KEGG   PATHWAY: hsa04150Help
Entry
hsa04150                    Pathway                                

Name
mTOR signaling pathway - Homo sapiens (human)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
mTOR signaling pathway
hsa04150

All organismsOrtholog table
Disease
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00666  
Peutz-Jeghers syndrome
H00896  
Lymphangioleiomyomatosis (LAM)
H00915  
Tuberous sclerosis complex (TSC)
H01112  
Polyhydramnios, megalencephaly, and symptomatic epilepsy
H01251  
Focal cortical dysplasia of Taylor
Drug
D00595  
Buformin (USAN/INN)
D00753  
Sirolimus (JAN/USAN/INN)
D00944  
Metformin hydrochloride (JP17/USP)
D02206  
Buformin hydrochloride (JP17)
D02714  
Everolimus (JAN/USAN/INN)
D03647  
Dapiclermin (USAN/INN)
D04966  
Metformin (USAN/INN)
D05393  
Pegsunercept (USAN)
D06068  
Temsirolimus (JAN/USAN/INN)
D06272  
Sorafenib tosylate (USAN)
D06409  
Bevacizumab (genetical recombination) (JAN)
D08351  
Phenformin (BAN)
D08352  
Phenformin hydrochloride
D08524  
Sorafenib (USAN/INN)
D08900  
Ridaforolimus (JAN/USAN)
D10076  
Olcorolimus (USAN)
D10635  
Gedatolisib (USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
8140  
SLC7A5; solute carrier family 7 member 5 [KO:K13780]
6520  
SLC3A2; solute carrier family 3 member 2 [KO:K06519]
153129  
SLC38A9; solute carrier family 38 member 9 [KO:K14995]
523  
ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:3.6.3.14]
525  
ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
526  
ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
245973  
ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
528  
ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
51382  
ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
90423  
ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
529  
ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
9296  
ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
9550  
ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
127124  
ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
534  
ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
51606  
ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
55004  
LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
28956  
LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
8649  
LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
389541  
LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [KO:K20399]
10542  
LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
201163  
FLCN; folliculin [KO:K09594]
96459  
FNIP1; folliculin interacting protein 1 [KO:K20400]
57600  
FNIP2; folliculin interacting protein 2 [KO:K20401]
10670  
RRAGA; Ras related GTP binding A [KO:K16185]
10325  
RRAGB; Ras related GTP binding B [KO:K16185]
64121  
RRAGC; Ras related GTP binding C [KO:K16186]
58528  
RRAGD; Ras related GTP binding D [KO:K16186]
57521  
RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
84335  
AKT1S1; AKT1 substrate 1 [KO:K16184]
2475  
MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
64798  
DEPTOR; DEP domain containing MTOR-interacting protein [KO:K20402]
64223  
MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
9894  
TELO2; telomere maintenance 2 [KO:K11137]
9675  
TTI1; TELO2 interacting protein 1 [KO:K20403]
6249  
CLIP1; CAP-Gly domain containing linker protein 1 [KO:K10421]
2887  
GRB10; growth factor receptor bound protein 10 [KO:K20064]
25989  
ULK3; unc-51 like kinase 3 [KO:K08269] [EC:2.7.11.1]
8408  
ULK1; unc-51 like autophagy activating kinase 1 [KO:K08269] [EC:2.7.11.1]
9706  
ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
1978  
EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
1977  
EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
9470  
EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
253314  
EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
6198  
RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
6199  
RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
1975  
EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
6194  
RPS6; ribosomal protein S6 [KO:K02991]
220441  
RNF152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
6502  
SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [KO:K03875]
9681  
DEPDC5; DEP domain containing 5 [KO:K20404]
10641  
NPRL2; NPR2-like, GATOR1 complex subunit [KO:K20405]
8131  
NPRL3; NPR3 like, GATOR1 complex subunit [KO:K20406]
54468  
MIOS; missing oocyte meiosis regulator homolog [KO:K20407]
81929  
SEH1L; SEH1 like nucleoporin [KO:K14299]
84219  
WDR24; WD repeat domain 24 [KO:K20408]
79726  
WDR59; WD repeat domain 59 [KO:K20409]
6396  
SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
83667  
SESN2; sestrin 2 [KO:K20394]
92335  
STRADA; STE20-related kinase adaptor alpha [KO:K08271]
55437  
STRADB; STE20-related kinase adaptor beta [KO:K17532]
6794  
STK11; serine/threonine kinase 11 [KO:K07298]
51719  
CAB39; calcium binding protein 39 [KO:K08272]
81617  
