KEGG   PATHWAY: hsa04740Help
Entry
hsa04740                    Pathway                                

Name
Olfactory transduction - Homo sapiens (human)
Description
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.
Class
Organismal Systems; Sensory system
BRITE hierarchy
Pathway map
Olfactory transduction
hsa04740

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
442186  
OR2J3; olfactory receptor family 2 subfamily J member 3 [KO:K04257]
442191  
OR14J1; olfactory receptor family 14 subfamily J member 1 [KO:K04257]
442194  
OR10C1; olfactory receptor family 10 subfamily C member 1 (gene/pseudogene) [KO:K04257]
442361  
OR2A2; olfactory receptor family 2 subfamily A member 2 [KO:K04257]
119774  
OR52K2; olfactory receptor family 52 subfamily K member 2 [KO:K04257]
120065  
OR5P2; olfactory receptor family 5 subfamily P member 2 [KO:K04257]
120066  
OR5P3; olfactory receptor family 5 subfamily P member 3 [KO:K04257]
120586  
OR8I2; olfactory receptor family 8 subfamily I member 2 [KO:K04257]
120775  
OR2D3; olfactory receptor family 2 subfamily D member 3 [KO:K04257]
119678  
OR52E2; olfactory receptor family 52 subfamily E member 2 [KO:K04257]
119679  
OR52J3; olfactory receptor family 52 subfamily J member 3 [KO:K04257]
119682  
OR51L1; olfactory receptor family 51 subfamily L member 1 [KO:K04257]
119687  
OR51A7; olfactory receptor family 51 subfamily A member 7 [KO:K04257]
119692  
OR51S1; olfactory receptor family 51 subfamily S member 1 [KO:K04257]
119694  
OR51F2; olfactory receptor family 51 subfamily F member 2 [KO:K04257]
119695  
OR52R1; olfactory receptor family 52 subfamily R member 1 (gene/pseudogene) [KO:K04257]
119749  
OR4C46; olfactory receptor family 4 subfamily C member 46 [KO:K04257]
119764  
OR4X2; olfactory receptor family 4 subfamily X member 2 (gene/pseudogene) [KO:K04257]
119772  
OR52M1; olfactory receptor family 52 subfamily M member 1 [KO:K04257]
8387  
OR1E1; olfactory receptor family 1 subfamily E member 1 [KO:K04257]
8388  
OR1E2; olfactory receptor family 1 subfamily E member 2 [KO:K04257]
4991  
OR1D2; olfactory receptor family 1 subfamily D member 2 [KO:K04257]
8386  
OR1D5; olfactory receptor family 1 subfamily D member 5 [KO:K04257]
8390  
OR1G1; olfactory receptor family 1 subfamily G member 1 [KO:K04257]
8383  
OR1A1; olfactory receptor family 1 subfamily A member 1 [KO:K04257]
26189  
OR1A2; olfactory receptor family 1 subfamily A member 2 [KO:K04257]
26707  
OR2J2; olfactory receptor family 2 subfamily J member 2 [KO:K04257]
79541  
OR2A4; olfactory receptor family 2 subfamily A member 4 [KO:K04257]
4993  
OR2C1; olfactory receptor family 2 subfamily C member 1 [KO:K04257]
26211  
OR2F1; olfactory receptor family 2 subfamily F member 1 (gene/pseudogene) [KO:K04257]
26692  
OR2W1; olfactory receptor family 2 subfamily W member 1 [KO:K04257]
4994  
OR3A1; olfactory receptor family 3 subfamily A member 1 [KO:K04257]
4995  
OR3A2; olfactory receptor family 3 subfamily A member 2 [KO:K04257]
8392  
OR3A3; olfactory receptor family 3 subfamily A member 3 [KO:K04257]
10798  
OR5I1; olfactory receptor family 5 subfamily I member 1 [KO:K04257]
81696  
OR5V1; olfactory receptor family 5 subfamily V member 1 [KO:K04257]
8590  
OR6A2; olfactory receptor family 6 subfamily A member 2 [KO:K04257]
26333  
OR7A17; olfactory receptor family 7 subfamily A member 17 [KO:K04257]
26659  
OR7A5; olfactory receptor family 7 subfamily A member 5 [KO:K04257]
26539  
OR10H1; olfactory receptor family 10 subfamily H member 1 [KO:K04257]
26538  
OR10H2; olfactory receptor family 10 subfamily H member 2 [KO:K04257]
26532  
OR10H3; olfactory receptor family 10 subfamily H member 3 [KO:K04257]
26476  
OR10J1; olfactory receptor family 10 subfamily J member 1 [KO:K04257]
26531  
OR11A1; olfactory receptor family 11 subfamily A member 1 [KO:K04257]
26529  
OR12D2; olfactory receptor family 12 subfamily D member 2 (gene/pseudogene) [KO:K04257]
81797  
OR12D3; olfactory receptor family 12 subfamily D member 3 [KO:K04257]
81285  
OR51E2; olfactory receptor family 51 subfamily E member 2 [KO:K04257]
23538  
OR52A1; olfactory receptor family 52 subfamily A member 1 [KO:K04257]
79339  
OR51B4; olfactory receptor family 51 subfamily B member 4 [KO:K04257]
79345  
OR51B2; olfactory receptor family 51 subfamily B member 2 (gene/pseudogene) [KO:K04257]
