KEGG PATHWAY: hsa04970

PATHWAY: hsa04970

Entry

hsa04970 Pathway

Name

Salivary secretion - Homo sapiens (human)

Description

Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP.

Class

Organismal Systems; Digestive system

Pathway map

hsa04970

Salivary secretion

Disease

H00845

Familial amyloidosis

Drug

D00076	Noradrenaline (JP16)
D00095	Adrenaline (JP16)
D00113	Atropine (USP)
D00124	Ephedrine (USP)
D00138	Scopolamine (INN)
D00147	Hyoscyamine (USP)
D00232	Methyloctatropine bromide (JAN)
D00235	Atenolol (JP16/USP/INN)
D00255	Carvedilol (JAN/USAN/INN)
D00283	Clozapine (JAN/USP/INN)
D00378	Timolol (USAN)
D00397	Tropicamide (JP16/USP/INN)
D00426	Risperidone (JP16/USAN/INN)
D00432	Nadolol (JP16/USP/INN)
D00454	Olanzapine (JAN/USAN/INN)
D00458	Quetiapine fumarate (JP16/USAN)
D00465	Oxybutynin (USAN/INN)
D00481	Propantheline bromide (JP16/USP/INN)
D00483	Propranolol hydrochloride (JP16/USP)
D00485	Pseudoephedrine hydrochloride (USP)
D00507	Phenoxybenzamine hydrochloride (USP)
D00509	Phentolamine mesilate (JAN/INN)
D00511	Phenylephrine hydrochloride (JP16/USP)
D00513	Pindolol (JP16/USP/INN)
D00524	Carbachol (JAN/USP/INN)
D00525	Pilocarpine (JAN/USP)
D00540	Glycopyrronium bromide (JAN/INN)
D00560	Pimozide (JP16/USP/INN)
D00597	Acebutolol hydrochloride (JP16/USP)
D00598	Betaxolol hydrochloride (JP16/USP)
D00599	Carteolol hydrochloride (JP16/USP)
D00600	Labetalol hydrochloride (JP16/USP)
D00601	Metoprolol tartrate (JP16/USP)
D00602	Penbutolol sulfate (JP16/USP)
D00603	Timolol maleate (JP16/USP)
D00607	Guanadrel sulfate (USP)
D00608	Doxazosin mesilate (JP16)
D00609	Prazosin hydrochloride (JP16/USP)
D00610	Terazosin hydrochloride hydrate (JAN)
D00632	Dobutamine hydrochloride (JP16/USP)
D00634	Bisoprolol fumarate (JP16/USP)
D00635	Metoprolol succinate (USP)
D00644	Esmolol hydrochloride (JAN/USAN)
D00646	Tolterodine (USAN/INN)
D00661	Cevimeline hydrochloride hydrate (JAN)
D00679	Ergotamine tartrate (JP16/USP)
D00680	Methylergometrine maleate (JP16)
D00683	Salbutamol sulfate (JP16)
D00684	Bitolterol mesilate (JAN)
D00685	Orciprenaline sulfate (JP16)
D00686	Pirbuterol acetate (USAN)
D00687	Salmeterol xinafoate (JAN/USAN)
D00688	Terbutaline sulfate (JP16/USP)
D00715	Hyoscine methobromide (INN)
D00719	Hyoscyamine sulfate (USP)
D00720	Mepenzolate bromide (JP16/INN)
D00721	Methanthelinium bromide (INN)
D00722	Oxybutynin hydrochloride (JAN)
D00723	Tridihexethyl chloride (BAN)
D00743	Naphazoline hydrochloride (JP16/USP)
D00756	Tetrahydrozoline nitrate (JAN)
D00774	Orphenadrine citrate (USP)
D00778	Benztropine mesilate (JAN)
D00779	Biperiden (JAN/USP/INN)
