KEGG PATHWAY: hsa05162

PATHWAY: hsa05162

Entry

hsa05162 Pathway

Name

Measles - Homo sapiens (human)

Description

Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation.

Class

Human Diseases; Infectious diseases

Pathway map

hsa05162

Measles

Disease

H00394

Measles

Organism

Homo sapiens (human) [GN:hsa]

Gene

4478	MSN; moesin [KO:K05763]
10332	CLEC4M; C-type lectin domain family 4, member M [KO:K06563]
30835	CD209; CD209 molecule [KO:K06563]
6869	TACR1; tachykinin receptor 1 [KO:K04222]
4179	CD46; CD46 molecule, complement regulatory protein [KO:K04007]
6504	SLAMF1; signaling lymphocytic activation molecule family member 1 [KO:K06536]
4068	SH2D1A; SH2 domain containing 1A [KO:K07990]
2534	FYN; FYN oncogene related to SRC, FGR, YES [KO:K05703] [EC:2.7.10.2]
1796	DOK1; docking protein 1, 62kDa (downstream of tyrosine kinase 1) [KO:K14752]
3596	IL13; interleukin 13 [KO:K05435]
3565	IL4; interleukin 4 [KO:K05430]
915	CD3D; CD3d molecule, delta (CD3-TCR complex) [KO:K06450]
916	CD3E; CD3e molecule, epsilon (CD3-TCR complex) [KO:K06451]
917	CD3G; CD3g molecule, gamma (CD3-TCR complex) [KO:K06452]
940	CD28; CD28 molecule [KO:K06470]
3558	IL2; interleukin 2 [KO:K05429]
3559	IL2RA; interleukin 2 receptor, alpha [KO:K05068]
3560	IL2RB; interleukin 2 receptor, beta [KO:K05069]
3561	IL2RG; interleukin 2 receptor, gamma [KO:K05070]
5295	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503	PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294	PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
207	AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
2932	GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
3716	JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
3718	JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
6774	STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) [KO:K04692]
6776	STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
6777	STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
23586	DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
64135	IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
57506	MAVS; mitochondrial antiviral signaling protein [KO:K12648]
9641	IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
29110	TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
3661	IRF3; interferon regulatory factor 3 [KO:K05411]
51284	TLR7; toll-like receptor 7 [KO:K05404]
54106	TLR9; toll-like receptor 9 [KO:K10161]
4615	MYD88; myeloid differentiation primary response 88 [KO:K04729]
3654	IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
51135	IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
3665	IRF7; interferon regulatory factor 7 [KO:K09447]
1147	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
7097	TLR2; toll-like receptor 2 [KO:K10159]
7099	TLR4; toll-like receptor 4 [KO:K10160]
7189	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
6885	MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
23118	TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
4793	NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [KO:K02581]
4792	NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
4790	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
5970	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
1457	CSNK2A1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
1459	CSNK2A2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
1460	CSNK2B; casein kinase 2, beta polypeptide [KO:K03115]
7128	TNFAIP3; tumor necrosis factor, alpha-induced protein 3 [KO:K11859] [EC:3.-.-.-]
3439	IFNA1; interferon, alpha 1 [KO:K05414]
3440	IFNA2; interferon, alpha 2 [KO:K05414]
3441	IFNA4; interferon, alpha 4 [KO:K05414]
3442	IFNA5; interferon, alpha 5 [KO:K05414]
3443	IFNA6; interferon, alpha 6 [KO:K05414]
3444	IFNA7; interferon, alpha 7 [KO:K05414]
3445	IFNA8; interferon, alpha 8 [KO:K05414]
3446	IFNA10; interferon, alpha 10 [KO:K05414]
3447	IFNA13; interferon, alpha 13 [KO:K05414]
3448	IFNA14; interferon, alpha 14 [KO:K05414]
3449	IFNA16; interferon, alpha 16 [KO:K05414]
3451	IFNA17; interferon, alpha 17 [KO:K05414]
3452	IFNA21; interferon, alpha 21 [KO:K05414]
3456	IFNB1; interferon, beta 1, fibroblast [KO:K05415]
3552	IL1A; interleukin 1, alpha [KO:K04383]
3553	IL1B; interleukin 1, beta [KO:K04519]
3569	IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
3592	IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
3593	IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
2213	FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32) [KO:K12560]
3454	IFNAR1; interferon (alpha, beta and omega) receptor 1 [KO:K05130]
3455	IFNAR2; interferon (alpha, beta and omega) receptor 2 [KO:K05131]
10399	GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [KO:K14753]
7297	TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6772	STAT1; signal transducer and activator of transcription 1, 91kDa [KO:K11220]
6773	STAT2; signal transducer and activator of transcription 2, 113kDa [KO:K11221]
10379	IRF9; interferon regulatory factor 9 [KO:K04693]
3458	IFNG; interferon, gamma [KO:K04687]
3459	IFNGR1; interferon gamma receptor 1 [KO:K05132]
3460	IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
3717	JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
4938	OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa [KO:K14216]
4939	OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa [KO:K14216]
4940	OAS3; 2'-5'-oligoadenylate synthetase 3, 100kDa [KO:K14216]
103	ADAR; adenosine deaminase, RNA-specific [KO:K12968] [EC:3.5.4.-]
4599	MX1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) [KO:K14754]
595	CCND1; cyclin D1 [KO:K04503]
894	CCND2; cyclin D2 [KO:K10151]
896	CCND3; cyclin D3 [KO:K10152]
898	CCNE1; cyclin E1 [KO:K06626]
9134	CCNE2; cyclin E2 [KO:K06626]
1019	CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
1021	CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
1017	CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
1027	CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) [KO:K06624]
9367	RAB9A; RAB9A, member RAS oncogene family [KO:K07899]
51209	RAB9B; RAB9B, member RAS oncogene family [KO:K07900]
3312	HSPA8; heat shock 70kDa protein 8 [KO:K03283]
3303	HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
3306	HSPA2; heat shock 70kDa protein 2 [KO:K03283]
3305	HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
3304	HSPA1B; heat shock 70kDa protein 1B [KO:K03283]
3310	HSPA6; heat shock 70kDa protein 6 (HSP70B') [KO:K03283]
8667	EIF3H; eukaryotic translation initiation factor 3, subunit H [KO:K03247]
27102	EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610	EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451	EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275	EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
1965	EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [KO:K03237]
25898	RCHY1; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase [KO:K10144] [EC:6.3.2.19]
7157	TP53; tumor protein p53 [KO:K04451]
7161	TP73; tumor protein p73 [KO:K10148]
27113	BBC3; BCL2 binding component 3 [KO:K10132]
356	FASLG; Fas ligand (TNF superfamily, member 6) [KO:K04389]
355	FAS; Fas (TNF receptor superfamily, member 6) [KO:K04390]
8743	TNFSF10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]
8797	TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a [KO:K04722]
8795	TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b [KO:K04722]
8794	TNFRSF10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain [KO:K04722]
8793	TNFRSF10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain [KO:K04722]
5588	PRKCQ; protein kinase C, theta [KO:K06068] [EC:2.7.11.13]
868	CBLB; Cbl proto-oncogene, E3 ubiquitin protein ligase B [KO:K04707] [EC:6.3.2.19]

