KEGG PATHWAY: hsa04740

PATHWAY: hsa04740

Entry

hsa04740 Pathway

Name

Olfactory transduction - Homo sapiens (human)

Description

Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase.

Class

Organismal Systems; Sensory system

Pathway map

hsa04740

Olfactory transduction

Other DBs

BSID:

83087

GO:

0007608

Organism

Homo sapiens (human) [GN:hsa]

Gene

442186	OR2J3; olfactory receptor, family 2, subfamily J, member 3 [KO:K04257]
442191	OR14J1; olfactory receptor, family 14, subfamily J, member 1 [KO:K04257]
442194	OR10C1; olfactory receptor, family 10, subfamily C, member 1 [KO:K04257]
442361	OR2A2; olfactory receptor, family 2, subfamily A, member 2 [KO:K04257]
119774	OR52K2; olfactory receptor, family 52, subfamily K, member 2 [KO:K04257]
120065	OR5P2; olfactory receptor, family 5, subfamily P, member 2 [KO:K04257]
120066	OR5P3; olfactory receptor, family 5, subfamily P, member 3 [KO:K04257]
120586	OR8I2; olfactory receptor, family 8, subfamily I, member 2 [KO:K04257]
120775	OR2D3; olfactory receptor, family 2, subfamily D, member 3 [KO:K04257]
119678	OR52E2; olfactory receptor, family 52, subfamily E, member 2 [KO:K04257]
119679	OR52J3; olfactory receptor, family 52, subfamily J, member 3 [KO:K04257]
119682	OR51L1; olfactory receptor, family 51, subfamily L, member 1 [KO:K04257]
119687	OR51A7; olfactory receptor, family 51, subfamily A, member 7 [KO:K04257]
119692	OR51S1; olfactory receptor, family 51, subfamily S, member 1 [KO:K04257]
119694	OR51F2; olfactory receptor, family 51, subfamily F, member 2 [KO:K04257]
119695	OR52R1; olfactory receptor, family 52, subfamily R, member 1 [KO:K04257]
119749	OR4C46; olfactory receptor, family 4, subfamily C, member 46 [KO:K04257]
119764	OR4X2; olfactory receptor, family 4, subfamily X, member 2 [KO:K04257]
119772	OR52M1; olfactory receptor, family 52, subfamily M, member 1 [KO:K04257]
8387	OR1E1; olfactory receptor, family 1, subfamily E, member 1 [KO:K04257]
8388	OR1E2; olfactory receptor, family 1, subfamily E, member 2 [KO:K04257]
4991	OR1D2; olfactory receptor, family 1, subfamily D, member 2 [KO:K04257]
8386	OR1D5; olfactory receptor, family 1, subfamily D, member 5 [KO:K04257]
8390	OR1G1; olfactory receptor, family 1, subfamily G, member 1 [KO:K04257]
8383	OR1A1; olfactory receptor, family 1, subfamily A, member 1 [KO:K04257]
26189	OR1A2; olfactory receptor, family 1, subfamily A, member 2 [KO:K04257]
26707	OR2J2; olfactory receptor, family 2, subfamily J, member 2 [KO:K04257]
79541	OR2A4; olfactory receptor, family 2, subfamily A, member 4 [KO:K04257]
4993	OR2C1; olfactory receptor, family 2, subfamily C, member 1 [KO:K04257]
26211	OR2F1; olfactory receptor, family 2, subfamily F, member 1 [KO:K04257]
26692	OR2W1; olfactory receptor, family 2, subfamily W, member 1 [KO:K04257]
4994	OR3A1; olfactory receptor, family 3, subfamily A, member 1 [KO:K04257]
4995	OR3A2; olfactory receptor, family 3, subfamily A, member 2 [KO:K04257]
8392	OR3A3; olfactory receptor, family 3, subfamily A, member 3 [KO:K04257]
10798	OR5I1; olfactory receptor, family 5, subfamily I, member 1 [KO:K04257]
81696	OR5V1; olfactory receptor, family 5, subfamily V, member 1 [KO:K04257]
8590	OR6A2; olfactory receptor, family 6, subfamily A, member 2 [KO:K04257]
26333	OR7A17; olfactory receptor, family 7, subfamily A, member 17 [KO:K04257]
26659	OR7A5; olfactory receptor, family 7, subfamily A, member 5 [KO:K04257]
26539	OR10H1; olfactory receptor, family 10, subfamily H, member 1 [KO:K04257]
26538	OR10H2; olfactory receptor, family 10, subfamily H, member 2 [KO:K04257]
26532	OR10H3; olfactory receptor, family 10, subfamily H, member 3 [KO:K04257]
26476	OR10J1; olfactory receptor, family 10, subfamily J, member 1 [KO:K04257]
26531	OR11A1; olfactory receptor, family 11, subfamily A, member 1 [KO:K04257]
26529	OR12D2; olfactory receptor, family 12, subfamily D, member 2 [KO:K04257]
81797	OR12D3; olfactory receptor, family 12, subfamily D, member 3 [KO:K04257]
81285	OR51E2; olfactory receptor, family 51, subfamily E, member 2 [KO:K04257]
23538	OR52A1; olfactory receptor, family 52, subfamily A, member 1 [KO:K04257]
79339	OR51B4; olfactory receptor, family 51, subfamily B, member 4 [KO:K04257]
79345	OR51B2; olfactory receptor, family 51, subfamily B, member 2 [KO:K04257]
283694	OR4N4; olfactory receptor, family 4, subfamily N, member 4 [KO:K04257]
441608	OR5B3; olfactory receptor, family 5, subfamily B, member 3 [KO:K04257]
441639	OR9K2; olfactory receptor, family 9, subfamily K, member 2 [KO:K04257]
441669	OR4Q3; olfactory receptor, family 4, subfamily Q, member 3 [KO:K04257]