283694  
OR4N4; olfactory receptor family 4 subfamily N member 4 [KO:K04257]
441608  
OR5B3; olfactory receptor family 5 subfamily B member 3 [KO:K04257]
441639  
OR9K2; olfactory receptor family 9 subfamily K member 2 [KO:K04257]
441669  
OR4Q3; olfactory receptor family 4 subfamily Q member 3 [KO:K04257]
441670  
OR4M1; olfactory receptor family 4 subfamily M member 1 [KO:K04257]
441933  
OR13G1; olfactory receptor family 13 subfamily G member 1 [KO:K04257]
284521  
OR2L13; olfactory receptor family 2 subfamily L member 13 [KO:K04257]
390078  
OR52E6; olfactory receptor family 52 subfamily E member 6 [KO:K04257]
390079  
OR52E8; olfactory receptor family 52 subfamily E member 8 [KO:K04257]
390081  
OR52E4; olfactory receptor family 52 subfamily E member 4 [KO:K04257]
390083  
OR56A3; olfactory receptor family 56 subfamily A member 3 [KO:K04257]
390084  
OR56A5; olfactory receptor family 56 subfamily A member 5 [KO:K04257]
390093  
OR10A6; olfactory receptor family 10 subfamily A member 6 (gene/pseudogene) [KO:K04257]
390113  
OR4X1; olfactory receptor family 4 subfamily X member 1 (gene/pseudogene) [KO:K04257]
390142  
OR5D13; olfactory receptor family 5 subfamily D member 13 (gene/pseudogene) [KO:K04257]
390144  
OR5D16; olfactory receptor family 5 subfamily D member 16 [KO:K04257]
390151  
OR8H2; olfactory receptor family 8 subfamily H member 2 [KO:K04257]
390152  
OR8H3; olfactory receptor family 8 subfamily H member 3 [KO:K04257]
390154  
OR5T3; olfactory receptor family 5 subfamily T member 3 [KO:K04257]
390155  
OR5T1; olfactory receptor family 5 subfamily T member 1 [KO:K04257]
390157  
OR8K1; olfactory receptor family 8 subfamily K member 1 [KO:K04257]
390162  
OR5M9; olfactory receptor family 5 subfamily M member 9 [KO:K04257]
390167  
OR5M10; olfactory receptor family 5 subfamily M member 10 [KO:K04257]
390168  
OR5M1; olfactory receptor family 5 subfamily M member 1 [KO:K04257]
390174  
OR9G1; olfactory receptor family 9 subfamily G member 1 [KO:K04257]
144125  
OR2AG1; olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene) [KO:K04257]
150681  
OR6B3; olfactory receptor family 6 subfamily B member 3 [KO:K04257]
158131  
OR1Q1; olfactory receptor family 1 subfamily Q member 1 [KO:K04257]
162998  
OR7D2; olfactory receptor family 7 subfamily D member 2 [KO:K04257]
196335  
OR56B4; olfactory receptor family 56 subfamily B member 4 [KO:K04257]
219417  
OR8U1; olfactory receptor family 8 subfamily U member 1 [KO:K04257]
219428  
OR4C16; olfactory receptor family 4 subfamily C member 16 (gene/pseudogene) [KO:K04257]
219429  
OR4C11; olfactory receptor family 4 subfamily C member 11 [KO:K04257]
219431  
OR4S2; olfactory receptor family 4 subfamily S member 2 [KO:K04257]
219432  
OR4C6; olfactory receptor family 4 subfamily C member 6 [KO:K04257]
219436  
OR5D14; olfactory receptor family 5 subfamily D member 14 [KO:K04257]
219437  
OR5L1; olfactory receptor family 5 subfamily L member 1 (gene/pseudogene) [KO:K04257]
219438  
OR5D18; olfactory receptor family 5 subfamily D member 18 [KO:K04257]
219447  
OR5AS1; olfactory receptor family 5 subfamily AS member 1 [KO:K04257]
219453  
OR8K5; olfactory receptor family 8 subfamily K member 5 [KO:K04257]
219464  
OR5T2; olfactory receptor family 5 subfamily T member 2 [KO:K04257]
219469  
OR8H1; olfactory receptor family 8 subfamily H member 1 [KO:K04257]
219473  
OR8K3; olfactory receptor family 8 subfamily K member 3 (gene/pseudogene) [KO:K04257]
219477  
OR8J1; olfactory receptor family 8 subfamily J member 1 [KO:K04257]
219479  
OR5R1; olfactory receptor family 5 subfamily R member 1 (gene/pseudogene) [KO:K04257]
219482  
OR5M3; olfactory receptor family 5 subfamily M member 3 [KO:K04257]
219484  
OR5M8; olfactory receptor family 5 subfamily M member 8 [KO:K04257]
219493  
OR5AR1; olfactory receptor family 5 subfamily AR member 1 (gene/pseudogene) [KO:K04257]
219858  
OR8B12; olfactory receptor family 8 subfamily B member 12 [KO:K04257]
219865  
OR8G5; olfactory receptor family 8 subfamily G member 5 [KO:K04257]
219869  
OR10G8; olfactory receptor family 10 subfamily G member 8 [KO:K04257]
219870  
OR10G9; olfactory receptor family 10 subfamily G member 9 [KO:K04257]
219873  
OR10S1; olfactory receptor family 10 subfamily S member 1 [KO:K04257]
