KEGG PATHWAY: ko00350

PATHWAY: ko00350

Entry

ko00350 Pathway

Name

Tyrosine metabolism

Class

Metabolism; Amino acid metabolism

Pathway map

ko00350

Tyrosine metabolism

Module

M00042	Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:ko00350]
M00043	Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:ko00350]
M00044	Tyrosine degradation, tyrosine => homogentisate [PATH:ko00350]
M00533	Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:ko00350]

Disease

H00163	Alkaptonuria
H00165	Tyrosinemia
H00168	Oculocutaneous albinism (OCA)
H00251	Thyroid dyshormonogenesis
H00548	Brunner syndrome
H00831	Primary dystonia
H01005	Dopamine beta-hydroxylase deficiency
H01161	Aromatic L-amino acid decarboxylase (AADC) deficiency

Other DBs

BSID:

325

GO:

0006570

Orthology

K14454	aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455	aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811	aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812	aspartate aminotransferase [EC:2.6.1.1]
K00813	aspartate aminotransferase [EC:2.6.1.1]
K11358	aspartate aminotransferase [EC:2.6.1.1]
K15849	bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.79 2.6.1.78 2.6.1.1]
K00815	tyrosine aminotransferase [EC:2.6.1.5]
K00817	histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832	aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838	aromatic amino acid aminotransferase I [EC:2.6.1.5 2.6.1.27 2.6.1.57]
K05821	aromatic amino acid aminotransferase II [EC:2.6.1.28 2.6.1.58]
K00270	phenylalanine dehydrogenase [EC:1.4.1.20]
K03334	L-amino-acid oxidase [EC:1.4.3.2]
K00457	4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00451	homogentisate 1,2-dioxygenase [EC:1.13.11.5]
K01800	maleylacetoacetate isomerase [EC:5.2.1.2]
K01555	fumarylacetoacetase [EC:3.7.1.2]
K16171	fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2]
K00422	polyphenol oxidase [EC:1.10.3.1]
K00505	tyrosinase [EC:1.14.18.1]
K00501	tyrosine 3-monooxygenase [EC:1.14.16.2]
K01827	dopachrome tautomerase [EC:5.3.3.12]
K00506	tyrosinase-related protein 1 [EC:1.14.18.-]
K01592	tyrosine decarboxylase [EC:4.1.1.25]
K01593	aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
K00503	dopamine beta-monooxygenase [EC:1.14.17.1]
K00553	phenylethanolamine N-methyltransferase [EC:2.1.1.28]
K00545	catechol O-methyltransferase [EC:2.1.1.6]
K00274	monoamine oxidase [EC:1.4.3.4]
K00276	primary-amine oxidase [EC:1.4.3.21]
K13371	aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372	aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K00129	aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K13951	alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980	alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121	S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.1.1.284]
K13952	alcohol dehydrogenase 6 [EC:1.1.1.1]
K04072	acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.2.1.10]
K13953	alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954	alcohol dehydrogenase [EC:1.1.1.1]
K00001	alcohol dehydrogenase [EC:1.1.1.1]
K00483	4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K16901	anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9 1.14.14.8]
K00484	flavin reductase (NADH) [EC:1.5.1.36]
K00455	3,4-dihydroxyphenylacetate 2,3-dioxygenase [EC:1.13.11.15]
K00151	5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60]
K10219	2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K01826	5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10]
K05921	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:5.3.3.- 4.1.1.68]
K02509	2-oxo-hept-3-ene-1,7-dioate hydratase [EC:4.2.1.-]
K02510	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [EC:4.1.2.-]
K00135	succinate-semialdehyde dehydrogenase (NADP+) [EC:1.2.1.16]
K01668	tyrosine phenol-lyase [EC:4.1.99.2]
K00431	thyroid peroxidase [EC:1.11.1.8]
K00055	aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00599	[EC:2.1.1.-]
K00468	[EC:1.13.12.-]
K00157	aldehyde oxidase [EC:1.2.3.1]
K00450	gentisate 1,2-dioxygenase [EC:1.13.11.4]
K01801	maleylpyruvate isomerase [EC:5.2.1.4]
K16163	maleylpyruvate isomerase [EC:5.2.1.4]
K01557	acylpyruvate hydrolase [EC:3.7.1.5]
K16164	acylpyruvate hydrolase [EC:3.7.1.5]
K16165	fumarylpyruvate hydrolase [EC:3.7.1.20]
K07253	phenylpyruvate tautomerase [EC:5.3.2.1]
K00680	[EC:2.3.1.-]