441670	OR4M1; olfactory receptor, family 4, subfamily M, member 1 [KO:K04257]
441933	OR13G1; olfactory receptor, family 13, subfamily G, member 1 [KO:K04257]
284521	OR2L13; olfactory receptor, family 2, subfamily L, member 13 [KO:K04257]
390078	OR52E6; olfactory receptor, family 52, subfamily E, member 6 [KO:K04257]
390079	OR52E8; olfactory receptor, family 52, subfamily E, member 8 [KO:K04257]
390081	OR52E4; olfactory receptor, family 52, subfamily E, member 4 [KO:K04257]
390083	OR56A3; olfactory receptor, family 56, subfamily A, member 3 [KO:K04257]
390084	OR56A5; olfactory receptor, family 56, subfamily A, member 5 [KO:K04257]
390093	OR10A6; olfactory receptor, family 10, subfamily A, member 6 [KO:K04257]
390113	OR4X1; olfactory receptor, family 4, subfamily X, member 1 [KO:K04257]
390142	OR5D13; olfactory receptor, family 5, subfamily D, member 13 [KO:K04257]
390144	OR5D16; olfactory receptor, family 5, subfamily D, member 16 [KO:K04257]
390151	OR8H2; olfactory receptor, family 8, subfamily H, member 2 [KO:K04257]
390152	OR8H3; olfactory receptor, family 8, subfamily H, member 3 [KO:K04257]
390154	OR5T3; olfactory receptor, family 5, subfamily T, member 3 [KO:K04257]
390155	OR5T1; olfactory receptor, family 5, subfamily T, member 1 [KO:K04257]
390157	OR8K1; olfactory receptor, family 8, subfamily K, member 1 [KO:K04257]
390162	OR5M9; olfactory receptor, family 5, subfamily M, member 9 [KO:K04257]
390167	OR5M10; olfactory receptor, family 5, subfamily M, member 10 [KO:K04257]
390168	OR5M1; olfactory receptor, family 5, subfamily M, member 1 [KO:K04257]
390174	OR9G1; olfactory receptor, family 9, subfamily G, member 1 [KO:K04257]
144125	OR2AG1; olfactory receptor, family 2, subfamily AG, member 1 [KO:K04257]
150681	OR6B3; olfactory receptor, family 6, subfamily B, member 3 [KO:K04257]
158131	OR1Q1; olfactory receptor, family 1, subfamily Q, member 1 [KO:K04257]
162998	OR7D2; olfactory receptor, family 7, subfamily D, member 2 [KO:K04257]
196335	OR56B4; olfactory receptor, family 56, subfamily B, member 4 [KO:K04257]
219417	OR8U1; olfactory receptor, family 8, subfamily U, member 1 [KO:K04257]
219428	OR4C16; olfactory receptor, family 4, subfamily C, member 16 [KO:K04257]
219429	OR4C11; olfactory receptor, family 4, subfamily C, member 11 [KO:K04257]
219431	OR4S2; olfactory receptor, family 4, subfamily S, member 2 [KO:K04257]
219432	OR4C6; olfactory receptor, family 4, subfamily C, member 6 [KO:K04257]
219436	OR5D14; olfactory receptor, family 5, subfamily D, member 14 [KO:K04257]
219437	OR5L1; olfactory receptor, family 5, subfamily L, member 1 [KO:K04257]
219438	OR5D18; olfactory receptor, family 5, subfamily D, member 18 [KO:K04257]
219447	OR5AS1; olfactory receptor, family 5, subfamily AS, member 1 [KO:K04257]
219453	OR8K5; olfactory receptor, family 8, subfamily K, member 5 [KO:K04257]
219464	OR5T2; olfactory receptor, family 5, subfamily T, member 2 [KO:K04257]
219469	OR8H1; olfactory receptor, family 8, subfamily H, member 1 [KO:K04257]
219473	OR8K3; olfactory receptor, family 8, subfamily K, member 3 [KO:K04257]
219477	OR8J1; olfactory receptor, family 8, subfamily J, member 1 [KO:K04257]
219479	OR5R1; olfactory receptor, family 5, subfamily R, member 1 [KO:K04257]
219482	OR5M3; olfactory receptor, family 5, subfamily M, member 3 [KO:K04257]
219484	OR5M8; olfactory receptor, family 5, subfamily M, member 8 [KO:K04257]
219493	OR5AR1; olfactory receptor, family 5, subfamily AR, member 1 [KO:K04257]
219858	OR8B12; olfactory receptor, family 8, subfamily B, member 12 [KO:K04257]
219865	OR8G5; olfactory receptor, family 8, subfamily G, member 5 [KO:K04257]
219869	OR10G8; olfactory receptor, family 10, subfamily G, member 8 [KO:K04257]
219870	OR10G9; olfactory receptor, family 10, subfamily G, member 9 [KO:K04257]
219873	OR10S1; olfactory receptor, family 10, subfamily S, member 1 [KO:K04257]
219874	OR6T1; olfactory receptor, family 6, subfamily T, member 1 [KO:K04257]
219875	OR4D5; olfactory receptor, family 4, subfamily D, member 5 [KO:K04257]
219952	OR6Q1; olfactory receptor, family 6, subfamily Q, member 1 [KO:K04257]
219954	OR9I1; olfactory receptor, family 9, subfamily I, member 1 [KO:K04257]
219956	OR9Q1; olfactory receptor, family 9, subfamily Q, member 1 [KO:K04257]
219957	OR9Q2; olfactory receptor, family 9, subfamily Q, member 2 [KO:K04257]
219958	OR1S2; olfactory receptor, family 1, subfamily S, member 2 [KO:K04257]
219959	OR1S1; olfactory receptor, family 1, subfamily S, member 1 [KO:K04257]
219960	OR10Q1; olfactory receptor, family 10, subfamily Q, member 1 [KO:K04257]