219874  
OR6T1; olfactory receptor family 6 subfamily T member 1 [KO:K04257]
219875  
OR4D5; olfactory receptor family 4 subfamily D member 5 [KO:K04257]
219952  
OR6Q1; olfactory receptor family 6 subfamily Q member 1 (gene/pseudogene) [KO:K04257]
219954  
OR9I1; olfactory receptor family 9 subfamily I member 1 [KO:K04257]
219956  
OR9Q1; olfactory receptor family 9 subfamily Q member 1 [KO:K04257]
219957  
OR9Q2; olfactory receptor family 9 subfamily Q member 2 [KO:K04257]
219958  
OR1S2; olfactory receptor family 1 subfamily S member 2 [KO:K04257]
219959  
OR1S1; olfactory receptor family 1 subfamily S member 1 (gene/pseudogene) [KO:K04257]
219960  
OR10Q1; olfactory receptor family 10 subfamily Q member 1 [KO:K04257]
219965  
OR5B17; olfactory receptor family 5 subfamily B member 17 [KO:K04257]
219968  
OR5B21; olfactory receptor family 5 subfamily B member 21 [KO:K04257]
219981  
OR5A2; olfactory receptor family 5 subfamily A member 2 [KO:K04257]
219982  
OR5A1; olfactory receptor family 5 subfamily A member 1 [KO:K04257]
219983  
OR4D6; olfactory receptor family 4 subfamily D member 6 [KO:K04257]
219986  
OR4D11; olfactory receptor family 4 subfamily D member 11 [KO:K04257]
254783  
OR6C74; olfactory receptor family 6 subfamily C member 74 [KO:K04257]
254786  
OR6C3; olfactory receptor family 6 subfamily C member 3 [KO:K04257]
254973  
OR1L4; olfactory receptor family 1 subfamily L member 4 [KO:K04257]
255725  
OR52B2; olfactory receptor family 52 subfamily B member 2 [KO:K04257]
256144  
OR4C3; olfactory receptor family 4 subfamily C member 3 [KO:K04257]
256148  
OR4S1; olfactory receptor family 4 subfamily S member 1 [KO:K04257]
256892  
OR51F1; olfactory receptor family 51 subfamily F member 1 (gene/pseudogene) [KO:K04257]
26188  
OR1C1; olfactory receptor family 1 subfamily C member 1 [KO:K04257]
26212  
OR2B6; olfactory receptor family 2 subfamily B member 6 [KO:K04257]
26219  
OR1J4; olfactory receptor family 1 subfamily J member 4 [KO:K04257]
26245  
OR2M4; olfactory receptor family 2 subfamily M member 4 [KO:K04257]
26246  
OR2L2; olfactory receptor family 2 subfamily L member 2 [KO:K04257]
26248  
OR2K2; olfactory receptor family 2 subfamily K member 2 [KO:K04257]
26338  
OR5L2; olfactory receptor family 5 subfamily L member 2 [KO:K04257]
26339  
OR5K1; olfactory receptor family 5 subfamily K member 1 [KO:K04257]
26492  
OR8G2; olfactory receptor family 8 subfamily G member 2 [KO:K04257]
26493  
OR8B8; olfactory receptor family 8 subfamily B member 8 [KO:K04257]
26496  
OR10A3; olfactory receptor family 10 subfamily A member 3 [KO:K04257]
26658  
OR7C2; olfactory receptor family 7 subfamily C member 2 [KO:K04257]
26664  
OR7C1; olfactory receptor family 7 subfamily C member 1 [KO:K04257]
26689  
OR4D1; olfactory receptor family 4 subfamily D member 1 [KO:K04257]
26696  
OR2T1; olfactory receptor family 2 subfamily T member 1 [KO:K04257]
26716  
OR2H1; olfactory receptor family 2 subfamily H member 1 [KO:K04257]
283092  
OR4C13; olfactory receptor family 4 subfamily C member 13 [KO:K04257]
283093  
OR4C12; olfactory receptor family 4 subfamily C member 12 [KO:K04257]
283111  
OR51V1; olfactory receptor family 51 subfamily V member 1 [KO:K04257]
283159  
OR8D1; olfactory receptor family 8 subfamily D member 1 [KO:K04257]
283160  
OR8D2; olfactory receptor family 8 subfamily D member 2 (gene/pseudogene) [KO:K04257]
283162  
OR8B4; olfactory receptor family 8 subfamily B member 4 (gene/pseudogene) [KO:K04257]
283189  
OR9G4; olfactory receptor family 9 subfamily G member 4 [KO:K04257]
283297  
OR10A4; olfactory receptor family 10 subfamily A member 4 [KO:K04257]
283365  
OR6C6; olfactory receptor family 6 subfamily C member 6 [KO:K04257]
284383  
OR2Z1; olfactory receptor family 2 subfamily Z member 1 [KO:K04257]
284433  
OR10H5; olfactory receptor family 10 subfamily H member 5 [KO:K04257]
284532  
OR14A16; olfactory receptor family 14 subfamily A member 16 [KO:K04257]
285659  
OR2V2; olfactory receptor family 2 subfamily V member 2 [KO:K04257]
286362  
OR13C9; olfactory receptor family 13 subfamily C member 9 [KO:K04257]
286365  
OR13D1; olfactory receptor family 13 subfamily D member 1 [KO:K04257]
338662  
OR8D4; olfactory receptor family 8 subfamily D member 4 [KO:K04257]
338674  
