KEGG   PATHWAY: ko00533Help
Entry
ko00533                     Pathway                                

Name
Glycosaminoglycan biosynthesis - keratan sulfate
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Glycosaminoglycan biosynthesis - keratan sulfate
ko00533

All organismsOrtholog table
Disease
H00768  
Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
H00954  
Macular corneal dystrophy (MCD)
Orthology
K00717  
glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
K07966  
beta-1,4-galactosyltransferase 1 [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
K07967  
beta-1,4-galactosyltransferase 2 [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
K07968  
beta-1,4-galactosyltransferase 3 [EC:2.4.1.- 2.4.1.38 2.4.1.90]
K00741  
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.149]
K09671  
carbohydrate 6-sulfotransferase 6 [EC:2.8.2.-]
K07969  
beta-1,4-galactosyltransferase 4 [EC:2.4.1.- 2.4.1.90]
K09664  
beta-1,3-N-acetylglucosaminyltransferase 7 [EC:2.4.1.-]
K01022  
keratan sulfate 6-sulfotransferase 1 [EC:2.8.2.21]
K00781  
N-acetyllactosaminide alpha-2,3-sialyltransferase (sialyltransferase 6) [EC:2.4.99.6]
K04745  
carbohydrate 6-sulfotransferase 2 [EC:2.8.2.-]
K04746  
carbohydrate 6-sulfotransferase 4 [EC:2.8.2.-]
K00780  
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.99.4]
K03368  
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B) [EC:2.4.99.4]
Reference
  Authors
Funderburgh JL.
  Title
Keratan sulfate: structure, biosynthesis, and function.
  Journal
Glycobiology 10:951-958 (2000)
Reference
  Authors
Seko A, Yamashita K.
  Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
  Journal
FEBS Lett 556:216-20 (2004)
Reference
  Authors
Seko A, Dohmae N, Takio K, Yamashita K.
  Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
  Journal
J Biol Chem 278:9150-8 (2003)

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