KEGG PATHWAY: ko00330

PATHWAY: ko00330

Entry

ko00330 Pathway

Name

Arginine and proline metabolism

Class

Metabolism; Amino acid metabolism

Pathway map

ko00330

Arginine and proline metabolism

Module

M00015	Proline biosynthesis, glutamate => proline [PATH:ko00330]
M00028	Ornithine biosynthesis, glutamate => ornithine [PATH:ko00330]
M00029	Urea cycle [PATH:ko00330]
M00047	Creatine pathway [PATH:ko00330]
M00133	Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:ko00330]
M00134	Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:ko00330]
M00135	GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:ko00330]
M00136	GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:ko00330]

Disease

H00164	Carbamoyl phosphate synthetase I deficiency
H00185	Citrullinemia (CTLN)
H00186	Hyperargininemia
H00187	Ornithine transcarbamylase deficiency
H00189	Ornithinaemia
H00190	Hyperprolinemia (HP)
H00597	Snyder-Robinson syndrome
H00834	Guanidinoacetate methyltransferase (GAMT) deficiency
H00849	Creatine deficiency syndrome
H00923	Congenital systemic glutamine deficiency (CSGD)
H01028	Argininosuccinic aciduria (ARGINSA)
H01032	N-acetylglutamate synthase (NAGS) deficiency
H01146	Aminoacylase 1 deficiency

Drug

D00829	Eflornithine hydrochloride (USAN)
D07883	Eflornithine (INN)

Other DBs

BSID:

323

GO:

