KEGG PATHWAY: ko00624

PATHWAY: ko00624

Entry

ko00624 Pathway

Name

Polycyclic aromatic hydrocarbon degradation

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

ko00624

Polycyclic aromatic hydrocarbon degradation

Other DBs

BSID:

377

UMBBD:

flu ant pha pyr bap pth

Orthology

K14579	naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12]
K14580	naphthalene 1,2-dioxygenase subunit beta [EC:1.14.12.12]
K14578	naphthalene 1,2-dioxygenase system ferredoxin subunit
K14581	naphthalene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component [EC:1.18.1.3]
K14599	dibenzofuran dioxygenase alpha subunit [EC:1.14.12.-]
K14600	dibenzofuran dioxygenase beta subunit [EC:1.14.12.-]
K14601	1,1a-dihydroxy-1-hydro-9-fluorenone dehydrogenase
K14602	2'-carboxy-2,3-dihydroxybiphenyl 1,2-dioxygenase large subunit
K14603	2'-carboxy-2,3-dihydroxybiphenyl 1,2-dioxygenase small subunit and ferredoxin fusion protein
K14604	2-hydroxy-6-oxo-6-(2'-carboxyphenyl)-hexa-2,4-dienoate hydrolase [EC:3.7.1.-]
K03384	[EC:1.14.12.-]
K00224	[EC:1.3.1.-]
K00517	[EC:1.14.-.-]
K14582	cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase [EC:1.3.1.60 1.3.1.29]
K00480	salicylate hydroxylase [EC:1.14.13.1]
K16269	cis-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC:1.3.1.19]
K00492	[EC:1.14.13.-]
K00599	[EC:2.1.1.-]
K11943	PAH dioxygenase large subunit [EC:1.13.11.-]
K11944	PAH dioxygenase small subunit [EC:1.13.11.-]
K11945	extradiol dioxygenase [EC:1.13.11.-]
K11946	hydratase-aldolase [EC:4.1.2.-]
K11947	aldehyde dehydrogenase [EC:1.2.1.-]
K11948	1-hydroxy-2-naphthoate dioxygenase [EC:1.13.11.38]
K11949	4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase [EC:4.1.2.34]
K07519	phthalate 4,5-dioxygenase [EC:1.14.12.7]
K04102	4,5-dihydroxyphthalate decarboxylase [EC:4.1.1.55]
K04100	protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8]
K04101	protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8]
K00448	protocatechuate 3,4-dioxygenase, alpha subunit [EC:1.13.11.3]
K00449	protocatechuate 3,4-dioxygenase, beta subunit [EC:1.13.11.3]

