KEGG PATHWAY: ko00190

PATHWAY: ko00190

Entry

ko00190 Pathway

Name

Oxidative phosphorylation

Class

Metabolism; Energy metabolism

Pathway map

ko00190

Oxidative phosphorylation

Module

M00142	NADH:ubiquinone oxidoreductase, mitochondria [PATH:ko00190]
M00143	NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:ko00190]
M00144	NADH:quinone oxidoreductase, prokaryotes [PATH:ko00190]
M00145	NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria [PATH:ko00190]
M00146	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:ko00190]
M00147	NADH dehydrogenase (ubiquinone) 1 beta subcomplex [PATH:ko00190]
M00148	Succinate dehydrogenase (ubiquinone) [PATH:ko00190]
M00149	Succinate dehydrogenase, prokaryotes [PATH:ko00190]
M00150	Fumarate reductase, prokaryotes [PATH:ko00190]
M00151	Cytochrome bc1 complex respiratory unit [PATH:ko00190]
M00152	Cytochrome bc1 complex [PATH:ko00190]
M00153	Cytochrome d ubiquinol oxidase [PATH:ko00190]
M00154	Cytochrome c oxidase [PATH:ko00190]
M00155	Cytochrome c oxidase, prokaryotes [PATH:ko00190]
M00156	Cytochrome c oxidase, cbb3-type [PATH:ko00190]
M00157	F-type ATPase, bacteria [PATH:ko00190]
M00158	F-type ATPase, eukaryotes [PATH:ko00190]
M00159	V-type ATPase, prokaryotes [PATH:ko00190]
M00160	V-type ATPase, eukaryotes [PATH:ko00190]
M00416	Cytochrome aa3-600 menaquinol oxidase [PATH:ko00190]
M00417	Cytochrome o ubiquinol oxidase [PATH:ko00190]

Disease

H00068	Leber optic atrophy
H00473	Mitochondrial respiratory chain deficiencies (MRCD)
H00920	Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis
H01177	Infantile bilateral striatal necrosis (IBSN)
H01222	Cowden-like syndrome