D00782	Procyclidine hydrochloride (USP)
D00787	Trihexyphenidyl hydrochloride (JP16/USP)
D00789	Chlorpromazine hydrochloride (JP16/USP)
D00996	Epinephrine hydrochloride (JAN)
D00997	Tolazoline hydrochloride (JAN/USP)
D00999	Acetylcholine chloride (JP16/USP/INN)
D01000	Bethanechol chloride (JP16/USP)
D01002	Cyclopentolate hydrochloride (JP16/USP)
D01003	Hexocyclium metilsulfate (INN)
D01004	Homatropine hydrobromide (JP16/USP)
D01005	Isopropamide iodide (JAN/USP/INN)
D01006	Oxyphencyclimine hydrochloride (JAN)
D01007	Propiverine hydrochloride (JP16)
D01017	Dipivefrin hydrochloride (JAN/USP)
D01019	Metaraminol bitartrate (JAN/USP)
D01020	Methoxamine hydrochloride (JAN)
D01021	Naphazoline nitrate (JP16)
D01022	Oxymetazoline hydrochloride (JAN/USP)
D01023	Tetrahydrozoline hydrochloride (JAN/USP)
D01024	Tamsulosin hydrochloride (JP16/USAN)
D01025	Levobunolol hydrochloride (JAN/USP)
D01077	Atropine methonitrate (JAN/INN)
D01103	Trospium chloride (JAN/USAN/INN)
D01118	Profenamine hydrochloride (JAN)
D01148	Tolterodine tartrate (JAN/USAN)
D01165	Piperidolate hydrochloride (JAN)
D01175	Carpronium chloride (JAN/INN)
D01182	Alprenolol hydrochloride (JP16/USAN)
D01201	Tiemonium iodide (JAN/INN)
D01231	Piroheptine hydrochloride (JAN)
D01263	Ritodrine hydrochloride (JP16/USP)
D01269	Solifenacin succinate (JAN/USAN/INN)
D01307	Midodrine hydrochloride (JAN/USAN)
D01315	Methylbenactyzium bromide (JP16/INN)
D01323	Azosemide (JAN/USAN/INN)
D01333	Urapidil (JP16/INN)
D01347	Tramazoline hydrochloride (JAN/USAN)
D01349	Pirbuterol hydrochloride (JAN/USAN)
D01359	Etomidoline (JAN/INN)
D01360	Clenbuterol hydrochloride (JAN/USP)
D01362	Tulobuterol hydrochloride (JP16)
D01369	Bevantolol hydrochloride (JAN/USAN)
D01373	Formoterol fumarate (USAN)
D01377	Prifinium bromide (JAN/INN)
D01386	Ephedrine hydrochloride (JP16/USP)
D01390	dl-Isoprenaline hydrochloride (JAN)
D01405	Norfenefrine hydrochloride (JAN)
D01428	Fenoterol hydrobromide (JAN)
D01444	Bunitrolol hydrochloride (JAN)
D01451	Scopolamine butylbromide (JP16)
D01454	Bupranolol hydrochloride (JP16)
D01463	Diponium bromide (JAN/INN)
D01469	Amosulalol hydrochloride (JP16)
D01471	Esatenolol (JAN/INN)
D01491	Butropium bromide (JP16/INN)
D01500	Trimebutine maleate (JP16)
D01504	Bufetolol hydrochloride (JP16)
D01512	Befunolol hydrochloride (JAN)
D01520	Levomepromazine hydrochloride (JAN/USAN)
D01521	Pipethanate hydrochloride (JAN)
D01538	Valethamate bromide (JAN)
D01543	Nylidrin hydrochloride (JAN)
D01571	Moxisylyte hydrochloride (JAN)
D01573	Etilefrine hydrochloride (JP16)
D01589	Mabuterol hydrochloride (JAN)
D01600	Diphenylpiperidinomethyldioxolan iodide (JAN)
