KEGG PATHWAY: hsa04672

PATHWAY: hsa04672

Entry

hsa04672 Pathway

Name

Intestinal immune network for IgA production - Homo sapiens (human)

Description

The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.

Class

Organismal Systems; Immune system

Pathway map

hsa04672

Intestinal immune network for IgA production

Drug

D03203	Abatacept (genetical recombination) (JAN)
D10028	Valategrast hydrochloride (USAN)

Other DBs

BSID:

128760

GO:

0002387

Organism

Homo sapiens (human) [GN:hsa]

Gene

941	CD80; CD80 molecule [KO:K05412]
942	CD86; CD86 molecule [KO:K05413]
3108	HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109	HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111	HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112	HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113	HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115	HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117	HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118	HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119	HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122	HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123	HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125	HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126	HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127	HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
100507709	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100507714	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100509457	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
101060835	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
940	CD28; CD28 molecule [KO:K06470]
3558	IL2; interleukin 2 [KO:K05429]
3565	IL4; interleukin 4 [KO:K05430]
3567	IL5; interleukin 5 (colony-stimulating factor, eosinophil) [KO:K05428]
3569	IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
3586	IL10; interleukin 10 [KO:K05443]
7040	TGFB1; transforming growth factor, beta 1 [KO:K13375]
8741	TNFSF13; tumor necrosis factor (ligand) superfamily, member 13 [KO:K05475]
10673	TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b [KO:K05476]
23495	TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B [KO:K05150]
608	TNFRSF17; tumor necrosis factor receptor superfamily, member 17 [KO:K05153]
115650	TNFRSF13C; tumor necrosis factor receptor superfamily, member 13C [KO:K05151]
57379	AICDA; activation-induced cytidine deaminase [KO:K10989] [EC:3.5.4.5]
958	CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
959	CD40LG; CD40 ligand [KO:K03161]
29851	ICOS; inducible T-cell co-stimulator [KO:K06713]
23308	ICOSLG; inducible T-cell co-stimulator ligand [KO:K06710]
10803	CCR9; chemokine (C-C motif) receptor 9 [KO:K04184]
3676	ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [KO:K06483]
3695	ITGB7; integrin, beta 7 [KO:K06590]
6387	CXCL12; chemokine (C-X-C motif) ligand 12 [KO:K10031]
7852	CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
56477	CCL28; chemokine (C-C motif) ligand 28 [KO:K05513]
2826	CCR10; chemokine (C-C motif) receptor 10 [KO:K04185]
6370	CCL25; chemokine (C-C motif) ligand 25 [KO:K13072]
8174	MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
4055	LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3) [KO:K03159]
9020	MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
3600	IL15; interleukin 15 [KO:K05433]
3601	IL15RA; interleukin 15 receptor, alpha [KO:K05074]
5284	PIGR; polymeric immunoglobulin receptor [KO:K13073]

Compound

C00777	Retinoate
C15493	9-cis-Retinoic acid

Reference

PMID:12511876

Authors

Fagarasan S, Honjo T

Title

Intestinal IgA synthesis: regulation of front-line body defences.

Journal

Nat Rev Immunol 3:63-72 (2003)

Reference

PMID:19079156

Authors

Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P

Title

The immune geography of IgA induction and function.

Journal

Mucosal Immunol 1:11-22 (2008)

Reference

PMID:15971106

Authors

Kunisawa J, Kiyono H

Title

A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.

Journal

Cell Mol Life Sci 62:1308-21 (2005)

Reference

PMID:18549797

Authors

Cerutti A, Rescigno M

Title

The biology of intestinal immunoglobulin A responses.

Journal

Immunity 28:740-50 (2008)

Reference

PMID:18243016

Authors

Tsuji M, Suzuki K, Kinoshita K, Fagarasan S

Title

Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.

Journal

Semin Immunol 20:59-66 (2008)

Reference

PMID:17182536

Authors

Corthesy B

Title

Roundtrip ticket for secretory IgA: role in mucosal homeostasis?

Journal

J Immunol 178:27-32 (2007)

Reference

PMID:18838301

Authors

Suzuki K, Fagarasan S

Title

How host-bacterial interactions lead to IgA synthesis in the gut.

Journal

Trends Immunol 29:523-31 (2008)

Reference

PMID:19079167

Authors

Mora JR, von Andrian UH

Title

Differentiation and homing of IgA-secreting cells.

Journal

Mucosal Immunol 1:96-109 (2008)

Reference

PMID:17161619

Authors

Suzuki K, Ha SA, Tsuji M, Fagarasan S

Title

Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.

Journal

Semin Immunol 19:127-35 (2007)

Reference

PMID:18483500

Authors

Cerutti A

Title

The regulation of IgA class switching.

Journal

Nat Rev Immunol 8:421-34 (2008)

KO pathway

ko04672

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   BioSystems (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (57)   

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