Orthology

K00329	NADH dehydrogenase [EC:1.6.5.3]
K00330	NADH-quinone oxidoreductase subunit A [EC:1.6.5.3]
K00331	NADH-quinone oxidoreductase subunit B [EC:1.6.5.3]
K00332	NADH-quinone oxidoreductase subunit C [EC:1.6.5.3]
K00333	NADH-quinone oxidoreductase subunit D [EC:1.6.5.3]
K13378	NADH-quinone oxidoreductase subunit C/D [EC:1.6.5.3]
K13380	NADH-quinone oxidoreductase subunit B/C/D [EC:1.6.5.3]
K00334	NADH-quinone oxidoreductase subunit E [EC:1.6.5.3]
K00335	NADH-quinone oxidoreductase subunit F [EC:1.6.5.3]
K00336	NADH-quinone oxidoreductase subunit G [EC:1.6.5.3]
K00337	NADH-quinone oxidoreductase subunit H [EC:1.6.5.3]
K00338	NADH-quinone oxidoreductase subunit I [EC:1.6.5.3]
K00339	NADH-quinone oxidoreductase subunit J [EC:1.6.5.3]
K00340	NADH-quinone oxidoreductase subunit K [EC:1.6.5.3]
K00341	NADH-quinone oxidoreductase subunit L [EC:1.6.5.3]
K00342	NADH-quinone oxidoreductase subunit M [EC:1.6.5.3]
K15863	NADH-quinone oxidoreductase subunit L/M [EC:1.6.5.3]
K00343	NADH-quinone oxidoreductase subunit N [EC:1.6.5.3]
K05572	NAD(P)H-quinone oxidoreductase subunit 1 [EC:1.6.5.3]
K05573	NAD(P)H-quinone oxidoreductase subunit 2 [EC:1.6.5.3]
K05574	NAD(P)H-quinone oxidoreductase subunit 3 [EC:1.6.5.3]
K05575	NAD(P)H-quinone oxidoreductase subunit 4 [EC:1.6.5.3]
K05576	NAD(P)H-quinone oxidoreductase subunit 4L [EC:1.6.5.3]
K05577	NAD(P)H-quinone oxidoreductase subunit 5 [EC:1.6.5.3]
K05578	NAD(P)H-quinone oxidoreductase subunit 6 [EC:1.6.5.3]
K05579	NAD(P)H-quinone oxidoreductase subunit H [EC:1.6.5.3]
K05580	NAD(P)H-quinone oxidoreductase subunit I [EC:1.6.5.3]
K05581	NAD(P)H-quinone oxidoreductase subunit J [EC:1.6.5.3]
K05582	NAD(P)H-quinone oxidoreductase subunit K [EC:1.6.5.3]
K05583	NAD(P)H-quinone oxidoreductase subunit L [EC:1.6.5.3]
K05584	NAD(P)H-quinone oxidoreductase subunit M [EC:1.6.5.3]
K05585	NAD(P)H-quinone oxidoreductase subunit N [EC:1.6.5.3]
K05586	bidirectional [NiFe] hydrogenase diaphorase subunit [EC:1.6.5.3]
K05587	bidirectional [NiFe] hydrogenase diaphorase subunit [EC:1.6.5.3]
K05588	bidirectional [NiFe] hydrogenase diaphorase subunit [EC:1.6.5.3]
K03878	NADH-ubiquinone oxidoreductase chain 1 [EC:1.6.5.3]
K03879	NADH-ubiquinone oxidoreductase chain 2 [EC:1.6.5.3]
K03880	NADH-ubiquinone oxidoreductase chain 3 [EC:1.6.5.3]
K03881	NADH-ubiquinone oxidoreductase chain 4 [EC:1.6.5.3]
K03882	NADH-ubiquinone oxidoreductase chain 4L [EC:1.6.5.3]
K03883	NADH-ubiquinone oxidoreductase chain 5 [EC:1.6.5.3]
K03884	NADH-ubiquinone oxidoreductase chain 6 [EC:1.6.5.3]
K03934	NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:1.6.99.3 1.6.5.3]
K03935	NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:1.6.99.3 1.6.5.3]
K03936	NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:1.6.99.3 1.6.5.3]
K03937	NADH dehydrogenase (ubiquinone) Fe-S protein 4 [EC:1.6.99.3 1.6.5.3]
K03938	NADH dehydrogenase (ubiquinone) Fe-S protein 5 [EC:1.6.99.3 1.6.5.3]
K03939	NADH dehydrogenase (ubiquinone) Fe-S protein 6 [EC:1.6.99.3 1.6.5.3]
K03940	NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:1.6.99.3 1.6.5.3]
K03941	NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:1.6.99.3 1.6.5.3]
K03942	NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:1.6.99.3 1.6.5.3]
K03943	NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:1.6.99.3 1.6.5.3]
K03944	NADH dehydrogenase (ubiquinone) flavoprotein 3 [EC:1.6.99.3 1.6.5.3]
K03945	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 [EC:1.6.99.3 1.6.5.3]
K03946	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 [EC:1.6.99.3 1.6.5.3]