Compound

C00090	Catechol
C00230	3,4-Dihydroxybenzoate
C00587	3-Hydroxybenzoate
C00805	Salicylate
C01163	3-Carboxy-cis,cis-muconate
C01198	3-(2-Hydroxyphenyl)propanoate
C01504	Indanone
C01606	Phthalate
C02274	Dihydrocoumarin
C03012	Naphthalene-1,2-diol
C03057	2-Carboxybenzaldehyde
C03164	Phenanthrene-3,4-diol
C03203	1-Hydroxy-2-naphthoate
C03223	3,4-Dihydroxyphthalate
C03233	4,5-Dihydroxyphthalate
C04468	(+)-cis-3,4-Dihydrophenanthrene-3,4-diol
C04484	4-Carboxy-2-hydroxymuconate semialdehyde
C04783	cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate
C06318	(3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate
C06337	Terephthalate
C06680	4-Hydroxyphthalate
C06711	Fluoren-9-ol
C06712	Fluoren-9-one
C07535	Benzo[a]pyrene
C07715	Fluorene
C07717	3,4-Dihydroxyfluorene
C07718	2-Hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene)-but-2-enoic acid
C07719	2-Formyl-1-indanone
C07720	3-Hydroxy-1-indanone
C07721	(+)-(3S,4R)-cis-3,4-Dihydroxy-3,4-dihydrofluorene
C07722	3,4-Dihydroxy-3,4-dihydro-9-fluorenone
C07723	4-Hydroxy-9-fluorenone
C07724	1,2-Dihydroxyfluorene
C07725	2-Hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene)but-2-enoic acid
C07726	1-Formyl-2-indanone
C07727	2-Indanone
C07728	3-Isochromanone
C11422	Phenanthrene
C11425	2-Hydroxy-2H-benzo[h]chromene-2-carboxylate
C11426	cis-4-(1'-Hydroxynaphth-2'-yl)-2-oxobut-3-enoate
C11427	1-Hydroxy-2-naphthaldehyde
C11428	trans-9(S),10(S)-Dihydrodiolphenanthrene
C11429	Phenanthrene-9,10-oxide
C11430	9-Hydroxyphenanthrene
C11431	Phenanthrene-1,2-oxide
C11432	1-Phenanthrol
C11433	1-Methoxyphenanthrene
C14315	Anthracene
C14335	Pyrene
C14519	1-Hydroxypyrene
C16149	(3Z)-4-(2-Carboxyphenyl)-2-oxobut-3-enoate
C16203	Anthracene-cis-1,2-dihydrodiol
C16204	1,2-Anthracenediol
C16205	Anthracene-9,10-dihydrodiol
C16206	9,10-Dihydroxyanthracene
C16207	Anthraquinone
C16208	1-Methoxy-2-hydroxyanthracene
C16209	3-(2-Carboxyvinyl)naphthalene-2-carboxylic acid
C16210	4-(3-Hydroxy-2-naphthyl)-2-oxobut-3-enoic acid
C16211	6,7-Benzocoumarin
C16212	3-Hydroxy-2-naphthoate
C16213	2,3-Dihydroxynaphthalene
C16214	3-[6-(Carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate
C16215	1,2-Dihydrophthalic acid
C16262	1-Hydro-1,1a-dihydroxy-9-fluorenone
C16263	2,3-Dihydroxy-2'-carboxybiphenyl
C16264	2-Hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate
C18249	cis-4,5-Dihydroxy-4,5-dihydropyrene
C18250	4,5-Dihydroxypyrene
C18251	Pyrene-4,5-dione
C18252	Phenanthrene-4,5-dicarboxylate
C18253	Phenanthrene-4-carboxylate
C18254	Pyrene-4,5-oxide
C18255	trans-4,5-Dihydroxy-4,5-dihydropyrene
C18256	cis-3,4-Phenanthrenedihydrodiol-4-carboxylate
C18257	Pyrene-1,6-dione
C18258	Pyrene-1,8-dione
C18259	1-Methoxypyrene
C18260	1,6-Dimethoxypyrene
C18261	1-Hydroxy-6-methoxypyrene
C18262	1-Methoxypyrene-6,7-oxide
C18263	1,6-Dihydroxypyrene
C18264	1,8-Dihydroxypyrene
C18265	1-Hydroxypyrene-6,7-oxide
C18266	1-Hydroxypyrene-7,8-oxide
C18267	Pyrene-1,2-oxide
C18269	1-Pyrenylsulfate
C18270	Benzo[a]pyrene-cis-4,5-dihydrodiol
C18271	cis-4-(7-Hydroxtpyren-8-yl)-2-oxobut-3-enoate
C18272	cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate
C18273	7,8-Dihydropyrene-8-carboxylate
C18274	7,8-Dihydropyrene-7-carboxylate
C18275	Benzo[a]pyrene-cis-7,8-dihydrodiol
C18276	Benzo[a]pyrene-cis-9,10-dihydrodiol
C18277	4,5-Chrysenedicarboxylate
C18278	9,10-Dihydroxybenzo[a]pyrene
C18279	4,5-Dihydroxybenzo[a]pyrene
C18280	11,12-Dihydroxybenzo[a]pyrene
C18281	10-Oxabenzo[def]chrysen-9-one
C18282	5-Chrysenecarboxylate
C18283	4-Chrysenecarboxylate
C18284	Benzo[a]pyrene-cis-11,12-dihydrodiol
C18285	Benzo[a]pyrene-trans-11,12-dihydrodiol
C18286	Benzo[a]pyrene-11,12-epoxide
C18314	Phthalate 3,4-cis-dihydrodiol

Reference

PMID:11766961

Authors

Wattiau P, Bastiaens L, van Herwijnen R, Daal L, Parsons JR, Renard ME, Springael D, Cornelis GR.

Title

Fluorene degradation by Sphingomonas sp. LB126 proceeds through protocatechuic acid: a genetic analysis.

Journal

Res Microbiol 152:861-72 (2001)

Reference

PMID:15386141

Authors

Story SP, Kline EL, Hughes TA, Riley MB, Hayasaka SS.

Title

Degradation of aromatic hydrocarbons by Sphingomonas paucimobilis strain EPA505.

Journal

Arch Environ Contam Toxicol 47:168-76 (2004)

Reference

PMID:15317800

Authors

Habe H, Chung JS, Kato H, Ayabe Y, Kasuga K, Yoshida T, Nojiri H, Yamane H, Omori T.