219965	OR5B17; olfactory receptor, family 5, subfamily B, member 17 [KO:K04257]
219968	OR5B21; olfactory receptor, family 5, subfamily B, member 21 [KO:K04257]
219981	OR5A2; olfactory receptor, family 5, subfamily A, member 2 [KO:K04257]
219982	OR5A1; olfactory receptor, family 5, subfamily A, member 1 [KO:K04257]
219983	OR4D6; olfactory receptor, family 4, subfamily D, member 6 [KO:K04257]
219986	OR4D11; olfactory receptor, family 4, subfamily D, member 11 [KO:K04257]
254783	OR6C74; olfactory receptor, family 6, subfamily C, member 74 [KO:K04257]
254786	OR6C3; olfactory receptor, family 6, subfamily C, member 3 [KO:K04257]
254973	OR1L4; olfactory receptor, family 1, subfamily L, member 4 [KO:K04257]
255725	OR52B2; olfactory receptor, family 52, subfamily B, member 2 [KO:K04257]
256144	OR4C3; olfactory receptor, family 4, subfamily C, member 3 [KO:K04257]
256148	OR4S1; olfactory receptor, family 4, subfamily S, member 1 [KO:K04257]
256892	OR51F1; olfactory receptor, family 51, subfamily F, member 1 [KO:K04257]
26188	OR1C1; olfactory receptor, family 1, subfamily C, member 1 [KO:K04257]
26212	OR2B6; olfactory receptor, family 2, subfamily B, member 6 [KO:K04257]
26219	OR1J4; olfactory receptor, family 1, subfamily J, member 4 [KO:K04257]
26245	OR2M4; olfactory receptor, family 2, subfamily M, member 4 [KO:K04257]
26246	OR2L2; olfactory receptor, family 2, subfamily L, member 2 [KO:K04257]
26248	OR2K2; olfactory receptor, family 2, subfamily K, member 2 [KO:K04257]
26338	OR5L2; olfactory receptor, family 5, subfamily L, member 2 [KO:K04257]
26339	OR5K1; olfactory receptor, family 5, subfamily K, member 1 [KO:K04257]
26492	OR8G2; olfactory receptor, family 8, subfamily G, member 2 [KO:K04257]
26493	OR8B8; olfactory receptor, family 8, subfamily B, member 8 [KO:K04257]
26496	OR10A3; olfactory receptor, family 10, subfamily A, member 3 [KO:K04257]
26658	OR7C2; olfactory receptor, family 7, subfamily C, member 2 [KO:K04257]
26664	OR7C1; olfactory receptor, family 7, subfamily C, member 1 [KO:K04257]
26689	OR4D1; olfactory receptor, family 4, subfamily D, member 1 [KO:K04257]
26696	OR2T1; olfactory receptor, family 2, subfamily T, member 1 [KO:K04257]
26716	OR2H1; olfactory receptor, family 2, subfamily H, member 1 [KO:K04257]
283092	OR4C13; olfactory receptor, family 4, subfamily C, member 13 [KO:K04257]
283093	OR4C12; olfactory receptor, family 4, subfamily C, member 12 [KO:K04257]
283111	OR51V1; olfactory receptor, family 51, subfamily V, member 1 [KO:K04257]
283159	OR8D1; olfactory receptor, family 8, subfamily D, member 1 [KO:K04257]
283160	OR8D2; olfactory receptor, family 8, subfamily D, member 2 [KO:K04257]
283162	OR8B4; olfactory receptor, family 8, subfamily B, member 4 [KO:K04257]
283189	OR9G4; olfactory receptor, family 9, subfamily G, member 4 [KO:K04257]
283297	OR10A4; olfactory receptor, family 10, subfamily A, member 4 [KO:K04257]
283365	OR6C6; olfactory receptor, family 6, subfamily C, member 6 [KO:K04257]
284383	OR2Z1; olfactory receptor, family 2, subfamily Z, member 1 [KO:K04257]
284433	OR10H5; olfactory receptor, family 10, subfamily H, member 5 [KO:K04257]
284532	OR14A16; olfactory receptor, family 14, subfamily A, member 16 [KO:K04257]
285659	OR2V2; olfactory receptor, family 2, subfamily V, member 2 [KO:K04257]
286362	OR13C9; olfactory receptor, family 13, subfamily C, member 9 [KO:K04257]
286365	OR13D1; olfactory receptor, family 13, subfamily D, member 1 [KO:K04257]
338662	OR8D4; olfactory receptor, family 8, subfamily D, member 4 [KO:K04257]
338674	OR5F1; olfactory receptor, family 5, subfamily F, member 1 [KO:K04257]
338675	OR5AP2; olfactory receptor, family 5, subfamily AP, member 2 [KO:K04257]
338751	OR52L1; olfactory receptor, family 52, subfamily L, member 1 [KO:K04257]
338755	OR2AG2; olfactory receptor, family 2, subfamily AG, member 2 [KO:K04257]
340980	OR52B6; olfactory receptor, family 52, subfamily B, member 6 [KO:K04257]
341152	OR2AT4; olfactory receptor, family 2, subfamily AT, member 4 [KO:K04257]
341276	OR10A2; olfactory receptor, family 10, subfamily A, member 2 [KO:K04257]
341416	OR6C2; olfactory receptor, family 6, subfamily C, member 2 [KO:K04257]
341418	OR6C4; olfactory receptor, family 6, subfamily C, member 4 [KO:K04257]
341568	OR8S1; olfactory receptor, family 8, subfamily S, member 1 [KO:K04257]
341799	OR6S1; olfactory receptor, family 6, subfamily S, member 1 [KO:K04257]
343169	OR6F1; olfactory receptor, family 6, subfamily F, member 1 [KO:K04257]
343173	OR2T3; olfactory receptor, family 2, subfamily T, member 3 [KO:K04257]
