 1 (proline-rich) [KO:K16184]
7248	TSC1; tuberous sclerosis 1 [KO:K07206]
7249	TSC2; tuberous sclerosis 2 [KO:K07207]
6009	RHEB; Ras homolog enriched in brain [KO:K07208]
64223	MLST8; MTOR associated protein, LST8 homolog (S. cerevisiae) [KO:K08266]
10670	RRAGA; Ras-related GTP binding A [KO:K16185]
10325	RRAGB; Ras-related GTP binding B [KO:K16185]
64121	RRAGC; Ras-related GTP binding C [KO:K16186]
58528	RRAGD; Ras-related GTP binding D [KO:K16186]
2475	MTOR; mechanistic target of rapamycin (serine/threonine kinase) [KO:K07203]
57521	RPTOR; regulatory associated protein of MTOR, complex 1 [KO:K07204]
253260	RICTOR; RPTOR independent companion of MTOR, complex 2 [KO:K08267]
3091	HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [KO:K08268]
7422	VEGFA; vascular endothelial growth factor A [KO:K05448]
6198	RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 [KO:K04688] [EC:2.7.11.1]
6199	RPS6KB2; ribosomal protein S6 kinase, 70kDa, polypeptide 2 [KO:K04688] [EC:2.7.11.1]
1975	EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
6194	RPS6; ribosomal protein S6 [KO:K02991]
1978	EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
1977	EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
9470	EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
253314	EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
25989	ULK3; unc-51-like kinase 3 (C. elegans) [KO:K08269] [EC:2.7.11.1]
8408	ULK1; unc-51-like kinase 1 (C. elegans) [KO:K08269] [EC:2.7.11.1]
9706	ULK2; unc-51-like kinase 2 (C. elegans) [KO:K08269] [EC:2.7.11.1]
5594	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
6197	RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3 [KO:K04373] [EC:2.7.11.1]
6195	RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 [KO:K04373] [EC:2.7.11.1]
6196	RPS6KA2; ribosomal protein S6 kinase, 90kDa, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
27330	RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6 [KO:K04373] [EC:2.7.11.1]
54541	DDIT4; DNA-damage-inducible transcript 4 [KO:K08270]
7124	TNF; tumor necrosis factor [KO:K03156]
3551	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
6794	STK11; serine/threonine kinase 11 [KO:K07298]
92335	STRADA; STE20-related kinase adaptor alpha [KO:K08271]
51719	CAB39; calcium binding protein 39 [KO:K08272]
81617	CAB39L; calcium binding protein 39-like [KO:K08272]
5562	PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.11]
5563	PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit [KO:K07198] [EC:2.7.11.11]
673	BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
5578	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]

Compound

C00020	AMP
C04677	1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981	Phosphatidylinositol-3,4,5-trisphosphate
C15181	Wortmannin
C15182	Temsirolimus
C15183	AP 23573
C15195	LY 294002
D00753	Sirolimus (USAN/INN)
D00944	Metformin hydrochloride (JP16/USP)
D02714	Everolimus (JAN/USAN/INN)

Reference

PMID:15624019

Authors

Inoki K, Corradetti MN, Guan KL.

Title

Dysregulation of the TSC-mTOR pathway in human disease.

Journal

Nat Genet 37:19-24 (2005)

Reference

PMID:16404421

Authors

Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N.

Title

mTOR signaling: implications for cancer and anticancer therapy.

Journal

Br J Cancer 94:195-9 (2006)

Reference

PMID:16226444

Authors

Sarbassov dos D, Ali SM, Sabatini DM.

Title

Growing roles for the mTOR pathway.

Journal

Curr Opin Cell Biol 17:596-603 (2005)

Reference

PMID:16469695

Authors

Wullschleger S, Loewith R, Hall MN.

Title

TOR signaling in growth and metabolism.

Journal

Cell 124:471-84 (2006)

Reference

PMID:16288290

Authors

Plas DR, Thompson CB.

Title

Akt-dependent transformation: there is more to growth than just surviving.

Journal

Oncogene 24:7435-42 (2005)

Reference

PMID:16452501

Authors

Levine AJ, Feng Z, Mak TW, You H, Jin S.

Title

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.

Journal

Genes Dev 20:267-75 (2006)

Reference

PMID:15509864

Authors

Hardie DG.

Title

The AMP-activated protein kinase pathway--new players upstream and downstream.

