KEGG   PATHWAY: hsa05216Help
Entry
hsa05216                    Pathway                                

Name
Thyroid cancer - Homo sapiens (human)
Description
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells.  Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
Class
Human Diseases; Cancers
BRITE hierarchy
Pathway map
Thyroid cancer
hsa05216

All organismsOrtholog table
Disease
H00032  
Thyroid cancer
Organism
Homo sapiens (human) [GN:hsa]
Gene
5979  
RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
8030  
CCDC6; coiled-coil domain containing 6 [KO:K09288]
8031  
NCOA4; nuclear receptor coactivator 4 [KO:K09289]
4914  
NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
7170  
TPM3; tropomyosin 3 [KO:K09290]
7175  
TPR; translocated promoter region, nuclear basket protein [KO:K09291]
10342  
TFG; TRK-fused gene [KO:K09292]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
4893  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
3845  
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
673  
BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
7849  
PAX8; paired box 8 [KO:K09293]
5468  
PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
6256  
RXRA; retinoid X receptor alpha [KO:K08524]
6257  
RXRB; retinoid X receptor beta [KO:K08525]
6258  
RXRG; retinoid X receptor gamma [KO:K08526]
7157  
TP53; tumor protein p53 [KO:K04451]
999  
CDH1; cadherin 1 [KO:K05689]
1499  
CTNNB1; catenin beta 1 [KO:K02105]
6932  
TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
83439  
TCF7L1; transcription factor 7 like 1 [KO:K04490]
6934  
TCF7L2; transcription factor 7 like 2 [KO:K04491]
51176  
LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
4609  
MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
595  
CCND1; cyclin D1 [KO:K04503]
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL.
  Title
THE PAX8/PPAR{gamma} ONCOGENE IN THYROID TUMORIGENESIS.
  Journal
Endocrinology : (2006)
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
KO pathway
 

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