KEGG   PATHWAY: hsa04666Help
Entry
hsa04666                    Pathway                                

Name
Fc gamma R-mediated phagocytosis - Homo sapiens (human)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Fc gamma R-mediated phagocytosis
hsa04666

All organismsOrtholog table
Disease
H00098  
Chronic granulomatous disease
H00698  
Nemaline myopathy
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
H01240  
Immune thrombocytopenia (ITP)
H01387  
Activated PI3K-delta syndrome (APDS)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
2209  
FCGR1A; Fc fragment of IgG receptor Ia [KO:K06498]
2212  
FCGR2A; Fc fragment of IgG receptor IIa [KO:K06472]
5788  
PTPRC; protein tyrosine phosphatase, receptor type C [KO:K06478] [EC:3.1.3.48]
3055  
HCK; HCK proto-oncogene, Src family tyrosine kinase [KO:K08893] [EC:2.7.10.2]
4067  
LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
6850  
SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5295  
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
207  
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
6198  
RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
6199  
RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
5335  
PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  
PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
5580  
PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
5581  
PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
4082  
MARCKS; myristoylated alanine rich protein kinase C substrate [KO:K12561]
65108  
MARCKSL1; MARCKS like 1 [KO:K13536]
5337  
PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
5338  
PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
8611  
PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
8613  
PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
8612  
PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
8877  
SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
56848  
SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
5578  
PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
653361  
NCF1; neutrophil cytosolic factor 1 [KO:K08011]
2934  
GSN; gelsolin [KO:K05768]
85477  
SCIN; scinderin [KO:K05768]
10451  
VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
7409  
VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
7410  
VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
998  
CDC42; cell division cycle 42 [KO:K04393]
7454  
WAS; Wiskott-Aldrich syndrome [KO:K05747]
8976  
WASL; Wiskott-Aldrich syndrome like [KO:K05747]
7408  
VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
10092  
ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
81873  
ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
10093  
ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10094  
ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10095  
ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10552  
ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10109  
ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
5880  
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
8936  
WASF1; WAS protein family member 1 [KO:K05753]
10163  
WASF2; WAS protein family member 2 [KO:K05748]
10810  
WASF3; WAS protein family member 3 [KO:K06083]
5058  
PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
3984  
LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
3985  
LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
1072  
CFL1; cofilin 1 [KO:K05765]
1073  
CFL2; cofilin 2 [KO:K05765]
23396  
PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
8394  
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
8395  
PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
382  
ARF6; ADP ribosylation factor 6 [KO:K07941]
1398  
CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
1399  
CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
1794  
DOCK2; dedicator of cytokinesis 2 [KO:K12367]
50807  
ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488]
55616  
ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
8853  
ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
2213  
FCGR2B; Fc fragment of IgG receptor IIb [KO:K12560]
3635  
INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
3636  
INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
9846  
GAB2; GRB2 associated binding protein 2 [KO:K08091]
27040  
LAT; linker for activation of T-cells [KO:K07362]
273  
AMPH; amphiphysin [KO:K12562]
274  
BIN1; bridging integrator 1 [KO:K12562]
4651  
MYO10; myosin X [KO:K12559]
PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
123745  
PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
1785  
DNM2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
2214  
FCGR3A; Fc fragment of IgG receptor IIIa [KO:K06463]
255189  
PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
8398  
PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00219  
Arachidonate
C00416  
Phosphatidate
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C06124  
Sphingosine 1-phosphate
Reference
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
Reference
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
Reference
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
Reference
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
Reference
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
Reference
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
Reference
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
Reference
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
Reference
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
Reference
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
Reference
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
Reference
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
Reference
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
Reference
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
Reference
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
Reference
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
KO pathway
 
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