D01634	Piretanide (JAN/USAN/INN)
D01635	Methoxyphenamine hydrochloride (JAN)
D01648	Hyoscyamine methylbromide (JAN)
D01674	Naftopidil (JAN/INN)
D01691	Nipradilol (JAN/INN)
D01692	Alfuzosin hydrochloride (JAN/USAN)
D01699	Darifenacin hydrobromide (JAN/USAN)
D01741	Celiprolol hydrochloride (JAN/USAN)
D01748	Isoxsuprine hydrochloride (JP16/USP)
D01794	Bopindolol malonate (JAN)
D01806	Oxprenolol hydrochloride (JP16/USP)
D01815	Oxapium iodide (JP16/INN)
D01830	Arotinolol hydrochloride (JP16)
D01835	Clorprenaline hydrochloride (JAN/USAN)
D01847	Landiolol hydrochloride (JAN)
D01871	Metixene hydrochloride (JAN)
D01875	Tiquizium bromide (JAN/INN)
D01887	Bunazosin hydrochloride (JP16)
D01929	Tiotropium bromide hydrate (JAN)
D01946	Oxitropium bromide (JAN/INN)
D01952	L-Methylephedrine hydrochloride (JAN)
D01955	Aclatonium napadisilate (JAN)
D01965	Silodosin (JAN/INN)
D01976	N-Methylscopolamine methylsulfate (JAN)
D01978	Trimetoquinol hydrochloride
D01987	Pipethanate ethobromide (JAN)
D02034	Setiptiline maleate (JAN)
D02066	Isoprenaline sulfate (JAN)
D02069	Atropine sulfate (JP16/USP)
D02070	Homatropine methylbromide (USP)
D02071	Scopolamine hydrobromide hydrate (JP16)
D02081	Metipranolol hydrochloride
D02093	Isoetharine hydrochloride (USP)
D02109	dl-Methylephedrine hydrochloride (JP16)
D02147	Albuterol (USP)
D02149	Epinephrine bitartrate (JAN/USP)
D02150	l-Isoprenaline hydrochloride (JP16)
D02151	Tulobuterol (JAN/INN)
D02200	Pilocarpine hydrochloride (JP16/USP)
D02211	Dihydroergotamine mesilate (JP16)
D02212	Ipratropium bromide hydrate (JP16)
D02246	Biperiden hydrochloride (JP16/USP)
D02247	Biperiden lactate (JAN/USP)
D02248	Levomepromazine maleate (JP16/USAN)
D02281	Levalbuterol hydrochloride (USAN)
D02338	Acebutolol (USAN/INN)
D02342	Bisoprolol (JAN/USAN/INN)
D02349	Dipivefrin (USAN)
D02358	Metoprolol (USAN/INN)
D02359	Ritodrine (USAN/INN)
D02374	Metipranolol (USAN/INN)
D02389	Primidolol (USAN/INN)
D02396	Hexoprenaline sulfate (USAN)
D02417	Flutropium bromide (JAN)
D02535	Timepidium bromide hydrate (JP16)
D02599	Orphenadrine hydrochloride
D02614	Denopamine (JAN/INN)
D02702	Talibegron hydrochloride (USAN)
D02834	Alprenoxime hydrochloride (USAN)
D02876	Alvameline maleate (USAN)
D02976	Arbutamine hydrochloride (USAN)
D02981	Arformoterol tartrate (USAN)
D02995	Asenapine maleate (USAN)
D03011	Atropine oxide hydrochloride (USAN)
D03170	Bucindolol hydrochloride (USAN)
D03177	Bunolol hydrochloride (USAN)
D03195	Butopamine (USAN/INN)
D03198	Butoxamine hydrochloride (USAN)
D03264	Mazaticol hydrochloride hydrate (JAN)
D03274	Chlorpromazine hibenzate (JAN)
D03276	Profenamine hibenzate (JAN)
