KEGG   PATHWAY: hsa05100Help
Entry
hsa05100                    Pathway                                

Name
Bacterial invasion of epithelial cells - Homo sapiens (human)
Description
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Bacterial invasion of epithelial cells
hsa05100

All organismsOrtholog table
Organism
Homo sapiens (human) [GN:hsa]
Gene
999  
CDH1; cadherin 1 [KO:K05689]
1499  
CTNNB1; catenin beta 1 [KO:K02105]
29119  
CTNNA3; catenin alpha 3 [KO:K05691]
1495  
CTNNA1; catenin alpha 1 [KO:K05691]
1496  
CTNNA2; catenin alpha 2 [KO:K05691]
79658  
ARHGAP10; Rho GTPase activating protein 10 [KO:K13736]
4233  
MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
2549  
GAB1; GRB2 associated binding protein 1 [KO:K09593]
5295  
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
1398  
CRK; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438]
1399  
CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
1793  
DOCK1; dedicator of cytokinesis 1 [KO:K13708]
998  
CDC42; cell division cycle 42 [KO:K04393]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
7454  
WAS; Wiskott-Aldrich syndrome [KO:K05747]
8976  
WASL; Wiskott-Aldrich syndrome like [KO:K05747]
8936  
WASF1; WAS protein family member 1 [KO:K05753]
10163  
WASF2; WAS protein family member 2 [KO:K05748]
10095  
ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10552  
ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10109  
ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
10094  
ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10093  
ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10092  
ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
81873  
ARPC5L; actin related protein 2/3 complex subunit 5-like [KO:K05754]
60  
ACTB; actin, beta [KO:K05692]
71  
ACTG1; actin gamma 1 [KO:K05692]
1731  
SEPT1; septin 1 [KO:K13737]
4735  
SEPT2; septin 2 [KO:K16942]
10801  
SEPT9; septin 9 [KO:K16938]
124404  
SEPT12; septin 12 [KO:K16938]
55964  
SEPT3; septin 3 [KO:K16938]
23157  
SEPT6; septin 6 [KO:K16939]
55752  
SEPT11; septin 11 [KO:K16939]
23176  
SEPT8; septin 8 [KO:K16939]
23624  
CBLC; Cbl proto-oncogene C [KO:K04707] [EC:2.3.2.27]
867  
CBL; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
868  
CBLB; Cbl proto-oncogene B [KO:K04707] [EC:2.3.2.27]
6464  
SHC1; SHC adaptor protein 1 [KO:K06279]
25759  
SHC2; SHC adaptor protein 2 [KO:K17447]
53358  
SHC3; SHC adaptor protein 3 [KO:K17448]
399694  
SHC4; SHC adaptor protein 4 [KO:K17449]
23607  
CD2AP; CD2-associated protein [KO:K13738]
1759  
DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
1785  
DNM2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
26052  
DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
1211  
CLTA; clathrin light chain A [KO:K04644]
1212  
CLTB; clathrin light chain B [KO:K04645]
1213  
CLTC; clathrin heavy chain [KO:K04646]
8218  
CLTCL1; clathrin heavy chain like 1 [KO:K04646]
857  
CAV1; caveolin 1 [KO:K06278]
858  
CAV2; caveolin 2 [KO:K12958]
859  
CAV3; caveolin 3 [KO:K12959]
2017  
CTTN; cortactin [KO:K06106]
3059  
HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
6714  
SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
5747  
PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
9564  
BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
5829  
PXN; paxillin [KO:K05760]
2335  
FN1; fibronectin 1 [KO:K05717]
3678  
ITGA5; integrin subunit alpha 5 [KO:K06484]
3688  
ITGB1; integrin subunit beta 1 [KO:K05719]
3611  
ILK; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
10459  
MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast) [KO:K13728]
26084  
ARHGEF26; Rho guanine nucleotide exchange factor 26 [KO:K13744]
391  
RHOG; ras homolog family member G [KO:K07863]
9844  
ELMO1; engulfment and cell motility 1 [KO:K12366]
63916  
ELMO2; engulfment and cell motility 2 [KO:K18985]
79767  
ELMO3; engulfment and cell motility 3 [KO:K19241]
387  
RHOA; ras homolog family member A [KO:K04513]
7414  
VCL; vinculin [KO:K05700]
Reference
  Authors
Mostowy S, Cossart P
  Title
Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
  Journal
Cell Motil Cytoskeleton 66:816-23 (2009)
Reference
  Authors
Hauck CR, Ohlsen K
  Title
Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
  Journal
Curr Opin Microbiol 9:5-11 (2006)
Reference
  Authors
Wang B, Li S, Dedhar S, Cleary PP
  Title
Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase  (ILK) in streptococcal invasion.
  Journal
Cell Microbiol 9:1519-28 (2007)
Reference
  Authors
Matsumoto H, Young GM
  Title
Translocated effectors of Yersinia.
  Journal
Curr Opin Microbiol 12:94-100 (2009)
Reference
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
Reference
  Authors
Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
  Title
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
  Journal
Cell 130:611-23 (2007)
Reference
  Authors
Ohno H, Yoshimori T (eds).
  Title
[Current Stream in Membrane Traffic] (in Japanese)
  Journal
Tanpakushitsu Kakusan Koso 53 (2008)
KO pathway
 

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