KEGG   PATHWAY: ko00362Help
Entry
ko00362                     Pathway                                
Name
Benzoate degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Benzoate degradation
ko00362

All organismsOrtholog table
Module
M00540  
Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA [PATH:ko00362]
M00541  
Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA [PATH:ko00362]
M00547  
Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:ko00362]
M00548  
Benzene degradation, benzene => catechol [PATH:ko00362]
M00551  
Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:ko00362]
M00568  
Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:ko00362]
M00569  
Catechol meta-cleavage, catechol => pyruvate + acetaldehyde [PATH:ko00362]
Other DBs
BSID: 
UMBBD: 
GO: 
Orthology
K05549  
benzoate/toluate 1,2-dioxygenase subunit alpha [EC:1.14.12.- 1.14.12.10]
K05550  
benzoate/toluate 1,2-dioxygenase subunit beta [EC:1.14.12.- 1.14.12.10]
K05784  
benzoate/toluate 1,2-dioxygenase electron transfer component
K05783  
dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.- 1.3.1.25]
K03381  
catechol 1,2-dioxygenase [EC:1.13.11.1]
K01856  
muconate cycloisomerase [EC:5.5.1.1]
K03464  
muconolactone D-isomerase [EC:5.3.3.4]
K01055  
3-oxoadipate enol-lactonase [EC:3.1.1.24]
K14727  
3-oxoadipate enol-lactonase / 4-carboxymuconolactone decarboxylase [EC:4.1.1.44 3.1.1.24]
K01031  
3-oxoadipate CoA-transferase, alpha subunit [EC:2.8.3.6]
K01032  
3-oxoadipate CoA-transferase, beta subunit [EC:2.8.3.6]
K00632  
acetyl-CoA acyltransferase [EC:2.3.1.16]
K07513  
acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K07508  
acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  
acetyl-CoA acyltransferase [EC:2.3.1.16]
K07823  
3-oxoadipyl-CoA thiolase [EC:2.3.1.174]
K03268  
benzene/toluene dioxygenase subunit alpha [EC:1.14.12.11 1.14.12.3]
K16268  
benzene/toluene dioxygenase subunit beta [EC:1.14.12.11 1.14.12.3]
K05710  
dioxygenase ferredoxin subunit
K00529  
ferredoxin--NAD+ reductase [EC:1.18.1.3]
K16269  
cis-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC:1.3.1.19]
K16249  
phenol hydroxylase P0 protein
K16243  
Phenol hydroxylase P1 protein
K16244  
phenol hydroxylase P2 protein
K16242  
phenol hydroxylase P3 protein [EC:1.14.13.-]
K16245  
phenol hydroxylase P4 protein
K16246  
phenol hydroxylase P5 protein
K14333  
2,3-dihydroxybenzoate decarboxylase [EC:4.1.1.46]
K00446  
catechol 2,3-dioxygenase [EC:1.13.11.2]
K10621  
2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase [EC:1.13.11.14 1.13.11.-]
K10622  
HCOMODA/2-hydroxy-3-carboxy-muconic semialdehyde decarboxylase [EC:4.1.1.-]
K10216  
2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9]
K02554  
2-keto-4-pentenoate hydratase [EC:4.2.1.80]
K01666  
4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
K00132  
acetaldehyde dehydrogenase (acetylating) [EC:1.2.1.10]
K04072  
acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.2.1.10]
K04073  
acetaldehyde dehydrogenase [EC:1.2.1.10]
K04021  
aldehyde dehydrogenase
K10217  
aminomuconate-semialdehyde dehydrogenase [EC:1.2.1.32]
K01821  
4-oxalocrotonate tautomerase [EC:5.3.2.-]
K01617  
4-oxalocrotonate decarboxylase [EC:4.1.1.77]
K04098  
hydroxyquinol 1,2-dioxygenase [EC:1.13.11.37]
K00217  
maleylacetate reductase [EC:1.3.1.32]
K00448  
protocatechuate 3,4-dioxygenase, alpha subunit [EC:1.13.11.3]
K00449  
protocatechuate 3,4-dioxygenase, beta subunit [EC:1.13.11.3]
K01857  
3-carboxy-cis,cis-muconate cycloisomerase [EC:5.5.1.2]
K01607  
4-carboxymuconolactone decarboxylase [EC:4.1.1.44]
K14334  
carboxy-cis,cis-muconate cyclase [EC:5.5.1.5]
K04100  
protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8]
K04101  
protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8]
K10219  
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K10221  
2-pyrone-4,6-dicarboxylate lactonase [EC:3.1.1.57]
K16514  
4-oxalomesaconate tautomerase [EC:5.3.2.8]
K10220  
4-oxalmesaconate hydratase [EC:4.2.1.83]
K16515  
4-oxalomesaconate hydratase [EC:4.2.1.83]
K10218  
4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17]
