KEGG PATHWAY: hsa05100

PATHWAY: hsa05100

Entry

hsa05100 Pathway

Name

Bacterial invasion of epithelial cells - Homo sapiens (human)

Description

Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.

Class

Human Diseases; Infectious diseases

Pathway map

hsa05100

Bacterial invasion of epithelial cells

Organism

Homo sapiens (human) [GN:hsa]

Gene

999	CDH1; cadherin 1, type 1, E-cadherin (epithelial) [KO:K05689]
1499	CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
29119	CTNNA3; catenin (cadherin-associated protein), alpha 3 [KO:K05691]
1495	CTNNA1; catenin (cadherin-associated protein), alpha 1, 102kDa [KO:K05691]
1496	CTNNA2; catenin (cadherin-associated protein), alpha 2 [KO:K05691]
79658	ARHGAP10; Rho GTPase activating protein 10 [KO:K13736]
4233	MET; met proto-oncogene (hepatocyte growth factor receptor) [KO:K05099] [EC:2.7.10.1]
2549	GAB1; GRB2-associated binding protein 1 [KO:K09593]
5295	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503	PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294	PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
1398	CRK; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
1399	CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
1793	DOCK1; dedicator of cytokinesis 1 [KO:K13708]
998	CDC42; cell division cycle 42 [KO:K04393]
5879	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
7454	WAS; Wiskott-Aldrich syndrome [KO:K05747]
8976	WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
8936	WASF1; WAS protein family, member 1 [KO:K05753]
10163	WASF2; WAS protein family, member 2 [KO:K05748]
10095	ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa [KO:K05757]
10552	ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa [KO:K05757]
10109	ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa [KO:K05758]
10094	ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa [KO:K05756]
10093	ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa [KO:K05755]
10092	ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa [KO:K05754]
81873	ARPC5L; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
60	ACTB; actin, beta [KO:K05692]
71	ACTG1; actin, gamma 1 [KO:K05692]
1731	SEPT1; septin 1 [KO:K13737]
4735	SEPT2; septin 2 [KO:K16942]
10801	SEPT9; septin 9 [KO:K16938]
124404	SEPT12; septin 12 [KO:K16938]
55964	SEPT3; septin 3 [KO:K16938]
23157	SEPT6; septin 6 [KO:K16939]
55752	SEPT11; septin 11 [KO:K16939]
23176	SEPT8; septin 8 [KO:K16939]
23624	CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C [KO:K04707] [EC:6.3.2.19]
867	CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase [KO:K04707] [EC:6.3.2.19]
868	CBLB; Cbl proto-oncogene, E3 ubiquitin protein ligase B [KO:K04707] [EC:6.3.2.19]
25759	SHC2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K06279]
399694	SHC4; SHC (Src homology 2 domain containing) family, member 4 [KO:K06279]
53358	SHC3; SHC (Src homology 2 domain containing) transforming protein 3 [KO:K06279]
6464	SHC1; SHC (Src homology 2 domain containing) transforming protein 1 [KO:K06279]
23607	CD2AP; CD2-associated protein [KO:K13738]
1759	DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
1785	DNM2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
26052	DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
1211	CLTA; clathrin, light chain A [KO:K04644]
1212	CLTB; clathrin, light chain B [KO:K04645]
1213	CLTC; clathrin, heavy chain (Hc) [KO:K04646]
8218	CLTCL1; clathrin, heavy chain-like 1 [KO:K04646]
857	CAV1; caveolin 1, caveolae protein, 22kDa [KO:K06278]
858	CAV2; caveolin 2 [KO:K12958]
859	CAV3; caveolin 3 [KO:K12959]
2017	CTTN; cortactin [KO:K06106]
3059	HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
6714	SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [KO:K05704] [EC:2.7.10.2]
5747	PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
9564	BCAR1; breast cancer anti-estrogen resistance 1 [KO:K05726]
5829	PXN; paxillin [KO:K05760]
2335	FN1; fibronectin 1 [KO:K05717]
3678	ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [KO:K06484]
3688	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
3611	ILK; integrin-linked kinase [KO:K06272] [EC:2.7.11.1]
10459	MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast) [KO:K13728]
26084	ARHGEF26; Rho guanine nucleotide exchange factor (GEF) 26 [KO:K13744]
391	RHOG; ras homolog family member G [KO:K07863]
9844	ELMO1; engulfment and cell motility 1 [KO:K12366]
387	RHOA; ras homolog family member A [KO:K04513]
7414	VCL; vinculin [KO:K05700]

Reference

PMID:19296488

Authors

Mostowy S, Cossart P

Title

Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.

Journal

Cell Motil Cytoskeleton 66:816-23 (2009)

Reference

PMID:16406780

Authors

Hauck CR, Ohlsen K

Title

Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.

Journal

Curr Opin Microbiol 9:5-11 (2006)

Reference

PMID:17298394

Authors

Wang B, Li S, Dedhar S, Cleary PP

Title

Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.

Journal

Cell Microbiol 9:1519-28 (2007)

Reference

PMID:19185531

Authors

Matsumoto H, Young GM

Title

Translocated effectors of Yersinia.

Journal

Curr Opin Microbiol 12:94-100 (2009)

Reference

PMID:19157959

Authors

McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V

Title

Salmonella takes control: effector-driven manipulation of the host.

Journal

Curr Opin Microbiol 12:117-24 (2009)

Reference

PMID:17719540

Authors

Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C

Title

A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.

Journal

Cell 130:611-23 (2007)

Reference

Authors

Ohno H, Yoshimori T (eds).

Title

[Current Stream in Membrane Traffic] (in Japanese)

Journal

Tanpakushitsu Kakusan Koso 53 (2008)

KO pathway

ko05100

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (76)   
   KEGG GENES (76)   
All databases (80)   

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