KEGG   PATHWAY: hsa04640Help
Entry
hsa04640                    Pathway                                

Name
Hematopoietic cell lineage - Homo sapiens (human)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
hsa04640  Hematopoietic cell lineage
hsa04640

Ortholog table
Disease
H00219  Hemophilia
H00224  Bernard-Soulier syndrome
H01479  Castleman disease
Drug
D00754  Thalidomide (JAN/USP/INN)
D01583  Pirfenidone (JAN/USAN/INN)
D02596  Tocilizumab (USAN/INN)
D02664  Mirimostim (JAN/INN)
D02937  Ancestim (USAN/INN)
D02994  Rituximab (USAN/INN)
D03058  Basiliximab (USAN/INN)
D03231  Epoetin alfa (USAN/INN)
D03232  Epoetin beta (USAN/INN)
D03235  Filgrastim (USAN/INN)
D03247  Lenograstim (USAN/INN)
D03259  Gemtuzumab ozogamicin (USAN)
D03497  Cilengitide (USAN/INN)
D03639  Daclizumab (USAN/INN)
D03645  Daniplestim (USAN/INN)
D03651  Darbepoetin alfa (USAN/INN)
D04032  Epoetin delta (USAN)
D04036  Epratuzumab (USAN/INN)
D04489  Ibritumomab tiuxetan (USAN/INN)
D04687  Lenalidomide (USAN/INN)
D05036  Milodistim (USAN/INN)
D05066  Molgramostim (USAN/INN)
D05218  Ocrelizumab (USAN)
D05266  Oprelvekin (USAN/INN)
D05803  Sargramostim (USAN/INN)
D05847  Siplizumab (USAN/INN)
D06463  Lumiliximab (USAN/INN)
D06889  Pegfilgrastim (INN)
D08621  Tositumomab (INN)
D08622  Tositumomab 131 iodine
D08933  Inotuzumab ozogamicin (USAN/INN)
D08976  Pomalidomide (JAN/USAN/INN)
D09031  Veltuzumab (USAN)
D09190  Anti-human thymocyte immunoglobulin, rabbit (JAN)
D09207  Catumaxomab (INN)
D09314  Ofatumumab (USAN/INN)
D09321  Obinutuzumab (USAN)
D09813  Lenalidomide hydrate (JAN)
D10000  Epoetin epsilon (INN)
D10028  Valategrast hydrochloride (USAN)
D10225  Sacubitril (JAN/USAN/INN)
D10242  Lipegfilgrastim (USAN)
D10310  Balugrastim (USAN/INN)
D10354  Dupilumab (USAN)
D10846  Epoetin theta (INN)
D10847  Epoetin zeta (INN)
D11026  Pegteograstim (INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
4254  KITLG; KIT ligand [KO:K05461]
3574  IL7; interleukin 7 [KO:K05431]
3565  IL4; interleukin 4 [KO:K05430]
1437  CSF2; colony stimulating factor 2 [KO:K05427]
2323  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
3567  IL5; interleukin 5 [KO:K05428]
1440  CSF3; colony stimulating factor 3 [KO:K05423]
3562  IL3; interleukin 3 [KO:K04736]
3569  IL6; interleukin 6 [KO:K05405]
3589  IL11; interleukin 11 [KO:K05417]
3552  IL1A; interleukin 1 alpha [KO:K04383]
3553  IL1B; interleukin 1 beta [KO:K04519]
7124  TNF; tumor necrosis factor [KO:K03156]
1435  CSF1; colony stimulating factor 1 [KO:K05453]
2056  EPO; erythropoietin [KO:K05437]
7066  THPO; thrombopoietin [KO:K06854]
947  CD34; CD34 molecule [KO:K06474]
2322  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
1791  DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
3108  HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
960  CD44; CD44 molecule (Indian blood group) [KO:K06256]
3815  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
3559  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3575  IL7R; interleukin 7 receptor [KO:K05072]
7037  TFRC; transferrin receptor [KO:K06503]
952  CD38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]
924  CD7; CD7 molecule [KO:K06457]
914  CD2; CD2 molecule [KO:K06449]
921  CD5; CD5 molecule [KO:K06455]
909  CD1A; CD1a molecule [KO:K06448]
910  CD1B; CD1b molecule [KO:K06448]
911  CD1C; CD1c molecule [KO:K06448]
912  CD1D; CD1d molecule [KO:K06448]
913  CD1E; CD1e molecule [KO:K06448]
920  CD4; CD4 molecule [KO:K06454]
925  CD8A; CD8a molecule [KO:K06458]
926  CD8B; CD8b molecule [KO:K06459]
915  CD3D; CD3d molecule [KO:K06450]
916  CD3E; CD3e molecule [KO:K06451]
917  CD3G; CD3g molecule [KO:K06452]
4311  MME; membrane metalloendopeptidase [KO:K01389] [EC:3.4.24.11]
928  CD9; CD9 molecule [KO:K06460]
930  CD19; CD19 molecule [KO:K06465]
933  CD22; CD22 molecule [KO:K06467]
100133941  CD24; CD24 molecule [KO:K06469]
931  MS4A1; membrane spanning 4-domains A1 [KO:K06466]
1380  CR2; complement C3d receptor 2 [KO:K04012]
951  CD37; CD37 molecule [KO:K06475]
102723407  IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
2208  FCER2; Fc fragment of IgE receptor II [KO:K06468]
1378  CR1; complement C3b/C4b receptor 1 (Knops blood group) [KO:K04011]
1438  CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
3563  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
945  CD33; CD33 molecule [KO:K06473]
3566  IL4R; interleukin 4 receptor [KO:K05071]
3570  IL6R; interleukin 6 receptor [KO:K05055]
2209  FCGR1A; Fc fragment of IgG receptor Ia [KO:K06498]
1436  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
290  ANPEP; alanyl aminopeptidase, membrane [KO:K11140] [EC:3.4.11.2]
3684  ITGAM; integrin subunit alpha M [KO:K06461]
929  CD14; CD14 molecule [KO:K04391]
3581  IL9R; interleukin 9 receptor [KO:K05073]
3554  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
7850  IL1R2; interleukin 1 receptor type 2 [KO:K04387]
1441  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
3568  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
2057  EPOR; erythropoietin receptor [KO:K05079]
948  CD36; CD36 molecule [KO:K06259]
2993  GYPA; glycophorin A (MNS blood group) [KO:K06575]
1604  CD55; CD55 molecule (Cromer blood group) [KO:K04006]
966  CD59; CD59 molecule (CD59 blood group) [KO:K04008]
3590  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
3690  ITGB3; integrin subunit beta 3 [KO:K06493]
3674  ITGA2B; integrin subunit alpha 2b [KO:K06476]
2815  GP9; glycoprotein IX platelet [KO:K06263]
2811  GP1BA; glycoprotein Ib platelet alpha subunit [KO:K06261]
2812  GP1BB; glycoprotein Ib platelet beta subunit [KO:K06262]
2814  GP5; glycoprotein V platelet [KO:K06260]
3672  ITGA1; integrin subunit alpha 1 [KO:K06480]
3673  ITGA2; integrin subunit alpha 2 [KO:K06481]
3675  ITGA3; integrin subunit alpha 3 [KO:K06482]
3676  ITGA4; integrin subunit alpha 4 [KO:K06483]
3678  ITGA5; integrin subunit alpha 5 [KO:K06484]
3655  ITGA6; integrin subunit alpha 6 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
(Japanese)
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   

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