K01726  
[EC:4.2.1.-]
K07824  
benzoate 4-monooxygenase [EC:1.14.13.12]
K00481  
p-hydroxybenzoate 3-monooxygenase [EC:1.14.13.2]
K04105  
4-hydroxybenzoate-CoA ligase [EC:6.2.1.25 6.2.1.27]
K01075  
4-hydroxybenzoyl-CoA thioesterase [EC:3.1.2.23]
K04107  
4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.3.7.9]
K04108  
4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.3.7.9]
K04109  
4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.3.7.9]
K04110  
benzoate-CoA ligase [EC:6.2.1.25]
K04112  
benzoyl-CoA reductase subunit [EC:1.3.7.8]
K04113  
benzoyl-CoA reductase subunit [EC:1.3.7.8]
K04114  
benzoyl-CoA reductase subunit [EC:1.3.7.8]
K04115  
benzoyl-CoA reductase subunit [EC:1.3.7.8]
K07537  
cyclohexa-1,5-dienecarbonyl-CoA hydratase [EC:4.2.1.100]
K07538  
6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase [EC:1.1.1.-]
K07539  
6-oxo-cyclohex-1-ene-carbonyl-CoA hydrolase [EC:3.7.1.-]
K04116  
cyclohexanecarboxylate-CoA ligase [EC:6.2.1.-]
K04117  
cyclohexanecarboxyl-CoA dehydrogenase [EC:1.3.99.-]
K07534  
cyclohex-1-ene-1-carboxyl-CoA hydratase [EC:4.2.1.-]
K07535  
2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-]
K07536  
2-ketocyclohexanecarboxyl-CoA hydrolase [EC:3.1.2.-]
K04118  
pimeloyl-CoA dehydrogenase [EC:1.3.1.62]
K00680  
[EC:2.3.1.-]
K16173  
glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32]
K01615  
glutaconyl-CoA decarboxylase [EC:4.1.1.70]
K01692  
enoyl-CoA hydratase [EC:4.2.1.17]
K07515  
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.211 4.2.1.17]
K07514  
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07511  
enoyl-CoA hydratase [EC:4.2.1.17]
K00074  
3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00036  
Oxaloacetate
C00084  
Acetaldehyde
C00090  
Catechol
C00091  
Succinyl-CoA
C00146  
Phenol
C00156  
4-Hydroxybenzoate
C00180  
Benzoate
C00196  
2,3-Dihydroxybenzoate
C00230  
3,4-Dihydroxybenzoate
C00332  
Acetoacetyl-CoA
C00512  
S-Benzoate coenzyme A
C00527  
Glutaryl-CoA
C00530  
Hydroquinone
C00587  
3-Hydroxybenzoate
C00596  
2-Hydroxy-2,4-pentadienoate
C00628  
2,5-Dihydroxybenzoate
C00682  
2-Hydroxymuconate semialdehyde
C00846  
3-Oxoadipate
C00877  
Crotonoyl-CoA
C01063  
6-Carboxyhexanoyl-CoA
C01144  
(S)-3-Hydroxybutanoyl-CoA
C01163  
3-Carboxy-cis,cis-muconate
C01278  
2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  
Benzene
C02222  
2-Maleylacetate
C02232  
3-Oxoadipyl-CoA
C02411  
Glutaconyl-1-CoA
C02480  
cis,cis-Muconate
C02501  
2-Hydroxymuconate
C02519  
4-Methoxybenzoate
C02814  
Benzene-1,2,4-triol
C02949  
4-Hydroxybenzoyl-CoA
C03453  
gamma-Oxalocrotonate
C03586  
2-Oxo-2,3-dihydrofuran-5-acetate
C03589  
4-Hydroxy-2-oxopentanoate
C03671  
2-Pyrone-4,6-dicarboxylate
C03676  
3-Hydroxy-cis,cis-muconate
C04091  
cis-1,2-Dihydrobenzene-1,2-diol
C04115  
4-Carboxy-4-hydroxy-2-oxoadipate
C04324  
(1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04434  
(1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  
3-Carboxy-2-hydroxymuconate semialdehyde
C04484  
4-Carboxy-2-hydroxymuconate semialdehyde
C04553  
3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  
2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  
Parapyruvate
C06035  
4-Methylene-2-oxoglutarate
C06321  
(1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  
S-1,5-Cyclohexadiene-1-carboxylate coenzymeA
C06333  
2-Aminobenzenesulfonate
C06336  
3-Sulfocatechol
C06714  
3-Hydroxypimeloyl-CoA
C06715  
3-Oxopimeloyl-CoA
C06723  
6-Carboxyhex-2-enoyl-CoA
C06749  
6-Hydroxycyclohex-1-enecarbonyl-CoA
C09809  
Cyclohex-2,5-diene-1-carboxyl-CoA
C09810  
Cyclohex-1,4-diene-1-carboxyl-CoA
C09811  
Cyclohex-1-ene-1-carboxyl-CoA
C09812  
2-Hydroxycyclohexane-1-carboxyl-CoA
C09813  
2-Ketocyclohexane-1-carboxyl-CoA
C09821  
6-Ketoxycyclohex-1-ene-1-carboxyl-CoA
C09822  
Cyclohexane-1-carboxylate
C09823  
Cyclohexane-1-carboxyl-CoA
C14610  
(S)-5-Oxo-2,5-dihydrofuran-2-acetate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker  for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
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