OR5F1; olfactory receptor family 5 subfamily F member 1 [KO:K04257]
338675  
OR5AP2; olfactory receptor family 5 subfamily AP member 2 [KO:K04257]
338751  
OR52L1; olfactory receptor family 52 subfamily L member 1 [KO:K04257]
338755  
OR2AG2; olfactory receptor family 2 subfamily AG member 2 [KO:K04257]
340980  
OR52B6; olfactory receptor family 52 subfamily B member 6 [KO:K04257]
341152  
OR2AT4; olfactory receptor family 2 subfamily AT member 4 [KO:K04257]
341276  
OR10A2; olfactory receptor family 10 subfamily A member 2 [KO:K04257]
341416  
OR6C2; olfactory receptor family 6 subfamily C member 2 [KO:K04257]
341418  
OR6C4; olfactory receptor family 6 subfamily C member 4 [KO:K04257]
341568  
OR8S1; olfactory receptor family 8 subfamily S member 1 [KO:K04257]
341799  
OR6S1; olfactory receptor family 6 subfamily S member 1 [KO:K04257]
343169  
OR6F1; olfactory receptor family 6 subfamily F member 1 [KO:K04257]
343173  
OR2T3; olfactory receptor family 2 subfamily T member 3 [KO:K04257]
343406  
OR10R2; olfactory receptor family 10 subfamily R member 2 [KO:K04257]
343563  
OR2T29; olfactory receptor family 2 subfamily T member 29 [KO:K04257]
346517  
OR6V1; olfactory receptor family 6 subfamily V member 1 [KO:K04257]
346525  
OR2A12; olfactory receptor family 2 subfamily A member 12 [KO:K04257]
346528  
OR2A1; olfactory receptor family 2 subfamily A member 1 [KO:K04257]
347168  
OR1J1; olfactory receptor family 1 subfamily J member 1 [KO:K04257]
347169  
OR1B1; olfactory receptor family 1 subfamily B member 1 (gene/pseudogene) [KO:K04257]
347468  
OR13H1; olfactory receptor family 13 subfamily H member 1 [KO:K04257]
387748  
OR56B1; olfactory receptor family 56 subfamily B member 1 [KO:K04257]
390036  
OR52K1; olfactory receptor family 52 subfamily K member 1 [KO:K04257]
390037  
OR52I1; olfactory receptor family 52 subfamily I member 1 [KO:K04257]
390038  
OR51D1; olfactory receptor family 51 subfamily D member 1 [KO:K04257]
390054  
OR52A5; olfactory receptor family 52 subfamily A member 5 [KO:K04257]
390058  
OR51B6; olfactory receptor family 51 subfamily B member 6 [KO:K04257]
120776  
OR2D2; olfactory receptor family 2 subfamily D member 2 [KO:K04257]
120787  
OR52W1; olfactory receptor family 52 subfamily W member 1 [KO:K04257]
120793  
OR56A4; olfactory receptor family 56 subfamily A member 4 [KO:K04257]
120796  
OR56A1; olfactory receptor family 56 subfamily A member 1 [KO:K04257]
121130  
OR10P1; olfactory receptor family 10 subfamily P member 1 [KO:K04257]
121275  
OR10AD1; olfactory receptor family 10 subfamily AD member 1 [KO:K04257]
121364  
OR10A7; olfactory receptor family 10 subfamily A member 7 [KO:K04257]
122740  
OR4K14; olfactory receptor family 4 subfamily K member 14 [KO:K04257]
122742  
OR4L1; olfactory receptor family 4 subfamily L member 1 [KO:K04257]
122748  
OR11H6; olfactory receptor family 11 subfamily H member 6 [KO:K04257]
124538  
OR4D2; olfactory receptor family 4 subfamily D member 2 [KO:K04257]
125958  
OR7D4; olfactory receptor family 7 subfamily D member 4 [KO:K04257]
125962  
OR7G1; olfactory receptor family 7 subfamily G member 1 [KO:K04257]
125963  
OR1M1; olfactory receptor family 1 subfamily M member 1 [KO:K04257]
126370  
OR1I1; olfactory receptor family 1 subfamily I member 1 [KO:K04257]
126541  
OR10H4; olfactory receptor family 10 subfamily H member 4 [KO:K04257]
127059  
OR2M5; olfactory receptor family 2 subfamily M member 5 [KO:K04257]
127062  
OR2M3; olfactory receptor family 2 subfamily M member 3 [KO:K04257]
127064  
OR2T12; olfactory receptor family 2 subfamily T member 12 [KO:K04257]
127066  
OR14C36; olfactory receptor family 14 subfamily C member 36 [KO:K04257]
127068  
OR2T34; olfactory receptor family 2 subfamily T member 34 [KO:K04257]
127069  
OR2T10; olfactory receptor family 2 subfamily T member 10 [KO:K04257]
127074  
OR2T4; olfactory receptor family 2 subfamily T member 4 [KO:K04257]
127077  
OR2T11; olfactory receptor family 2 subfamily T member 11 (gene/pseudogene) [KO:K04257]
127385  
OR10J5; olfactory receptor family 10 subfamily J member 5 [KO:K04257]
127623  
OR2B11; olfactory receptor family 2 subfamily B member 11 [KO:K04257]
128360  
OR10T2; olfactory receptor family 10 subfamily T member 2 [KO:K04257]
128367  
OR10X1; olfactory receptor family 10 subfamily X member 1 (gene/pseudogene) [KO:K04257]