Journal

J Cell Sci 117:5479-87 (2004)

Reference

PMID:15780593

Authors

Hardie DG.

Title

New roles for the LKB1-->AMPK pathway.

Journal

Curr Opin Cell Biol 17:167-73 (2005)

Reference

PMID:16288294

Authors

Astrinidis A, Henske EP.

Title

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.

Journal

Oncogene 24:7475-81 (2005)

Reference

PMID:15928081

Authors

Feng Z, Zhang H, Levine AJ, Jin S.

Title

The coordinate regulation of the p53 and mTOR pathways in cells.

Journal

Proc Natl Acad Sci U S A 102:8204-9 (2005)

Reference

PMID:16288292

Authors

Altomare DA, Testa JR.

Title

Perturbations of the AKT signaling pathway in human cancer.

Journal

Oncogene 24:7455-64 (2005)

Reference

PMID:16244323

Authors

Kwiatkowski DJ, Manning BD.

Title

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

Journal

Hum Mol Genet 14 Spec No. 2:R251-8 (2005)

Reference

PMID:16002336

Authors

Guertin DA, Sabatini DM.

Title

An expanding role for mTOR in cancer.

Journal

Trends Mol Med 11:353-61 (2005)

Reference

PMID:14684182

Authors

Tokunaga C, Yoshino K, Yonezawa K.

Title

mTOR integrates amino acid- and energy-sensing pathways.

Journal

Biochem Biophys Res Commun 313:443-6 (2004)

Reference

PMID:16341064

Authors

Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB.

Title

Exploiting the PI3K/AKT pathway for cancer drug discovery.

Journal

Nat Rev Drug Discov 4:988-1004 (2005)

Reference

PMID:15681023

Authors

Luo Z, Saha AK, Xiang X, Ruderman NB.

Title

AMPK, the metabolic syndrome and cancer.

Journal

Trends Pharmacol Sci 26:69-76 (2005)

Reference

PMID:15659337

Authors

Tee AR, Blenis J.

Title

mTOR, translational control and human disease.

Journal

Semin Cell Dev Biol 16:29-37 (2005)

Reference

PMID:15276465

Authors

Proud CG.

Title

Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy.

Journal

Cardiovasc Res 63:403-13 (2004)

Reference

PMID:15988001

Authors

Sofer A, Lei K, Johannessen CM, Ellisen LW.

Title

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Journal

Mol Cell Biol 25:5834-45 (2005)

Reference

PMID:16099218

Authors

Deretic V.

Title

Autophagy in innate and adaptive immunity.

Journal

Trends Immunol 26:523-8 (2005)

Reference

PMID:15928708

Authors

Lum JJ, DeBerardinis RJ, Thompson CB.

Title

Autophagy in metazoans: cell survival in the land of plenty.

Journal

Nat Rev Mol Cell Biol 6:439-48 (2005)

Reference

PMID:15261137

Authors

Brugarolas J, Kaelin WG Jr.

Title

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.

Journal

Cancer Cell 6:7-10 (2004)

Reference

PMID:16109716

Authors

Hui L, Rodrik V, Pielak RM, Knirr S, Zheng Y, Foster DA.

Title

mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells.

Journal

J Biol Chem 280:35829-35 (2005)

Reference

PMID:19100909

Authors

Hall MN

Title

mTOR-what does it do?

Journal

Transplant Proc 40:S5-8 (2008)

Reference

PMID:18598780

Authors

Rosner M, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschlager M

Title

The mTOR pathway and its role in human genetic diseases.

Journal

Mutat Res 659:284-92 (2008)

Reference

PMID:18604198

Authors

Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL

Title

Regulation of TORC1 by Rag GTPases in nutrient response.

Journal

Nat Cell Biol 10:935-45 (2008)

Reference

PMID:18497260

Authors

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM

Title

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Journal

Science 320:1496-501 (2008)

Reference

PMID:19963289

Authors

Hoeffer CA, Klann E

Title

mTOR signaling: at the crossroads of plasticity, memory and disease.

Journal

Trends Neurosci 33:67-75 (2010)

KO pathway

ko04150

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (1)   
   BioSystems (1)   
Disease (6)   
   KEGG DISEASE (6)   
Drug (16)   
   KEGG DRUG (16)   
Genome (1)   
   KEGG GENOME (1)   
Gene (60)   
   KEGG GENES (60)   
All databases (85)   

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