K03947	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 3 [EC:1.6.99.3 1.6.5.3]
K03948	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 [EC:1.6.99.3 1.6.5.3]
K03949	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 [EC:1.6.99.3 1.6.5.3]
K03950	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 6 [EC:1.6.99.3 1.6.5.3]
K03951	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 7 [EC:1.6.99.3 1.6.5.3]
K03952	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8 [EC:1.6.99.3 1.6.5.3]
K03953	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 9 [EC:1.6.99.3 1.6.5.3]
K03954	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 [EC:1.6.99.3 1.6.5.3]
K03955	NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 [EC:1.6.99.3 1.6.5.3]
K03956	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 [EC:1.6.5.3]
K11352	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 12 [EC:1.6.99.3 1.6.5.3]
K11353	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 13 [EC:1.6.99.3 1.6.5.3]
K03957	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 1 [EC:1.6.99.3 1.6.5.3]
K03958	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 2 [EC:1.6.99.3 1.6.5.3]
K03959	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 [EC:1.6.99.3 1.6.5.3]
K03960	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4 [EC:1.6.99.3 1.6.5.3]
K03961	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 5 [EC:1.6.99.3 1.6.5.3]
K03962	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 6 [EC:1.6.99.3 1.6.5.3]
K03963	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 7 [EC:1.6.99.3 1.6.5.3]
K03964	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 [EC:1.6.99.3 1.6.5.3]
K03965	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 9 [EC:1.6.99.3 1.6.5.3]
K03966	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 10 [EC:1.6.99.3 1.6.5.3]
K11351	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 11 [EC:1.6.99.3 1.6.5.3]
K03967	NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 1 [EC:1.6.99.3 1.6.5.3]
K03968	NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 2 [EC:1.6.99.3 1.6.5.3]
K00356	NADH dehydrogenase [EC:1.6.99.3]
K03885	NADH dehydrogenase [EC:1.6.99.3]
K05903	NADH dehydrogenase (quinone) [EC:1.6.99.5]
K00239	succinate dehydrogenase flavoprotein subunit [EC:1.3.99.1]
K00240	succinate dehydrogenase iron-sulfur subunit [EC:1.3.99.1]
K00241	succinate dehydrogenase cytochrome b556 subunit
K00242	succinate dehydrogenase membrane anchor subunit
K00244	fumarate reductase flavoprotein subunit [EC:1.3.99.1]
K00245	fumarate reductase iron-sulfur subunit [EC:1.3.99.1]
K00246	fumarate reductase subunit C
K00247	fumarate reductase subunit D
K00236	succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237	succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00234	succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235	succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00411	ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]
K00412	ubiquinol-cytochrome c reductase cytochrome b subunit
K00413	ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00410	ubiquinol-cytochrome c reductase cytochrome b/c1 subunit
K00414	ubiquinol-cytochrome c reductase core subunit 1
K00415	ubiquinol-cytochrome c reductase core subunit 2
K00416	ubiquinol-cytochrome c reductase subunit 6
K00417	ubiquinol-cytochrome c reductase subunit 7
K00418	ubiquinol-cytochrome c reductase subunit 8
K00419	ubiquinol-cytochrome c reductase subunit 9
K00420	ubiquinol-cytochrome c reductase subunit 10
K03886	menaquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.-]
