KEGG   PATHWAY: hsa04512Help
Entry
hsa04512                    Pathway                                

Name
ECM-receptor interaction - Homo sapiens (human)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ECM-receptor interaction
hsa04512

All organismsOrtholog table
Disease
H00219  
Hemophilia
H00224  
Bernard-Soulier syndrome
H00226  
Glanzmann thrombasthenia
H00576  
Pierson syndrome
H00579  
Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
H00581  
Alport syndrome
H00582  
Benign familial hematuria
H00585  
Epidermolysis bullosa, hemidesmosomal
H00586  
Epidermolysis bullosa, junctional
H00770  
Congenital myasthenic syndrome
H00802  
Ehlers-Danlos syndrome (EDS)
H00805  
Vitreoretinal degeneration
H00813  
Laryngo onycho cutaneous syndrome
H00839  
Porencephaly
H00877  
Brain small vessel disease with Axenfeld-Rieger anomaly
H01260  
Glomerulopathy with fibronectin deposits (GFND)
H01338  
Myosclerosis
H01340  
Bethlem myopathy
H01341  
Collagen VI myopathy
H01526  
Legg-Calve-Perthes Disease
Drug
D00709  
Levetiracetam (JAN/USAN/INN)
D01029  
Tirofiban hydrochloride (USAN)
D01914  
Piracetam (JAN/USAN/INN)
D02778  
Abciximab (genetical recombination) (JAN)
D03497  
Cilengitide (USAN/INN)
D03971  
Elarofiban (USAN)
D04659  
Lamifiban (USAN/INN)
D04660  
Lamifiban hydrochloride (USAN)
D04785  
Lotrafiban hydrochloride (USAN)
D05267  
Orbofiban acetate (USAN)
D05772  
Roxifiban acetate (USAN)
D05834  
Sibrafiban (USAN/INN)
D06319  
Volociximab (USAN)
D06335  
Xemilofiban hydrochloride (USAN)
D06590  
Firategrast (USAN)
D06649  
Tadocizumab (USAN)
D06886  
Natalizumab (genetical recombination) (JAN)
D06888  
Eptifibatide (INN)
D08083  
Vedolizumab (genetical recombination) (JAN)
D08607  
Tirofiban (INN)
D08879  
Brivaracetam (USAN/INN)
D09342  
Etaracizumab (USAN/INN)
D09631  
Intetumumab (USAN/INN)
D09901  
Etrolizumab (USAN/INN)
D09903  
Fluciclatide F 18 (USAN/INN)
D09929  
Maraciclatide (USAN/INN)
D10028  
Valategrast hydrochloride (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
1277  
COL1A1; collagen type I alpha 1 [KO:K06236]
1278  
COL1A2; collagen type I alpha 2 [KO:K06236]
1280  
COL2A1; collagen type II alpha 1 [KO:K19719]
1284  
COL4A2; collagen type IV alpha 2 [KO:K06237]
1286  
COL4A4; collagen type IV alpha 4 [KO:K06237]
1288  
COL4A6; collagen type IV alpha 6 [KO:K06237]
1282  
COL4A1; collagen type IV alpha 1 [KO:K06237]
1287  
COL4A5; collagen type IV alpha 5 [KO:K06237]
1285  
COL4A3; collagen type IV alpha 3 [KO:K06237]
1291  
COL6A1; collagen type VI alpha 1 [KO:K06238]
1292  
COL6A2; collagen type VI alpha 2 [KO:K06238]
1293  
COL6A3; collagen type VI alpha 3 [KO:K06238]
131873  
COL6A6; collagen type VI alpha 6 [KO:K06238]
256076  
COL6A5; collagen type VI alpha 5 [KO:K06238]
1297  
COL9A1; collagen type IX alpha 1 [KO:K08131]
1298  
COL9A2; collagen type IX alpha 2 [KO:K08131]
1299  
COL9A3; collagen type IX alpha 3 [KO:K08131]
284217  
LAMA1; laminin subunit alpha 1 [KO:K05637]
3908  
LAMA2; laminin subunit alpha 2 [KO:K05637]
3909  
LAMA3; laminin subunit alpha 3 [KO:K06240]
3911  
LAMA5; laminin subunit alpha 5 [KO:K06240]
3910  
LAMA4; laminin subunit alpha 4 [KO:K06241]
3912  
LAMB1; laminin subunit beta 1 [KO:K05636]
3913  
LAMB2; laminin subunit beta 2 [KO:K06243]
3914  
LAMB3; laminin subunit beta 3 [KO:K06244]
22798  
LAMB4; laminin subunit beta 4 [KO:K06245]
3915  
LAMC1; laminin subunit gamma 1 [KO:K05635]
