KEGG   PATHWAY: ko00514Help
Entry
ko00514                     Pathway                                

Name
Other types of O-glycan biosynthesis
Description
O-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or threonine residue, which is catalyzed by protein O-mannosyltransferases POMT1 and POMT2. Defects of these genes are linked to human diseases, such as muscular dystrophies caused by reduced O-mannosylation of alpha-dystroglycan in skeletal muscles [DS:H00120].
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Other types of O-glycan biosynthesis
ko00514

All organismsOrtholog table
Disease
H00120  
Dystroglycanopathy
H00590  
Congenital muscular dystrophies (CMD/MDC)
H00593  
Limb-girdle muscular dystrophy (LGMD)
H00768  
Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
H01075  
Peters anomaly
H01192  
Lysyl hydroxylase 3 (LH3) deficiency
Orthology
K00728  
dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]
K09666  
beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.-]
K07966  
beta-1,4-galactosyltransferase 1 [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
K07967  
beta-1,4-galactosyltransferase 2 [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
K07968  
beta-1,4-galactosyltransferase 3 [EC:2.4.1.- 2.4.1.38 2.4.1.90]
K00781  
N-acetyllactosaminide alpha-2,3-sialyltransferase (sialyltransferase 6) [EC:2.4.99.6]
K03663  
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase [EC:2.4.1.152]
K07632  
galactoside alpha-1,3-fucosyltransferase 4 [EC:2.4.1.-]
K07635  
galactoside alpha-1,3-fucosyltransferase 7 [EC:2.4.1.-]
K09661  
mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B [EC:2.4.1.-]
K00715  
ganglioside galactosyltransferase [EC:2.4.1.62]
K00735  
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 [EC:2.4.1.135]
K10157  
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 [EC:2.4.1.135]
K09674  
carbohydrate 3-sulfotransferase 10 [EC:2.8.2.-]
K10967  
alpha 1,2-mannosyltransferase [EC:2.4.1.-]
K05538  
alpha 1,3-mannosyltransferase [EC:2.4.1.-]
K10968  
alpha 1,3-mannosyltransferase [EC:2.4.1.-]
K10969  
alpha 1,3-mannosyltransferase [EC:2.4.1.-]
K10970  
alpha 1,2-mannosyltransferase [EC:2.4.1.-]
K10971  
alpha 1,2-galactosyltransferase [EC:2.4.1.-]
K09667  
protein O-GlcNAc transferase [EC:2.4.1.255]
K18134  
protein O-GlcNAc transferase [EC:2.4.1.255]
K03691  
peptide-O-fucosyltransferase [EC:2.4.1.221]
K05948  
fringe [EC:2.4.1.222]
K00778  
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.99.1]
K00779  
beta-galactoside alpha2,6-sialyltransferase (sialyltransferase 2) [EC:2.4.99.1]
K13675  
UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase [EC:2.4.1.-]
K13667  
protein glucosyltransferase [EC:2.4.1.-]
K13676  
UDP-xylose:glucoside alpha-1,3-xylosyltransferase [EC:2.4.2.-]
K11703  
collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:2.4.1.66 2.4.1.50 1.14.11.4]
Reference
  Authors
Kizuka Y, Oka S
  Title
Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate.
  Journal
Cell Mol Life Sci 69:4135-47 (2012)
Reference
  Authors
Lommel M, Strahl S
  Title
Protein O-mannosylation: conserved from bacteria to humans.
  Journal
Glycobiology 19:816-28 (2009)

DBGET integrated database retrieval system