KEGG   PATHWAY: hsa05152Help
Entry
hsa05152                    Pathway                                

Name
Tuberculosis - Homo sapiens (human)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Tuberculosis
hsa05152

All organismsOrtholog table
Disease
H00342  
Tuberculosis
Organism
Homo sapiens (human) [GN:hsa]
Gene
7124  
TNF; tumor necrosis factor [KO:K03156]
7132  
TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
8717  
TRADD; TNFRSF1A associated via death domain [KO:K03171]
8772  
FADD; Fas associated via death domain [KO:K02373]
841  
CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
843  
CASP10; caspase 10 [KO:K04400] [EC:3.4.22.63]
836  
CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
637  
BID; BH3 interacting domain death agonist [KO:K04726]
581  
BAX; BCL2 associated X protein [KO:K02159]
54205  
CYCS; cytochrome c, somatic [KO:K08738]
842  
CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
317  
APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
207  
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
572  
BAD; BCL2 associated agonist of cell death [KO:K02158]
596  
BCL2; B-cell CLL/lymphoma 2 [KO:K02161]
815  
CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
817  
CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
816  
CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
818  
CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
3458  
IFNG; interferon, gamma [KO:K04687]
3459  
IFNGR1; interferon gamma receptor 1 [KO:K05132]
3460  
IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
3716  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
3717  
JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
6772  
STAT1; signal transducer and activator of transcription 1 [KO:K11220]
4261  
CIITA; class II, major histocompatibility complex, transactivator [KO:K08060]
5993  
RFX5; regulatory factor X5 [KO:K08061]
8625  
RFXANK; regulatory factor X associated ankyrin containing protein [KO:K08062]
5994  
RFXAP; regulatory factor X associated protein [KO:K08063]
4800  
NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
4801  
NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
4802  
NFYC; nuclear transcription factor Y subunit gamma [KO:K08066]
1385  
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
3108  
HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  
HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  
HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  
HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  
HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
HLA-DRB1; HLA class II histocompatibility antigen, DRB1-7 beta chain [KO:K06752]
972  
CD74; CD74 molecule [KO:K06505]
1387  
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
3586  
IL10; interleukin 10 [KO:K05443]
3587  
IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
3588  
IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
1520  
CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
26253  
CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
2207  
FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
64581  
CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
6714  
SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
6850  
SYK; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
64170  
CARD9; caspase recruitment domain family member 9 [KO:K12794]
10892  
MALT1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]
8915  
BCL10; B-cell CLL/lymphoma 10 [KO:K07368]
64127  
NOD2; nucleotide binding oligomerization domain containing 2 [KO:K10165]
8767  
RIPK2; receptor interacting serine/threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
3313  
HSPA9; heat shock protein family A (Hsp70) member 9 [KO:K04043]
3329  
HSPD1; heat shock protein family D (Hsp60) member 1 [KO:K04077]
3929  
LBP; lipopolysaccharide binding protein [KO:K05399]
7097  
TLR2; toll like receptor 2 [KO:K10159]
7096  
TLR1; toll like receptor 1 [KO:K05398]
10333  
TLR6; toll like receptor 6 [KO:K10169]
7099  
TLR4; toll like receptor 4 [KO:K10160]
929  
CD14; CD14 molecule [KO:K04391]
114609  
TIRAP; toll-interleukin 1 receptor (TIR) domain containing adaptor protein [KO:K05403]
4615  
MYD88; myeloid differentiation primary response 88 [KO:K04729]
51135  
IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
3654  
IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
3656  
IRAK2; interleukin 1 receptor associated kinase 2 [KO:K04731] [EC:2.7.11.1]
7189  
TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
4790  
NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  
RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
5600  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5599  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
4843  
NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
3569  
IL6; interleukin 6 [KO:K05405]
3592  
IL12A; interleukin 12A [KO:K05406]
3593  
IL12B; interleukin 12B [KO:K05425]
3606  
IL18; interleukin 18 [KO:K05482]
51561  
IL23A; interleukin 23 subunit alpha [KO:K05426]
3552  
IL1A; interleukin 1 alpha [KO:K04383]
3553  
IL1B; interleukin 1 beta [KO:K04519]
1051  
CEBPB; CCAAT/enhancer binding protein beta [KO:K10048]
1054  
CEBPG; CCAAT/enhancer binding protein gamma [KO:K10049]
54106  
TLR9; toll like receptor 9 [KO:K10161]
3439  
IFNA1; interferon, alpha 1 [KO:K05414]
3440  
IFNA2; interferon, alpha 2 [KO:K05414]
3441  
IFNA4; interferon, alpha 4 [KO:K05414]
3442  
IFNA5; interferon alpha 5 [KO:K05414]
3443  
IFNA6; interferon alpha 6 [KO:K05414]