3918  
LAMC2; laminin subunit gamma 2 [KO:K06246]
10319  
LAMC3; laminin subunit gamma 3 [KO:K06247]
1101  
CHAD; chondroadherin [KO:K06248]
5649  
RELN; reelin [KO:K06249] [EC:3.4.21.-]
7057  
THBS1; thrombospondin 1 [KO:K16857]
1311  
COMP; cartilage oligomeric matrix protein [KO:K04659]
7058  
THBS2; thrombospondin 2 [KO:K04659]
7059  
THBS3; thrombospondin 3 [KO:K04659]
7060  
THBS4; thrombospondin 4 [KO:K04659]
2335  
FN1; fibronectin 1 [KO:K05717]
6696  
SPP1; secreted phosphoprotein 1 [KO:K06250]
7448  
VTN; vitronectin [KO:K06251]
3371  
TNC; tenascin C [KO:K06252]
63923  
TNN; tenascin N [KO:K06252]
7143  
TNR; tenascin R [KO:K06252]
7148  
TNXB; tenascin XB [KO:K06252]
7450  
VWF; von Willebrand factor [KO:K03900]
3381  
IBSP; integrin binding sialoprotein [KO:K06253]
375790  
AGRN; agrin [KO:K06254]
3339  
HSPG2; heparan sulfate proteoglycan 2 [KO:K06255]
3672  
ITGA1; integrin subunit alpha 1 [KO:K06480]
3673  
ITGA2; integrin subunit alpha 2 [KO:K06481]
3674  
ITGA2B; integrin subunit alpha 2b [KO:K06476]
3675  
ITGA3; integrin subunit alpha 3 [KO:K06482]
3676  
ITGA4; integrin subunit alpha 4 [KO:K06483]
3678  
ITGA5; integrin subunit alpha 5 [KO:K06484]
3655  
ITGA6; integrin subunit alpha 6 [KO:K06485]
3679  
ITGA7; integrin subunit alpha 7 [KO:K06583]
8516  
ITGA8; integrin subunit alpha 8 [KO:K06584]
3680  
ITGA9; integrin subunit alpha 9 [KO:K06585]
8515  
ITGA10; integrin subunit alpha 10 [KO:K06586]
22801  
ITGA11; integrin subunit alpha 11 [KO:K06587]
3685  
ITGAV; integrin subunit alpha V [KO:K06487]
3688  
ITGB1; integrin subunit beta 1 [KO:K05719]
3690  
ITGB3; integrin subunit beta 3 [KO:K06493]
3691  
ITGB4; integrin subunit beta 4 [KO:K06525]
3693  
ITGB5; integrin subunit beta 5 [KO:K06588]
3694  
ITGB6; integrin subunit beta 6 [KO:K06589]
3695  
ITGB7; integrin subunit beta 7 [KO:K06590]
3696  
ITGB8; integrin subunit beta 8 [KO:K06591]
960  
CD44; CD44 molecule (Indian blood group) [KO:K06256]
6382  
SDC1; syndecan 1 [KO:K06257]
6385  
SDC4; syndecan 4 [KO:K16338]
22987  
SV2C; synaptic vesicle glycoprotein 2C [KO:K06258]
9899  
SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
9900  
SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
948  
CD36; CD36 molecule [KO:K06259]
2814  
GP5; glycoprotein V platelet [KO:K06260]
2811  
GP1BA; glycoprotein Ib platelet alpha subunit [KO:K06261]
2812  
GP1BB; glycoprotein Ib platelet beta subunit [KO:K06262]
2815  
GP9; glycoprotein IX platelet [KO:K06263]
51206  
GP6; glycoprotein VI platelet [KO:K06264]
1605  
DAG1; dystroglycan 1 [KO:K06265]
961  
CD47; CD47 molecule [KO:K06266]
3161  
HMMR; hyaluronan mediated motility receptor [KO:K06267]
Compound
G10505  
Hyaluronic acid
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
Reference
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
Reference
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
Reference
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
Reference
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
Reference
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
Reference
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
Reference
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
Reference
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
Reference
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
KO pathway
 

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