K03887	menaquinol-cytochrome c reductase cytochrome b subunit
K03888	menaquinol-cytochrome c reductase cytochrome b/c subunit
K03889	ubiquinol-cytochrome c reductase cytochrome c subunit
K03890	ubiquinol-cytochrome c reductase iron-sulfur subunit
K03891	ubiquinol-cytochrome c reductase cytochrome b subunit
K02301	protoheme IX farnesyltransferase [EC:2.5.1.-]
K02257	protoheme IX farnesyltransferase [EC:2.5.1.-]
K02300	cytochrome o ubiquinol oxidase operon protein cyoD
K02277	cytochrome c oxidase subunit IV [EC:1.9.3.1]
K02276	cytochrome c oxidase subunit III [EC:1.9.3.1]
K02274	cytochrome c oxidase subunit I [EC:1.9.3.1]
K15408	cytochrome c oxidase subunit I+III [EC:1.9.3.1]
K02275	cytochrome c oxidase subunit II [EC:1.9.3.1]
K02262	cytochrome c oxidase subunit 3
K02256	cytochrome c oxidase subunit 1 [EC:1.9.3.1]
K02261	cytochrome c oxidase subunit 2
K02263	cytochrome c oxidase subunit 4
K02264	cytochrome c oxidase subunit 5a
K02265	cytochrome c oxidase subunit 5b
K02266	cytochrome c oxidase subunit 6a
K02267	cytochrome c oxidase subunit 6b
K02268	cytochrome c oxidase subunit 6c
K02269	cytochrome c oxidase subunit 7
K02270	cytochrome c oxidase subunit 7a
K02271	cytochrome c oxidase subunit 7b
K02272	cytochrome c oxidase subunit 7c
K02273	cytochrome c oxidase subunit 8
K02258	cytochrome c oxidase assembly protein subunit 11
K02259	cytochrome c oxidase assembly protein subunit 15
K02260	cytochrome c oxidase assembly protein subunit 17
K00404	cytochrome c oxidase cbb3-type subunit I [EC:1.9.3.1]
K00405	cytochrome c oxidase cbb3-type subunit II
K15862	cytochrome c oxidase cbb3-type subunit I/II [EC:1.9.3.1]
K00407	cytochrome c oxidase cbb3-type subunit IV
K00406	cytochrome c oxidase cbb3-type subunit III
K02829	cytochrome aa3-600 menaquinol oxidase subunit IV [EC:1.10.3.12]
K02828	cytochrome aa3-600 menaquinol oxidase subunit III [EC:1.10.3.12]
K02827	cytochrome aa3-600 menaquinol oxidase subunit I [EC:1.10.3.12]
K02826	cytochrome aa3-600 menaquinol oxidase subunit II [EC:1.10.3.12]
K02299	cytochrome o ubiquinol oxidase subunit III [EC:1.10.3.-]
K02298	cytochrome o ubiquinol oxidase subunit I [EC:1.10.3.-]
K02297	cytochrome o ubiquinol oxidase subunit II [EC:1.10.3.-]
K00425	cytochrome d ubiquinol oxidase subunit I [EC:1.10.3.-]
K00426	cytochrome d ubiquinol oxidase subunit II [EC:1.10.3.-]
K02114	F-type H+-transporting ATPase subunit epsilon [EC:3.6.3.14]
K02112	F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]
K02115	F-type H+-transporting ATPase subunit gamma [EC:3.6.3.14]
K02111	F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]
K02113	F-type H+-transporting ATPase subunit delta [EC:3.6.3.14]
K02109	F-type H+-transporting ATPase subunit b [EC:3.6.3.14]
K02110	F-type H+-transporting ATPase subunit c [EC:3.6.3.14]
K02108	F-type H+-transporting ATPase subunit a [EC:3.6.3.14]
K02135	F-type H+-transporting ATPase subunit epsilon [EC:3.6.3.14]
K02134	F-type H+-transporting ATPase subunit delta [EC:3.6.3.14]
K02133	F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]
K02136	F-type H+-transporting ATPase subunit gamma [EC:3.6.3.14]
K02132	F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]
K02137	F-type H+-transporting ATPase oligomycin sensitivity conferral protein [EC:3.6.3.14]
K02125	F-type H+-transporting ATPase subunit 8 [EC:3.6.3.14]
K02128	F-type H+-transporting ATPase subunit c [EC:3.6.3.14]
K02126	F-type H+-transporting ATPase subunit a [EC:3.6.3.14]
K02127	F-type H+-transporting ATPase subunit b [EC:3.6.3.14]
K02129	F-type H+-transporting ATPase subunit e [EC:3.6.3.14]
