KEGG PATHWAY: hsa04622

PATHWAY: hsa04622

Entry

hsa04622 Pathway

Name

RIG-I-like receptor signaling pathway - Homo sapiens (human)

Description

Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.

Class

Organismal Systems; Immune system

Pathway map

hsa04622

RIG-I-like receptor signaling pathway

Disease

H00827	Brooke-Spiegler syndrome
H00882	Cocoon syndrome

Organism

Homo sapiens (human) [GN:hsa]

Gene

23586	DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
64135	IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
57506	MAVS; mitochondrial antiviral signaling protein [KO:K12648]
79132	DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58 [KO:K12649] [EC:3.6.3.14]
7187	TRAF3; TNF receptor-associated factor 3 [KO:K03174]
10010	TANK; TRAF family member-associated NFKB activator [KO:K12650]
64343	AZI2; 5-azacytidine induced 2 [KO:K12651]
9755	TBKBP1; TBK1 binding protein 1 [KO:K12652]
8517	IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
29110	TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
9641	IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
3661	IRF3; interferon regulatory factor 3 [KO:K05411]
3665	IRF7; interferon regulatory factor 7 [KO:K09447]
3439	IFNA1; interferon, alpha 1 [KO:K05414]
3440	IFNA2; interferon, alpha 2 [KO:K05414]
3441	IFNA4; interferon, alpha 4 [KO:K05414]
3442	IFNA5; interferon, alpha 5 [KO:K05414]
3443	IFNA6; interferon, alpha 6 [KO:K05414]
3444	IFNA7; interferon, alpha 7 [KO:K05414]
3445	IFNA8; interferon, alpha 8 [KO:K05414]
3446	IFNA10; interferon, alpha 10 [KO:K05414]
3447	IFNA13; interferon, alpha 13 [KO:K05414]
3448	IFNA14; interferon, alpha 14 [KO:K05414]
3449	IFNA16; interferon, alpha 16 [KO:K05414]
3451	IFNA17; interferon, alpha 17 [KO:K05414]
3452	IFNA21; interferon, alpha 21 [KO:K05414]
3456	IFNB1; interferon, beta 1, fibroblast [KO:K05415]
3467	IFNW1; interferon, omega 1 [KO:K05440]
338376	IFNE; interferon, epsilon [KO:K05442]
56832	IFNK; interferon, kappa [KO:K05441]
8717	TRADD; TNFRSF1A-associated via death domain [KO:K03171]
8772	FADD; Fas (TNFRSF6)-associated via death domain [KO:K02373]
8737	RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
841	CASP8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
843	CASP10; caspase 10, apoptosis-related cysteine peptidase [KO:K04400] [EC:3.4.22.63]
1147	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
4793	NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [KO:K02581]
4792	NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
4790	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
5970	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
7186	TRAF2; TNF receptor-associated factor 2 [KO:K03173]
6885	MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
7189	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
4214	MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
5599	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5600	MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300	MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603	MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432	MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
3576	IL8; interleukin 8 [KO:K10030]
7124	TNF; tumor necrosis factor [KO:K03156]
3592	IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
3593	IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
3627	CXCL10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
7706	TRIM25; tripartite motif containing 25 [KO:K10652]
1540	CYLD; cylindromatosis (turban tumor syndrome) [KO:K08601] [EC:3.1.2.15]
54941	RNF125; ring finger protein 125, E3 ubiquitin protein ligase [KO:K12170] [EC:6.3.2.19]
9636	ISG15; ISG15 ubiquitin-like modifier [KO:K12159]
9474	ATG5; autophagy related 5 [KO:K08339]
9140	ATG12; autophagy related 12 [KO:K08336]
79671	NLRX1; NLR family member X1 [KO:K12653]
340061	TMEM173; transmembrane protein 173 [KO:K12654]
55593	OTUD5; OTU domain containing 5 [KO:K12655] [EC:3.1.2.15]
80143	SIKE1; suppressor of IKBKE 1 [KO:K12656]
1654	DDX3X; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked [KO:K11594] [EC:3.6.4.13]
8653	DDX3Y; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked [KO:K11594] [EC:3.6.4.13]
5300	PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
26007	DAK; dihydroxyacetone kinase 2 homolog (S. cerevisiae) [KO:K00863] [EC:2.7.1.29]

Reference

PMID:15208624

Authors

Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T

Title

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

Journal

Nat Immunol 5:730-7 (2004)

Reference

PMID:18272355

Authors

Takeuchi O, Akira S

Title

MDA5/RIG-I and virus recognition.

Journal

Curr Opin Immunol 20:17-22 (2008)

Reference

PMID:19120475

Authors

Yoneyama M, Fujita T

Title

RNA recognition and signal transduction by RIG-I-like receptors.

Journal

Immunol Rev 227:54-65 (2009)

Reference

PMID:19539500

Authors

Nakhaei P, Genin P, Civas A, Hiscott J

Title

RIG-I-like receptors: Sensing and responding to RNA virus infection.

Journal

Semin Immunol (2009)

Reference

PMID:18549796

Authors

Moore CB, Ting JP

Title

Regulation of mitochondrial antiviral signaling pathways.

Journal

Immunity 28:735-9 (2008)

Reference

PMID:19615405

Authors

Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB

Title

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.

Journal

Pharmacol Ther 124:219-34 (2009)

Reference

PMID:19120476

Authors

Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G

Title

Approaching the RNA ligand for RIG-I?

Journal

Immunol Rev 227:66-74 (2009)

Reference

PMID:18591413

Authors

Saito T, Gale M Jr

Title

Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

Journal

J Exp Med 205:1523-7 (2008)

Reference

PMID:19076341

Authors

Kawai T, Akira S

Title

Toll-like receptor and RIG-I-like receptor signaling.

Journal

Ann N Y Acad Sci 1143:1-20 (2008)

Reference

PMID:18439848

Authors

Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J

Title

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Journal

Immunity 28:651-61 (2008)

Reference

PMID:18984593

Authors

Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T

Title

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.

Journal

J Biol Chem 283:36211-20 (2008)

Reference

PMID:19224920

Authors

Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR

Title

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

Journal

J Biol Chem 284:10774-82 (2009)

KO pathway

ko04622

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Disease (2)   
   KEGG DISEASE (2)   
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   KEGG GENOME (1)   
Gene (71)   
   KEGG GENES (71)   
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