Entry |
|
Name |
Fc gamma R-mediated phagocytosis - Homo sapiens (human)
|
Description |
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
|
Class |
Organismal Systems; Immune system
 |
Pathway map |
hsa04666 | Fc gamma R-mediated phagocytosis |

 |
Disease |
H00098 | Chronic granulomatous disease |
H01240 | Immune thrombocytopenia (ITP) |
H01387 | Activated PI3K-delta syndrome (APDS) |
|
Other DBs |
|
Organism |
Homo sapiens (human) [GN: hsa]
|
Gene |
102723407 | IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856] |
2209 | FCGR1A; Fc fragment of IgG receptor Ia [KO:K06498] |
2212 | FCGR2A; Fc fragment of IgG receptor IIa [KO:K06472] |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153] |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153] |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153] |
5295 | PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] |
5296 | PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] |
8503 | PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649] |
4082 | MARCKS; myristoylated alanine rich protein kinase C substrate [KO:K12561] |
10451 | VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730] |
7409 | VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730] |
7410 | VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730] |
998 | CDC42; cell division cycle 42 [KO:K04393] |
8976 | WASL; Wiskott-Aldrich syndrome like [KO:K05747] |
7408 | VASP; vasodilator stimulated phosphoprotein [KO:K06274] |
10092 | ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754] |
81873 | ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754] |
10093 | ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755] |
10094 | ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756] |
10095 | ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757] |
10552 | ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757] |
10109 | ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758] |
8936 | WASF1; WAS protein family member 1 [KO:K05753] |
23396 | PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68] |
8394 | PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68] |
8395 | PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68] |
382 | ARF6; ADP ribosylation factor 6 [KO:K07941] |
1398 | CRK; CRK proto-oncogene, adaptor protein [KO:K04438] |
1399 | CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438] |
1794 | DOCK2; dedicator of cytokinesis 2 [KO:K12367] |
50807 | ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488] |
55616 | ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488] |
8853 | ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488] |
2213 | FCGR2B; Fc fragment of IgG receptor IIb [KO:K12560] |
9846 | GAB2; GRB2 associated binding protein 2 [KO:K08091] |
27040 | LAT; linker for activation of T cells [KO:K07362] |
2214 | FCGR3A; Fc fragment of IgG receptor IIIa [KO:K06463] |
|
Compound |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
C04637 | 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
C06124 | Sphingosine 1-phosphate |
|
Reference |
|
Authors |
Garcia-Garcia E, Rosales C |
Title |
Signal transduction during Fc receptor-mediated phagocytosis. |
Journal |
J Leukoc Biol 72:1092-108 (2002) |
Reference |
|
Authors |
Cox D, Greenberg S |
Title |
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system. |
Journal |
|
Reference |
|
Authors |
Swanson JA, Hoppe AD |
Title |
The coordination of signaling during Fc receptor-mediated phagocytosis. |
Journal |
|
Reference |
|
Authors |
Ravetch JV, Bolland S |
Title |
IgG Fc receptors. |
Journal |
|
Reference |
|
Authors |
Groves E, Dart AE, Covarelli V, Caron E |
Title |
Molecular mechanisms of phagocytic uptake in mammalian cells. |
Journal |
|
Reference |
|
Authors |
Kwiatkowska K, Sobota A |
Title |
Signaling pathways in phagocytosis. |
Journal |
|
Reference |
|
Authors |
Greenberg S |
Title |
Modular components of phagocytosis. |
Journal |
J Leukoc Biol 66:712-7 (1999) |
Reference |
|
Authors |
Lennartz MR |
Title |
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis. |
Journal |
|
Reference |
|
Authors |
May RC, Machesky LM |
Title |
Phagocytosis and the actin cytoskeleton. |
Journal |
J Cell Sci 114:1061-77 (2001) |
Reference |
|
Authors |
Joshi T, Butchar JP, Tridandapani S |
Title |
Fcgamma receptor signaling in phagocytes. |
Journal |
|
Reference |
|
Authors |
Lee WL, Cosio G, Ireton K, Grinstein S |
Title |
Role of CrkII in Fcgamma receptor-mediated phagocytosis. |
Journal |
|
Reference |
|
Authors |
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H |
Title |
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages. |
Journal |
|
Reference |
|
Authors |
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S |
Title |
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. |
Journal |
|
Reference |
|
Authors |
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM |
Title |
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. |
Journal |
|
Reference |
|
Authors |
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG |
Title |
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. |
Journal |
|
Reference |
|
Authors |
Dana R, Leto TL, Malech HL, Levy R |
Title |
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. |
Journal |
|
Reference |
|
Authors |
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A |
Title |
Dynamin 2 is required for phagocytosis in macrophages. |
Journal |
|
Reference |
|
Authors |
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A |
Title |
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis. |
Journal |
|
Reference |
|
Authors |
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA |
Title |
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis. |
Journal |
J Immunol 163:6785-93 (1999) |
Reference |
|
Authors |
Sanchez-Mejorada G, Rosales C |
Title |
Signal transduction by immunoglobulin Fc receptors. |
Journal |
J Leukoc Biol 63:521-33 (1998) |
Reference |
|
Authors |
Rosales C (ed). |
Title |
Molecular Mechanisms of Phagocytosis |
Journal |
Springer (2005) |
KO pathway |
|