KEGG PATHWAY: hsa04640

PATHWAY: hsa04640

Entry

hsa04640 Pathway

Name

Hematopoietic cell lineage - Homo sapiens (human)

Description

Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.

Class

Organismal Systems; Immune system

Pathway map

hsa04640

Hematopoietic cell lineage

Disease

H00219	Hemophilia
H00224	Bernard-Soulier syndrome
H01479	Castleman disease

Drug

D01441	Imatinib mesylate (USAN)
D02596	Tocilizumab (USAN/INN)
D02994	Rituximab (USAN/INN)
D03058	Basiliximab (USAN/INN)
D03231	Epoetin alfa (USAN/INN)
D03232	Epoetin beta (USAN/INN)
D03259	Gemtuzumab ozogamicin (USAN)
D03639	Daclizumab (USAN/INN)
D03645	Daniplestim (USAN/INN)
D03651	Darbepoetin alfa (USAN/INN)
D04032	Epoetin delta (USAN)
D04036	Epratuzumab (USAN/INN)
D04489	Ibritumomab tiuxetan (USAN/INN)
D05036	Milodistim (USAN/INN)
D05218	Ocrelizumab (USAN)
D05847	Siplizumab (USAN/INN)
D06348	Yttrium Y 90 epratuzumab (USAN)
D06349	Yttrium Y 90 epratuzumab tetraxetan (USAN)
D06381	Zolimomab aritox (USAN)
D06463	Lumiliximab (USAN/INN)
D08066	Imatinib (INN)
D08621	Tositumomab (INN)
D08622	Tositumomab 131 iodine
D09031	Veltuzumab (USAN)
D09207	Catumaxomab (INN)
D09314	Ofatumumab (USAN/INN)
D09321	Obinutuzumab (USAN)
D10028	Valategrast hydrochloride (USAN)
D10225	Sacubitril (JAN/USAN/INN)
D10354	Dupilumab (USAN)
D10482	Ocaratuzumab (USAN/INN)

Organism

Homo sapiens (human) [GN:hsa]

Gene

4254	KITLG; KIT ligand [KO:K05461]
3574	IL7; interleukin 7 [KO:K05431]
3565	IL4; interleukin 4 [KO:K05430]
1437	CSF2; colony stimulating factor 2 [KO:K05427]
2323	FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
3567	IL5; interleukin 5 [KO:K05428]
1440	CSF3; colony stimulating factor 3 [KO:K05423]
3562	IL3; interleukin 3 [KO:K04736]
3569	IL6; interleukin 6 [KO:K05405]
3589	IL11; interleukin 11 [KO:K05417]
3552	IL1A; interleukin 1 alpha [KO:K04383]
3553	IL1B; interleukin 1 beta [KO:K04519]
7124	TNF; tumor necrosis factor [KO:K03156]
1435	CSF1; colony stimulating factor 1 [KO:K05453]
2056	EPO; erythropoietin [KO:K05437]
7066	THPO; thrombopoietin [KO:K06854]
947	CD34; CD34 molecule [KO:K06474]
2322	FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
1791	DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
960	CD44; CD44 molecule (Indian blood group) [KO:K06256]
3815	KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
3559	IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3575	IL7R; interleukin 7 receptor [KO:K05072]
7037	TFRC; transferrin receptor [KO:K06503]
924	CD7; CD7 molecule [KO:K06457]
914	CD2; CD2 molecule [KO:K06449]
921	CD5; CD5 molecule [KO:K06455]
909	CD1A; CD1a molecule [KO:K06448]
910	CD1B; CD1b molecule [KO:K06448]
911	CD1C; CD1c molecule [KO:K06448]
912	CD1D; CD1d molecule [KO:K06448]
913	CD1E; CD1e molecule [KO:K06448]
920	CD4; CD4 molecule [KO:K06454]
925	CD8A; CD8a molecule [KO:K06458]
926	CD8B; CD8b molecule [KO:K06459]
915	CD3D; CD3d molecule [KO:K06450]
916	CD3E; CD3e molecule [KO:K06451]
917	CD3G; CD3g molecule [KO:K06452]
4311	MME; membrane metallo-endopeptidase [KO:K01389] [EC:3.4.24.11]
928	CD9; CD9 molecule [KO:K06460]
930	CD19; CD19 molecule [KO:K06465]
933	CD22; CD22 molecule [KO:K06467]
100133941	CD24; CD24 molecule [KO:K06469]
931	MS4A1; membrane spanning 4-domains A1 [KO:K06466]
1380	CR2; complement component 3d receptor 2 [KO:K04012]
951	CD37; CD37 molecule [KO:K06475]
102723407	IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
2208	FCER2; Fc fragment of IgE receptor II [KO:K06468]
1378	CR1; complement component 3b/4b receptor 1 (Knops blood group) [KO:K04011]
1438	CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
3563	IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
945	CD33; CD33 molecule [KO:K06473]
3566	IL4R; interleukin 4 receptor [KO:K05071]
3570	IL6R; interleukin 6 receptor [KO:K05055]
2209	FCGR1A; Fc fragment of IgG receptor Ia [KO:K06498]
1436	CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
290	ANPEP; alanyl aminopeptidase, membrane [KO:K11140] [EC:3.4.11.2]
3684	ITGAM; integrin subunit alpha M [KO:K06461]
929	CD14; CD14 molecule [KO:K04391]
3581	IL9R; interleukin 9 receptor [KO:K05073]
3554	IL1R1; interleukin 1 receptor type 1 [KO:K04386]
7850	IL1R2; interleukin 1 receptor type 2 [KO:K04387]
1441	CSF3R; colony stimulating factor 3 receptor [KO:K05061]
3568	IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
2057	EPOR; erythropoietin receptor [KO:K05079]
948	CD36; CD36 molecule [KO:K06259]
1604	CD55; CD55 molecule (Cromer blood group) [KO:K04006]
966	CD59; CD59 molecule [KO:K04008]
3590	IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
3690	ITGB3; integrin subunit beta 3 [KO:K06493]
3674	ITGA2B; integrin subunit alpha 2b [KO:K06476]
2815	GP9; glycoprotein IX platelet [KO:K06263]
2811	GP1BA; glycoprotein Ib platelet alpha subunit [KO:K06261]
2812	GP1BB; glycoprotein Ib platelet beta subunit [KO:K06262]
2814	GP5; glycoprotein V platelet [KO:K06260]
3672	ITGA1; integrin subunit alpha 1 [KO:K06480]
3673	ITGA2; integrin subunit alpha 2 [KO:K06481]
3675	ITGA3; integrin subunit alpha 3 [KO:K06482]
3676	ITGA4; integrin subunit alpha 4 [KO:K06483]
3678	ITGA5; integrin subunit alpha 5 [KO:K06484]
3655	ITGA6; integrin subunit alpha 6 [KO:K06485]
2993	GYPA; glycophorin A (MNS blood group) [KO:K06575]
3122	HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123	HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125	HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126	HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127	HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
952	CD38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]