128368  
OR10Z1; olfactory receptor family 10 subfamily Z member 1 [KO:K04257]
128371  
OR6K6; olfactory receptor family 6 subfamily K member 6 [KO:K04257]
128372  
OR6N1; olfactory receptor family 6 subfamily N member 1 [KO:K04257]
130075  
OR9A4; olfactory receptor family 9 subfamily A member 4 [KO:K04257]
134083  
OR2Y1; olfactory receptor family 2 subfamily Y member 1 [KO:K04257]
135924  
OR9A2; olfactory receptor family 9 subfamily A member 2 [KO:K04257]
135941  
OR2A14; olfactory receptor family 2 subfamily A member 14 [KO:K04257]
135946  
OR6B1; olfactory receptor family 6 subfamily B member 1 [KO:K04257]
135948  
OR2F2; olfactory receptor family 2 subfamily F member 2 [KO:K04257]
138799  
OR13C5; olfactory receptor family 13 subfamily C member 5 [KO:K04257]
138802  
OR13C8; olfactory receptor family 13 subfamily C member 8 [KO:K04257]
138803  
OR13C3; olfactory receptor family 13 subfamily C member 3 [KO:K04257]
138804  
OR13C4; olfactory receptor family 13 subfamily C member 4 [KO:K04257]
138805  
OR13F1; olfactory receptor family 13 subfamily F member 1 [KO:K04257]
138881  
OR1L8; olfactory receptor family 1 subfamily L member 8 [KO:K04257]
138882  
OR1N2; olfactory receptor family 1 subfamily N member 2 [KO:K04257]
138883  
OR1N1; olfactory receptor family 1 subfamily N member 1 [KO:K04257]
143496  
OR52B4; olfactory receptor family 52 subfamily B member 4 (gene/pseudogene) [KO:K04257]
143502  
OR52I2; olfactory receptor family 52 subfamily I member 2 [KO:K04257]
144124  
OR10A5; olfactory receptor family 10 subfamily A member 5 [KO:K04257]
390059  
OR51M1; olfactory receptor family 51 subfamily M member 1 [KO:K04257]
390061  
OR51Q1; olfactory receptor family 51 subfamily Q member 1 (gene/pseudogene) [KO:K04257]
390063  
OR51I1; olfactory receptor family 51 subfamily I member 1 [KO:K04257]
390064  
OR51I2; olfactory receptor family 51 subfamily I member 2 [KO:K04257]
390066  
OR52D1; olfactory receptor family 52 subfamily D member 1 [KO:K04257]
390067  
OR52H1; olfactory receptor family 52 subfamily H member 1 [KO:K04257]
390072  
OR52N4; olfactory receptor family 52 subfamily N member 4 (gene/pseudogene) [KO:K04257]
390075  
OR52N5; olfactory receptor family 52 subfamily N member 5 [KO:K04257]
390077  
OR52N2; olfactory receptor family 52 subfamily N member 2 [KO:K04257]
390181  
OR5AK2; olfactory receptor family 5 subfamily AK member 2 [KO:K04257]
390191  
OR5B12; olfactory receptor family 5 subfamily B member 12 [KO:K04257]
390195  
OR5AN1; olfactory receptor family 5 subfamily AN member 1 [KO:K04257]
390197  
OR4D10; olfactory receptor family 4 subfamily D member 10 [KO:K04257]
390199  
OR4D9; olfactory receptor family 4 subfamily D member 9 [KO:K04257]
390201  
OR10V1; olfactory receptor family 10 subfamily V member 1 [KO:K04257]
390260  
OR6X1; olfactory receptor family 6 subfamily X member 1 [KO:K04257]
390261  
OR6M1; olfactory receptor family 6 subfamily M member 1 [KO:K04257]
390264  
OR10G4; olfactory receptor family 10 subfamily G member 4 [KO:K04257]
390265  
OR10G7; olfactory receptor family 10 subfamily G member 7 [KO:K04257]
390275  
OR8A1; olfactory receptor family 8 subfamily A member 1 [KO:K04257]
390321  
OR6C1; olfactory receptor family 6 subfamily C member 1 [KO:K04257]
390323  
OR6C75; olfactory receptor family 6 subfamily C member 75 [KO:K04257]
390326  
OR6C76; olfactory receptor family 6 subfamily C member 76 [KO:K04257]
390327  
OR6C70; olfactory receptor family 6 subfamily C member 70 [KO:K04257]
390429  
OR4N2; olfactory receptor family 4 subfamily N member 2 [KO:K04257]
390431  
OR4K2; olfactory receptor family 4 subfamily K member 2 [KO:K04257]
390433  
OR4K13; olfactory receptor family 4 subfamily K member 13 [KO:K04257]
390436  
OR4K17; olfactory receptor family 4 subfamily K member 17 [KO:K04257]
390437  
OR4N5; olfactory receptor family 4 subfamily N member 5 [KO:K04257]
390439  
OR11G2; olfactory receptor family 11 subfamily G member 2 [KO:K04257]
390442  
OR11H4; olfactory receptor family 11 subfamily H member 4 [KO:K04257]
390445  
OR5AU1; olfactory receptor family 5 subfamily AU member 1 [KO:K04257]
390538  
OR4M2; olfactory receptor family 4 subfamily M member 2 [KO:K04257]
390648  
OR4F6; olfactory receptor family 4 subfamily F member 6 [KO:K04257]
390649  