D03402	Carbuterol hydrochloride (USAN)
D03415	Carvedilol phosphate hydrate (JAN)
D03449	Cetamolol hydrochloride (USAN)
D03490	Cicloprolol hydrochloride (USAN)
D03502	Cimaterol (USAN/INN)
D03587	Colterol mesylate (USAN)
D03648	Dapiprazole hydrochloride (USAN)
D03654	Darifenacin (USAN/INN)
D03711	Dexetimide (USAN/INN)
D03729	Dexpropranolol hydrochloride (USAN)
D03759	Diacetolol hydrochloride (USAN)
D03814	Atropine methylbromide (JAN)
D03879	Dobutamine (USP/INN)
D03880	Dobutamine lactobionate (USAN)
D03881	Dobutamine tartrate (USP)
D03891	Dopexamine (USAN/INN)
D04018	Ephedrine sulfate (USP)
D04034	Chlorpromazine phenolphthalinate (JAN)
D04057	Esoxybutynin chloride (USAN)
D04087	Ethybenztropine (USAN)
D04116	Eucatropine hydrochloride (USP XXXII)
D04157	Fenoterol (USAN/INN)
D04184	Fiduxosin hydrochloride (USAN)
D04190	Flestolol sulfate (USAN)
D04479	Hyoscyamine hydrobromide (USP)
D04531	Indoramin (USAN/INN)
D04532	Indoramin hydrochloride (USAN)
D04625	Isoetharine (USP)
D04626	Isoetharine mesylate (USP)
D04701	Levalbuterol sulfate (USAN)
D04703	Levalbuterol tartrate (USAN)
D04708	Levdobutamine lactobionate (USAN)
D04710	Levobetaxolol hydrochloride (USAN)
D04888	Medroxalol (USAN/INN)
D04889	Medroxalol hydrochloride (USAN)
D04954	Metaproterenol polistirex (USAN)
D04970	Methacholine chloride (USAN/INN)
D05011	Metoprolol fumarate (USP)
D05035	Milameline hydrochloride (USAN)
D05037	Trimetoquinol hydrochloride hydrate (JP16)
D05127	Nebivolol (USAN/INN)
D05206	Norepinephrine bitartrate (USP)
D05277	Formoterol fumarate hydrate (JP16)
D05345	Pamatolol sulfate (USAN)
D05366	Procaterol hydrochloride hydrate (JP16)
D05476	Picumeterol fumarate (USAN)
D05478	Pilocarpine nitrate (USP)
D05587	Practolol (USAN)
D05606	Prenalterol hydrochloride (USAN)
D05648	Pseudoephedrine polistirex (USAN)
D05649	Pseudoephedrine sulfate (USP)
D05691	Ractopamine hydrochloride (USAN)
D05718	Reproterol hydrochloride (USAN)
D05730	Rimiterol hydrobromide (USAN)
D05792	Salmeterol (USAN/INN)
D05832	Sibenadet hydrochloride (USAN)
D05879	Solabegron hydrochloride (USAN)
D05902	Soterenol hydrochloride (USAN)
D06273	Imidafenacin (JAN/INN)
D06328	Xamoterol (USAN)
D06329	Xamoterol fumarate (USAN)
D06374	Zinterol hydrochloride (USAN)
D06622	Nebivolol hydrochloride (USAN)
D06623	Olanzapine pamoate (USAN)
D06646	Epanolol (USAN/INN)
D07099	Cimetropium bromide (INN)
D07124	Alfuzosin (INN)
D07148	Oxedrine (BAN)
D07156	Alprenolol (INN)
D07181	Mepindolol (INN)
D07182	Tertatolol (INN)
D07183	Cloranolol (INN)
D07184	Talinolol (INN)
D07349	Choline alfoscerate (INN)
D07377	Bambuterol (INN)
D07451	Amosulalol (INN)