3444  
IFNA7; interferon, alpha 7 [KO:K05414]
3445  
IFNA8; interferon alpha 8 [KO:K05414]
3446  
IFNA10; interferon, alpha 10 [KO:K05414]
3447  
IFNA13; interferon, alpha 13 [KO:K05414]
3448  
IFNA14; interferon alpha 14 [KO:K05414]
3449  
IFNA16; interferon, alpha 16 [KO:K05414]
3451  
IFNA17; interferon, alpha 17 [KO:K05414]
3452  
IFNA21; interferon, alpha 21 [KO:K05414]
3456  
IFNB1; interferon beta 1 [KO:K05415]
10332  
CLEC4M; C-type lectin domain family 4 member M [KO:K06563]
30835  
CD209; CD209 molecule [KO:K06563]
23365  
ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
387  
RHOA; ras homolog family member A [KO:K04513]
4046  
LSP1; lymphocyte-specific protein 1 [KO:K14957]
1263  
PLK3; polo like kinase 3 [KO:K08862] [EC:2.7.11.21]
8844  
KSR1; kinase suppressor of ras 1 [KO:K14958]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
7040  
TGFB1; transforming growth factor beta 1 [KO:K13375]
7042  
TGFB2; transforming growth factor beta 2 [KO:K13376]
7043  
TGFB3; transforming growth factor beta 3 [KO:K13377]
1594  
CYP27B1; cytochrome P450 family 27 subfamily B member 1 [KO:K07438] [EC:1.14.13.13]
7421  
VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor [KO:K08539]
820  
CAMP; cathelicidin antimicrobial peptide [KO:K13916]
718  
C3; complement component 3 [KO:K03990]
1378  
CR1; complement component 3b/4b receptor 1 (Knops blood group) [KO:K04011]
3687  
ITGAX; integrin subunit alpha X [KO:K06462]
3689  
ITGB2; integrin subunit beta 2 [KO:K06464]
3684  
ITGAM; integrin subunit alpha M [KO:K06461]
22925  
PLA2R1; phospholipase A2 receptor 1 [KO:K06560]
4360  
MRC1; mannose receptor, C type 1 [KO:K06560]
9902  
MRC2; mannose receptor C type 2 [KO:K06560]
8877  
SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
56848  
SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
810  
CALML3; calmodulin like 3 [KO:K02183]
805  
CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808  
CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801  
CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688  
CALML6; calmodulin like 6 [KO:K02183]
51806  
CALML5; calmodulin like 5 [KO:K02183]
5289  
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
5868  
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869  
RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878  
RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
8411  
EEA1; early endosome antigen 1 [KO:K12478]
7879  
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
1509  
CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
10312  
TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
23545  
ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
50617  
ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
535  
ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
9114  
ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
245972  
ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
51606  
ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
537  
ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
527  
ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
533  
ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
3916  
LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
3920  
LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
5530  
PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
5532  
PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
5533  
PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
5534  
PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
5535  
PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
11151  
CORO1A; coronin 1A [KO:K13882]
putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8; K06856 immunoglobulin heavy chain [KO:K06856]
2209  
FCGR1A; Fc fragment of IgG receptor Ia [KO:K06498]
2212  
FCGR2A; Fc fragment of IgG receptor IIa [KO:K06472]
2213  
FCGR2B; Fc fragment of IgG receptor IIb [KO:K12560]
9103  
FCGR2C; Fc fragment of IgG receptor IIc (gene/pseudogene) [KO:K16824]
2214  
FCGR3A; Fc fragment of IgG receptor IIIa [KO:K06463]
2215  
FCGR3B; Fc fragment of IgG receptor IIIb [KO:K06463]
Compound
C00076  
Calcium cation
C00338  
Lipopolysaccharide
C01194  
1-Phosphatidyl-D-myo-inositol
C01561  
Calcidiol
C01673  
Calcitriol
C04465  
alpha,alpha'-Trehalose 6,6'-bismycolate
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  
Sphingosine 1-phosphate
C19190  
Trehalose-6,6'-dibehenate
Reference
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
Reference
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
Reference
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
Reference
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
Reference
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
Reference
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
Reference
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
Reference
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
Reference
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
Reference
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
Reference
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
Reference
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
Reference
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
Reference
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
Reference
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
Reference
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
KO pathway
 

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