OR4F15; olfactory receptor family 4 subfamily F member 15 [KO:K04257]
390882  
OR7G2; olfactory receptor family 7 subfamily G member 2 [KO:K04257]
390883  
OR7G3; olfactory receptor family 7 subfamily G member 3 [KO:K04257]
390892  
OR7A10; olfactory receptor family 7 subfamily A member 10 [KO:K04257]
391107  
OR10K2; olfactory receptor family 10 subfamily K member 2 [KO:K04257]
391109  
OR10K1; olfactory receptor family 10 subfamily K member 1 [KO:K04257]
391112  
OR6Y1; olfactory receptor family 6 subfamily Y member 1 [KO:K04257]
391114  
OR6K3; olfactory receptor family 6 subfamily K member 3 [KO:K04257]
391189  
OR11L1; olfactory receptor family 11 subfamily L member 1 [KO:K04257]
391190  
OR2L8; olfactory receptor family 2 subfamily L member 8 (gene/pseudogene) [KO:K04257]
391191  
OR2AK2; olfactory receptor family 2 subfamily AK member 2 [KO:K04257]
391192  
OR2L3; olfactory receptor family 2 subfamily L member 3 [KO:K04257]
391194  
OR2M2; olfactory receptor family 2 subfamily M member 2 [KO:K04257]
391195  
OR2T33; olfactory receptor family 2 subfamily T member 33 [KO:K04257]
391196  
OR2M7; olfactory receptor family 2 subfamily M member 7 [KO:K04257]
391211  
OR2G6; olfactory receptor family 2 subfamily G member 6 [KO:K04257]
392138  
OR2A25; olfactory receptor family 2 subfamily A member 25 [KO:K04257]
392309  
OR13J1; olfactory receptor family 13 subfamily J member 1 [KO:K04257]
392376  
OR13C2; olfactory receptor family 13 subfamily C member 2 [KO:K04257]
392390  
OR1L6; olfactory receptor family 1 subfamily L member 6 [KO:K04257]
392391  
OR5C1; olfactory receptor family 5 subfamily C member 1 [KO:K04257]
392392  
OR1K1; olfactory receptor family 1 subfamily K member 1 [KO:K04257]
393046  
OR2A5; olfactory receptor family 2 subfamily A member 5 [KO:K04257]
401427  
OR2A7; olfactory receptor family 2 subfamily A member 7 [KO:K04257]
401665  
OR51T1; olfactory receptor family 51 subfamily T member 1 [KO:K04257]
401666  
OR51A4; olfactory receptor family 51 subfamily A member 4 [KO:K04257]
401667  
OR51A2; olfactory receptor family 51 subfamily A member 2 [KO:K04257]
401992  
OR2T2; olfactory receptor family 2 subfamily T member 2 [KO:K04257]
401993  
OR2T5; olfactory receptor family 2 subfamily T member 5 [KO:K04257]
401994  
OR14I1; olfactory receptor family 14 subfamily I member 1 [KO:K04257]
402135  
OR5K2; olfactory receptor family 5 subfamily K member 2 [KO:K04257]
402317  
OR2A42; olfactory receptor family 2 subfamily A member 42 [KO:K04257]
4992  
OR1F1; olfactory receptor family 1 subfamily F member 1 [KO:K04257]
56656  
OR2S2; olfactory receptor family 2 subfamily S member 2 (gene/pseudogene) [KO:K04257]
79290  
OR13A1; olfactory receptor family 13 subfamily A member 1 [KO:K04257]
7932  
OR2H2; olfactory receptor family 2 subfamily H member 2 [KO:K04257]
81472  
OR2C3; olfactory receptor family 2 subfamily C member 3 [KO:K04257]
81697  
OR2B2; olfactory receptor family 2 subfamily B member 2 [KO:K04257]
119765  
OR4B1; olfactory receptor family 4 subfamily B member 1 [KO:K04257]
219487  
OR5M11; olfactory receptor family 5 subfamily M member 11 [KO:K04257]
254879  
OR2T6; olfactory receptor family 2 subfamily T member 6 [KO:K04257]
143503  
OR51E1; olfactory receptor family 51 subfamily E member 1 [KO:K04257]
26494  
OR8G1; olfactory receptor family 8 subfamily G member 1 (gene/pseudogene) [KO:K04257]
26533  
OR10G3; olfactory receptor family 10 subfamily G member 3 [KO:K04257]
26534  
OR10G2; olfactory receptor family 10 subfamily G member 2 [KO:K04257]
26682  
OR4F4; olfactory receptor family 4 subfamily F member 4 [KO:K04257]
26683  
OR4F3; olfactory receptor family 4 subfamily F member 3 [KO:K04257]
26686  
OR4E2; olfactory receptor family 4 subfamily E member 2 [KO:K04257]
26735  
OR1L3; olfactory receptor family 1 subfamily L member 3 [KO:K04257]
26737  
OR1L1; olfactory receptor family 1 subfamily L member 1 [KO:K04257]
26740  
OR1J2; olfactory receptor family 1 subfamily J member 2 [KO:K04257]
282763  
OR51B5; olfactory receptor family 51 subfamily B member 5 [KO:K04257]
282770  
OR10AG1; olfactory receptor family 10 subfamily AG member 1 [KO:K04257]
282775  
OR5J2; olfactory receptor family 5 subfamily J member 2 [KO:K04257]
441911  
OR10J3; olfactory receptor family 10 subfamily J member 3 [KO:K04257]
