KEGG   PATHWAY: hsa04672Help
Entry
hsa04672                    Pathway                                

Name
Intestinal immune network for IgA production - Homo sapiens (human)
Description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Intestinal immune network for IgA production
hsa04672

All organismsOrtholog table
Drug
D03203  
Abatacept (USAN/INN)
D10028  
Valategrast hydrochloride (USAN)
D10378  
Vercirnon (USAN/INN)
D10379  
Vercirnon sodium (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
941  
CD80; CD80 molecule [KO:K05412]
942  
CD86; CD86 molecule [KO:K05413]
3108  
HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  
HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  
HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  
HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  
HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
940  
CD28; CD28 molecule [KO:K06470]
3558  
IL2; interleukin 2 [KO:K05429]
3565  
IL4; interleukin 4 [KO:K05430]
3567  
IL5; interleukin 5 [KO:K05428]
3569  
IL6; interleukin 6 [KO:K05405]
3586  
IL10; interleukin 10 [KO:K05443]
7040  
TGFB1; transforming growth factor beta 1 [KO:K13375]
8741  
TNFSF13; tumor necrosis factor superfamily member 13 [KO:K05475]
10673  
TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476]
23495  
TNFRSF13B; TNF receptor superfamily member 13B [KO:K05150]
608  
TNFRSF17; TNF receptor superfamily member 17 [KO:K05153]
115650  
TNFRSF13C; TNF receptor superfamily member 13C [KO:K05151]
IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
57379  
AICDA; activation-induced cytidine deaminase [KO:K10989] [EC:3.5.4.38]
958  
CD40; CD40 molecule [KO:K03160]
959  
CD40LG; CD40 ligand [KO:K03161]
29851  
ICOS; inducible T-cell costimulator [KO:K06713]
23308  
ICOSLG; inducible T-cell costimulator ligand [KO:K06710]
ICOS ligand; K06710 inducible T-cell co-stimulator ligand [KO:K06710]
10803  
CCR9; C-C motif chemokine receptor 9 [KO:K04184]
3676  
ITGA4; integrin subunit alpha 4 [KO:K06483]
3695  
ITGB7; integrin subunit beta 7 [KO:K06590]
6387  
CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
7852  
CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
56477  
CCL28; C-C motif chemokine ligand 28 [KO:K05513]
2826  
CCR10; C-C motif chemokine receptor 10 [KO:K04185]
6370  
CCL25; C-C motif chemokine ligand 25 [KO:K13072]
8174  
MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
4055  
LTBR; lymphotoxin beta receptor [KO:K03159]
9020  
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
3600  
IL15; interleukin 15 [KO:K05433]
3601  
IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
5284  
PIGR; polymeric immunoglobulin receptor [KO:K13073]
Compound
C00777  
Retinoate
C15493  
9-cis-Retinoic acid
Reference
  Authors
Fagarasan S, Honjo T
  Title
Intestinal IgA synthesis: regulation of front-line body defences.
  Journal
Nat Rev Immunol 3:63-72 (2003)
Reference
  Authors
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
  Title
The immune geography of IgA induction and function.
  Journal
Mucosal Immunol 1:11-22 (2008)
Reference
  Authors
Kunisawa J, Kiyono H
  Title
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
  Journal
Cell Mol Life Sci 62:1308-21 (2005)
Reference
  Authors
Cerutti A, Rescigno M
  Title
The biology of intestinal immunoglobulin A responses.
  Journal
Immunity 28:740-50 (2008)
Reference
  Authors
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
  Title
Dynamic interactions between bacteria and immune cells leading to intestinal IgA  synthesis.
  Journal
Semin Immunol 20:59-66 (2008)
Reference
  Authors
Corthesy B
  Title
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
  Journal
J Immunol 178:27-32 (2007)
Reference
  Authors
Suzuki K, Fagarasan S
  Title
How host-bacterial interactions lead to IgA synthesis in the gut.
  Journal
Trends Immunol 29:523-31 (2008)
Reference
  Authors
Mora JR, von Andrian UH
  Title
Differentiation and homing of IgA-secreting cells.
  Journal
Mucosal Immunol 1:96-109 (2008)
Reference
  Authors
Suzuki K, Ha SA, Tsuji M, Fagarasan S
  Title
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
  Journal
Semin Immunol 19:127-35 (2007)
Reference
  Authors
Cerutti A
  Title
The regulation of IgA class switching.
  Journal
Nat Rev Immunol 8:421-34 (2008)
KO pathway
 

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