K02131	F-type H+-transporting ATPase subunit 6 [EC:3.6.3.14]
K02130	F-type H+-transporting ATPase subunit f [EC:3.6.3.14]
K02138	F-type H+-transporting ATPase subunit d [EC:3.6.3.14]
K02139	F-type H+-transporting ATPase subunit f [EC:3.6.3.14]
K02141	F-type H+-transporting ATPase subunit h [EC:3.6.3.14]
K02142	F-type H+-transporting ATPase subunit j [EC:3.6.3.14]
K02143	F-type H+-transporting ATPase subunit k [EC:3.6.3.14]
K02140	F-type H+-transporting ATPase subunit g [EC:3.6.3.14]
K02119	V-type H+-transporting ATPase subunit C [EC:3.6.3.14]
K02122	V-type H+-transporting ATPase subunit F [EC:3.6.3.14]
K02117	V-type H+-transporting ATPase subunit A [EC:3.6.3.14]
K02118	V-type H+-transporting ATPase subunit B [EC:3.6.3.14]
K02121	V-type H+-transporting ATPase subunit E [EC:3.6.3.14]
K02124	V-type H+-transporting ATPase subunit K [EC:3.6.3.14]
K02123	V-type H+-transporting ATPase subunit I [EC:3.6.3.14]
K02120	V-type H+-transporting ATPase subunit D [EC:3.6.3.14]
K02146	V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]
K02151	V-type H+-transporting ATPase subunit F [EC:3.6.3.14]
K02148	V-type H+-transporting ATPase subunit C [EC:3.6.3.14]
K02145	V-type H+-transporting ATPase subunit A [EC:3.6.3.14]
K02147	V-type H+-transporting ATPase subunit B [EC:3.6.3.14]
K02150	V-type H+-transporting ATPase subunit E [EC:3.6.3.14]
K02155	V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14]
K03661	V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14]
K02154	V-type H+-transporting ATPase subunit I [EC:3.6.3.14]
K02149	V-type H+-transporting ATPase subunit D [EC:3.6.3.14]
K02153	V-type H+-transporting ATPase subunit H [EC:3.6.3.14]
K02152	V-type H+-transporting ATPase subunit G [EC:3.6.3.14]
K02144	V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14]
K03662	V-type H+-transporting ATPase S1 subunit [EC:3.6.3.14]
K01535	H+-transporting ATPase [EC:3.6.3.6]
K01541	H+/K+-exchanging ATPase [EC:3.6.3.10]
K01542	H+/K+-exchanging ATPase alpha polypeptide [EC:3.6.3.10]
K01543	H+/K+-exchanging ATPase beta polypeptide [EC:3.6.3.10]
K01544	non-gastric H+/K+-exchanging ATPase [EC:3.6.3.10]
K01507	inorganic pyrophosphatase [EC:3.6.1.1]
K15986	manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]
K06019	pyrophosphatase PpaX [EC:3.6.1.1]
K15987	K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1]
K11725	phospholysine phosphohistidine inorganic pyrophosphate phosphatase [EC:3.1.3.- 3.6.1.1]
K11726	nucleosome-remodeling factor 38 kDa subunit [EC:3.6.1.1]
K00937	polyphosphate kinase [EC:2.7.4.1]

Compound

C00001	H2O
C00002	ATP
C00003	NAD+
C00004	NADH
C00007	Oxygen
C00008	ADP
C00009	Orthophosphate
C00013	Diphosphate
C00042	Succinate
C00061	FMN
C00080	H+
C00122	Fumarate
C00390	Ubiquinol
C00399	Ubiquinone
C00524	Cytochrome c
C00536	Triphosphate

Reference

PMID:16469879

Authors

Sazanov LA, Hinchliffe P.

Title

Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.

Journal

Science 311:1430-6 (2006)

Reference

PMID:16584177

Authors

Hinchliffe P, Carroll J, Sazanov LA.

Title

Identification of a novel subunit of respiratory complex I from Thermus thermophilus.

Journal

Biochemistry 45:4413-20 (2006)

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (25)   
   KEGG PATHWAY (3)   
   KEGG MODULE (21)   
   BioSystems (1)   
Disease (5)   
   KEGG DISEASE (5)   
Chemical substance (16)   
   KEGG COMPOUND (16)   
Chemical reaction (17)   
   KEGG ENZYME (17)   
Gene (212)   
   KEGG ORTHOLOGY (212)   
Literature (2)   
   PubMed (2)   
All databases (278)   

Download RDF

DBGET integrated database retrieval system