KEGG   PATHWAY: ko00350Help
Entry
ko00350                     Pathway                                

Name
Tyrosine metabolism
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Tyrosine metabolism
ko00350

All organismsOrtholog table
Module
M00042  
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:ko00350]
M00043  
Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:ko00350]
M00044  
Tyrosine degradation, tyrosine => homogentisate [PATH:ko00350]
M00533  
Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:ko00350]
Disease
H00163  
Alkaptonuria
H00165  
Tyrosinemia
H00168  
Oculocutaneous albinism (OCA)
H00251  
Thyroid dyshormonogenesis
H00548  
Brunner syndrome
H00831  
Primary dystonia
H01005  
Dopamine beta-hydroxylase deficiency
H01161  
Aromatic L-amino acid decarboxylase (AADC) deficiency
Other DBs
BSID: 
GO: 
Orthology
K14454  
aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  
aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811  
aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  
aspartate aminotransferase [EC:2.6.1.1]
K00813  
aspartate aminotransferase [EC:2.6.1.1]
K11358  
aspartate aminotransferase [EC:2.6.1.1]
K15849  
bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.79 2.6.1.78 2.6.1.1]
K00815  
tyrosine aminotransferase [EC:2.6.1.5]
K00817  
histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832  
aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838  
aromatic amino acid aminotransferase I [EC:2.6.1.5 2.6.1.27 2.6.1.57]
K05821  
aromatic amino acid aminotransferase II [EC:2.6.1.28 2.6.1.58]
K00270  
phenylalanine dehydrogenase [EC:1.4.1.20]
K03334  
L-amino-acid oxidase [EC:1.4.3.2]
K00457  
4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00451  
homogentisate 1,2-dioxygenase [EC:1.13.11.5]
K01800  
maleylacetoacetate isomerase [EC:5.2.1.2]
K01555  
fumarylacetoacetase [EC:3.7.1.2]
K16171  
fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2]
K00422  
polyphenol oxidase [EC:1.10.3.1]
K00505  
tyrosinase [EC:1.14.18.1]
K00501  
tyrosine 3-monooxygenase [EC:1.14.16.2]
K01827  
dopachrome tautomerase [EC:5.3.3.12]
K00506  
tyrosinase-related protein 1 [EC:1.14.18.-]
K01592  
tyrosine decarboxylase [EC:4.1.1.25]
K01593  
aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
K00503  
dopamine beta-monooxygenase [EC:1.14.17.1]
K00553  
phenylethanolamine N-methyltransferase [EC:2.1.1.28]
K00545  
catechol O-methyltransferase [EC:2.1.1.6]
K00274  
monoamine oxidase [EC:1.4.3.4]
K00276  
primary-amine oxidase [EC:1.4.3.21]
K13371  
aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372  
aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K00129  
aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K13951  
alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980  
alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121  
S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.1.1.284]
K13952  
alcohol dehydrogenase 6 [EC:1.1.1.1]
K04072  
acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.2.1.10]
K13953  
alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954  
alcohol dehydrogenase [EC:1.1.1.1]
K00001  
alcohol dehydrogenase [EC:1.1.1.1]
K00483  
4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K16901  
anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9 1.14.14.8]
K00484  
flavin reductase (NADH) [EC:1.5.1.36]
K00455  
3,4-dihydroxyphenylacetate 2,3-dioxygenase [EC:1.13.11.15]
K00151  
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60]
K10219  
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K01826  
5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10]
