| Entry |
|
| Name |
Pathways in cancer - Homo sapiens (human)
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| Class |
Human Diseases; Cancers
 |
| Pathway map |

  |
| Disease |
| von Hippel-Lindau syndrome | | Odontoonychodermal dysplasia | | Oligodontia-colorectal cancer syndrome | | Li-Fraumeni syndrome | | Basal cell nevus syndrome | | Pilomatricoma | | Choroid plexus papilloma | | Juvenile polyposis syndrome | | Familial adenomatous polyposis |
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| Drug |
| Testosterone (JAN/USP) | | Danazol (JP16/USP/INN) | | Flutamide (JP16/USP/INN) | | Sirolimus (USAN/INN) | | Bicalutamide (JAN/USP/INN) | | Nilutamide (USAN/INN) | | Metenolone enanthate (JP16) | | Imatinib mesilate (JAN) | | Gefitinib (JAN/USAN/INN) | | Everolimus (JAN/USAN/INN) | | Alitretinoin (USAN) | | Bexarotene (USAN/INN) | | Axitinib (JAN/USAN) | | Bosutinib (USAN) | | Trastuzumab (genetical recombination) (JAN) | | Cetuximab (genetical recombination) (JAN) | | Dasatinib (INN) | | Enzastaurin hydrochloride (JAN/USAN) | | Erlotinib hydrochloride (JAN/USAN) | | Lapatinib tosilate hydrate (JAN) | | Fenretinide (USAN/INN) | | Lestaurtinib (USAN/INN) | | Midostaurin (USAN/INN) | | Panitumumab (genetical recombination) (JAN) | | Pazopanib hydrochloride (JAN/USAN) | | Pegaptanib sodium (JAN/USAN) | | Semaxanib (USAN/INN) | | Tandutinib (USAN/INN) | | Temsirolimus (JAN/USAN/INN) | | Sorafenib tosilate (JAN) | | Vatalanib (USAN/INN) | | Vorinostat (JAN/USAN) | | Sunitinib malate (JAN/USAN) | | Vandetanib (JAN/USAN/INN) | | Bevacizumab (genetical recombination) (JAN) | | Nilotinib hydrochloride hydrate (JAN) | | Dasatinib hydrate (JAN) | | Romidepsin (JAN/USAN/INN) | | Erlotinib (INN) | | Imatinib (INN) | | Lapatinib (INN) | | Tozasertib (USAN) | | Tozasertib lactate (USAN) | | Sorafenib (USAN/INN) | | Sunitinib (INN) | | Belinostat (USAN/INN) | | Cediranib (USAN/INN) | | Cediranib maleate (JAN/USAN) | | Ridaforolimus (JAN/USAN) | | Neratinib (INN/USAN) | | Nilotinib (USAN/INN) | | Cixutumumab (USAN) | | Entinostat (USAN/INN) | | Figitumumab (USAN) | | Mocetinostat dihydrobromide (USAN) | | Aflibercept (genetical recombination) (JAN) | | Mocetinostat (USAN/INN) | | Rilotumumab (USAN/INN) | | Afatinib (USAN/INN) | | Afatinib maleate (JAN) | | Dalotuzumab (USAN) | | Amuvatinib (USAN/INN) | | Amuvatinib hydrochloride (USAN) | | Ganitumab (USAN/INN) | | Gataparsen (USAN/INN) | | Gataparsen sodium (USAN) | | Lenvatinib (USAN/INN) | | Lenvatinib mesilate (JAN) | | Ponatinib (USAN/INN) | | Ponatinib hydrochloride (USAN) | | Quizartinib (USAN/INN) | | Quizartinib dihydrochloride (USAN) | | Trastuzumab emtansine (genetical recombination) (JAN) | | Vismodegib (USAN/INN) | | Vemurafenib (USAN/INN) | | Panobinostat lactate (JAN) | | Zalutumumab (USAN/INN) | | Abexinostat (USAN) | | Cabozantinib (USAN) | | Olcorolimus (USAN) | | Abexinostat hydrochloride (USAN) | | Crenolanib (USAN) | | Crenolanib besylate (USAN) | | Ficlatuzumab (USAN) | | Ganetespib (USAN) | | Regorafenib hydrate (JAN) | | Regorafenib (USAN/INN) | | Sepantronium bromide (USAN) | | Tivantinib (USAN/INN) | | Pictilisib (USAN) | | Enzalutamide (USAN) | | Panobinostat (USAN/INN) | | Rebastinib (USAN) |
|
| Organism |
Homo sapiens (human) [GN: hsa]
|
| Gene |
| DCC; deleted in colorectal carcinoma [KO: K06765] | | CASP3; caspase 3, apoptosis-related cysteine peptidase [KO: K02187] [EC: 3.4.22.56] | | CASP9; caspase 9, apoptosis-related cysteine peptidase [KO: K04399] [EC: 3.4.22.62] | | APPL1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 [KO: K08733] | | CDH1; cadherin 1, type 1, E-cadherin (epithelial) [KO: K05689] | | CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO: K02105] | | CTNNA3; catenin (cadherin-associated protein), alpha 3 [KO: K05691] | | CTNNA1; catenin (cadherin-associated protein), alpha 1, 102kDa [KO: K05691] | | CTNNA2; catenin (cadherin-associated protein), alpha 2 [KO: K05691] | | | | | | APC; adenomatous polyposis coli [KO: K02085] | | APC2; adenomatosis polyposis coli 2 [KO: K02085] | | | | TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO: K02620] | | TCF7L1; transcription factor 7-like 1 (T-cell specific, HMG-box) [KO: K04490] | | TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box) [KO: K04491] | | LEF1; lymphoid enhancer-binding factor 1 [KO: K04492] | | BIRC5; baculoviral IAP repeat containing 5 [KO: K08731] | | MYC; v-myc myelocytomatosis viral oncogene homolog (avian) [KO: K04377] | | | | WNT1; wingless-type MMTV integration site family, member 1 [KO: K03209] | | WNT2; wingless-type MMTV integration site family member 2 [KO: K00182] | | WNT2B; wingless-type MMTV integration site family, member 2B [KO: K00182] | | WNT3; wingless-type MMTV integration site family, member 3 [KO: K00312] | | WNT3A; wingless-type MMTV integration site family, member 3A [KO: K00312] | | WNT4; wingless-type MMTV integration site family, member 4 [KO: K00408] | | WNT5A; wingless-type MMTV integration site family, member 5A [KO: K00444] | | WNT5B; wingless-type MMTV integration site family, member 5B [KO: K00444] | | WNT6; wingless-type MMTV integration site family, member 6 [KO: K00445] | | WNT7A; wingless-type MMTV integration site family, member 7A [KO: K00572] | | WNT7B; wingless-type MMTV integration site family, member 7B [KO: K00572] | | WNT8A; wingless-type MMTV integration site family, member 8A [KO: K00714] | | WNT8B; wingless-type MMTV integration site family, member 8B [KO: K00714] | | WNT9A; wingless-type MMTV integration site family, member 9A [KO: K01064] | | WNT9B; wingless-type MMTV integration site family, member 9B [KO: K01064] | | WNT10B; wingless-type MMTV integration site family, member 10B [KO: K01357] | | WNT10A; wingless-type MMTV integration site family, member 10A [KO: K01357] | | WNT11; wingless-type MMTV integration site family, member 11 [KO: K01384] | | WNT16; wingless-type MMTV integration site family, member 16 [KO: K01558] | | FZD1; frizzled family receptor 1 [KO: K02432] | | FZD7; frizzled family receptor 7 [KO: K02432] | | FZD2; frizzled family receptor 2 [KO: K02235] | | FZD3; frizzled family receptor 3 [KO: K02329] | | FZD4; frizzled