CAB39L; calcium binding protein 39 like [KO:K08272]
5562  
PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.11]
5563  
PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.11]
7248  
TSC1; tuberous sclerosis 1 [KO:K07206]
7249  
TSC2; tuberous sclerosis 2 [KO:K07207]
51256  
TBC1D7; TBC1 domain family member 7 [KO:K20396]
TBC1D7-LOC100130357 readthrough; K20396 TBC1 domain family member 7 [KO:K20396]
6009  
RHEB; Ras homolog enriched in brain [KO:K07208]
54541  
DDIT4; DNA damage inducible transcript 4 [KO:K08270]
7471  
WNT1; Wnt family member 1 [KO:K03209]
7472  
WNT2; Wnt family member 2 [KO:K00182]
7482  
WNT2B; Wnt family member 2B [KO:K00182]
7473  
WNT3; Wnt family member 3 [KO:K00312]
89780  
WNT3A; Wnt family member 3A [KO:K00312]
54361  
WNT4; Wnt family member 4 [KO:K00408]
7474  
WNT5A; Wnt family member 5A [KO:K00444]
81029  
WNT5B; Wnt family member 5B [KO:K00444]
7475  
WNT6; Wnt family member 6 [KO:K00445]
7476  
WNT7A; Wnt family member 7A [KO:K00572]
7477  
WNT7B; Wnt family member 7B [KO:K00572]
7478  
WNT8A; Wnt family member 8A [KO:K00714]
7479  
WNT8B; Wnt family member 8B [KO:K00714]
7483  
WNT9A; Wnt family member 9A [KO:K01064]
7484  
WNT9B; Wnt family member 9B [KO:K01064]
7480  
WNT10B; Wnt family member 10B [KO:K01357]
80326  
WNT10A; Wnt family member 10A [KO:K01357]
7481  
WNT11; Wnt family member 11 [KO:K01384]
51384  
WNT16; Wnt family member 16 [KO:K01558]
8321  
FZD1; frizzled class receptor 1 [KO:K02432]
8324  
FZD7; frizzled class receptor 7 [KO:K02432]
2535  
FZD2; frizzled class receptor 2 [KO:K02235]
7976  
FZD3; frizzled class receptor 3 [KO:K02329]
8322  
FZD4; frizzled class receptor 4 [KO:K02354]
7855  
FZD5; frizzled class receptor 5 [KO:K02375]
8325  
FZD8; frizzled class receptor 8 [KO:K02375]
8323  
FZD6; frizzled class receptor 6 [KO:K02376]
11211  
FZD10; frizzled class receptor 10 [KO:K02842]
8326  
FZD9; frizzled class receptor 9 [KO:K02842]
4041  
LRP5; LDL receptor related protein 5 [KO:K03068]
4040  
LRP6; LDL receptor related protein 6 [KO:K03068]
1857  
DVL3; dishevelled segment polarity protein 3 [KO:K02353]
1856  
DVL2; dishevelled segment polarity protein 2 [KO:K02353]
1855  
DVL1; dishevelled segment polarity protein 1 [KO:K02353]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
7124  
TNF; tumor necrosis factor [KO:K03156]
7132  
TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
3630  
INS; insulin [KO:K04526]
3479  
IGF1; insulin like growth factor 1 [KO:K05459]
3643  
INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
3480  
IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
2885  
GRB2; growth factor receptor bound protein 2 [KO:K04364]
6654  
SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  
SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
673  
BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
6197  
RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
6195  
RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
6196  
RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
27330  
RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
3667  
IRS1; insulin receptor substrate 1 [KO:K16172]
5295  
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5728  
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
5170  
PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
207  
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
79109  
MAPKAP1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
253260  
RICTOR; RPTOR independent companion of MTOR complex 2 [KO:K08267]
55615  
PRR5; proline rich 5 [KO:K20411]
387  
RHOA; ras homolog family member A [KO:K04513]
5578  
PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
6446  
SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
23175  
LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
Compound
C00020  
AMP
C00123  
L-Leucine
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
Reference
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
Reference
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
Reference
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
Reference
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
Reference
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
Reference
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
Reference
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
Reference
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
Reference
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
Reference
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
Reference
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
Reference
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
Reference
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
Reference
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
Reference
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget (2016)
KO pathway
 

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