0006525 0006560

Orthology

K00613	glycine amidinotransferase [EC:2.1.4.1]
K00542	guanidinoacetate N-methyltransferase [EC:2.1.1.2]
K00933	creatine kinase [EC:2.7.3.2]
K01470	creatinine amidohydrolase [EC:3.5.2.10]
K01485	cytosine deaminase [EC:3.5.4.1]
K01473	N-methylhydantoinase A [EC:3.5.2.14]
K01474	N-methylhydantoinase B [EC:3.5.2.14]
K08687	N-carbamoylsarcosine amidase [EC:3.5.1.59]
K08688	creatinase [EC:3.5.3.3]
K01583	arginine decarboxylase [EC:4.1.1.19]
K01584	arginine decarboxylase [EC:4.1.1.19]
K01585	arginine decarboxylase [EC:4.1.1.19]
K02626	arginine decarboxylase [EC:4.1.1.19]
K01480	agmatinase [EC:3.5.3.11]
K10536	agmatine deiminase [EC:3.5.3.12]
K12251	N-carbamoylputrescine amidase [EC:3.5.1.53]
K14329	agmatine coumaroyltransferase [EC:2.3.1.- 2.3.1.64]
K01581	ornithine decarboxylase [EC:4.1.1.17]
K00797	spermidine synthase [EC:2.5.1.16]
K00802	spermine synthase [EC:2.5.1.22]
K01611	S-adenosylmethionine decarboxylase [EC:4.1.1.50]
K13746	carboxynorspermidine synthase [EC:1.5.1.43]
K13747	carboxynorspermidine decarboxylase [EC:4.1.1.-]
K11182	diamine oxidase [EC:1.4.3.22]
K09251	putrescine aminotransferase [EC:2.6.1.82]
K12256	putrescine aminotransferase [EC:2.6.1.-]
K03343	putrescine oxidase [EC:1.4.3.10]
K00316	spermidine dehydrogenase [EC:1.5.99.6]
K00128	aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085	aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00149	aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.3 1.2.1.47]
K00137	aminobutyraldehyde dehydrogenase [EC:1.2.1.19]
K12254	4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase [EC:1.2.1.- 1.2.1.54]
K05604	beta-Ala-His dipeptidase [EC:3.4.13.20]
K08660	cytosolic nonspecific dipeptidase [EC:3.4.13.18]
K14755	carnosine synthase [EC:6.3.2.11]
K00657	diamine N-acetyltransferase [EC:2.3.1.57]
K00274	monoamine oxidase [EC:1.4.3.4]
K12252	arginine:pyruvate transaminase [EC:2.6.1.84]
K12253	5-guanidino-2-oxopentanoate decarboxylase [EC:4.1.1.75]
K12255	guanidinobutyrase [EC:3.5.3.7]
K01426	amidase [EC:3.5.1.4]
K00673	arginine N-succinyltransferase [EC:2.3.1.109]
K01484	succinylarginine dihydrolase [EC:3.5.3.23]
K00840	succinylornithine aminotransferase [EC:2.6.1.81]
K06447	succinylglutamic semialdehyde dehydrogenase [EC:1.2.1.71]
K05526	succinylglutamate desuccinylase [EC:3.5.1.96]
K09470	gamma-glutamylputrescine synthase [EC:6.3.1.11]
K09471	gamma-glutamylputrescine oxidase [EC:1.4.3.-]
K09472	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [EC:1.2.1.-]
K09473	gamma-glutamyl-gamma-aminobutyrate hydrolase [EC:3.5.1.94]
K00296	D-nopaline dehydrogenase [EC:1.5.1.19]
K00934	arginine kinase [EC:2.7.3.3]
K00819	ornithine--oxo-acid transaminase [EC:2.6.1.13]
K00286	pyrroline-5-carboxylate reductase [EC:1.5.1.2]
K00318	proline dehydrogenase [EC:1.5.99.8]
K13821	proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.1.12 1.5.99.8]
K01750	ornithine cyclodeaminase [EC:4.3.1.12]
K00294	1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.1.12]
K00931	glutamate 5-kinase [EC:2.7.2.11]
K00147	glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
K12657	delta-1-pyrroline-5-carboxylate synthetase [EC:1.2.1.41 2.7.2.11]
K01259	proline iminopeptidase [EC:3.4.11.5]
K11142	cytosol aminopeptidase [EC:3.4.11.5 3.4.11.1]
K00472	prolyl 4-hydroxylase [EC:1.14.11.2]
K11394	hydroxyproline oxidase [EC:1.5.-.-]
K14454	aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455	aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811	aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812	aspartate aminotransferase [EC:2.6.1.1]
K00813	aspartate aminotransferase [EC:2.6.1.1]
K11358	aspartate aminotransferase [EC:2.6.1.1]
K00824	D-alanine transaminase [EC:2.6.1.21]
K01625	2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16 4.1.2.14]
K01571	oxaloacetate decarboxylase, alpha subunit [EC:4.1.1.3]
K01572	oxaloacetate decarboxylase, beta subunit [EC:4.1.1.3]
K01573	oxaloacetate decarboxylase, gamma subunit [EC:4.1.1.3]
K12658	4-hydroxyproline epimerase [EC:5.1.1.8]
K01777	proline racemase [EC:5.1.1.4]
K10793	D-proline reductase (dithiol) PrdA [EC:1.21.4.1]
K10794	D-proline reductase (dithiol) PrdB [EC:1.21.4.1]
K10795	D-proline reductase (dithiol) PrdD [EC:1.21.4.1]
K10796	D-proline reductase (dithiol) PrdE [EC:1.21.4.1]
K00273	D-amino-acid oxidase [EC:1.4.3.3]
K00611	ornithine carbamoyltransferase [EC:2.1.3.3]
K09065	N-acetylornithine carbamoyltransferase [EC:2.1.3.9]
K13043	N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11]
K01940	argininosuccinate synthase [EC:6.3.4.5]
K01755	argininosuccinate lyase [EC:4.3.2.1]
K14681	argininosuccinate lyase / amino-acid N-acetyltransferase [EC:2.3.1.1 4.3.2.1]
K01476	arginase [EC:3.5.3.1]
K01941	urea carboxylase [EC:6.3.4.6]
K01457	allophanate hydrolase [EC:3.5.1.54]
K14541	urea carboxylase / allophanate hydrolase [EC:3.5.1.54 6.3.4.6]
K01427	urease [EC:3.5.1.5]
K01428	urease subunit alpha [EC:3.5.1.5]
K01429	urease subunit beta [EC:3.5.1.5]
K01430	urease subunit gamma [EC:3.5.1.5]
K14048	urease subunit gamma/beta [EC:3.5.1.5]
K01478	arginine deiminase [EC:3.5.3.6]
K00491	nitric-oxide synthase, bacterial [EC:1.14.13.39]
K13240	nitric-oxide synthase, brain [EC:1.14.13.39]
K13241	nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242	nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13253	nitric-oxide synthase, invertebrate [EC:1.14.13.39]
K13427	nitric-oxide synthase, plant [EC:1.14.13.39]
K01425	glutaminase [EC:3.5.1.2]
K05597	glutamin-(asparagin-)ase [EC:3.5.1.38]
K01915	glutamine synthetase [EC:6.3.1.2]
K15371	glutamate dehydrogenase [EC:1.4.1.2]
K00260	glutamate dehydrogenase [EC:1.4.1.2]
K00261	glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]
K00262	glutamate dehydrogenase (NADP+) [EC:1.4.1.4]
K01948	carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16]
K00926	carbamate kinase [EC:2.7.2.2]
K00618	amino-acid N-acetyltransferase [EC:2.3.1.1]
K00619	amino-acid N-acetyltransferase [EC:2.3.1.1]
K14682	amino-acid N-acetyltransferase [EC:2.3.1.1]
K00620	glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.1 2.3.1.35]
K11067	N-acetylglutamate synthase [EC:2.3.1.1]
K00930	acetylglutamate kinase [EC:2.7.2.8]
K05828	acetylglutamate/LysW-gamma-L-alpha-aminoadipate kinase [EC:2.7.2.- 2.7.2.8]
K00145	N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]
K05829	N-acetyl-gamma-glutamyl-phosphate/LysW-gamma-L-alpha-aminoadipyl-6-phosphate reductase [EC:1.2.1.- 1.2.1.38]
K12659	N-acetyl-gamma-glutamyl-phosphate reductase / acetylglutamate kinase [EC:2.7.2.8 1.2.1.38]
K00818	acetylornithine aminotransferase [EC:2.6.1.11]
K00821	acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17 2.6.1.11]
K05830	acetylornithine/LysW-gamma-L-lysine aminotransferase [EC:2.6.1.- 2.6.1.11]
K14677	aminoacylase [EC:3.5.1.14]
K01438	acetylornithine deacetylase [EC:3.5.1.16]
K03365	creatinine deaminase [EC:3.5.4.21]