family receptor 4 [KO: K02354] | | FZD5; frizzled family receptor 5 [KO: K02375] | | FZD8; frizzled family receptor 8 [KO: K02375] | | FZD6; frizzled family receptor 6 [KO: K02376] | | FZD10; frizzled family receptor 10 [KO: K02842] | | FZD9; frizzled family receptor 9 [KO: K02842] | | DVL3; dishevelled, dsh homolog 3 (Drosophila) [KO: K02353] | | DVL2; dishevelled, dsh homolog 2 (Drosophila) [KO: K02353] | | DVL1; dishevelled, dsh homolog 1 (Drosophila) [KO: K02353] | | COL4A2; collagen, type IV, alpha 2 [KO: K06237] | | COL4A4; collagen, type IV, alpha 4 [KO: K06237] | | COL4A6; collagen, type IV, alpha 6 [KO: K06237] | | COL4A1; collagen, type IV, alpha 1 [KO: K06237] | | COL4A5; collagen, type IV, alpha 5 [KO: K06237] | | COL4A3; collagen, type IV, alpha 3 (Goodpasture antigen) [KO: K06237] | | LAMA1; laminin, alpha 1 [KO: K05637] | | LAMA2; laminin, alpha 2 [KO: K05637] | | LAMA3; laminin, alpha 3 [KO: K06240] | | LAMA5; laminin, alpha 5 [KO: K06240] | | LAMA4; laminin, alpha 4 [KO: K06241] | | LAMB1; laminin, beta 1 [KO: K05636] | | LAMB2; laminin, beta 2 (laminin S) [KO: K06243] | | LAMB3; laminin, beta 3 [KO: K06244] | | LAMB4; laminin, beta 4 [KO: K06245] | | LAMC1; laminin, gamma 1 (formerly LAMB2) [KO: K05635] | | LAMC2; laminin, gamma 2 [KO: K06246] | | LAMC3; laminin, gamma 3 [KO: K06247] | | FN1; fibronectin 1 [KO: K05717] | | ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [KO: K06481] | | ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [KO: K06476] | | ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) [KO: K06482] | | ITGA6; integrin, alpha 6 [KO: K06485] | | ITGAV; integrin, alpha V [KO: K06487] | | ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO: K05719] | | | | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO: K00922] [EC: 2.7.1.153] | | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO: K00922] [EC: 2.7.1.153] | | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO: K00922] [EC: 2.7.1.153] | | PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO: K00922] [EC: 2.7.1.153] | | PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO: K02649] | | PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO: K02649] | | PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO: K02649] | | PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO: K02649] | | | | NKX3-1; NK3 homeobox 1 [KO: K09348] | | AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO: K04456] [EC: 2.7.11.1] | | AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO: K04456] [EC: 2.7.11.1] | | AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO: K04456] [EC: 2.7.11.1] | | CHUK; conserved helix-loop-helix ubiquitous kinase [KO: K04467] [EC: 2.7.11.10] | | IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO: K07209] [EC: 2.7.11.10] | | IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO: K07210] | | NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO: K04734] | | NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO: K02580] | | NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO: K04469] | | RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO: K04735] | | PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [KO: K11987] [EC: 1.14.99.1] | | | | BCL2; B-cell CLL/lymphoma 2 [KO: K02161] | | BIRC2; baculoviral IAP repeat containing 2 [KO: K16060] | | BIRC3; baculoviral IAP repeat containing 3 [KO: K16060] | | XIAP; X-linked inhibitor of apoptosis [KO: K04725] | | BIRC7; baculoviral IAP repeat containing 7 [KO: K16061] | | BIRC8; baculoviral IAP repeat containing 8 [KO: K16061] | | BCL2L1; BCL2-like 1 [KO: K04570] | | TRAF1; TNF receptor-associated factor 1 [KO: K03172] | | TRAF2; TNF receptor-associated factor 2 [KO: K03173] | | TRAF3; TNF receptor-associated factor 3 [KO: K03174] | | TRAF4; TNF receptor-associated factor 4 [KO: K09848] | | TRAF5; TNF receptor-associated factor 5 [KO: K09849] | | TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO: K03175] | | MTOR; mechanistic target of rapamycin (serine/threonine kinase) [KO: K07203] | | BAD; BCL2-associated agonist of cell death [KO: K02158] | | FOXO1; forkhead box O1 [KO: K07201] | | MDM2; MDM2 oncogene, E3 ubiquitin protein ligase [KO: K06643] [EC: 6.3.2.19] | | TP53; tumor protein p53 [KO: K04451] | | CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) [KO: K06624] | | CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO: K06625] | | | | ABL1; c-abl oncogene 1, non-receptor tyrosine kinase [KO: K06619] [EC: 2.7.10.2] | | CRK; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO: K04438] | | CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO: K04438] | | CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C [KO: K04707] [EC: 6.3.2.19] | | CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase [KO: K04707] [EC: 6.3.2.19] | | CBLB; Cbl proto-oncogene, E3 ubiquitin protein ligase B [KO: K04707] [EC: 6.3.2.19] | | STAT5A; signal transducer and activator of transcription 5A [KO: K11223] | | STAT5B; signal transducer and activator of transcription 5B [KO: K11224] | | | | STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) [KO: K04692] | | STAT1; signal transducer and activator of transcription 1, 91kDa [KO: K11220] | | VEGFA; vascular endothelial growth factor A [KO: K05448] | | VEGFB; vascular endothelial growth factor B [KO: K16858] | | PGF; placental growth factor [KO: K16859] | | VEGFC; vascular endothelial growth factor C [KO: K05449] | | FIGF; c-fos induced growth factor (vascular endothelial growth factor D) [KO: K05449] | | TGFA; transforming growth factor, alpha [KO: K08774] | | EGF; epidermal growth factor [KO: K04357] | | | | ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [KO: K05083] [EC: 2.7.10.1] | | PDGFB; platelet-derived growth factor beta polypeptide [KO: K04359] | | PDGFA; platelet-derived growth factor alpha polypeptide [KO: K04359] | | PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO: K04363] [EC: 2.7.10.1] | | PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO: K05089] [EC: 2.7.10.1] | | IGF1; insulin-like growth factor 1 (somatomedin C) [KO: K05459] | | IGF1R; insulin-like growth factor 1 receptor [KO: K05087] [EC: 