D07463	Arformoterol (INN)
D07465	Arotinolol (INN)
D07477	Atropine oxide (INN)
D07489	Bambuterol hydrochloride
D07511	Benzatropine (INN)
D07526	Betaxolol (INN)
D07534	Bitolterol (INN)
D07537	Bopindolol (INN)
D07550	Bunazosin (INN)
D07551	Buphenine (INN)
D07590	Bupranolol (INN)
D07608	Carazolol (INN)
D07624	Carteolol (INN)
D07660	Celiprolol (INN)
D07667	Cevimeline (INN)
D07713	Clenbuterol (INN)
D07759	Cyclopentolate (INN)
D07837	Dihydroergotamine (INN)
D07838	Dihydroergotamine tartrate
D07874	Doxazosin (INN)
D07905	Ergometrine (INN)
D07906	Ergotamine (INN)
D07916	Esmolol (INN)
D07931	Etilefrine (INN)
D07951	Fentonium bromide (INN)
D07990	Formoterol (INN)
D08039	Hexoprenaline (INN)
D08074	Penbutolol (INN)
D08090	Isoprenaline (INN)
D08092	Isoxsuprine (INN)
D08093	Isoxsuprine lactate
D08106	Labetalol (INN)
D08115	Levobunolol (INN)
D08124	Levosalbutamol (INN)
D08157	Mazaticol (INN)
D08192	Metaraminol (INN)
D08206	Methylephedrine (BAN)
D08207	Methylergometrine (INN)
D08209	Metixene (INN)
D08220	Midodrine (INN)
D08239	Moxisylyte (INN)
D08253	Naphazoline (INN)
D08284	Norepinephrine hydrochoride
D08286	Norfenefrine (INN)
D08300	Orciprenaline (INN)
D08305	Orphenadrine (INN)
D08308	Oxedrine tartrate
D08309	Oxedrine hydrochloride
D08318	Oxprenolol (INN)
D08322	Oxymetazoline (INN)
D08325	Oxyphencyclimine (INN)
D08358	Phenoxybenzamine (INN)
D08362	Phentolamine (INN)
D08365	Phenylephrine (INN)
D08366	Phenylephrine tartrate
D08376	Pilocarpine borate
D08382	Piperidolate (INN)
D08384	Pipethanate (INN)
D08387	Pirbuterol (INN)
D08395	Piroheptine (INN)
D08411	Prazosin (INN)
D08424	Procaterol (INN)
D08425	Procyclidine (INN)
D08426	Profenamine (INN)
D08441	Propiverine (INN)
D08443	Propranolol (INN)
D08449	Pseudoephedrine (INN)
D08456	Quetiapine (INN)
D08474	Reproterol (INN)
D08511	Setiptiline (INN)
D08522	Solifenacin (INN)
D08560	Tamsulosin (INN)
D08569	Terazosin (INN)
D08570	Terbutaline (INN)
D08572	Tertatolol hydrochloride
D08578	Tetryzoline (INN)
D08595	Tiemonium methylsulfate
D08600	Timolol (INN)
D08614	Tolazoline (INN)
D08624	Tramazoline (INN)
D08629	Tretoquinol (INN)
D08638	Trihexyphenidyl (INN)
D08639	Trimebutine (INN)
D08662	Urapidil hydrochloride
D08966	Phenylephrine bitartrate (USP)
D09318	Indacaterol (USAN/INN)
D09319	Indacaterol maleate (JAN/USAN)
D09535	Mirabegron (USAN/JAN)
D09732	Ritobegron ethyl hydrochloride (JAN)
D09752	Carpronium chloride hydrate (JAN)
D09794	Norepinephrine hydrochloride (JAN)
D09842	dl-Methylephedrine saccharinate (JAN)
D10020	Olodaterol hydrochloride (JAN/USAN)
D10145	Olodaterol (USAN/INN)
D10219	abediterol (USAN/INN)
D10220	Abediterol napadisylate (USAN)