389090  
OR6B2; olfactory receptor family 6 subfamily B member 2 [KO:K04257]
79295  
OR5H6; olfactory receptor family 5 subfamily H member 6 (gene/pseudogene) [KO:K04257]
79310  
OR5H2; olfactory receptor family 5 subfamily H member 2 [KO:K04257]
79317  
OR4K5; olfactory receptor family 4 subfamily K member 5 [KO:K04257]
79324  
OR51G1; olfactory receptor family 51 subfamily G member 1 (gene/pseudogene) [KO:K04257]
79473  
OR52N1; olfactory receptor family 52 subfamily N member 1 [KO:K04257]
79501  
OR4F5; olfactory receptor family 4 subfamily F member 5 [KO:K04257]
79544  
OR4K1; olfactory receptor family 4 subfamily K member 1 [KO:K04257]
81050  
OR5AC2; olfactory receptor family 5 subfamily AC member 2 [KO:K04257]
81061  
OR11H1; olfactory receptor family 11 subfamily H member 1 [KO:K04257]
81099  
OR4F17; olfactory receptor family 4 subfamily F member 17 [KO:K04257]
81127  
OR4K15; olfactory receptor family 4 subfamily K member 15 [KO:K04257]
81168  
OR8J3; olfactory receptor family 8 subfamily J member 3 [KO:K04257]
81282  
OR51G2; olfactory receptor family 51 subfamily G member 2 [KO:K04257]
81300  
OR4P4; olfactory receptor family 4 subfamily P member 4 [KO:K04257]
81309  
OR4C15; olfactory receptor family 4 subfamily C member 15 [KO:K04257]
81318  
OR4A5; olfactory receptor family 4 subfamily A member 5 [KO:K04257]
81327  
OR4A16; olfactory receptor family 4 subfamily A member 16 [KO:K04257]
81328  
OR4A15; olfactory receptor family 4 subfamily A member 15 [KO:K04257]
81392  
OR2AE1; olfactory receptor family 2 subfamily AE member 1 [KO:K04257]
81399  
OR4F16; olfactory receptor family 4 subfamily F member 16 [KO:K04257]
81442  
OR6N2; olfactory receptor family 6 subfamily N member 2 [KO:K04257]
81448  
OR6K2; olfactory receptor family 6 subfamily K member 2 [KO:K04257]
81469  
OR2G3; olfactory receptor family 2 subfamily G member 3 [KO:K04257]
81470  
OR2G2; olfactory receptor family 2 subfamily G member 2 [KO:K04257]
343171  
OR2W3; olfactory receptor family 2 subfamily W member 3 [KO:K04257]
343172  
OR2T8; olfactory receptor family 2 subfamily T member 8 [KO:K04257]
504189  
OR8U8; olfactory receptor family 8 subfamily U member 8 [KO:K04257]
442184  
OR2B3; olfactory receptor family 2 subfamily B member 3 [KO:K04257]
403282  
OR6C65; olfactory receptor family 6 subfamily C member 65 [KO:K04257]
403284  
OR6C68; olfactory receptor family 6 subfamily C member 68 [KO:K04257]
26648  
OR7E24; olfactory receptor family 7 subfamily E member 24 [KO:K04257]
403257  
OR4C45; olfactory receptor family 4 subfamily C member 45 [KO:K04257]
403253  
OR4A47; olfactory receptor family 4 subfamily A member 47 [KO:K04257]
403239  
OR2T27; olfactory receptor family 2 subfamily T member 27 [KO:K04257]
441308  
OR4F21; olfactory receptor family 4 subfamily F member 21 [KO:K04257]
390148  
OR5W2; olfactory receptor family 5 subfamily W member 2 [KO:K04257]
128366  
OR6P1; olfactory receptor family 6 subfamily P member 1 [KO:K04257]
504190  
OR8U9; olfactory receptor family 8 subfamily U member 9 [KO:K04257]
504191  
OR9G9; olfactory receptor family 9 subfamily G member 9 [KO:K04257]
26341  
OR5H1; olfactory receptor family 5 subfamily H member 1 [KO:K04257]
390271  
OR8B3; olfactory receptor family 8 subfamily B member 3 [KO:K04257]
26595  
OR8B2; olfactory receptor family 8 subfamily B member 2 [KO:K04257]
390190  
OR5B2; olfactory receptor family 5 subfamily B member 2 [KO:K04257]
440153  
OR11H12; olfactory receptor family 11 subfamily H member 12 [KO:K04257]
403277  
OR5K3; olfactory receptor family 5 subfamily K member 3 [KO:K04257]
403278  
OR5K4; olfactory receptor family 5 subfamily K member 4 [KO:K04257]
81341  
OR10W1; olfactory receptor family 10 subfamily W member 1 [KO:K04257]
729759  
OR4F29; olfactory receptor family 4 subfamily F member 29 [KO:K04257]
121129  
OR2AP1; olfactory receptor family 2 subfamily AP member 1 [KO:K04257]
26693  
OR2V1; olfactory receptor family 2 subfamily V member 1 [KO:K04257]
81466  
OR2L5; olfactory receptor family 2 subfamily L member 5 [KO:K04257]
olfactory receptor 4N4; K04257 olfactory receptor [KO:K04257]
403273  
OR5H14; olfactory receptor family 5 subfamily H member 14 [KO:K04257]
olfactory receptor 4N4; K04257 olfactory receptor [KO:K04257]
26687  