2.7.10.1] | | | | KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KO: K05091] [EC: 2.7.10.1] | | FLT3LG; fms-related tyrosine kinase 3 ligand [KO: K05454] | | | | HGF; hepatocyte growth factor (hepapoietin A [KO: K05460] | | MET; met proto-oncogene (hepatocyte growth factor receptor) [KO: K05099] [EC: 2.7.10.1] | | FGF1; fibroblast growth factor 1 (acidic) [KO: K04358] | | FGF2; fibroblast growth factor 2 (basic) [KO: K04358] | | FGF3; fibroblast growth factor 3 [KO: K04358] | | FGF4; fibroblast growth factor 4 [KO: K04358] | | FGF17; fibroblast growth factor 17 [KO: K04358] | | FGF6; fibroblast growth factor 6 [KO: K04358] | | FGF7; fibroblast growth factor 7 [KO: K04358] | | FGF8; fibroblast growth factor 8 (androgen-induced) [KO: K04358] | | FGF9; fibroblast growth factor 9 (glia-activating factor) [KO: K04358] | | FGF10; fibroblast growth factor 10 [KO: K04358] | | FGF11; fibroblast growth factor 11 [KO: K04358] | | FGF12; fibroblast growth factor 12 [KO: K04358] | | FGF13; fibroblast growth factor 13 [KO: K04358] | | FGF14; fibroblast growth factor 14 [KO: K04358] | | FGF16; fibroblast growth factor 16 [KO: K04358] | | FGF5; fibroblast growth factor 5 [KO: K04358] | | FGF18; fibroblast growth factor 18 [KO: K04358] | | FGF19; fibroblast growth factor 19 [KO: K04358] | | FGF20; fibroblast growth factor 20 [KO: K04358] | | FGF21; fibroblast growth factor 21 [KO: K04358] | | FGF22; fibroblast growth factor 22 [KO: K04358] | | FGF23; fibroblast growth factor 23 [KO: K04358] | | | | | | | | GRB2; growth factor receptor-bound protein 2 [KO: K04364] | | SOS1; son of sevenless homolog 1 (Drosophila) [KO: K03099] | | SOS2; son of sevenless homolog 2 (Drosophila) [KO: K03099] | | HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO: K02833] | | KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO: K07827] | | NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO: K07828] | | ARAF; v-raf murine sarcoma 3611 viral oncogene homolog [KO: K08845] [EC: 2.7.11.1] | | BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO: K04365] [EC: 2.7.11.1] | | RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO: K04366] [EC: 2.7.11.1] | | MAP2K1; mitogen-activated protein kinase kinase 1 [KO: K04368] [EC: 2.7.12.2] | | MAP2K2; mitogen-activated protein kinase kinase 2 [KO: K04369] [EC: 2.7.12.2] | | | | | | JUN; jun proto-oncogene [KO: K04448] | | FOS; FBJ murine osteosarcoma viral oncogene homolog [KO: K04379] | | MMP1; matrix metallopeptidase 1 (interstitial collagenase) [KO: K01388] [EC: 3.4.24.7] | | MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [KO: K01398] [EC: 3.4.24.24] | | MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [KO: K01403] [EC: 3.4.24.35] | | IL8; interleukin 8 [KO: K10030] | | | | | | CCDC6; coiled-coil domain containing 6 [KO: K09288] | | NCOA4; nuclear receptor coactivator 4 [KO: K09289] | | NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO: K03176] [EC: 2.7.10.1] | | TPM3; tropomyosin 3 [KO: K09290] | | TPR; translocated promoter region, nuclear basket protein [KO: K09291] | | TFG; TRK-fused gene [KO: K09292] | | RASSF1; Ras association (RalGDS/AF-6) domain family member 1 [KO: K09850] | | RASSF5; Ras association (RalGDS/AF-6) domain family member 5 [KO: K08015] | | STK4; serine/threonine kinase 4 [KO: K04411] | | | | | | | | | | PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO: K05859] [EC: 3.1.4.11] | | | | | | | | RALGDS; ral guanine nucleotide dissociation stimulator [KO: K08732] | | RALA; v-ral simian leukemia viral oncogene homolog A (ras related) [KO: K07834] | | RALB; v-ral simian leukemia viral oncogene homolog B (ras related [KO: K07835] | | RALBP1; ralA binding protein 1 [KO: K08773] | | CDC42; cell division cycle 42 [KO: K04393] | | RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO: K04392] | | RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO: K07860] | | RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO: K07861] | | RHOA; ras homolog family member A [KO: K04513] | | | | | | | | PAX8; paired box 8 [KO: K09293] | | PPARG; peroxisome proliferator-activated receptor gamma [KO: K08530] | | RXRA; retinoid X receptor, alpha [KO: K08524] | | RXRB; retinoid X receptor, beta [KO: K08525] | | RXRG; retinoid X receptor, gamma [KO: K08526] | | RARB; retinoic acid receptor, beta [KO: K08528] | | PPARD; peroxisome proliferator-activated receptor delta [KO: K04504] | | JUP; junction plakoglobin [KO: K10056] | | ZBTB16; zinc finger and BTB domain containing 16 [KO: K10055] | | PML; promyelocytic leukemia [KO: K10054] | | RARA; retinoic acid receptor, alpha [KO: K08527] | | RUNX1; runt-related transcription factor 1 [KO: K08367] | | RUNX1T1; runt-related transcription factor 1 [KO: K10053] | | SPI1; spleen focus forming virus (SFFV) proviral integration oncogene spi1 [KO: K09438] | | CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha [KO: K09055] | | CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO: K05066] | | CSF3R; colony stimulating factor 3 receptor (granulocyte) [KO: K05061] | | | | IL6; interleukin 6 (interferon, beta 2) [KO: K05405] | | CDKN2A; cyclin-dependent kinase inhibitor 2A [KO: K06621] | | E2F1; E2F transcription factor 1 [KO: K06620] | | E2F3; E2F transcription factor 3 [KO: K06620] | | E2F2; E2F transcription factor 2 [KO: K09389] | | MAX; MYC associated factor X [KO: K04453] | | PIAS2; protein inhibitor of activated STAT, 2 [KO: K16063] [EC:6.3.2.-] | | CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO: K04685] | | | | CKS1B; CDC28 protein kinase regulatory subunit 1B [KO: K02219] | | CKS2; CDC28 protein kinase regulatory subunit 2 [KO: K02219] | | SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [KO: K03875] | | | | | | | | RB1; retinoblastoma 1 [KO: K06618] | | MITF; microphthalmia-associated transcription factor [KO: K09455] | | TGFB1; transforming growth factor, beta 1 [KO: K13375] | | TGFB2; transforming growth factor, beta 2 [KO: K13376] | | TGFB3; transforming growth factor, beta 3 [KO: K13377] | | TGFBR1; transforming growth factor, beta receptor 1 [KO: K04674] [EC: 2.7.11.30] | | TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO: K04388] [EC: 2.7.11.30] | | SMAD2; SMAD family member 2 [KO: K04500] | | SMAD3; SMAD family member 3 [KO: K04500] | | SMAD4; SMAD family member 4 [KO: K04501] | | MECOM; MDS1 and EVI1 complex locus [KO: K04462] | | CTBP1; C-terminal binding protein 1 [KO: K04496] | | CTBP2; C-terminal binding protein 2 [KO: K04496] | | | | | | MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [KO: K08734] | | MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) [KO: K08735] | | MSH3; mutS homolog 3 (E. coli) [KO: K08736] | | MSH6; mutS homolog 6 (E. coli) [KO: K08737] | | BAX; BCL2-associated X protein [KO: K02159] | | BRCA2; breast cancer 2, early onset [KO: K08775] | | RAD51; RAD51 homolog (S. cerevisiae) [KO: K04482] | | FASLG; Fas ligand (TNF superfamily, member 6) [KO: K04389] | | FAS; Fas (TNF receptor superfamily, member 6) [KO: K04390] | | FADD; Fas (TNFRSF6)-associated via death domain [KO: K02373] | | CASP8; caspase 8, apoptosis-related cysteine peptidase [KO: K04398] [EC: 3.4.22.61] | | BID; BH3 interacting domain death agonist [KO: K04726] | | CYCS; cytochrome c, somatic [KO: K08738] | | VHL; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase [KO: K03871] | | TCEB1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) [KO: K03872] | | TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) [KO: K03873] | | RBX1; ring-box 1, E3 ubiquitin protein ligase [KO: K03868] | | | | EGLN1; egl nine homolog 1 (C. elegans) [KO: K09592] [EC:1.14.11.-] | | EGLN3; egl nine homolog 3 (C. elegans) [KO: K09592] [EC:1.14.11.-] | | EGLN2; egl nine homolog 2 (C. elegans) [KO: K09592] [EC:1.14.11.-] | | | | HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [KO: K08268] | | EPAS1; endothelial PAS domain protein 1 [KO: K09095] | | ARNT; aryl hydrocarbon receptor nuclear translocator [KO: K09097] | | ARNT2; aryl-hydrocarbon receptor nuclear translocator 2 [KO: K15589] | | | | | | SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO: K07299] | | SHH; sonic hedgehog [KO: K11988] | | | | SMO; smoothened, frizzled family receptor [KO: K06226] | | | | SUFU; suppressor of fused homolog (Drosophila) [KO: K06229] | | GLI1; GLI family zinc finger 1 [KO: K16797] | | GLI2; GLI family zinc finger 2 [KO: K16798] | | GLI3; GLI family zinc finger 3 [KO: K06230] | | BMP2; bone morphogenetic protein 2 [KO: K04662] | | BMP4; bone morphogenetic protein 4 [KO: K04662] | | HHIP; hedgehog interacting protein [KO: K06231] | | | | AR; androgen receptor [KO: K08557] | | HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 [KO: K04079] | | HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 [KO: K04079] | | HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 [KO: K09487] | | | | ETS1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [KO: K02678] | | | | PLD1; phospholipase D1, phosphatidylcholine-specific [KO: K01115] [EC: 3.1.4.4] | | |
|
| Compound |
| Calcium cation | | Fumarate | | (S)-Malate | | Diacylglycerol | | Cholesterol | | Androstenedione | | Progesterone | | Phosphatidate | | Testosterone | | Cortisol | | Cortisone | | Retinoate | | Estradiol-17beta | | Dehydroepiandrosterone | | D-myo-Inositol 1,4,5-trisphosphate | | Dihydrotestosterone | | Phosphatidylinositol-3,4,5-trisphosphate | | Flutamide | | 9-cis-Retinoic acid | | 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine |
|
| Reference |
|
| Authors |
Weinberg RA. |
| Title |
The biology of cancer |
| Journal |
Garland Science, Taylor & Francis Group, LLC (2007) |
| Reference |
|
| Authors |
Hanahan D, Weinberg RA |
| Title |
The hallmarks of cancer. |
| Journal |
Cell 100:57-70 (2000) |
| Reference |
|
| Authors |
Grady WM. |
| Title |
Genomic instability and colon cancer. |
| Journal |
Cancer Metastasis Rev 23:11-27 (2004) |
| Reference |
|
| Authors |
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP. |
| Title |
Microsatellite instability in colorectal cancer. |
| Journal |
Br J Surg 93:395-406 (2006) |
| Reference |
|
| Authors |
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB. |
| Title |
Hereditary non-polyposis colorectal cancer: an updated review. |
| Journal |
Eur J Surg Oncol 26:635-45 (2000) |
| Reference |
|
| Authors |
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y. |
| Title |
Colorectal cancer: genetics of development and metastasis. |
| Journal |
J Gastroenterol 41:185-92 (2006) |
| Reference |
|
| Authors |
Lynch HT, de la Chapelle A. |
| Title |
Hereditary colorectal cancer. |
| Journal |
N Engl J Med 348:919-32 (2003) |
| Reference |
|
| Authors |
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. |
| Title |
The significance of unstable chromosomes in colorectal cancer. |
| Journal |
Nat Rev Cancer 3:695-701 (2003) |
| Reference |
|
| Authors |
Behrens J. |
| Title |
Cadherins and catenins: role in signal transduction and tumor progression. |
| Journal |
Cancer Metastasis Rev 18:15-30 (1999) |
| Reference |
|
| Authors |
Behrens J. |
| Title |
The role of the Wnt signalling pathway in colorectal tumorigenesis. |
| Journal |
Biochem Soc Trans 33:672-5 (2005) |
| Reference |
|
| Authors |
Behrens J, Lustig B. |
| Title |
The Wnt connection to tumorigenesis. |
| Journal |
Int J Dev Biol 48:477-87 (2004) |
| Reference |
|
| Authors |
Polakis P. |
| Title |
The adenomatous polyposis coli (APC) tumor suppressor. |
| Journal |
Biochim Biophys Acta 1332:F127-47 (1997) |
| Reference |
|
| Authors |
Janssen KP. |
| Title |
Murine models of colorectal cancer: studying the role of oncogenic K-ras. |
| Journal |
Cell Mol Life Sci 60:495-506 (2003) |
| Reference |
|
| Authors |
Adjei AA. |
| Title |
Blocking oncogenic Ras signaling for cancer therapy. |
| Journal |
J Natl Cancer Inst 93:1062-74 (2001) |
| Reference |
|
| Authors |
Arakawa H. |
| Title |
Netrin-1 and its receptors in tumorigenesis. |
| Journal |
Nat Rev Cancer 4:978-87 (2004) |
| Reference |
|
| Authors |
Mehlen P, Fearon ER. |
| Title |
Role of the dependence receptor DCC in colorectal cancer pathogenesis. |
| Journal |
J Clin Oncol 22:3420-8 (2004) |
| Reference |
|
| Authors |
Peltomaki P. |
| Title |
DNA mismatch repair and cancer. |
| Journal |
Mutat Res 488:77-85 (2001) |
| Reference |
|
| Authors |
Li F, Cao Y, Townsend CM Jr, Ko TC. |
