KEGG   PATHWAY: ko00350Help
Entry
ko00350                     Pathway                                

Name
Tyrosine metabolism
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
ko00350  Tyrosine metabolism
ko00350

Ortholog table
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:ko00350]
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:ko00350]
M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:ko00350]
M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:ko00350]
Disease
H00163  Alkaptonuria
H00165  Tyrosinemia
H00168  Oculocutaneous albinism (OCA)
H00251  Thyroid dyshormonogenesis
H00548  Brunner syndrome
H00831  Primary dystonia
H01005  Dopamine beta-hydroxylase deficiency
H01161  Aromatic L-amino acid decarboxylase (AADC) deficiency
Other DBs
BSID: 325
GO: 0006570
Orthology
K14454  aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811  aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspartate aminotransferase [EC:2.6.1.1]
K00813  aspartate aminotransferase [EC:2.6.1.1]
K11358  aspartate aminotransferase [EC:2.6.1.1]
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.79 2.6.1.78 2.6.1.1]
K00815  tyrosine aminotransferase [EC:2.6.1.5]
K00817  histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832  aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838  aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.5 2.6.1.27 2.6.1.39 2.6.1.57]
K05821  aromatic amino acid aminotransferase II [EC:2.6.1.28 2.6.1.58]
K00270  phenylalanine dehydrogenase [EC:1.4.1.20]
K03334  L-amino-acid oxidase [EC:1.4.3.2]
K00457  4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00451  homogentisate 1,2-dioxygenase [EC:1.13.11.5]
K01800  maleylacetoacetate isomerase [EC:5.2.1.2]
K01555  fumarylacetoacetase [EC:3.7.1.2]
K16171  fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2]
K00422  polyphenol oxidase [EC:1.10.3.1]
K00505  tyrosinase [EC:1.14.18.1]
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
K01827  dopachrome tautomerase [EC:5.3.3.12]
K22203  dopachrome tautomerase [EC:5.3.3.12]
K00506  tyrosinase-related protein 1 [EC:1.14.18.-]
K22329  tyrosine decarboxylase [EC:4.1.1.25]
K01592  tyrosine decarboxylase [EC:4.1.1.25]
K22330  tyrosine decarboxylase [EC:4.1.1.25]
K18933  tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.11 4.1.1.25]
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.105 4.1.1.28]
K00503  dopamine beta-monooxygenase [EC:1.14.17.1]
K00553  phenylethanolamine N-methyltransferase [EC:2.1.1.28]
K00545  catechol O-methyltransferase [EC:2.1.1.6]
K00274  monoamine oxidase [EC:1.4.3.4]
K00276  primary-amine oxidase [EC:1.4.3.21]
K13371  aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372  aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K01618  3,4-dihydroxyphenylacetaldehyde synthase [EC:4.1.1.107]
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K13951  alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980  alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.1.1.284]
K13952  alcohol dehydrogenase 6 [EC:1.1.1.1]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.2.1.10]
K13953  alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954  alcohol dehydrogenase [EC:1.1.1.1]
K18857  alcohol dehydrogenase class-P [EC:1.1.1.1]
K00001  alcohol dehydrogenase [EC:1.1.1.1]
K22327  4-hydroxyphenylacetaldehyde synthase [EC:4.1.1.108]
K00483  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9 1.14.14.8]
K00484  flavin reductase (NADH) [EC:1.5.1.36]
K00455  3,4-dihydroxyphenylacetate 2,3-dioxygenase [EC:1.13.11.15]
K00151  5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60]
K10219  2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K01826  5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10]
K05921  5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:5.3.3.- 4.1.1.68]
K02509  2-oxo-hept-3-ene-1,7-dioate hydratase [EC:4.2.1.-]
K02510  4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52]
K00135  succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.20 1.2.1.79 1.2.1.16]
K01668  tyrosine phenol-lyase [EC:4.1.99.2]
K10774  tyrosine ammonia-lyase [EC:4.3.1.23]
K00431  thyroid peroxidase [EC:1.11.1.8]
K00055  aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00157  aldehyde oxidase [EC:1.2.3.1]
K00450  gentisate 1,2-dioxygenase [EC:1.13.11.4]
K01801  maleylpyruvate isomerase [EC:5.2.1.4]
K16163  maleylpyruvate isomerase [EC:5.2.1.4]
K01557  acylpyruvate hydrolase [EC:3.7.1.5]
K16164  acylpyruvate hydrolase [EC:3.7.1.5]
K16165  fumarylpyruvate hydrolase [EC:3.7.1.20]
K20758  maleylpyruvate hydrolase [EC:3.7.1.23]
K07253  phenylpyruvate tautomerase [EC:5.3.2.1]
K18606  hydroxyphenylpyruvate reductase [EC:1.1.1.237]
K21425  rosmarinate synthase [EC:2.3.1.140]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01207  3-(3,4-Dihydroxyphenyl)lactate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03672  3-(4-Hydroxyphenyl)lactate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
Reference
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131

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