KEGG   PATHWAY: hsa04978Help
Entry
hsa04978                    Pathway                                

Name
Mineral absorption - Homo sapiens (human)
Description
Minerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an intracellular messenger in muscle contraction/relaxation, neural networks, the immune system, and endocrine/exocrine cells. Iron, copper, and other metals are required for redox reactions (as cofactors) and for oxygen transport and binding (in hemoglobin and myoglobin). Many enzymes require specific metal atoms to complete their catalytic functions. Animal tissues need moderate quantities of some elements (Ca, P, K, Na, Mg, S, and Cl) and trace amounts of others (Mn, Fe, I, Co, Cr, Cu, Zn, and Se). The minerals are absorbed by either passive or active transport systems through the intestinal mucosa, often using specialized transport proteins, such as ferritin for Fe3+ and vitamin D-induced protein for calcium.
Class
Organismal Systems; Digestive system
BRITE hierarchy
Pathway map
Mineral absorption
hsa04978

All organismsOrtholog table
Disease
H00784  
Localized autosomal recessive hypotrichosis
H00808  
Idiopathic generalized epilepsies (IGEs)
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
H00843  
Hartnup disorder
H00856  
Distal hereditary motor neuropathies (dHMN)
H00905  
Iminoglycinuria
H01143  
Vitamin D-dependent rickets
H01145  
Atransferrinemia
H01174  
Congenital diarrhea
H01196  
Hypochromic microcytic anemia
H01210  
Hypomagnesemia
H01252  
Hereditary folate malabsorption (HFM)
H01304  
Hyperglycinuria
Drug
D00129  
Calcitriol (JAN/USP/INN)
D00930  
Paricalcitol (JAN/USAN/INN)
D01098  
Maxacalcitol (JAN/USAN/INN)
D01125  
Calcipotriol (JAN)
D01472  
Tacalcitol hydrate (JP17)
D01518  
Alfacalcidol (JAN/INN)
D01662  
Falecalcitriol (JAN/INN)
D07578  
Eldecalcitol (JAN/INN)
D08554  
Tacalcitol (INN)
D10198  
Calcipotriol hydrate (JAN)
D10669  
Sotagliflozin (USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
7421  
VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor [KO:K08539]
140803  
TRPM6; transient receptor potential cation channel subfamily M member 6 [KO:K04981] [EC:2.7.11.1]
54822  
TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
55503  
TRPV6; transient receptor potential cation channel subfamily V member 6 [KO:K04975]
795  
S100G; S100 calcium binding protein G [KO:K14734]
1811  
SLC26A3; solute carrier family 26 member 3 [KO:K14078]
65010  
SLC26A6; solute carrier family 26 member 6 [KO:K14704]
115019  
SLC26A9; solute carrier family 26 member 9 [KO:K14706]
1181  
CLCN2; chloride voltage-gated channel 2 [KO:K05011]
6550  
SLC9A3; solute carrier family 9 member A3 [KO:K12040]
6523  
SLC5A1; solute carrier family 5 member 1 [KO:K14158]
340024  
SLC6A19; solute carrier family 6 member 19 [KO:K05334]
476  
ATP1A1; ATPase Na+/K+ transporting subunit alpha 1 [KO:K01539] [EC:3.6.3.9]
477  
ATP1A2; ATPase Na+/K+ transporting subunit alpha 2 [KO:K01539] [EC:3.6.3.9]
478  
ATP1A3; ATPase Na+/K+ transporting subunit alpha 3 [KO:K01539] [EC:3.6.3.9]
480  
ATP1A4; ATPase Na+/K+ transporting subunit alpha 4 [KO:K01539] [EC:3.6.3.9]
23439  
ATP1B4; ATPase Na+/K+ transporting family member beta 4 [KO:K01540]
481  
ATP1B1; ATPase Na+/K+ transporting subunit beta 1 [KO:K01540]
482  
ATP1B2; ATPase Na+/K+ transporting subunit beta 2 [KO:K01540]
483  
ATP1B3; ATPase Na+/K+ transporting subunit beta 3 [KO:K01540]
486  
FXYD2; FXYD domain containing ion transport regulator 2 [KO:K01538]
3162  
HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
3163  
HMOX2; heme oxygenase 2 [KO:K00510] [EC:1.14.14.18]
79901  
CYBRD1; cytochrome b reductase 1 [KO:K08370] [EC:1.16.5.1]
6556  
SLC11A1; solute carrier family 11 member 1 [KO:K12347]
4891  
SLC11A2; solute carrier family 11 member 2 [KO:K12347]
2495  
FTH1; ferritin, heavy polypeptide 1 [KO:K00522] [EC:1.16.3.2]
2512  
FTL; ferritin, light polypeptide [KO:K13625]
30061  
SLC40A1; solute carrier family 40 member 1 [KO:K14685]
9843  
HEPH; hephaestin [KO:K14735] [EC:1.16.3.1]
7018  
TF; transferrin [KO:K14736]
55630  
SLC39A4; solute carrier family 39 member 4 [KO:K14710]
7779  
SLC30A1; solute carrier family 30 member 1 [KO:K14688]
1317  
SLC31A1; solute carrier family 31 member 1 [KO:K14686]
26872  
STEAP1; six transmembrane epithelial antigen of the prostate 1 [KO:K14737] [EC:1.16.1.-]