| Title |
TGF-beta signaling in colon cancer cells. |
| Journal |
World J Surg 29:306-11 (2005) |
| Reference |
|
| Authors |
Roman C, Saha D, Beauchamp R. |
| Title |
TGF-beta and colorectal carcinogenesis. |
| Journal |
Microsc Res Tech 52:450-7 (2001) |
| Reference |
|
| Authors |
Watson AJ. |
| Title |
An overview of apoptosis and the prevention of colorectal cancer. |
| Journal |
Crit Rev Oncol Hematol 57:107-21 (2006) |
| Reference |
|
| Authors |
Watson AJ. |
| Title |
Apoptosis and colorectal cancer. |
| Journal |
Gut 53:1701-9 (2004) |
| Reference |
|
| Authors |
Houlston RS. |
| Title |
What we could do now: molecular pathology of colorectal cancer. |
| Journal |
Mol Pathol 54:206-14 (2001) |
| Reference |
|
| Authors |
Von Hoff DD, Evans DB, Hruban RH (ed). |
| Title |
Pancreatic Cancer |
| Journal |
Jones and bartlett publishers (2005) |
| Reference |
|
| Authors |
Niitsu Y, Yokota J (ed). |
| Title |
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese) |
| Journal |
Nankodo (1999) |
| Reference |
|
| Authors |
Bardeesy N, DePinho RA. |
| Title |
Pancreatic cancer biology and genetics. |
| Journal |
Nat Rev Cancer 2:897-909 (2002) |
| Reference |
|
| Authors |
Bardeesy N, Sharpless NE, DePinho RA, Merlino G. |
| Title |
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. |
| Journal |
Semin Cancer Biol 11:201-18 (2001) |
| Reference |
|
| Authors |
Cowgill SM, Muscarella P. |
| Title |
The genetics of pancreatic cancer. |
| Journal |
Am J Surg 186:279-86 (2003) |
| Reference |
|
| Authors |
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. |
| Title |
Genetics and biology of pancreatic ductal adenocarcinoma. |
| Journal |
Genes Dev 20:1218-49 (2006) |
| Reference |
|
| Authors |
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ. |
| Title |
Understanding Ras: 'it ain't over 'til it's over'. |
| Journal |
Trends Cell Biol 10:147-54 (2000) |
| Reference |
|
| Authors |
Holbro T, Civenni G, Hynes NE. |
| Title |
The ErbB receptors and their role in cancer progression. |
| Journal |
Exp Cell Res 284:99-110 (2003) |
| Reference |
|
| Authors |
Marmor MD, Skaria KB, Yarden Y. |
| Title |
Signal transduction and oncogenesis by ErbB/HER receptors. |
| Journal |
Int J Radiat Oncol Biol Phys 58:903-13 (2004) |
| Reference |
|
| Authors |
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW. |
| Title |
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines. |
| Journal |
Oncogene 22:7781-95 (2003) |
| Reference |
|
| Authors |
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. |
| Title |
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. |
| Journal |
Oncogene 22:319-29 (2003) |
| Reference |
|
| Authors |
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M. |
| Title |
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. |
| Journal |
Cancer Lett 201:107-16 (2003) |
| Reference |
|
| Authors |
Schmid RM. |
| Title |
Genetic basis of pancreatic cancer. |
| Journal |
Best Pract Res Clin Gastroenterol 16:421-33 (2002) |
| Reference |
|
| Authors |
Elliott RL, Blobe GC. |
| Title |
Role of transforming growth factor Beta in human cancer. |
| Journal |
J Clin Oncol 23:2078-93 (2005) |
| Reference |
|
| Authors |
Rudkin TM, Foulkes WD. |
| Title |
BRCA2: breaks, mistakes and failed separations. |
| Journal |
Trends Mol Med 11:145-8 (2005) |
| Reference |
|
| Authors |
Venkitaraman AR. |
| Title |
Functions of BRCA1 and BRCA2 in the biological response to DNA damage. |
| Journal |
J Cell Sci 114:3591-8 (2001) |
| Reference |
|
| Authors |
Soni D, King JA, Kaye AH, Hovens CM. |
| Title |
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. |
| Journal |
J Clin Neurosci 12:1-5 (2005) |
| Reference |
|
| Authors |
Zhu Y, Parada LF. |
| Title |
The molecular and genetic basis of neurological tumours. |
| Journal |
Nat Rev Cancer 2:616-26 (2002) |
| Reference |
|
| Authors |
Holland EC. |
| Title |
Gliomagenesis: genetic alterations and mouse models. |
| Journal |
Nat Rev Genet 2:120-9 (2001) |
| Reference |
|
| Authors |
Bansal K, Liang ML, Rutka JT. |
| Title |
Molecular biology of human gliomas. |
| Journal |
Technol Cancer Res Treat 5:185-94 (2006) |
| Reference |
|
| Authors |
Tabuchi K (ed). |
| Title |
[Gliomas: Research and therapy] (In Japanese) |
| Journal |
Springer-Verlag Tokyo (2006) |
| Reference |
|
| Authors |
Kapoor GS, O'Rourke DM. |
| Title |
Mitogenic signaling cascades in glial tumors. |
| Journal |
Neurosurgery 52:1425-34; discussion 1434-5 (2003) |
| Reference |
|
| Authors |
Hulleman E, Helin K. |
| Title |
Molecular mechanisms in gliomagenesis. |
| Journal |
Adv Cancer Res 94:1-27 (2005) |
| Reference |
|
| Authors |
Schlessinger J. |
| Title |
Cell signaling by receptor tyrosine kinases. |
| Journal |
Cell 103:211-25 (2000) |
| Reference |
|
| Authors |
Ng HK, Lam PY. |
| Title |
The molecular genetics of central nervous system tumors. |
| Journal |
Pathology 30:196-202 (1998) |
| Reference |
|
| Authors |
Knobbe CB, Merlo A, Reifenberger G. |
| Title |
Pten signaling in gliomas. |
| Journal |
Neuro-oncol 4:196-211 (2002) |
| Reference |
|
| Authors |
Kondo T, Ezzat S, Asa SL. |
| Title |
Pathogenetic mechanisms in thyroid follicular-cell neoplasia. |
| Journal |
Nat Rev Cancer 6:292-306 (2006) |
| Reference |
|
| Authors |
Chiloeches A, Marais R. |
| Title |
Is BRAF the Achilles' Heel of thyroid cancer? |
| Journal |
Clin Cancer Res 12:1661-4 (2006) |
| Reference |
|
| Authors |
Reddi HV, McIver B, Grebe SK, Eberhardt NL. |
| Title |
THE PAX8/PPAR{gamma} ONCOGENE IN THYROID TUMORIGENESIS. |
| Journal |
Endocrinology : (2006) |
| Reference |
|
| Authors |
Santoro M, Melillo RM, Fusco A. |
| Title |
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. |
| Journal |
Eur J Endocrinol 155:645-653 (2006) |
| Reference |
|
| Authors |
Pierotti MA, Greco A. |
| Title |
Oncogenic rearrangements of the NTRK1/NGF receptor. |
| Journal |
Cancer Lett 232:90-8 (2006) |
| Reference |
|
| Authors |
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P. |
| Title |
Molecular pathology of well-differentiated thyroid carcinomas. |
| Journal |
Virchows Arch 447:787-93 (2005) |
| Reference |
|
| Authors |
Gimm O. |