343406	OR10R2; olfactory receptor, family 10, subfamily R, member 2 [KO:K04257]
343563	OR2T29; olfactory receptor, family 2, subfamily T, member 29 [KO:K04257]
346517	OR6V1; olfactory receptor, family 6, subfamily V, member 1 [KO:K04257]
346525	OR2A12; olfactory receptor, family 2, subfamily A, member 12 [KO:K04257]
346528	OR2A1; olfactory receptor, family 2, subfamily A, member 1 [KO:K04257]
347168	OR1J1; olfactory receptor, family 1, subfamily J, member 1 [KO:K04257]
347169	OR1B1; olfactory receptor, family 1, subfamily B, member 1 [KO:K04257]
347468	OR13H1; olfactory receptor, family 13, subfamily H, member 1 [KO:K04257]
387748	OR56B1; olfactory receptor, family 56, subfamily B, member 1 [KO:K04257]
390036	OR52K1; olfactory receptor, family 52, subfamily K, member 1 [KO:K04257]
390037	OR52I1; olfactory receptor, family 52, subfamily I, member 1 [KO:K04257]
390038	OR51D1; olfactory receptor, family 51, subfamily D, member 1 [KO:K04257]
390054	OR52A5; olfactory receptor, family 52, subfamily A, member 5 [KO:K04257]
390058	OR51B6; olfactory receptor, family 51, subfamily B, member 6 [KO:K04257]
120776	OR2D2; olfactory receptor, family 2, subfamily D, member 2 [KO:K04257]
120787	OR52W1; olfactory receptor, family 52, subfamily W, member 1 [KO:K04257]
120793	OR56A4; olfactory receptor, family 56, subfamily A, member 4 [KO:K04257]
120796	OR56A1; olfactory receptor, family 56, subfamily A, member 1 [KO:K04257]
121130	OR10P1; olfactory receptor, family 10, subfamily P, member 1 [KO:K04257]
121275	OR10AD1; olfactory receptor, family 10, subfamily AD, member 1 [KO:K04257]
121364	OR10A7; olfactory receptor, family 10, subfamily A, member 7 [KO:K04257]
122740	OR4K14; olfactory receptor, family 4, subfamily K, member 14 [KO:K04257]
122742	OR4L1; olfactory receptor, family 4, subfamily L, member 1 [KO:K04257]
122748	OR11H6; olfactory receptor, family 11, subfamily H, member 6 [KO:K04257]
124538	OR4D2; olfactory receptor, family 4, subfamily D, member 2 [KO:K04257]
125958	OR7D4; olfactory receptor, family 7, subfamily D, member 4 [KO:K04257]
125962	OR7G1; olfactory receptor, family 7, subfamily G, member 1 [KO:K04257]
125963	OR1M1; olfactory receptor, family 1, subfamily M, member 1 [KO:K04257]
126370	OR1I1; olfactory receptor, family 1, subfamily I, member 1 [KO:K04257]
126541	OR10H4; olfactory receptor, family 10, subfamily H, member 4 [KO:K04257]
127059	OR2M5; olfactory receptor, family 2, subfamily M, member 5 [KO:K04257]
127062	OR2M3; olfactory receptor, family 2, subfamily M, member 3 [KO:K04257]
127064	OR2T12; olfactory receptor, family 2, subfamily T, member 12 [KO:K04257]
127066	OR14C36; olfactory receptor, family 14, subfamily C, member 36 [KO:K04257]
127068	OR2T34; olfactory receptor, family 2, subfamily T, member 34 [KO:K04257]
127069	OR2T10; olfactory receptor, family 2, subfamily T, member 10 [KO:K04257]
127074	OR2T4; olfactory receptor, family 2, subfamily T, member 4 [KO:K04257]
127077	OR2T11; olfactory receptor, family 2, subfamily T, member 11 [KO:K04257]
127385	OR10J5; olfactory receptor, family 10, subfamily J, member 5 [KO:K04257]
127623	OR2B11; olfactory receptor, family 2, subfamily B, member 11 [KO:K04257]
128360	OR10T2; olfactory receptor, family 10, subfamily T, member 2 [KO:K04257]
128367	OR10X1; olfactory receptor, family 10, subfamily X, member 1 [KO:K04257]
128368	OR10Z1; olfactory receptor, family 10, subfamily Z, member 1 [KO:K04257]
128371	OR6K6; olfactory receptor, family 6, subfamily K, member 6 [KO:K04257]
128372	OR6N1; olfactory receptor, family 6, subfamily N, member 1 [KO:K04257]
130075	OR9A4; olfactory receptor, family 9, subfamily A, member 4 [KO:K04257]
134083	OR2Y1; olfactory receptor, family 2, subfamily Y, member 1 [KO:K04257]
135924	OR9A2; olfactory receptor, family 9, subfamily A, member 2 [KO:K04257]
135941	OR2A14; olfactory receptor, family 2, subfamily A, member 14 [KO:K04257]
135946	OR6B1; olfactory receptor, family 6, subfamily B, member 1 [KO:K04257]
135948	OR2F2; olfactory receptor, family 2, subfamily F, member 2 [KO:K04257]
138799	OR13C5; olfactory receptor, family 13, subfamily C, member 5 [KO:K04257]
138802	OR13C8; olfactory receptor, family 13, subfamily C, member 8 [KO:K04257]
138803	OR13C3; olfactory receptor, family 13, subfamily C, member 3 [KO:K04257]
138804	OR13C4; olfactory receptor, family 13, subfamily C, member 4 [KO:K04257]
138805	OR13F1; olfactory receptor, family 13, subfamily F, member 1 [KO:K04257]
138881	OR1L8; olfactory receptor, family 1, subfamily L, member 8 [KO:K04257]