K05921  
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:5.3.3.- 4.1.1.68]
K02509  
2-oxo-hept-3-ene-1,7-dioate hydratase [EC:4.2.1.-]
K02510  
4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52]
K00135  
succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.20 1.2.1.79 1.2.1.16]
K01668  
tyrosine phenol-lyase [EC:4.1.99.2]
K00431  
thyroid peroxidase [EC:1.11.1.8]
K00055  
aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00599  
[EC:2.1.1.-]
K00468  
[EC:1.13.12.-]
K00157  
aldehyde oxidase [EC:1.2.3.1]
K00450  
gentisate 1,2-dioxygenase [EC:1.13.11.4]
K01801  
maleylpyruvate isomerase [EC:5.2.1.4]
K16163  
maleylpyruvate isomerase [EC:5.2.1.4]
K01557  
acylpyruvate hydrolase [EC:3.7.1.5]
K16164  
acylpyruvate hydrolase [EC:3.7.1.5]
K16165  
fumarylpyruvate hydrolase [EC:3.7.1.20]
K07253  
phenylpyruvate tautomerase [EC:5.3.2.1]
K00680  
[EC:2.3.1.-]
Compound
C00022  
Pyruvate
C00042  
Succinate
C00082  
L-Tyrosine
C00122  
Fumarate
C00146  
Phenol
C00164  
Acetoacetate
C00232  
Succinate semialdehyde
C00355  
3,4-Dihydroxy-L-phenylalanine
C00483  
Tyramine
C00530  
Hydroquinone
C00544  
Homogentisate
C00547  
L-Noradrenaline
C00628  
2,5-Dihydroxybenzoate
C00642  
4-Hydroxyphenylacetate
C00788  
L-Adrenaline
C00822  
Dopaquinone
C01036  
4-Maleylacetoacetate
C01060  
3,5-Diiodo-L-tyrosine
C01061  
4-Fumarylacetoacetate
C01161  
3,4-Dihydroxyphenylacetate
C01179  
3-(4-Hydroxyphenyl)pyruvate
C01207  
3-(3,4-Dihydroxyphenyl)lactate
C01693  
L-Dopachrome
C01829  
Thyroxine
C01850  
Rosmarinate
C02167  
Maleylpyruvate
C02442  
N-Methyltyramine
C02465  
Triiodothyronine
C02514  
3-Fumarylpyruvate
C02515  
3-Iodo-L-tyrosine
C03063  
2-Oxohept-3-enedioate
C03077  
4-Chlorophenylacetate
C03672  
3-(4-Hydroxyphenyl)lactate
C03758  
Dopamine
C03765  
4-Hydroxyphenylacetaldehyde
C04043  
3,4-Dihydroxyphenylacetaldehyde
C04045  
3-(3,4-Dihydroxyphenyl)pyruvate
C04052  
5-Carboxy-2-oxohept-3-enedioate
C04185  
5,6-Dihydroxyindole-2-carboxylate
C04186  
5-Carboxymethyl-2-hydroxymuconate
C04368  
3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  
2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  
4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  
5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  
4-Hydroxyphenylacetyl-CoA
C05350  
2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  
3,4-Dihydroxyphenylethyleneglycol
C05577  
3,4-Dihydroxymandelaldehyde
C05578  
5,6-Dihydroxyindole
C05579  
Indole-5,6-quinone
C05580  
3,4-Dihydroxymandelate
C05581  
3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  
Homovanillate
C05583  
3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  
3-Methoxy-4-hydroxymandelate
C05585  
Gentisate aldehyde
C05587  
3-Methoxytyramine
C05588  
L-Metanephrine
C05589  
L-Normetanephrine
C05593  
3-Hydroxyphenylacetate
C05594  
3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  
4-Hydroxyphenylacetylglutamic acid
C05596  
p-Hydroxyphenylacetylglycine
C05600  
2-Hydroxyhepta-2,4-dienedioate
C05604  
2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  
4-Hydroxyphenylethanol
C06046  
Salidroside
C06047  
Stizolobate
C06048  
Stizolobinate
C06199  
Hordenine
C06201  
2,4-Dihydroxyhept-2-enedioate
C10447  
3,4-Dihydroxyphenylpropanoate
C17935  
Cysteinyldopa
C17936  
Phaeomelanin
C17937  
Eumelanin
C17938  
5,6-Indolequinone-2-carboxylic acid
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
Reference
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
Reference
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)

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