OR4E1; olfactory receptor family 4 subfamily E member 1 (gene/pseudogene) [KO:K04257]
403274  
OR5H15; olfactory receptor family 5 subfamily H member 15 [KO:K04257]
2774  
GNAL; G protein subunit alpha L [KO:K04633]
2782  
GNB1; G protein subunit beta 1 [KO:K04536]
2788  
GNG7; G protein subunit gamma 7 [KO:K04543]
51764  
GNG13; G protein subunit gamma 13 [KO:K04547]
109  
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
1260  
CNGA2; cyclic nucleotide gated channel alpha 2 [KO:K04949]
1262  
CNGA4; cyclic nucleotide gated channel alpha 4 [KO:K04951]
1258  
CNGB1; cyclic nucleotide gated channel beta 1 [KO:K04952]
57101  
ANO2; anoctamin 2 [KO:K19497]
3000  
GUCY2D; guanylate cyclase 2D, retinal [KO:K12321] [EC:4.6.1.2]
1261  
CNGA3; cyclic nucleotide gated channel alpha 3 [KO:K04950]
83988  
NCALD; neurocalcin delta [KO:K19695]
5592  
PRKG1; protein kinase, cGMP-dependent, type I [KO:K07376] [EC:2.7.11.12]
5593  
PRKG2; protein kinase, cGMP-dependent, type II [KO:K19477] [EC:2.7.11.12]
6546  
SLC8A1; solute carrier family 8 member A1 [KO:K05849]
6543  
SLC8A2; solute carrier family 8 member A2 [KO:K05849]
6547  
SLC8A3; solute carrier family 8 member A3 [KO:K05849]
123041  
SLC24A4; solute carrier family 24 member 4 [KO:K13752]
156  
GRK2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
157  
GRK3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
408  
ARRB1; arrestin beta 1 [KO:K04439]
409  
ARRB2; arrestin beta 2 [KO:K04439]
5997  
RGS2; regulator of G-protein signaling 2 [KO:K18154]
5566  
PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
815  
CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
817  
CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
816  
CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
818  
CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
810  
CALML3; calmodulin like 3 [KO:K02183]
805  
CALM2; calmodulin 2 [KO:K02183]
808  
CALM3; calmodulin 3 [KO:K02183]
801  
CALM1; calmodulin 1 [KO:K02183]
163688  
CALML6; calmodulin like 6 [KO:K02183]
51806  
CALML5; calmodulin like 5 [KO:K02183]
91860  
CALML4; calmodulin like 4 [KO:K02183]
5136  
PDE1A; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
5153  
PDE1B; phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
5137  
PDE1C; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
5138  
PDE2A; phosphodiesterase 2A [KO:K18283] [EC:3.1.4.17]
Compound
C00020  
AMP
C00076  
Calcium cation
C00144  
GMP
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C00698  
Cl-
C00942  
3',5'-Cyclic GMP
C01330  
Sodium cation
Reference
  Authors
Kaupp UB
  Title
Olfactory signalling in vertebrates and insects: differences and commonalities.
  Journal
Nat Rev Neurosci 11:188-200 (2010)
Reference
  Authors
Peterlin Z, Firestein S, Rogers ME
  Title
The state of the art of odorant receptor deorphanization: a report from the orphanage.
  Journal
J Gen Physiol 143:527-42 (2014)
Reference
  Authors
Kato A, Touhara K
  Title
Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization.
  Journal
Cell Mol Life Sci 66:3743-53 (2009)
Reference
  Authors
Firestein S.
  Title
How the olfactory system makes sense of scents.
  Journal
Nature 413:211-8 (2001)
Reference
  Authors
Ache BW, Young JM.
  Title
Olfaction: diverse species, conserved principles.
  Journal
Neuron 48:417-30 (2005)
Reference
  Authors
Zufall F, Leinders-Zufall T.
  Title
The cellular and molecular basis of odor adaptation.
  Journal
Chem Senses 25:473-81 (2000)
Reference
  Authors
Lodovichi C, Belluscio L
  Title
Odorant receptors in the formation of the olfactory bulb circuitry.
  Journal
Physiology (Bethesda) 27:200-12 (2012)
Reference
  Authors
Kohout TA, Lefkowitz RJ.
  Title
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
  Journal
Mol Pharmacol 63:9-18 (2003)
Reference
  Authors
De Palo G, Boccaccio A, Miri A, Menini A, Altafini C
  Title
A dynamical feedback model for adaptation in the olfactory transduction pathway.
  Journal
Biophys J 102:2677-86 (2012)
Reference
  Authors
Zufall F, Munger SD
  Title
Receptor guanylyl cyclases in mammalian olfactory function.
  Journal
Mol Cell Biochem 334:191-7 (2010)
Reference
  Authors
Duda T, Sharma RK
  Title
Ca2+-modulated ONE-GC odorant signal transduction.
  Journal
FEBS Lett 583:1327-30 (2009)
KO pathway
 

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