138882	OR1N2; olfactory receptor, family 1, subfamily N, member 2 [KO:K04257]
138883	OR1N1; olfactory receptor, family 1, subfamily N, member 1 [KO:K04257]
143496	OR52B4; olfactory receptor, family 52, subfamily B, member 4 [KO:K04257]
143502	OR52I2; olfactory receptor, family 52, subfamily I, member 2 [KO:K04257]
144124	OR10A5; olfactory receptor, family 10, subfamily A, member 5 [KO:K04257]
390059	OR51M1; olfactory receptor, family 51, subfamily M, member 1 [KO:K04257]
390061	OR51Q1; olfactory receptor, family 51, subfamily Q, member 1 [KO:K04257]
390063	OR51I1; olfactory receptor, family 51, subfamily I, member 1 [KO:K04257]
390064	OR51I2; olfactory receptor, family 51, subfamily I, member 2 [KO:K04257]
390066	OR52D1; olfactory receptor, family 52, subfamily D, member 1 [KO:K04257]
390067	OR52H1; olfactory receptor, family 52, subfamily H, member 1 [KO:K04257]
390072	OR52N4; olfactory receptor, family 52, subfamily N, member 4 [KO:K04257]
390075	OR52N5; olfactory receptor, family 52, subfamily N, member 5 [KO:K04257]
390077	OR52N2; olfactory receptor, family 52, subfamily N, member 2 [KO:K04257]
390181	OR5AK2; olfactory receptor, family 5, subfamily AK, member 2 [KO:K04257]
390191	OR5B12; olfactory receptor, family 5, subfamily B, member 12 [KO:K04257]
390195	OR5AN1; olfactory receptor, family 5, subfamily AN, member 1 [KO:K04257]
390197	OR4D10; olfactory receptor, family 4, subfamily D, member 10 [KO:K04257]
390199	OR4D9; olfactory receptor, family 4, subfamily D, member 9 [KO:K04257]
390201	OR10V1; olfactory receptor, family 10, subfamily V, member 1 [KO:K04257]
390260	OR6X1; olfactory receptor, family 6, subfamily X, member 1 [KO:K04257]
390261	OR6M1; olfactory receptor, family 6, subfamily M, member 1 [KO:K04257]
390264	OR10G4; olfactory receptor, family 10, subfamily G, member 4 [KO:K04257]
390265	OR10G7; olfactory receptor, family 10, subfamily G, member 7 [KO:K04257]
390275	OR8A1; olfactory receptor, family 8, subfamily A, member 1 [KO:K04257]
390321	OR6C1; olfactory receptor, family 6, subfamily C, member 1 [KO:K04257]
390323	OR6C75; olfactory receptor, family 6, subfamily C, member 75 [KO:K04257]
390326	OR6C76; olfactory receptor, family 6, subfamily C, member 76 [KO:K04257]
390327	OR6C70; olfactory receptor, family 6, subfamily C, member 70 [KO:K04257]
390429	OR4N2; olfactory receptor, family 4, subfamily N, member 2 [KO:K04257]
390431	OR4K2; olfactory receptor, family 4, subfamily K, member 2 [KO:K04257]
390433	OR4K13; olfactory receptor, family 4, subfamily K, member 13 [KO:K04257]
390436	OR4K17; olfactory receptor, family 4, subfamily K, member 17 [KO:K04257]
390437	OR4N5; olfactory receptor, family 4, subfamily N, member 5 [KO:K04257]
390439	OR11G2; olfactory receptor, family 11, subfamily G, member 2 [KO:K04257]
390442	OR11H4; olfactory receptor, family 11, subfamily H, member 4 [KO:K04257]
390445	OR5AU1; olfactory receptor, family 5, subfamily AU, member 1 [KO:K04257]
390538	OR4M2; olfactory receptor, family 4, subfamily M, member 2 [KO:K04257]
390648	OR4F6; olfactory receptor, family 4, subfamily F, member 6 [KO:K04257]
390649	OR4F15; olfactory receptor, family 4, subfamily F, member 15 [KO:K04257]
390882	OR7G2; olfactory receptor, family 7, subfamily G, member 2 [KO:K04257]
390883	OR7G3; olfactory receptor, family 7, subfamily G, member 3 [KO:K04257]
390892	OR7A10; olfactory receptor, family 7, subfamily A, member 10 [KO:K04257]
391107	OR10K2; olfactory receptor, family 10, subfamily K, member 2 [KO:K04257]
391109	OR10K1; olfactory receptor, family 10, subfamily K, member 1 [KO:K04257]
391112	OR6Y1; olfactory receptor, family 6, subfamily Y, member 1 [KO:K04257]
391114	OR6K3; olfactory receptor, family 6, subfamily K, member 3 [KO:K04257]
391189	OR11L1; olfactory receptor, family 11, subfamily L, member 1 [KO:K04257]
391190	OR2L8; olfactory receptor, family 2, subfamily L, member 8 [KO:K04257]
391191	OR2AK2; olfactory receptor, family 2, subfamily AK, member 2 [KO:K04257]
391192	OR2L3; olfactory receptor, family 2, subfamily L, member 3 [KO:K04257]
391194	OR2M2; olfactory receptor, family 2, subfamily M, member 2 [KO:K04257]
391195	OR2T33; olfactory receptor, family 2, subfamily T, member 33 [KO:K04257]
391196	OR2M7; olfactory receptor, family 2, subfamily M, member 7 [KO:K04257]
391211	OR2G6; olfactory receptor, family 2, subfamily G, member 6 [KO:K04257]
392138	OR2A25; olfactory receptor, family 2, subfamily A, member 25 [KO:K04257]
392309	OR13J1; olfactory receptor, family 13, subfamily J, member 1 [KO:K04257]
392376	OR13C2; olfactory receptor, family 13, subfamily C, member 2 [KO:K04257]