Compound

C05981	Phosphatidylinositol-3,4,5-trisphosphate
C18991	Protein P
C18997	Protein C
C18998	Non-structural protein V

Reference

PMID:19203113

Authors

Schneider-Schaulies S, Schneider-Schaulies J

Title

Measles virus-induced immunosuppression.

Journal

Curr Top Microbiol Immunol 330:243-69 (2009)

Reference

PMID:19198562

Authors

Navaratnarajah CK, Leonard VH, Cattaneo R

Title

Measles virus glycoprotein complex assembly, receptor attachment, and cell entry.

Journal

Curr Top Microbiol Immunol 329:59-76 (2009)

Reference

PMID:19203114

Authors

Hahm B

Title

Hostile communication of measles virus with host innate immunity and dendritic cells.

Journal

Curr Top Microbiol Immunol 330:271-87 (2009)

Reference

PMID:19203109

Authors

Naniche D

Title

Human immunology of measles virus infection.

Journal

Curr Top Microbiol Immunol 330:151-71 (2009)

Reference

PMID:19198566

Authors

Gerlier D, Valentin H

Title

Measles virus interaction with host cells and impact on innate immunity.

Journal

Curr Top Microbiol Immunol 329:163-91 (2009)

Reference

PMID:12620806

Authors

Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N

Title

Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.

Journal

Virology 306:135-46 (2003)

Reference

PMID:16963735

Authors

Yanagi Y, Takeda M, Ohno S

Title

Measles virus: cellular receptors, tropism and pathogenesis.

Journal

J Gen Virol 87:2767-79 (2006)

Reference

PMID:16237742

Authors

Kerdiles YM, Sellin CI, Druelle J, Horvat B

Title

Immunosuppression caused by measles virus: role of viral proteins.

Journal

Rev Med Virol 16:49-63 (2006)

Reference

PMID:16690907

Authors

Schneider-Schaulies S, Dittmer U

Title

Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.

Journal

J Gen Virol 87:1423-38 (2006)

Reference

PMID:20376484

Authors

Avota E, Gassert E, Schneider-Schaulies S

Title

Measles virus-induced immunosuppression: from effectors to mechanisms.

Journal

Med Microbiol Immunol 199:227-37 (2010)

Reference

PMID:11582511

Authors

Schneider-Schaulies J, ter Meulen V, Schneider-Schaulies S

Title

Measles virus interactions with cellular receptors: consequences for viral pathogenesis.

Journal

J Neurovirol 7:391-9 (2001)

Reference

PMID:20636817

Authors

Griffin DE

Title

Measles virus-induced suppression of immune responses.

Journal

Immunol Rev 236:176-89 (2010)

Reference

PMID:11385511

Authors

Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S

Title

Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.

Journal

Nat Med 7:725-31 (2001)

Reference

PMID:18922877

Authors

Pfaller CK, Conzelmann KK

Title

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.

Journal

J Virol 82:12365-73 (2008)

Reference

PMID:17720800

Authors

Yokota S, Okabayashi T, Yokosawa N, Fujii N

Title

Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.

Journal

FASEB J 22:74-83 (2008)

Reference

PMID:12804771

Authors

Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K

Title

Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.

Journal

FEBS Lett 545:177-82 (2003)

Reference

PMID:12410527

Authors

Gotoh B, Komatsu T, Takeuchi K, Yokoo J

Title

Paramyxovirus strategies for evading the interferon response.

Journal

Rev Med Virol 12:337-57 (2002)

Reference

PMID:12805463

Authors

Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM

Title

STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.

Journal

J Virol 77:7635-44 (2003)

Reference

PMID:14585342

Authors

Shaffer JA, Bellini WJ, Rota PA

Title

The C protein of measles virus inhibits the type I interferon response.

Journal

Virology 315:389-97 (2003)

KO pathway

ko05162

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   BioSystems (1)   
Disease (1)   
   KEGG DISEASE (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (134)   
   KEGG GENES (134)   
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