Entry |
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Name |
Hematopoietic cell lineage - Homo sapiens (human)
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Description |
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
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Class |
Organismal Systems; Immune system
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Pathway map |

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Disease |
H00224 | Bernard-Soulier syndrome |
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Drug |
D00754 | Thalidomide (JAN/USP/INN) |
D01583 | Pirfenidone (JAN/USAN/INN) |
D03231 | Epoetin alfa (USAN/INN) |
D03232 | Epoetin beta (USAN/INN) |
D03259 | Gemtuzumab ozogamicin (USAN) |
D03651 | Darbepoetin alfa (USAN/INN) |
D04489 | Ibritumomab tiuxetan (USAN/INN) |
D04687 | Lenalidomide (USAN/INN) |
D05066 | Molgramostim (USAN/INN) |
D05803 | Sargramostim (USAN/INN) |
D08933 | Inotuzumab ozogamicin (USAN/INN) |
D08976 | Pomalidomide (JAN/USAN/INN) |
D09190 | Anti-human thymocyte immunoglobulin, rabbit (JAN) |
D09813 | Lenalidomide hydrate (JAN) |
D10028 | Valategrast hydrochloride (USAN) |
D10225 | Sacubitril (JAN/USAN/INN) |
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Organism |
Homo sapiens (human) [GN: hsa]
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Gene |
1437 | CSF2; colony stimulating factor 2 [KO:K05427] |
2323 | FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454] |
1440 | CSF3; colony stimulating factor 3 [KO:K05423] |
1435 | CSF1; colony stimulating factor 1 [KO:K05453] |
3108 | HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752] |
3109 | HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752] |
3111 | HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752] |
3112 | HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752] |
3113 | HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752] |
3115 | HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752] |
3117 | HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752] |
3118 | HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752] |
3119 | HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752] |
3122 | HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752] |
3123 | HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752] |
3125 | HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752] |
3126 | HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752] |
3127 | HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752] |
960 | CD44; CD44 molecule (Indian blood group) [KO:K06256] |
3559 | IL2RA; interleukin 2 receptor subunit alpha [KO:K05068] |
931 | MS4A1; membrane spanning 4-domains A1 [KO:K06466] |
102723407 | IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856] |
2208 | FCER2; Fc fragment of IgE receptor II [KO:K06468] |
1378 | CR1; complement C3b/C4b receptor 1 (Knops blood group) [KO:K04011] |
1438 | CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066] |
3563 | IL3RA; interleukin 3 receptor subunit alpha [KO:K04737] |
2209 | FCGR1A; Fc fragment of IgG receptor Ia [KO:K06498] |
3554 | IL1R1; interleukin 1 receptor type 1 [KO:K04386] |
7850 | IL1R2; interleukin 1 receptor type 2 [KO:K04387] |
1441 | CSF3R; colony stimulating factor 3 receptor [KO:K05061] |
3568 | IL5RA; interleukin 5 receptor subunit alpha [KO:K05067] |
2993 | GYPA; glycophorin A (MNS blood group) [KO:K06575] |
1604 | CD55; CD55 molecule (Cromer blood group) [KO:K04006] |
966 | CD59; CD59 molecule (CD59 blood group) [KO:K04008] |
3590 | IL11RA; interleukin 11 receptor subunit alpha [KO:K05056] |
3674 | ITGA2B; integrin subunit alpha 2b [KO:K06476] |
2811 | GP1BA; glycoprotein Ib platelet alpha subunit [KO:K06261] |
2812 | GP1BB; glycoprotein Ib platelet beta subunit [KO:K06262] |
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Reference |
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Authors |
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ |
Title |
Immunobiology - International editon: The immune system in health and disease |
Journal |
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001) |
Reference |
(Japanese) |
Authors |
Abe T |
Title |
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese) |
Journal |
Nihonijishinhousya (2000) |
Reference |
|
Authors |
Rothenberg EV, Taghon T. |
Title |
Molecular genetics of T cell development. |
Journal |
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Reference |
|
Authors |
Ceredig R, Rolink T. |
Title |
A positive look at double-negative thymocytes. |
Journal |
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Reference |
|
Authors |
de Bruijn MF, Speck NA. |
Title |
Core-binding factors in hematopoiesis and immune function. |
Journal |
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Reference |
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Authors |
Radtke F, Wilson A, Mancini SJ, MacDonald HR. |
Title |
Notch regulation of lymphocyte development and function. |
Journal |
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Reference |
|
Authors |
Spits H. |
Title |
Development of alphabeta T cells in the human thymus. |
Journal |
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Reference |
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Authors |
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B. |
Title |
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. |
Journal |
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Reference |
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Authors |
Mak TW, Penninger JM, Ohashi PS. |
Title |
Knockout mice: a paradigm shift in modern immunology. |
Journal |
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Reference |
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Authors |
Shapiro-Shelef M, Calame K. |
Title |
Regulation of plasma-cell development. |
Journal |
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Reference |
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Authors |
Maillard I, Adler SH, Pear WS. |
Title |
Notch and the immune system. |
Journal |
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Reference |
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Authors |
Alpdogan O, van den Brink MR. |
Title |
IL-7 and IL-15: therapeutic cytokines for immunodeficiency. |
Journal |
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KO pathway |
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