Other DBs

BSID:

153376

GO:

0046541

Organism

Homo sapiens (human) [GN:hsa]

Gene

153	ADRB1; adrenoceptor beta 1 [KO:K04141]
154	ADRB2; adrenoceptor beta 2, surface [KO:K04142]
155	ADRB3; adrenoceptor beta 3 [KO:K04143]
2778	GNAS; GNAS complex locus [KO:K04632]
107	ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
108	ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
109	ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883	ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111	ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112	ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113	ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114	ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
115	ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566	PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567	PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568	PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613	PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
6844	VAMP2; vesicle-associated membrane protein 2 (synaptobrevin 2) [KO:K13504]
148	ADRA1A; adrenoceptor alpha 1A [KO:K04135]
147	ADRA1B; adrenoceptor alpha 1B [KO:K04136]
146	ADRA1D; adrenoceptor alpha 1D [KO:K04137]
1131	CHRM3; cholinergic receptor, muscarinic 3 [KO:K04131]
2776	GNAQ; guanine nucleotide binding protein (G protein), q polypeptide [KO:K04634]
23236	PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330	PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331	PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332	PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
5578	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
3708	ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
3709	ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
3710	ITPR3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
6263	RYR3; ryanodine receptor 3 [KO:K04963]
810	CALML3; calmodulin-like 3 [KO:K02183]
805	CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808	CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801	CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688	CALML6; calmodulin-like 6 [KO:K02183]
51806	CALML5; calmodulin-like 5 [KO:K02183]
4842	NOS1; nitric oxide synthase 1 (neuronal) [KO:K13240] [EC:1.14.13.39]
2977	GUCY1A2; guanylate cyclase 1, soluble, alpha 2 [KO:K12318] [EC:4.6.1.2]
2982	GUCY1A3; guanylate cyclase 1, soluble, alpha 3 [KO:K12318] [EC:4.6.1.2]
2983	GUCY1B3; guanylate cyclase 1, soluble, beta 3 [KO:K12319] [EC:4.6.1.2]
5592	PRKG1; protein kinase, cGMP-dependent, type I [KO:K07376] [EC:2.7.11.12]
5593	PRKG2; protein kinase, cGMP-dependent, type II [KO:K07376] [EC:2.7.11.12]
952	CD38; CD38 molecule [KO:K01242] [EC:3.2.2.5]
683	BST1; bone marrow stromal cell antigen 1 [KO:K01242] [EC:3.2.2.5]
54831	BEST2; bestrophin 2 [KO:K13879]
362	AQP5; aquaporin 5 [KO:K09867]
476	ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide [KO:K01539] [EC:3.6.3.9]
477	ATP1A2; ATPase, Na+/K+ transporting, alpha 2 polypeptide [KO:K01539] [EC:3.6.3.9]
478	ATP1A3; ATPase, Na+/K+ transporting, alpha 3 polypeptide [KO:K01539] [EC:3.6.3.9]
480	ATP1A4; ATPase, Na+/K+ transporting, alpha 4 polypeptide [KO:K01539] [EC:3.6.3.9]
23439	ATP1B4; ATPase, Na+/K+ transporting, beta 4 polypeptide [KO:K01540]
481	ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide [KO:K01540]
482	ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide [KO:K01540]
483	ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide [KO:K01540]
486	FXYD2; FXYD domain containing ion transport regulator 2 [KO:K01538]
490	ATP2B1; ATPase, Ca++ transporting, plasma membrane 1 [KO:K05850] [EC:3.6.3.8]
492	ATP2B3; ATPase, Ca++ transporting, plasma membrane 3 [KO:K05850] [EC:3.6.3.8]
493	ATP2B4; ATPase, Ca++ transporting, plasma membrane 4 [KO:K05850] [EC:3.6.3.8]
491	ATP2B2; ATPase, Ca++ transporting, plasma membrane 2 [KO:K05850] [EC:3.6.3.8]
6558	SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2 [KO:K10951]
3783	KCNN4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [KO:K04945]
3778	KCNMA1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [KO:K04936]
6522	SLC4A2; solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) [KO:K13855]
6548	SLC9A1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 [KO:K05742]
55503	TRPV6; transient receptor potential cation channel, subfamily V, member 6 [KO:K04975]
727897	MUC5B; mucin 5B, oligomeric mucus/gel-forming [KO:K13908]
4589	MUC7; mucin 7, secreted [KO:K13909]
5555	PRH2; proline-rich protein HaeIII subfamily 2 [KO:K13910]
5554	PRH1; proline-rich protein HaeIII subfamily 1 [KO:K13910]
5542	PRB1; proline-rich protein BstNI subfamily 1 [KO:K13911]
653247	PRB2; proline-rich protein BstNI subfamily 2 [KO:K13911]
1755	DMBT1; deleted in malignant brain tumors 1 [KO:K13912]
1469	CST1; cystatin SN [KO:K13897]
1470	CST2; cystatin SA [KO:K13898]
1471	CST3; cystatin C [KO:K13899]
1472	CST4; cystatin S [KO:K13900]
1473	CST5; cystatin D [KO:K13901]
3346	HTN1; histatin 1 [KO:K13913]
3347	HTN3; histatin 3 [KO:K13913]
6779	STATH; statherin [KO:K13914]
4069	LYZ; lysozyme [KO:K13915] [EC:3.2.1.17]
4025	LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
820	CAMP; cathelicidin antimicrobial peptide [KO:K13916]
276	AMY1A; amylase, alpha 1A (salivary) [KO:K01176] [EC:3.2.1.1]
277	AMY1B; amylase, alpha 1B (salivary) [KO:K01176] [EC:3.2.1.1]
278	AMY1C; amylase, alpha 1C (salivary) [KO:K01176] [EC:3.2.1.1]