| Title |
Thyroid cancer. |
| Journal |
Cancer Lett 163:143-56 (2001) |
| Reference |
|
| Authors |
Williams D. |
| Title |
Cancer after nuclear fallout: lessons from the Chernobyl accident. |
| Journal |
Nat Rev Cancer 2:543-9 (2002) |
| Reference |
|
| Authors |
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H. |
| Title |
The molecular pathogenesis of acute myeloid leukemia. |
| Journal |
Crit Rev Oncol Hematol 56:195-221 (2005) |
| Reference |
|
| Authors |
Tenen DG. |
| Title |
Disruption of differentiation in human cancer: AML shows the way. |
| Journal |
Nat Rev Cancer 3:89-101 (2003) |
| Reference |
|
| Authors |
Choudhary C, Muller-Tidow C, Berdel WE, Serve H. |
| Title |
Signal transduction of oncogenic Flt3. |
| Journal |
Int J Hematol 82:93-9 (2005) |
| Reference |
|
| Authors |
Stirewalt DL, Radich JP. |
| Title |
The role of FLT3 in haematopoietic malignancies. |
| Journal |
Nat Rev Cancer 3:650-65 (2003) |
| Reference |
|
| Authors |
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L. |
| Title |
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. |
| Journal |
Leukemia 20:911-28 (2006) |
| Reference |
|
| Authors |
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R. |
| Title |
Normal and oncogenic forms of the receptor tyrosine kinase kit. |
| Journal |
Stem Cells 23:16-43 (2005) |
| Reference |
|
| Authors |
Lorsbach RB, Downing JR. |
| Title |
The role of the AML1 transcription factor in leukemogenesis. |
| Journal |
Int J Hematol 74:258-65 (2001) |
| Reference |
|
| Authors |
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H. |
| Title |
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. |
| Journal |
Blood 101:3164-73 (2003) |
| Reference |
|
| Authors |
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C. |
| Title |
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. |
| Journal |
Leukemia : (2007) |
| Reference |
|
| Authors |
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG. |
| Title |
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression. |
| Journal |
Blood 107:3330-8 (2006) |
| Reference |
|
| Authors |
Ren R. |
| Title |
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. |
| Journal |
Nat Rev Cancer 5:172-83 (2005) |
| Reference |
|
| Authors |
Deininger MW, Goldman JM, Melo JV. |
| Title |
The molecular biology of chronic myeloid leukemia. |
| Journal |
Blood 96:3343-56 (2000) |
| Reference |
|
| Authors |
Calabretta B, Perrotti D. |
| Title |
The biology of CML blast crisis. |
| Journal |
Blood 103:4010-22 (2004) |
| Reference |
|
| Authors |
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. |
| Title |
The biology of chronic myeloid leukemia. |
| Journal |
N Engl J Med 341:164-72 (1999) |
| Reference |
|
| Authors |
Mitani K. |
| Title |
Molecular mechanisms of leukemogenesis by AML1/EVI-1. |
| Journal |
Oncogene 23:4263-9 (2004) |
| Reference |
|
| Authors |
Dong M, Blobe GC. |
| Title |
Role of transforming growth factor-beta in hematologic malignancies. |
| Journal |
Blood 107:4589-96 (2006) |
| Reference |
|
| Authors |
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H. |
| Title |
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells. |
| Journal |
Blood 92:4003-12 (1998) |
| Reference |
|
| Authors |
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA. |
| Title |
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase. |
| Journal |
Haematologica 88:622-30 (2003) |
| Reference |
|
| Authors |
Baldwin AS. |
| Title |
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. |
| Journal |
J Clin Invest 107:241-6 (2001) |
| Reference |
|
| Authors |
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL. |
| Title |
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. |
| Journal |
Nat Med 8:1145-52 (2002) |
| Reference |
|
| Authors |
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC. |
| Title |
Molecular aetiology and pathogenesis of basal cell carcinoma. |
| Journal |
Br J Dermatol 152:1108-24 (2005) |
| Reference |
|
| Authors |
Saldanha G, Fletcher A, Slater DN. |
| Title |
Basal cell carcinoma: a dermatopathological and molecular biological update. |
| Journal |
Br J Dermatol 148:195-202 (2003) |
| Reference |
|
| Authors |
Daya-Grosjean L, Couve-Privat S. |
| Title |
Sonic hedgehog signaling in basal cell carcinomas. |
| Journal |
Cancer Lett 225:181-92 (2005) |
| Reference |
|
| Authors |
Tsai KY, Tsao H. |
| Title |
The genetics of skin cancer. |
| Journal |
Am J Med Genet C Semin Med Genet 131C:82-92 (2004) |
| Reference |
|
| Authors |
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL. |
| Title |
Hedgehog signalling in skin development and cancer. |
| Journal |
Exp Dermatol 15:667-77 (2006) |
| Reference |
|
| Authors |
Rubin AI, Chen EH, Ratner D. |
| Title |
Basal-cell carcinoma. |
| Journal |
N Engl J Med 353:2262-9 (2005) |
| Reference |
|
| Authors |
Saldanha G. |
| Title |
The Hedgehog signalling pathway and cancer. |
| Journal |
J Pathol 193:427-32 (2001) |
| Reference |
|
| Authors |
Saldanha G, Ghura V, Potter L, Fletcher A. |
| Title |
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation. |
| Journal |
Br J Dermatol 151:157-64 (2004) |
| Reference |
|
| Authors |
Pasca di Magliano M, Hebrok M. |
| Title |
Hedgehog signalling in cancer formation and maintenance. |
| Journal |
Nat Rev Cancer 3:903-11 (2003) |
| Reference |
|
| Authors |
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G. |
| Title |
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. |
| Journal |
Br J Dermatol 152:43-51 (2005) |
| Reference |
|
| Authors |
Cohen MM Jr. |
| Title |
The hedgehog signaling network. |
| Journal |
Am J Med Genet A 123:5-28 (2003) |
| Reference |
|
| Authors |
Yamazaki F, Aragane Y, Kawada A, Tezuka T. |
| Title |
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma. |
| Journal |
Br J Dermatol 145:771-7 (2001) |
| Reference |
|
| Authors |
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA. |
| Title |
Role of apoptosis in basal cell and squamous cell carcinoma formation. |
| Journal |
Immunol Lett 100:68-72 (2005) |
| Reference |
|
| Authors |
Toftgard R. |
| Title |
Hedgehog signalling in cancer. |
| Journal |
