KEGG   PATHWAY: hsa05130Help
Entry
hsa05130                    Pathway                                

Name
Pathogenic Escherichia coli infection - Homo sapiens (human)
Description
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Pathogenic Escherichia coli infection
hsa05130

All organismsOrtholog table
Disease
H00277  
Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  
Enteropathogenic Escherichia coli (EPEC) infection
Organism
Homo sapiens (human) [GN:hsa]
Gene
7100  
TLR5; toll-like receptor 5 [KO:K10168]
929  
CD14; CD14 molecule [KO:K04391]
7099  
TLR4; toll-like receptor 4 [KO:K10160]
23643  
LY96; lymphocyte antigen 96 [KO:K05400]
10376  
TUBA1B; tubulin, alpha 1b [KO:K07374]
7277  
TUBA4A; tubulin, alpha 4a [KO:K07374]
7278  
TUBA3C; tubulin, alpha 3c [KO:K07374]
7846  
TUBA1A; tubulin, alpha 1a [KO:K07374]
84790  
TUBA1C; tubulin, alpha 1c [KO:K07374]
51807  
TUBA8; tubulin, alpha 8 [KO:K07374]
112714  
TUBA3E; tubulin, alpha 3e [KO:K07374]
113457  
TUBA3D; tubulin, alpha 3d [KO:K07374]
79861  
TUBAL3; tubulin, alpha-like 3 [KO:K07374]
84617  
TUBB6; tubulin, beta 6 class V [KO:K07375]
203068  
TUBB; tubulin, beta class I [KO:K07375]
81027  
TUBB1; tubulin, beta 1 class VI [KO:K07375]
7280  
TUBB2A; tubulin, beta 2A class IIa [KO:K07375]
10381  
TUBB3; tubulin, beta 3 class III [KO:K07375]
10382  
TUBB4A; tubulin, beta 4A class IVa [KO:K07375]
347688  
TUBB8; tubulin, beta 8 class VIII [KO:K07375]
347733  
TUBB2B; tubulin, beta 2B class IIb [KO:K07375]
10383  
TUBB4B; tubulin, beta 4B class IVb [KO:K07375]
9181  
ARHGEF2; Rho/Rac guanine nucleotide exchange factor (GEF) 2 [KO:K12791]
387  
RHOA; ras homolog family member A [KO:K04513]
6093  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
9475  
ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
4690  
NCK1; NCK adaptor protein 1 [KO:K07365]
8440  
NCK2; NCK adaptor protein 2 [KO:K07365]
7454  
WAS; Wiskott-Aldrich syndrome [KO:K05747]
8976  
WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
10095  
ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa [KO:K05757]
10552  
ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa [KO:K05757]
10109  
ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa [KO:K05758]
10094  
ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa [KO:K05756]
10093  
ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa [KO:K05755]
10092  
ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa [KO:K05754]
81873  
ARPC5L; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
60  
ACTB; actin, beta [KO:K05692]
71  
ACTG1; actin, gamma 1 [KO:K05692]
2534  
FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
25  
ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
2017  
CTTN; cortactin [KO:K06106]
3059  
HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
4691  
NCL; nucleolin [KO:K11294]
3688  
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
998  
CDC42; cell division cycle 42 [KO:K04393]
OCLN; occludin [KO:K06088]
7430  
EZR; ezrin [KO:K08007]
999  
CDH1; cadherin 1, type 1, E-cadherin (epithelial) [KO:K05689]
1499  
CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
10971  
YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta [KO:K16197]
3875  
KRT18; keratin 18 [KO:K07604]
5578  
PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
7534  
YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta [KO:K16197]
9076  
CLDN1; claudin 1 [KO:K06087]
Compound
C00350  
Phosphatidylethanolamine
Reference
  Authors
Kaper JB, Nataro JP, Mobley HL.
  Title
Pathogenic Escherichia coli.
  Journal
Nat Rev Microbiol 2:123-40 (2004)
Reference
  Authors
Torres AG, Zhou X, Kaper JB.
  Title
Adherence of diarrheagenic Escherichia coli strains to epithelial cells.
  Journal
Infect Immun 73:18-29 (2005)
Reference
  Authors
Dean P, Maresca M, Kenny B.
  Title
EPEC's weapons of mass subversion.
  Journal
Curr Opin Microbiol 8:28-34 (2005)
Reference
  Authors
Garmendia J, Frankel G, Crepin VF.
  Title
Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation.
  Journal
Infect Immun 73:2573-85 (2005)
Reference
  Authors
Spears KJ, Roe AJ, Gally DL.
  Title
A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis.
  Journal
FEMS Microbiol Lett 255:187-202 (2006)
Reference
  Authors
Kenny B.
  Title
Enteropathogenic Escherichia coli (EPEC)-- a crafty subversive little bug.
  Journal
Microbiology 148:1967-78 (2002)
Reference
  Authors
Hayward RD, Leong JM, Koronakis V, Campellone KG.
  Title
Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling.
  Journal
Nat Rev Microbiol 4:358-70 (2006)
Reference
  Authors
Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A.
  Title
Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
  Journal
EMBO J 23:3570-82 (2004)
Reference
  Authors
Dean P, Kenny B
  Title
The effector repertoire of enteropathogenic E. coli: ganging up on the host cell.
  Journal
Curr Opin Microbiol 12:101-9 (2009)
KO pathway
 

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