392390	OR1L6; olfactory receptor, family 1, subfamily L, member 6 [KO:K04257]
392391	OR5C1; olfactory receptor, family 5, subfamily C, member 1 [KO:K04257]
392392	OR1K1; olfactory receptor, family 1, subfamily K, member 1 [KO:K04257]
393046	OR2A5; olfactory receptor, family 2, subfamily A, member 5 [KO:K04257]
401427	OR2A7; olfactory receptor, family 2, subfamily A, member 7 [KO:K04257]
401665	OR51T1; olfactory receptor, family 51, subfamily T, member 1 [KO:K04257]
401666	OR51A4; olfactory receptor, family 51, subfamily A, member 4 [KO:K04257]
401667	OR51A2; olfactory receptor, family 51, subfamily A, member 2 [KO:K04257]
401992	OR2T2; olfactory receptor, family 2, subfamily T, member 2 [KO:K04257]
401993	OR2T5; olfactory receptor, family 2, subfamily T, member 5 [KO:K04257]
401994	OR14I1; olfactory receptor, family 14, subfamily I, member 1 [KO:K04257]
402135	OR5K2; olfactory receptor, family 5, subfamily K, member 2 [KO:K04257]
402317	OR2A42; olfactory receptor, family 2, subfamily A, member 42 [KO:K04257]
4992	OR1F1; olfactory receptor, family 1, subfamily F, member 1 [KO:K04257]
56656	OR2S2; olfactory receptor, family 2, subfamily S, member 2 [KO:K04257]
79290	OR13A1; olfactory receptor, family 13, subfamily A, member 1 [KO:K04257]
7932	OR2H2; olfactory receptor, family 2, subfamily H, member 2 [KO:K04257]
81472	OR2C3; olfactory receptor, family 2, subfamily C, member 3 [KO:K04257]
81697	OR2B2; olfactory receptor, family 2, subfamily B, member 2 [KO:K04257]
119765	OR4B1; olfactory receptor, family 4, subfamily B, member 1 [KO:K04257]
219487	OR5M11; olfactory receptor, family 5, subfamily M, member 11 [KO:K04257]
254879	OR2T6; olfactory receptor, family 2, subfamily T, member 6 [KO:K04257]
143503	OR51E1; olfactory receptor, family 51, subfamily E, member 1 [KO:K04257]
26494	OR8G1; olfactory receptor, family 8, subfamily G, member 1 [KO:K04257]
26533	OR10G3; olfactory receptor, family 10, subfamily G, member 3 [KO:K04257]
26534	OR10G2; olfactory receptor, family 10, subfamily G, member 2 [KO:K04257]
26682	OR4F4; olfactory receptor, family 4, subfamily F, member 4 [KO:K04257]
26683	OR4F3; olfactory receptor, family 4, subfamily F, member 3 [KO:K04257]
26686	OR4E2; olfactory receptor, family 4, subfamily E, member 2 [KO:K04257]
26735	OR1L3; olfactory receptor, family 1, subfamily L, member 3 [KO:K04257]
26737	OR1L1; olfactory receptor, family 1, subfamily L, member 1 [KO:K04257]
26740	OR1J2; olfactory receptor, family 1, subfamily J, member 2 [KO:K04257]
282763	OR51B5; olfactory receptor, family 51, subfamily B, member 5 [KO:K04257]
282770	OR10AG1; olfactory receptor, family 10, subfamily AG, member 1 [KO:K04257]
282775	OR5J2; olfactory receptor, family 5, subfamily J, member 2 [KO:K04257]
441911	OR10J3; olfactory receptor, family 10, subfamily J, member 3 [KO:K04257]
389090	OR6B2; olfactory receptor, family 6, subfamily B, member 2 [KO:K04257]
79295	OR5H6; olfactory receptor, family 5, subfamily H, member 6 [KO:K04257]
79310	OR5H2; olfactory receptor, family 5, subfamily H, member 2 [KO:K04257]
79317	OR4K5; olfactory receptor, family 4, subfamily K, member 5 [KO:K04257]
79324	OR51G1; olfactory receptor, family 51, subfamily G, member 1 [KO:K04257]
79473	OR52N1; olfactory receptor, family 52, subfamily N, member 1 [KO:K04257]
79501	OR4F5; olfactory receptor, family 4, subfamily F, member 5 [KO:K04257]
79544	OR4K1; olfactory receptor, family 4, subfamily K, member 1 [KO:K04257]
81050	OR5AC2; olfactory receptor, family 5, subfamily AC, member 2 [KO:K04257]
81061	OR11H1; olfactory receptor, family 11, subfamily H, member 1 [KO:K04257]
81099	OR4F17; olfactory receptor, family 4, subfamily F, member 17 [KO:K04257]
81127	OR4K15; olfactory receptor, family 4, subfamily K, member 15 [KO:K04257]
81168	OR8J3; olfactory receptor, family 8, subfamily J, member 3 [KO:K04257]
81282	OR51G2; olfactory receptor, family 51, subfamily G, member 2 [KO:K04257]
81300	OR4P4; olfactory receptor, family 4, subfamily P, member 4 [KO:K04257]
81309	OR4C15; olfactory receptor, family 4, subfamily C, member 15 [KO:K04257]
81318	OR4A5; olfactory receptor, family 4, subfamily A, member 5 [KO:K04257]
81327	OR4A16; olfactory receptor, family 4, subfamily A, member 16 [KO:K04257]
81328	OR4A15; olfactory receptor, family 4, subfamily A, member 15 [KO:K04257]
81392	OR2AE1; olfactory receptor, family 2, subfamily AE, member 1 [KO:K04257]
81399	OR4F16; olfactory receptor, family 4, subfamily F, member 16 [KO:K04257]
81442	OR6N2; olfactory receptor, family 6, subfamily N, member 2 [KO:K04257]