Cell Mol Life Sci 57:1720-31 (2000) |
| Reference |
|
| Authors |
Miller AJ, Mihm MC Jr. |
| Title |
Melanoma. |
| Journal |
N Engl J Med 355:51-65 (2006) |
| Reference |
|
| Authors |
Chin L. |
| Title |
The genetics of malignant melanoma: lessons from mouse and man. |
| Journal |
Nat Rev Cancer 3:559-70 (2003) |
| Reference |
|
| Authors |
Takata M, Saida T. |
| Title |
Genetic alterations in melanocytic tumors. |
| Journal |
J Dermatol Sci 43:1-10 (2006) |
| Reference |
|
| Authors |
Chudnovsky Y, Khavari PA, Adams AE. |
| Title |
Melanoma genetics and the development of rational therapeutics. |
| Journal |
J Clin Invest 115:813-24 (2005) |
| Reference |
|
| Authors |
Merlino G. |
| Title |
Cancer biology: the weakest link? |
| Journal |
Nature 436:33-5 (2005) |
| Reference |
|
| Authors |
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. |
| Title |
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. |
| Journal |
Nature 436:117-22 (2005) |
| Reference |
|
| Authors |
Levy C, Khaled M, Fisher DE. |
| Title |
MITF: master regulator of melanocyte development and melanoma oncogene. |
| Journal |
Trends Mol Med 12:406-14 (2006) |
| Reference |
|
| Authors |
Tsao H, Goel V, Wu H, Yang G, Haluska FG. |
| Title |
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. |
| Journal |
J Invest Dermatol 122:337-41 (2004) |
| Reference |
|
| Authors |
Gruss C, Herlyn M. |
| Title |
Role of cadherins and matrixins in melanoma. |
| Journal |
Curr Opin Oncol 13:117-23 (2001) |
| Reference |
|
| Authors |
Thompson JF, Scolyer RA, Kefford RF. |
| Title |
Cutaneous melanoma. |
| Journal |
Lancet 365:687-701 (2005) |
| Reference |
|
| Authors |
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J. |
| Title |
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. |
| Journal |
Clin Cancer Res 9:6483-8 (2003) |
| Reference |
|
| Authors |
Hussein MR. |
| Title |
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship? |
| Journal |
Tumour Biol 25:200-7 (2004) |
| Reference |
|
| Authors |
Lazar-Molnar E, Hegyesi H, Toth S, Falus A. |
| Title |
Autocrine and paracrine regulation by cytokines and growth factors in melanoma. |
| Journal |
Cytokine 12:547-54 (2000) |
| Reference |
|
| Authors |
Cohen HT, McGovern FJ. |
| Title |
Renal-cell carcinoma. |
| Journal |
N Engl J Med 353:2477-90 (2005) |
| Reference |
|
| Authors |
Pavlovich CP, Schmidt LS. |
| Title |
Searching for the hereditary causes of renal-cell carcinoma. |
| Journal |
Nat Rev Cancer 4:381-93 (2004) |
| Reference |
|
| Authors |
Linehan WM, Walther MM, Zbar B. |
| Title |
The genetic basis of cancer of the kidney. |
| Journal |
J Urol 170:2163-72 (2003) |
| Reference |
|
| Authors |
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. |
| Title |
Met, metastasis, motility and more. |
| Journal |
Nat Rev Mol Cell Biol 4:915-25 (2003) |
| Reference |
|
| Authors |
Kim WY, Kaelin WG. |
| Title |
Role of VHL gene mutation in human cancer. |
| Journal |
J Clin Oncol 22:4991-5004 (2004) |
| Reference |
|
| Authors |
Sudarshan S, Linehan WM, Neckers L. |
| Title |
HIF and fumarate hydratase in renal cancer. |
| Journal |
Br J Cancer 96:403-7 (2007) |
| Reference |
|
| Authors |
Sudarshan S, Pinto PA, Neckers L, Linehan WM. |
| Title |
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. |
| Journal |
Nat Clin Pract Urol 4:104-10 (2007) |
| Reference |
|
| Authors |
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG. |
| Title |
Understanding familial and non-familial renal cell cancer. |
| Journal |
Hum Mol Genet 11:2489-98 (2002) |
| Reference |
|
| Authors |
Mitra AP, Datar RH, Cote RJ. |
| Title |
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification. |
| Journal |
J Clin Oncol 24:5552-64 (2006) |
| Reference |
|
| Authors |
Wolff EM, Liang G, Jones PA. |
| Title |
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer. |
| Journal |
Nat Clin Pract Urol 2:502-10 (2005) |
| Reference |
|
| Authors |
Wu XR. |
| Title |
Urothelial tumorigenesis: a tale of divergent pathways. |
| Journal |
Nat Rev Cancer 5:713-25 (2005) |
| Reference |
|
| Authors |
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R. |
| Title |
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. |
| Journal |
Cancer Res 60:6298-302 (2000) |
| Reference |
|
| Authors |
Bellmunt J, Hussain M, Dinney CP. |
| Title |
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family. |
| Journal |
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003) |
| Reference |
|
| Authors |
Sugano K, Kakizoe T. |
| Title |
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging. |
| Journal |
Nat Clin Pract Urol 3:642-52 (2006) |
| Reference |
|
| Authors |
Dunn KL, Espino PS, Drobic B, He S, Davie JR. |
| Title |
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling. |
| Journal |
Biochem Cell Biol 83:1-14 (2005) |
| Reference |
|
| Authors |
Williams SG, Stein JP. |
| Title |
Molecular pathways in bladder cancer. |
| Journal |
Urol Res 32:373-85 (2004) |
| Reference |
|
| Authors |
Nelson WG, De Marzo AM, Isaacs WB. |
| Title |
Prostate cancer. |
| Journal |
N Engl J Med 349:366-81 (2003) |
| Reference |
|
| Authors |
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC. |
| Title |
The emerging role of the PI3-K-Akt pathway in prostate cancer progression. |
| Journal |
Prostate Cancer Prostatic Dis 8:108-18 (2005) |
| Reference |
|
| Authors |
Pienta KJ, Bradley D. |
| Title |
Mechanisms underlying the development of androgen-independent prostate cancer. |
| Journal |
Clin Cancer Res 12:1665-71 (2006) |
| Reference |
|
| Authors |
Feldman BJ, Feldman D. |
| Title |
The development of androgen-independent prostate cancer. |
| Journal |
Nat Rev Cancer 1:34-45 (2001) |
| Reference |
|
| Authors |
Heinlein CA, Chang C. |
| Title |
Androgen receptor in prostate cancer. |
| Journal |
Endocr Rev 25:276-308 (2004) |
| Reference |
|
| Authors |
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP. |
| Title |
Androgen receptor gene and hormonal therapy failure of prostate cancer. |
| Journal |
Am J Pathol 152:1-9 (1998) |
| Reference |
|
| Authors |
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D. |
| Title |
