KEGG   PATHWAY: hsa04664Help
Entry
hsa04664                    Pathway                                

Name
Fc epsilon RI signaling pathway - Homo sapiens (human)
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Fc epsilon RI signaling pathway
hsa04664

All organismsOrtholog table
Disease
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
H01387  
Activated PI3K-delta syndrome (APDS)
Drug
D04358  
Golimumab (USAN/INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8; K06856 immunoglobulin heavy chain [KO:K06856]
2205  
FCER1A; Fc fragment of IgE receptor Ia [KO:K08089]
2206  
MS4A2; membrane spanning 4-domains A2 [KO:K08090]
2207  
FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
6850  
SYK; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
4067  
LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
695  
BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]
3635  
INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
5335  
PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  
PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
5578  
PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5295  
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5170  
PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
207  
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
5880  
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
5881  
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
6416  
MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
5609  
MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
5606  
MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
5608  
MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
5599  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5600  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
3565  
IL4; interleukin 4 [KO:K05430]
3596  
IL13; interleukin 13 [KO:K05435]
3562  
IL3; interleukin 3 [KO:K04736]
3567  
IL5; interleukin 5 [KO:K05428]
1437  
CSF2; colony stimulating factor 2 [KO:K05427]
7124  
TNF; tumor necrosis factor [KO:K03156]
3937  
LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
10451  
VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
7409  
VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
7410  
VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
2534  
FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
9846  
GAB2; GRB2 associated binding protein 2 [KO:K08091]
27040  
LAT; linker for activation of T-cells [KO:K07362]
2885  
GRB2; growth factor receptor bound protein 2 [KO:K04364]
6654  
SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  
SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123745  
PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
8681  
JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
8605  
PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
255189  
PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00219  
Arachidonate
C00374  
Heparin
C00388  
Histamine
C00696  
Prostaglandin D2
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C02166  
Leukotriene C4
C05951  
Leukotriene D4
C05952  
Leukotriene E4
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kawakami T, Galli SJ.
  Title
Regulation of mast-cell and basophil function and survival by IgE.
  Journal
Nat Rev Immunol 2:773-86 (2002)
Reference
  Authors
Siraganian RP.
  Title
Mast cell signal transduction from the high-affinity IgE receptor.
  Journal
Curr Opin Immunol 15:639-46 (2003)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Turner H, Kinet JP.
  Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
  Journal
Nature 402:B24-30 (1999)
Reference
  Authors
Gilfillan AM, Tkaczyk C.
  Title
Integrated signalling pathways for mast-cell activation.
  Journal
Nat Rev Immunol 6:218-30 (2006)
Reference
  Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
  Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
  Journal
Adv Immunol 76:325-55 (2000)
Reference
  Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Title
Essential role for Gab2 in the allergic response.
  Journal
Nature 412:186-90 (2001)
Reference
  Authors
Nadler MJ, Kinet JP.
  Title
Uncovering new complexities in mast cell signaling.
  Journal
Nat Immunol 3:707-8 (2002)
KO pathway
 

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