81448	OR6K2; olfactory receptor, family 6, subfamily K, member 2 [KO:K04257]
81469	OR2G3; olfactory receptor, family 2, subfamily G, member 3 [KO:K04257]
81470	OR2G2; olfactory receptor, family 2, subfamily G, member 2 [KO:K04257]
343171	OR2W3; olfactory receptor, family 2, subfamily W, member 3 [KO:K04257]
343172	OR2T8; olfactory receptor, family 2, subfamily T, member 8 [KO:K04257]
504189	OR8U8; olfactory receptor, family 8, subfamily U, member 8 [KO:K04257]
442184	OR2B3; olfactory receptor, family 2, subfamily B, member 3 [KO:K04257]
403282	OR6C65; olfactory receptor, family 6, subfamily C, member 65 [KO:K04257]
403284	OR6C68; olfactory receptor, family 6, subfamily C, member 68 [KO:K04257]
26648	OR7E24; olfactory receptor, family 7, subfamily E, member 24 [KO:K04257]
403257	OR4C45; olfactory receptor, family 4, subfamily C, member 45 [KO:K04257]
403253	OR4A47; olfactory receptor, family 4, subfamily A, member 47 [KO:K04257]
403239	OR2T27; olfactory receptor, family 2, subfamily T, member 27 [KO:K04257]
441308	OR4F21; olfactory receptor, family 4, subfamily F, member 21 [KO:K04257]
390148	OR5W2; olfactory receptor, family 5, subfamily W, member 2 [KO:K04257]
128366	OR6P1; olfactory receptor, family 6, subfamily P, member 1 [KO:K04257]
504190	OR8U9; olfactory receptor, family 8, subfamily U, member 9 [KO:K04257]
504191	OR9G9; olfactory receptor, family 9, subfamily G, member 9 [KO:K04257]
26341	OR5H1; olfactory receptor, family 5, subfamily H, member 1 [KO:K04257]
390271	OR8B3; olfactory receptor, family 8, subfamily B, member 3 [KO:K04257]
26595	OR8B2; olfactory receptor, family 8, subfamily B, member 2 [KO:K04257]
390190	OR5B2; olfactory receptor, family 5, subfamily B, member 2 [KO:K04257]
440153	OR11H12; olfactory receptor, family 11, subfamily H, member 12 [KO:K04257]
403277	OR5K3; olfactory receptor, family 5, subfamily K, member 3 [KO:K04257]
403278	OR5K4; olfactory receptor, family 5, subfamily K, member 4 [KO:K04257]
81341	OR10W1; olfactory receptor, family 10, subfamily W, member 1 [KO:K04257]
729759	OR4F29; olfactory receptor, family 4, subfamily F, member 29 [KO:K04257]
121129	OR2AP1; olfactory receptor, family 2, subfamily AP, member 1 [KO:K04257]
26693	OR2V1; olfactory receptor, family 2, subfamily V, member 1 [KO:K04257]
81466	OR2L5; olfactory receptor, family 2, subfamily L, member 5 [KO:K04257]
100996718	olfactory receptor 9G1-like; K04257 olfactory receptor [KO:K04257]
101060660	olfactory receptor 4F6-like; K04257 olfactory receptor [KO:K04257]
101060702	olfactory receptor 2A1/2A42-like; K04257 olfactory receptor [KO:K04257]
2774	GNAL; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type [KO:K04633]
5566	PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567	PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568	PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613	PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
5132	PDC; phosducin [KO:K08327]
5592	PRKG1; protein kinase, cGMP-dependent, type I [KO:K07376] [EC:2.7.11.12]
5593	PRKG2; protein kinase, cGMP-dependent, type II [KO:K07376] [EC:2.7.11.12]
109	ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
815	CAMK2A; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
817	CAMK2D; calcium/calmodulin-dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
816	CAMK2B; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
818	CAMK2G; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
810	CALML3; calmodulin-like 3 [KO:K02183]
805	CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808	CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801	CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688	CALML6; calmodulin-like 6 [KO:K02183]
51806	CALML5; calmodulin-like 5 [KO:K02183]
2978	GUCA1A; guanylate cyclase activator 1A (retina) [KO:K08328]
2979	GUCA1B; guanylate cyclase activator 1B (retina) [KO:K08328]
9626	GUCA1C; guanylate cyclase activator 1C [KO:K08328]
1261	CNGA3; cyclic nucleotide gated channel alpha 3 [KO:K04950]
1262	CNGA4; cyclic nucleotide gated channel alpha 4 [KO:K04951]
1258	CNGB1; cyclic nucleotide gated channel beta 1 [KO:K04952]
1179	CLCA1; chloride channel accessory 1 [KO:K05027]
9635	CLCA2; chloride channel accessory 2 [KO:K05028]
22802	CLCA4; chloride channel accessory 4 [KO:K05030]
157	ADRBK2; adrenergic, beta, receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
3000	GUCY2D; guanylate cyclase 2D, membrane (retina-specific) [KO:K12321] [EC:4.6.1.2]
409	ARRB2; arrestin, beta 2 [KO:K04439]
5137	PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa [KO:K13755] [EC:3.1.4.17]