Compound

C00001	H2O
C00011	CO2
C00076	Calcium cation
C00080	H+
C00165	Diacylglycerol
C00238	Potassium cation
C00288	HCO3-
C00533	Nitric oxide
C00547	L-Noradrenaline
C00575	3',5'-Cyclic AMP
C00698	Cl-
C00942	3',5'-Cyclic GMP
C01245	D-myo-Inositol 1,4,5-trisphosphate
C01330	Sodium cation
C01353	Carbonic acid
C01996	Acetylcholine
C13050	Cyclic ADP-ribose

Reference

PMID:16799262

Authors

Ishikawa Y, Cho G, Yuan Z, Skowronski MT, Pan Y, Ishida H

Title

Water channels and zymogen granules in salivary glands.

Journal

J Pharmacol Sci 100:495-512 (2006)

Reference

PMID:16712780

Authors

Ishikawa Y, Cho G, Yuan Z, Inoue N, Nakae Y

Title

Aquaporin-5 water channel in lipid rafts of rat parotid glands.

Journal

Biochim Biophys Acta 1758:1053-60 (2006)

Reference

PMID:10682899

Authors

Ambudkar IS

Title

Regulation of calcium in salivary gland secretion.

Journal

Crit Rev Oral Biol Med 11:4-25 (2000)

Reference

PMID:10928320

Authors

Ishikawa Y, Ishida H

Title

Aquaporin water channel in salivary glands.

Journal

Jpn J Pharmacol 83:95-101 (2000)

Reference

PMID:8105741

Authors

Baum BJ

Title

Principles of saliva secretion.

Journal

Ann N Y Acad Sci 694:17-23 (1993)

Reference

PMID:9720759

Authors

Fujita-Yoshigaki J

Title

Divergence and convergence in regulated exocytosis: the characteristics of cAMP-dependent enzyme secretion of parotid salivary acinar cells.

Journal

Cell Signal 10:371-5 (1998)

Reference

PMID:18626068

Authors

Heitzmann D, Warth R

Title

Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.

Journal

Physiol Rev 88:1119-82 (2008)

Reference

PMID:17157080

Authors

Proctor GB, Carpenter GH

Title

Regulation of salivary gland function by autonomic nerves.

Journal

Auton Neurosci 133:3-18 (2007)

Reference

PMID:11936453

Authors

Turner RJ, Sugiya H

Title

Understanding salivary fluid and protein secretion.

Journal

Oral Dis 8:3-11 (2002)

Reference

PMID:15153696

Authors

Van Nieuw Amerongen A, Bolscher JG, Veerman EC

Title

Salivary proteins: protective and diagnostic value in cariology?

Journal

Caries Res 38:247-53 (2004)

Reference

PMID:17347411

Authors

Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE

Title

Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells.

Journal

Am J Physiol Regul Integr Comp Physiol 292:R2380-90 (2007)

Reference

PMID:15709965

Authors

Melvin JE, Yule D, Shuttleworth T, Begenisich T

Title

Regulation of fluid and electrolyte secretion in salivary gland acinar cells.

Journal

Annu Rev Physiol 67:445-69 (2005)

Reference

PMID:20224180

Authors

Catalan MA, Nakamoto T, Melvin JE

Title

The salivary gland fluid secretion mechanism.

Journal

J Med Invest 56 Suppl:192-6 (2009)

KO pathway

ko04970

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