261729  
STEAP2; STEAP2 metalloreductase [KO:K14738] [EC:1.16.1.-]
4490  
MT1B; metallothionein 1B [KO:K14739]
4493  
MT1E; metallothionein 1E [KO:K14739]
4494  
MT1F; metallothionein 1F [KO:K14739]
4495  
MT1G; metallothionein 1G [KO:K14739]
4496  
MT1H; metallothionein 1H [KO:K14739]
4499  
MT1M; metallothionein 1M [KO:K14739]
4501  
MT1X; metallothionein 1X [KO:K14739]
4502  
MT2A; metallothionein 2A [KO:K14739]
4489  
MT1A; metallothionein 1A [KO:K14739]
475  
ATOX1; antioxidant 1 copper chaperone [KO:K07213]
10568  
SLC34A2; solute carrier family 34 member 2 [KO:K14683]
113235  
SLC46A1; solute carrier family 46 member 1 [KO:K14613]
490  
ATP2B1; ATPase plasma membrane Ca2+ transporting 1 [KO:K05850] [EC:3.6.3.8]
538  
ATP7A; ATPase copper transporting alpha [KO:K17686] [EC:3.6.3.54]
6546  
SLC8A1; solute carrier family 8 member A1 [KO:K05849]
Compound
C00009  
Orthophosphate
C00031  
D-Glucose
C00032  
Heme
C00037  
Glycine
C00038  
Zinc cation
C00041  
L-Alanine
C00064  
L-Glutamine
C00065  
L-Serine
C00070  
Copper
C00073  
L-Methionine
C00076  
Calcium cation
C00078  
L-Tryptophan
C00079  
L-Phenylalanine
C00080  
H+
C00123  
L-Leucine
C00124  
D-Galactose
C00148  
L-Proline
C00152  
L-Asparagine
C00183  
L-Valine
C00188  
L-Threonine
C00238  
Potassium cation
C00288  
HCO3-
C00305  
Magnesium cation
C00407  
L-Isoleucine
C00698  
Cl-
C01330  
Sodium cation
C01673  
Calcitriol
C14818  
Fe2+
C14819  
Fe3+
Reference
  Authors
Perez AV, Picotto G, Carpentieri AR, Rivoira MA, Peralta Lopez ME, Tolosa de Talamoni NG
  Title
Minireview on regulation of intestinal calcium absorption. Emphasis on molecular  mechanisms of transcellular pathway.
  Journal
Digestion 77:22-34 (2008)
Reference
  Authors
Khanal RC, Nemere I
  Title
Regulation of intestinal calcium transport.
  Journal
Annu Rev Nutr 28:179-96 (2008)
Reference
  Authors
Hoenderop JG, Nilius B, Bindels RJ
  Title
Calcium absorption across epithelia.
  Journal
Physiol Rev 85:373-422 (2005)
Reference
  Authors
Bouillon R, Van Cromphaut S, Carmeliet G
  Title
Intestinal calcium absorption: Molecular vitamin D mediated mechanisms.
  Journal
J Cell Biochem 88:332-9 (2003)
Reference
  Authors
Chua AC, Graham RM, Trinder D, Olynyk JK
  Title
The regulation of cellular iron metabolism.
  Journal
Crit Rev Clin Lab Sci 44:413-59 (2007)
Reference
  Authors
West AR, Oates PS
  Title
Mechanisms of heme iron absorption: current questions and controversies.
  Journal
World J Gastroenterol 14:4101-10 (2008)
Reference
  Authors
Dunn LL, Rahmanto YS, Richardson DR
  Title
Iron uptake and metabolism in the new millennium.
  Journal
Trends Cell Biol 17:93-100 (2007)
Reference
  Authors
Donovan A, Roy CN, Andrews NC
  Title
The ins and outs of iron homeostasis.
  Journal
Physiology (Bethesda) 21:115-23 (2006)
Reference
  Authors
Lonnerdal B
  Title
Intestinal regulation of copper homeostasis: a developmental perspective.
  Journal
Am J Clin Nutr 88:846S-50S (2008)
Reference
  Authors
Prohaska JR
  Title
Role of copper transporters in copper homeostasis.
  Journal
Am J Clin Nutr 88:826S-9S (2008)
Reference
  Authors
Wang X, Zhou B
  Title
Dietary zinc absorption: A play of Zips and ZnTs in the gut.
  Journal
IUBMB Life 62:176-82 (2010)
Reference
  Authors
Lichten LA, Cousins RJ
  Title
Mammalian zinc transporters: nutritional and physiologic regulation.
  Journal
Annu Rev Nutr 29:153-76 (2009)
Reference
  Authors
Quamme GA
  Title
Recent developments in intestinal magnesium absorption.
  Journal
Curr Opin Gastroenterol 24:230-5 (2008)
Reference
  Authors
Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X
  Title
NHE3 regulatory complexes.
  Journal
J Exp Biol 212:1638-46 (2009)
Reference
  Authors
Kato A, Romero MF
  Title
Regulation of Electroneutral NaCl Absorption by the Small Intestine.
  Journal
Annu Rev Physiol 73:261-81 (2011)
Reference
  Authors
Sabbagh Y, O'Brien SP, Song W, Boulanger JH, Stockmann A, Arbeeny C, Schiavi SC
  Title
Intestinal npt2b plays a major role in phosphate absorption and homeostasis.
  Journal
J Am Soc Nephrol 20:2348-58 (2009)
Reference
  Authors
Marks J, Srai SK, Biber J, Murer H, Unwin RJ, Debnam ES
  Title
Intestinal phosphate absorption and the effect of vitamin D: a comparison of rats with mice.
  Journal
Exp Physiol 91:531-7 (2006)
KO pathway
 

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