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. |
| Journal |
Nat Med 6:703-6 (2000) |
| Reference |
|
| Authors |
Macri E, Loda M. |
| Title |
Role of p27 in prostate carcinogenesis. |
| Journal |
Cancer Metastasis Rev 17:337-44 (1998) |
| Reference |
|
| Authors |
Steers WD. |
| Title |
5alpha-reductase activity in the prostate. |
| Journal |
Urology 58:17-24; discussion 24 (2001) |
| Reference |
|
| Authors |
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF. |
| Title |
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis. |
| Journal |
Cancer Res 54:4920-6 (1994) |
| Reference |
|
| Authors |
Grimes CA, Jope RS. |
| Title |
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. |
| Journal |
Prog Neurobiol 65:391-426 (2001) |
| Reference |
|
| Authors |
Ryan AJ, Susil B, Jobling TW, Oehler MK. |
| Title |
Endometrial cancer. |
| Journal |
Cell Tissue Res 322:53-61 (2005) |
| Reference |
|
| Authors |
Lax SF. |
| Title |
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. |
| Journal |
Virchows Arch 444:213-23 (2004) |
| Reference |
|
| Authors |
Shiozawa T, Konishi I. |
| Title |
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment. |
| Journal |
Int J Clin Oncol 11:13-21 (2006) |
| Reference |
|
| Authors |
Hecht JL, Mutter GL. |
| Title |
Molecular and pathologic aspects of endometrial carcinogenesis. |
| Journal |
J Clin Oncol 24:4783-91 (2006) |
| Reference |
|
| Authors |
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J. |
| Title |
Molecular pathology of endometrial hyperplasia and carcinoma. |
| Journal |
Hum Pathol 32:569-77 (2001) |
| Reference |
|
| Authors |
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH. |
| Title |
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma. |
| Journal |
J Clin Oncol 22:3126-32 (2004) |
| Reference |
|
| Authors |
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF. |
| Title |
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival. |
| Journal |
Cancer Res 55:5693-8 (1995) |
| Reference |
|
| Authors |
Kim D, Chung J. |
| Title |
Akt: versatile mediator of cell survival and beyond. |
| Journal |
J Biochem Mol Biol 35:106-15 (2002) |
| Reference |
|
| Authors |
Sanchez-Cespedes M. |
| Title |
Dissecting the genetic alterations involved in lung carcinogenesis. |
| Journal |
Lung Cancer 40:111-21 (2003) |
| Reference |
|
| Authors |
Kaye FJ. |
| Title |
Molecular biology of lung cancer. |
| Journal |
Lung Cancer 34 Suppl 2:S35-41 (2001) |
| Reference |
|
| Authors |
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF. |
| Title |
Apoptosis and lung cancer: a review. |
| Journal |
J Cell Biochem 88:885-98 (2003) |
| Reference |
|
| Authors |
Sartorius UA, Krammer PH. |
| Title |
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. |
| Journal |
Int J Cancer 97:584-92 (2002) |
| Reference |
|
| Authors |
Adhikary S, Eilers M. |
| Title |
Transcriptional regulation and transformation by Myc proteins. |
| Journal |
Nat Rev Mol Cell Biol 6:635-45 (2005) |
| Reference |
|
| Authors |
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI. |
| Title |
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. |
| Journal |
Mol Cell 7:639-50 (2001) |
| Reference |
|
| Authors |
Buttery RC, Rintoul RC, Sethi T. |
| Title |
Small cell lung cancer: the importance of the extracellular matrix. |
| Journal |
Int J Biochem Cell Biol 36:1154-60 (2004) |
| Reference |
|
| Authors |
Yamada KM, Araki M. |
| Title |
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. |
| Journal |
J Cell Sci 114:2375-82 (2001) |
| Reference |
|
| Authors |
Rintoul RC, Sethi T. |
| Title |
The role of extracellular matrix in small-cell lung cancer. |
| Journal |
Lancet Oncol 2:437-42 (2001) |
| Reference |
|
| Authors |
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B. |
| Title |
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells. |
| Journal |
Exp Cell Res 279:277-90 (2002) |
| Reference |
|
| Authors |
Osada H, Takahashi T. |
| Title |
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
| Journal |
Oncogene 21:7421-34 (2002) |
| Reference |
|
| Authors |
Yokota J, Nishioka M, Tani M, Kohno T. |
| Title |
Genetic alterations responsible for metastatic phenotypes of lung cancer cells. |
| Journal |
Clin Exp Metastasis 20:189-93 (2003) |
| Reference |
|
| Authors |
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS. |
| Title |
K-ras mutations in non-small-cell lung carcinoma: a review. |
| Journal |
Clin Lung Cancer 8:30-8 (2006) |
| Reference |
|
| Authors |
Pfeifer GP, Dammann R. |
| Title |
Methylation of the tumor suppressor gene RASSF1A in human tumors. |
| Journal |
Biochemistry (Mosc) 70:576-83 (2005) |
| Reference |
|
| Authors |
Altucci L, Gronemeyer H. |
| Title |
The promise of retinoids to fight against cancer. |
| Journal |
Nat Rev Cancer 1:181-93 (2001) |
| Reference |
|
| Authors |
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF. |
| Title |
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas. |
| Journal |
J Natl Cancer Inst 92:1303-7 (2000) |
| Reference |
|
| Authors |
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA. |
| Title |
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies. |
| Journal |
Lung Cancer 41 Suppl 1:S29-42 (2003) |
| Reference |
|
| Authors |
Panani AD, Roussos C. |
| Title |
Cytogenetic and molecular aspects of lung cancer. |
| Journal |
Cancer Lett 239:1-9 (2006) |
| Reference |
|
| Authors |
Mitsuuchi Y, Testa JR. |
| Title |
Cytogenetics and molecular genetics of lung cancer. |
| Journal |
Am J Med Genet 115:183-8 (2002) |
| Reference |
|
| Authors |
Breuer RH, Postmus PE, Smit EF. |
| Title |
Molecular pathology of non-small-cell lung cancer. |
| Journal |
Respiration 72:313-30 (2005) |
| Reference |
|
| Authors |
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE. |
| Title |
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung. |
| Journal |
Clin Cancer Res 8:734-44 (2002) |
| Reference |
|
| Authors |
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K. |
| Title |
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung. |
| Journal |
J Clin Pathol 58:1076-80 (2005) |
| KO pathway |
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