Compound

C00076	Calcium cation
C00575	3',5'-Cyclic AMP
C00698	Cl-
C00942	3',5'-Cyclic GMP
C01330	Sodium cation

Reference

PMID:11557990

Authors

Firestein S.

Title

How the olfactory system makes sense of scents.

Journal

Nature 413:211-8 (2001)

Reference

PMID:16269360

Authors

Ache BW, Young JM.

Title

Olfaction: diverse species, conserved principles.

Journal

Neuron 48:417-30 (2005)

Reference

PMID:10908849

Authors

Nakamura T.

Title

Cellular and molecular constituents of olfactory sensation in vertebrates.

Journal

Comp Biochem Physiol A Mol Integr Physiol 126:17-32 (2000)

Reference

PMID:10944513

Authors

Zufall F, Leinders-Zufall T.

Title

The cellular and molecular basis of odor adaptation.

Journal

Chem Senses 25:473-81 (2000)

Reference

PMID:9547228

Authors

Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K, Ronnett GV.

Title

Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons.

Journal

J Neurosci 18:3195-205 (1998)

Reference

PMID:11826268

Authors

Ronnett GV, Moon C.

Title

G proteins and olfactory signal transduction.

Journal

Annu Rev Physiol 64:189-222 (2002)

Reference

PMID:12939389

Authors

Barry PH.

Title

The relative contributions of cAMP and InsP3 pathways to olfactory responses in vertebrate olfactory receptor neurons and the specificity of odorants for both pathways.

Journal

J Gen Physiol 122:247-50 (2003)

Reference

PMID:12488531

Authors

Kohout TA, Lefkowitz RJ.

Title

Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.

Journal

Mol Pharmacol 63:9-18 (2003)

Reference

PMID:9020189

Authors

Boekhoff I, Touhara K, Danner S, Inglese J, Lohse MJ, Breer H, Lefkowitz RJ.

Title

Phosducin, potential role in modulation of olfactory signaling.

Journal

J Biol Chem 272:4606-12 (1997)

KO pathway

ko04740

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Ontology (2)   
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Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (408)   
   KEGG GENES (408)   
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