KEGG PATHWAY: ko00310

PATHWAY: ko00310

Entry

ko00310 Pathway

Name

Lysine degradation

Class

Metabolism; Amino acid metabolism

Pathway map

ko00310

Lysine degradation

Module

M00032

Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:ko00310]

Disease

H00178	Glutaric acidemia
H00188	Hyperlysinemia
H00570	Kabuki syndrome
H00802	Ehlers-Danlos syndrome (EDS)
H00907	Kleefstra syndrome
H00980	Nevo syndrome
H01192	Lysyl hydroxylase 3 (LH3) deficiency
H01242	Saccharopinuria
H01247	Pyridoxine-dependent epilepsy (PDE)

Orthology

K00290	saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
K00291	saccharopine dehydrogenase (NADP+, L-lysine forming) [EC:1.5.1.8]
K00292	saccharopine dehydrogenase (NAD+, L-glutamate forming) [EC:1.5.1.9]
K14157	alpha-aminoadipic semialdehyde synthase [EC:1.5.1.9 1.5.1.8]
K00293	saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
K00143	L-aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31]
K14085	aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00825	kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.39 2.6.1.7]
K00164	2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00658	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K00252	glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01692	enoyl-CoA hydratase [EC:4.2.1.17]
K01825	3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:5.3.3.8 5.1.2.3 4.2.1.17 1.1.1.35]
K01782	3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:5.1.2.3 4.2.1.17 1.1.1.35]
K07515	enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.211 4.2.1.17]
K07514	enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07511	enoyl-CoA hydratase [EC:4.2.1.17]
K00022	3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00626	acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K01582	lysine decarboxylase [EC:4.1.1.18]
K14268	5-aminovalerate aminotransferase [EC:2.6.1.48]
K14269	glutarate semialdehyde dehydrogenase [EC:1.2.1.20]
K03897	lysine N6-hydroxylase [EC:1.14.13.59]
K03896	acetyl CoA:N6-hydroxylysine acetyl transferase [EC:2.3.1.102]
K03894	N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38]
K03895	aerobactin synthase [EC:6.3.2.39]
K01843	lysine 2,3-aminomutase [EC:5.4.3.2]
K01844	beta-lysine 5,6-aminomutase [EC:5.4.3.3]
K00824	D-alanine transaminase [EC:2.6.1.21]
K13609	delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
K00306	sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.7 1.5.3.1]
K06101	histone-lysine N-methyltransferase ASH1L [EC:2.1.1.43]
K11427	histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
K11420	euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]
K15588	histone-lysine N-methyltransferase NSD1 [EC:2.1.1.43]
K11424	histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
K11425	histone-lysine N-methyltransferase NSD3 [EC:2.1.1.43]
K11422	histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]
K11423	histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43]
K11431	histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]
K11428	histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]
K11421	histone-lysine N-methyltransferase SETDB [EC:2.1.1.43]
K11433	histone-lysine N-methyltransferase SETMAR [EC:2.1.1.43]
K11419	histone-lysine N-methyltransferase SUV39H [EC:2.1.1.43]
K11429	histone-lysine N-methyltransferase SUV420H [EC:2.1.1.43]
K09186	histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
K09187	histone-lysine N-methyltransferase MLL2 [EC:2.1.1.43]
K09188	histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]
K14959	histone-lysine N-methyltransferase MLL4 [EC:2.1.1.43]
K09189	histone-lysine N-methyltransferase MLL5 [EC:2.1.1.43]
K01423	[EC:3.4.-.-]
K00474	trimethyllysine dioxygenase [EC:1.14.11.8]
K00128	aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K00149	aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.3 1.2.1.47]
K00471	gamma-butyrobetaine dioxygenase [EC:1.14.11.1]
K00473	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]
K13645	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]
K13646	lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:2.4.1.66 2.4.1.50 1.14.11.4]
K13647	procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4]
K11703	collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]

Compound

C00024	Acetyl-CoA
C00037	Glycine
C00047	L-Lysine
C00322	2-Oxoadipate
C00332	Acetoacetyl-CoA
C00408	L-Pipecolate
C00431	5-Aminopentanoate
C00449	N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450	(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487	Carnitine
C00489	Glutarate
C00527	Glutaryl-CoA
C00739	D-Lysine
C00877	Crotonoyl-CoA
C00956	L-2-Aminoadipate
C00990	5-Aminopentanamide
C01028	N6-Hydroxy-L-lysine
C01142	(3S)-3,6-Diaminohexanoate
C01144	(S)-3-Hydroxybutanoyl-CoA
C01149	4-Trimethylammoniobutanal
C01181	4-Trimethylammoniobutanoate
C01186	(3S,5S)-3,5-Diaminohexanoate
C01211	Procollagen 5-hydroxy-L-lysine
C01259	3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672	Cadaverine
C02188	Protein lysine
C02727	N6-Acetyl-L-lysine
C03087	5-Acetamidopentanoate
C03239	6-Amino-2-oxohexanoate
C03273	5-Oxopentanoate
C03656	(S)-5-Amino-3-oxohexanoic acid
C03793	N6,N6,N6-Trimethyl-L-lysine
C03955	N6-Acetyl-N6-hydroxy-L-lysine
C04020	D-Lysopine
C04076	L-2-Aminoadipate 6-semialdehyde
C04092	delta1-Piperideine-2-carboxylate
C04487	5-(D-Galactosyloxy)-L-lysine-procollagen
C05161	2,5-Diaminohexanoate
C05544	Protein N6-methyl-L-lysine
C05545	Protein N6,N6-dimethyl-L-lysine
C05546	Protein N6,N6,N6-trimethyl-L-lysine
C05548	6-Acetamido-2-oxohexanoate
C05554	Aerobactin
C05825	2-Amino-5-oxohexanoate
C06157	[Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C06181	Piperideine
C20333	N2-citryl-N6-acetyl-N6-hydroxy-L-lysine

Reference

PMID:11802770

Authors

Vaz FM, Wanders RJ.

Title

Carnitine biosynthesis in mammals.

Journal

Biochem J 361:417-29 (2002)

Reference

PMID:1682209

Authors

Large PJ, Robertson A.

Title

The route of lysine breakdown in Candida tropicalis.

Journal

FEMS Microbiol Lett 66:209-13 (1991)

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
   BioSystems (1)   
Disease (9)   
   KEGG DISEASE (9)   
Chemical substance (47)   
   KEGG COMPOUND (47)   
Chemical reaction (39)   
   KEGG ENZYME (39)   
Gene (60)   
   KEGG ORTHOLOGY (60)   
Literature (2)   
   PubMed (2)   
All databases (164)   

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