Compound

C00022	Pyruvate
C00042	Succinate
C00082	L-Tyrosine
C00122	Fumarate
C00146	Phenol
C00164	Acetoacetate
C00232	Succinate semialdehyde
C00355	3,4-Dihydroxy-L-phenylalanine
C00483	Tyramine
C00530	Hydroquinone
C00544	Homogentisate
C00547	L-Noradrenaline
C00628	2,5-Dihydroxybenzoate
C00642	4-Hydroxyphenylacetate
C00788	L-Adrenaline
C00822	Dopaquinone
C01036	4-Maleylacetoacetate
C01060	3,5-Diiodo-L-tyrosine
C01061	4-Fumarylacetoacetate
C01161	3,4-Dihydroxyphenylacetate
C01179	3-(4-Hydroxyphenyl)pyruvate
C01207	3-(3,4-Dihydroxyphenyl)lactate
C01693	L-Dopachrome
C01829	Thyroxine
C01850	Rosmarinate
C02167	Maleylpyruvate
C02442	N-Methyltyramine
C02465	Triiodothyronine
C02514	3-Fumarylpyruvate
C02515	3-Iodo-L-tyrosine
C03063	2-Oxohept-3-enedioate
C03077	4-Chlorophenylacetate
C03672	3-(4-Hydroxyphenyl)lactate
C03758	Dopamine
C03765	4-Hydroxyphenylacetaldehyde
C04043	3,4-Dihydroxyphenylacetaldehyde
C04045	3-(3,4-Dihydroxyphenyl)pyruvate
C04052	5-Carboxy-2-oxohept-3-enedioate
C04185	5,6-Dihydroxyindole-2-carboxylate
C04186	5-Carboxymethyl-2-hydroxymuconate
C04368	3-Amino-3-(4-hydroxyphenyl)propanoate
C04642	2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796	4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797	5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338	4-Hydroxyphenylacetyl-CoA
C05350	2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576	3,4-Dihydroxyphenylethyleneglycol
C05577	3,4-Dihydroxymandelaldehyde
C05578	5,6-Dihydroxyindole
C05579	Indole-5,6-quinone
C05580	3,4-Dihydroxymandelate
C05581	3-Methoxy-4-hydroxyphenylacetaldehyde
C05582	Homovanillate
C05583	3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584	3-Methoxy-4-hydroxymandelate
C05585	Gentisate aldehyde
C05587	3-Methoxytyramine
C05588	L-Metanephrine
C05589	L-Normetanephrine
C05593	3-Hydroxyphenylacetate
C05594	3-Methoxy-4-hydroxyphenylethyleneglycol
C05595	4-Hydroxyphenylacetylglutamic acid
C05596	p-Hydroxyphenylacetylglycine
C05600	2-Hydroxyhepta-2,4-dienedioate
C05604	2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044	4-Hydroxyphenylethanol
C06046	Salidroside
C06047	Stizolobate
C06048	Stizolobinate
C06199	Hordenine
C06201	2,4-Dihydroxyhept-2-enedioate
C10447	3,4-Dihydroxyphenylpropanoate
C17935	Cysteinyldopa
C17936	Phaeomelanin
C17937	Eumelanin
C17938	5,6-Indolequinone-2-carboxylic acid

Reference

PMID:8550403

Authors

Prieto MA, Diaz E, Garcia JL.

Title

Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.

Journal

J Bacteriol 178:111-20 (1996)

Reference

PMID:1194238

Authors

Sparnins VL, Dagley S.

Title

Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.

Journal

J Bacteriol 124:1374-81 (1975)

Reference

PMID:18435614

Authors

Ito S, Wakamatsu K

Title

Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.

Journal

Photochem Photobiol 84:582-92 (2008)

Reference

PMID:11171088

Authors

Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC

Title

The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.

Journal

Biochem J 354:131-9 (2001)

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Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (9)   
   KEGG PATHWAY (4)   
   KEGG MODULE (4)   
   BioSystems (1)   
Disease (8)   
   KEGG DISEASE (8)   
Chemical substance (76)   
   KEGG COMPOUND (76)   
Chemical reaction (56)   
   KEGG ENZYME (56)   
Gene (67)   
   KEGG ORTHOLOGY (67)   
Literature (4)   
   PubMed (4)   
All databases (222)   

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