Compound

C00011	CO2
C00012	Peptide
C00014	NH3
C00019	S-Adenosyl-L-methionine
C00022	Pyruvate
C00025	L-Glutamate
C00048	Glyoxylate
C00049	L-Aspartate
C00062	L-Arginine
C00064	L-Glutamine
C00077	L-Ornithine
C00086	Urea
C00122	Fumarate
C00134	Putrescine
C00148	L-Proline
C00169	Carbamoyl phosphate
C00179	Agmatine
C00213	Sarcosine
C00223	p-Coumaroyl-CoA
C00300	Creatine
C00315	Spermidine
C00327	L-Citrulline
C00334	4-Aminobutanoate
C00406	Feruloyl-CoA
C00431	5-Aminopentanoate
C00433	2,5-Dioxopentanoate
C00436	N-Carbamoylputrescine
C00437	N-Acetylornithine
C00441	L-Aspartate 4-semialdehyde
C00533	Nitric oxide
C00555	4-Aminobutyraldehyde
C00581	Guanidinoacetate
C00624	N-Acetyl-L-glutamate
C00750	Spermine
C00763	D-Proline
C00791	Creatinine
C00884	Homocarnosine
C00986	1,3-Diaminopropane
C01010	Urea-1-carboxylate
C01035	4-Guanidinobutanoate
C01043	N-Carbamoylsarcosine
C01110	5-Amino-2-oxopentanoic acid
C01137	S-Adenosylmethioninamine
C01157	Hydroxyproline
C01165	L-Glutamate 5-semialdehyde
C01250	N-Acetyl-L-glutamate 5-semialdehyde
C01682	Nopaline
C01877	4-Oxoproline
C02305	Phosphocreatine
C02565	N-Methylhydantoin
C02647	4-Guanidinobutanal
C02714	N-Acetylputrescine
C02946	4-Acetamidobutanoate
C03078	4-Guanidinobutanamide
C03166	Phosphoguanidinoacetate
C03287	L-Glutamyl 5-phosphate
C03296	N2-Succinyl-L-arginine
C03375	Norspermidine
C03406	N-(L-Arginino)succinate
C03415	N2-Succinyl-L-ornithine
C03440	cis-4-Hydroxy-D-proline
C03564	1-Pyrroline-2-carboxylate
C03771	5-Guanidino-2-oxopentanoate
C03912	(S)-1-Pyrroline-5-carboxylate
C04133	N-Acetyl-L-glutamate 5-phosphate
C04137	D-Octopine
C04281	L-1-Pyrroline-3-hydroxy-5-carboxylate
C04282	1-Pyrroline-4-hydroxy-2-carboxylate
C04498	p-Coumaroylagmatine
C05931	N-Succinyl-L-glutamate
C05932	N-Succinyl-L-glutamate 5-semialdehyde
C05933	N-(omega)-Hydroxyarginine
C05936	N4-Acetylaminobutanal
C05938	L-4-Hydroxyglutamate semialdehyde
C05939	Linatine
C05941	2-Oxo-4-hydroxy-5-aminovalerate
C05942	Pyrrole-2-carboxylate
C05945	L-Arginine phosphate
C05946	D-4-Hydroxy-2-oxoglutarate
C05947	L-erythro-4-Hydroxyglutamate
C10497	Feruloylputrescine
C15532	N-Acetyl-L-citrulline
C15699	gamma-L-Glutamylputrescine
C15700	gamma-Glutamyl-gamma-aminobutyraldehyde
C15767	4-(L-gamma-Glutamylamino)butanoate
C18048	N-Succinyl-L-citrulline
C18172	Carboxyspermidine
C18174	Carboxynorspermidine
C18325	Feruloylagmatine
C18326	p-Coumaroylputrescine

Reference

PMID:5288244

Authors

Haake P, Allen GW.

Title

Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).

Journal

Proc Natl Acad Sci U S A 68:2691-3 (1971)

Reference

PMID:16499623

Authors

Kurihara S, Oda S, Kumagai H, Suzuki H.

Title

Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.

Journal

FEMS Microbiol Lett 256:318-23 (2006)

Reference

PMID:15590624

Authors

Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.

Title

A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.

Journal

J Biol Chem 280:4602-8 (2005)

All links

Ontology (3)   
   KEGG BRITE (1)   
   GO (2)   
Pathway (13)   
   KEGG PATHWAY (4)   
   KEGG MODULE (8)   
   BioSystems (1)   
Disease (13)   
   KEGG DISEASE (13)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (90)   
   KEGG COMPOUND (90)   
Chemical reaction (100)   
   KEGG ENZYME (100)   
Gene (131)   
   KEGG ORTHOLOGY (131)   
Literature (3)   
   PubMed (3)   
All databases (355)   

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