Compound

G01078	Lewis x-sulfated
G01493	Lewis x-sulfated

Reference

Authors

Janeway CA Jr, Travers P, Walport M, Shlomchik MJ

Title

Immunobiology - International editon: The immune system in health and disease

Journal

Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)

Reference

(Japanese)

Authors

Abe T

Title

[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese)

Journal

Nihonijishinhousya (2000)

Reference

PMID:15771582

Authors

Rothenberg EV, Taghon T.

Title

Molecular genetics of T cell development.

Journal

Annu Rev Immunol 23:601-49 (2005)

Reference

PMID:12415312

Authors

Ceredig R, Rolink T.

Title

A positive look at double-negative thymocytes.

Journal

Nat Rev Immunol 2:888-97 (2002)

Reference

PMID:15156179

Authors

de Bruijn MF, Speck NA.

Title

Core-binding factors in hematopoiesis and immune function.

Journal

Oncogene 23:4238-48 (2004)

Reference

PMID:14985712

Authors

Radtke F, Wilson A, Mancini SJ, MacDonald HR.

Title

Notch regulation of lymphocyte development and function.

Journal

Nat Immunol 5:247-53 (2004)

Reference

PMID:12360214

Authors

Spits H.

Title

Development of alphabeta T cells in the human thymus.

Journal

Nat Rev Immunol 2:760-72 (2002)

Reference

PMID:9927518

Authors

Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.

Title

The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.

Journal

J Exp Med 189:563-74 (1999)

Reference

PMID:11905810

Authors

Mak TW, Penninger JM, Ohashi PS.

Title

Knockout mice: a paradigm shift in modern immunology.

Journal

Nat Rev Immunol 1:11-9 (2001)

Reference

PMID:15738953

Authors

Shapiro-Shelef M, Calame K.

Title

Regulation of plasma-cell development.

Journal

Nat Rev Immunol 5:230-42 (2005)

Reference

PMID:14670296

Authors

Maillard I, Adler SH, Pear WS.

Title

Notch and the immune system.

Journal

Immunity 19:781-91 (2003)

Reference

PMID:15629410

Authors

Alpdogan O, van den Brink MR.

Title

IL-7 and IL-15: therapeutic cytokines for immunodeficiency.

Journal

Trends Immunol 26:56-64 (2005)

KO pathway

ko04640

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Pathway (1)   
   BioSystems (1)   
Disease (3)   
   KEGG DISEASE (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (88)   
   KEGG GENES (88)   
All databases (93)   

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