KEGG   PATHWAY: ko00514Help
Entry
ko00514                     Pathway                                

Name
Other types of O-glycan biosynthesis
Description
O-linked glycosylation is the attachment of monosaccharides to the hydroxyl groups of amino acids, mostly serine and threonine, and is found in eukaryotes, archaea and bacteria. O-glycans exhibit diverse types of modifications where the innermost monosaccharide is N-acetylgalactosamine (map00512, mannose in mammals (map00515, and others (this map) including N-acetylglucosamine, fucose, glucose, galactose, mannose in yeast and arabinose in plants.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Other types of O-glycan biosynthesis
ko00514

All organismsOrtholog table
Disease
H00590  
Congenital muscular dystrophies (CMD/MDC)
H00593  
Limb-girdle muscular dystrophy (LGMD)
H00768  
Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
H00944  
Dowling-Degos disease
H01075  
Peters anomaly
H01192  
Lysyl hydroxylase 3 (LH3) deficiency
Orthology
K09667  
protein O-GlcNAc transferase [EC:2.4.1.255]
K18134  
protein O-GlcNAc transferase [EC:2.4.1.255]
K03691  
peptide-O-fucosyltransferase [EC:2.4.1.221]
K05948  
fringe [EC:2.4.1.222]
K07966  
beta-1,4-galactosyltransferase 1 [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
K07967  
beta-1,4-galactosyltransferase 2 [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
K07968  
beta-1,4-galactosyltransferase 3 [EC:2.4.1.- 2.4.1.38 2.4.1.90]
K00778  
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.99.1]
K00779  
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2) [EC:2.4.99.1]
K00781  
neolactotetraosylceramide alpha-2,3-sialyltransferase (sialyltransferase 6) [EC:2.4.99.6]
K13675  
UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase [EC:2.4.1.-]
K13667  
protein glucosyltransferase [EC:2.4.1.-]
K13676  
UDP-xylose:glucoside alpha-1,3-xylosyltransferase [EC:2.4.2.-]
K11703  
collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:2.4.1.66 2.4.1.50 1.14.11.4]
K00728  
dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]
K10967  
alpha 1,2-mannosyltransferase [EC:2.4.1.-]
K05538  
alpha 1,3-mannosyltransferase [EC:2.4.1.-]
K10968  
alpha 1,3-mannosyltransferase [EC:2.4.1.-]
K10969  
alpha 1,3-mannosyltransferase [EC:2.4.1.-]
K10970  
alpha 1,2-mannosyltransferase [EC:2.4.1.-]
K10971  
alpha 1,2-galactosyltransferase [EC:2.4.1.-]
K20781  
peptidyl serine alpha-galactosyltransferase [EC:2.4.1.-]
K20782  
hydroxyproline O-arabinosyltransferase [EC:2.4.2.58]
K20783  
arabinosyltransferase [EC:2.4.2.-]
K20784  
arabinosyltransferase [EC:2.4.2.-]
Reference
  Authors
Kizuka Y, Oka S
  Title
Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate.
  Journal
Cell Mol Life Sci 69:4135-47 (2012)
DOI:10.1007/s00018-012-1036-z
Reference
  Authors
Lommel M, Strahl S
  Title
Protein O-mannosylation: conserved from bacteria to humans.
  Journal
Glycobiology 19:816-28 (2009)
DOI:10.1093/glycob/cwp066

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