Title

Characterization of the upper pathway genes for fluorene metabolism in Terrabacter sp. strain DBF63.

Journal

J Bacteriol 186:5938-44 (2004)

Reference

PMID:12483604

Authors

Nojiri H, Habe H, Omori T.

Title

Bacterial degradation of aromatic compounds via angular dioxygenation.

Journal

J Gen Appl Microbiol 47:279-305 (2001)

Reference

PMID:17258432

Authors

Pagnout C, Frache G, Poupin P, Maunit B, Muller JF, Ferard JF.

Title

Isolation and characterization of a gene cluster involved in PAH degradation in Mycobacterium sp. strain SNP11: expression in Mycobacterium smegmatis mc(2)155.

Journal

Res Microbiol 158:175-86 (2007)

Reference

PMID:11682202

Authors

Dean-Ross D, Moody JD, Freeman JP, Doerge DR, Cerniglia CE.

Title

Metabolism of anthracene by a Rhodococcus species.

Journal

FEMS Microbiol Lett 204:205-11 (2001)

Reference

PMID:11282593

Authors

Moody JD, Freeman JP, Doerge DR, Cerniglia CE.

Title

Degradation of phenanthrene and anthracene by cell suspensions of Mycobacterium sp. strain PYR-1.

Journal

Appl Environ Microbiol 67:1476-83 (2001)

Reference

PMID:12513994

Authors

van Herwijnen R, Springael D, Slot P, Govers HA, Parsons JR.

Title

Degradation of anthracene by Mycobacterium sp. strain LB501T proceeds via a novel pathway, through o-phthalic acid.

Journal

Appl Environ Microbiol 69:186-90 (2003)

Reference

PMID:19442441

Authors

Haritash AK, Kaushik CP

Title

Biodegradation aspects of polycyclic aromatic hydrocarbons (PAHs): a review.

Journal

J Hazard Mater 169:1-15 (2009)

Reference

PMID:17041157

Authors

Liang Y, Gardner DR, Miller CD, Chen D, Anderson AJ, Weimer BC, Sims RC

Title

Study of biochemical pathways and enzymes involved in pyrene degradation by Mycobacterium sp. strain KMS.

Journal

Appl Environ Microbiol 72:7821-8 (2006)

Reference

PMID:15488584

Authors

da Silva M, Esposito E, Moody JD, Canhos VP, Cerniglia CE

Title

Metabolism of aromatic hydrocarbons by the filamentous fungus Cyclothyrium sp.

Journal

Chemosphere 57:943-52 (2004)

Reference

PMID:17085566

Authors

Kim SJ, Kweon O, Jones RC, Freeman JP, Edmondson RD, Cerniglia CE

Title

Complete and integrated pyrene degradation pathway in Mycobacterium vanbaalenii PYR-1 based on systems biology.

Journal

J Bacteriol 189:464-72 (2007)

Reference

PMID:9094229

Authors

Wunder T, Marr J, Kremer S, Sterner O, Anke H

Title

1-Methoxypyrene and 1,6-dimethoxypyrene: two novel metabolites in fungal metabolism of polycyclic aromatic hydrocarbons.

Journal

Arch Microbiol 167:310-6 (1997)

Reference

PMID:8572690

Authors

Schneider J, Grosser R, Jayasimhulu K, Xue W, Warshawsky D

Title

Degradation of pyrene, benz[a]anthracene, and benzo[a]pyrene by Mycobacterium sp. strain RJGII-135, isolated from a former coal gasification site.

Journal

Appl Environ Microbiol 62:13-9 (1996)

Reference

PMID:14711661

Authors

Moody JD, Freeman JP, Fu PP, Cerniglia CE

Title

Degradation of benzo[a]pyrene by Mycobacterium vanbaalenii PYR-1.

Journal

Appl Environ Microbiol 70:340-5 (2004)

Reference

PMID:11371533

Authors

Eaton RW

Title

Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B.

Journal

J Bacteriol 183:3689-703 (2001)

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (2)   
   BioSystems (1)   
   UMBBD-PATH (6)   
Chemical substance (105)   
   KEGG COMPOUND (105)   
Chemical reaction (21)   
   KEGG ENZYME (21)   
Gene (31)   
   KEGG ORTHOLOGY (31)   
Literature (16)   
   PubMed (16)   
All databases (183)   

Download RDF

DBGET integrated database retrieval system