KEGG   PATHWAY: ko00650Help
Entry
ko00650                     Pathway                                

Name
Butanoate metabolism
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
ko00650  Butanoate metabolism
ko00650

Ortholog table
Disease
H00179  3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
H00835  Succinic semialdehyde dehydrogenase (SSADH) deficiency
H01121  Succinyl CoA:3-oxoacid CoA transferase (SCOT) deficiency
H01123  HMG-CoA synthase (HMGCS) deficiency
H01280  L-2-hydroxyglutaric aciduria (L2HGA)
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
Orthology
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00074  3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:5.3.3.8 5.1.2.3 4.2.1.17 1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:5.1.2.3 4.2.1.17 1.1.1.35]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01715  enoyl-CoA hydratase [EC:4.2.1.17]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.211 4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00209  enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.44 1.3.1.9]
K17829  crotonyl-CoA reductase [EC:1.3.1.86]
K01034  acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.9 2.8.3.8]
K01035  acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.9 2.8.3.8]
K19709  acetate CoA-transferase [EC:2.8.3.8]
K01896  medium-chain acyl-CoA synthetase [EC:6.2.1.2]
K00929  butyrate kinase [EC:2.7.2.7]
K00634  phosphate butyryltransferase [EC:2.3.1.19]
K00132  acetaldehyde dehydrogenase (acetylating) [EC:1.2.1.10]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.2.1.10]
K04073  acetaldehyde dehydrogenase [EC:1.2.1.10]
K18366  acetaldehyde/propanal dehydrogenase [EC:1.2.1.87 1.2.1.10]
K00100  butanol dehydrogenase [EC:1.1.1.-]
K21317  butane monooxygenase alpha subunit [EC:1.14.13.230]
K21318  butane monooxygenase beta subunit [EC:1.14.13.230]
K21319  butane monooxygenase gamma subunit [EC:1.14.13.230]
K21320  butane monooxygenase reductase
K21321  butane monooxygenase regulatory protein
K21322  butane monooxygenase hypothetical assembly protein
K17865  3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55]
K03821  polyhydroxyalkanoate synthase [EC:2.3.1.-]
K05973  poly(3-hydroxybutyrate) depolymerase [EC:3.1.1.75]
K00023  acetoacetyl-CoA reductase [EC:1.1.1.36]
K01615  glutaconyl-CoA decarboxylase [EC:4.1.1.70]
K01039  glutaconate CoA-transferase, subunit A [EC:2.8.3.12]
K01040  glutaconate CoA-transferase, subunit B [EC:2.8.3.12]
K00109  2-hydroxyglutarate dehydrogenase [EC:1.1.99.2]
K07246  tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase [EC:1.1.1.83 4.1.1.73 1.1.1.93]
K01799  maleate isomerase [EC:5.2.1.1]
K00239  succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.4 1.3.5.1]
K00240  succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.4 1.3.5.1]
K00241  succinate dehydrogenase / fumarate reductase, cytochrome b subunit
K00242  succinate dehydrogenase / fumarate reductase, membrane anchor subunit
K18859  succinate dehydrogenase / fumarate reductase, subunit D
K18860  putative succinate dehydrogenase / fumarate reductase, subunit D
K00244  fumarate reductase flavoprotein subunit [EC:1.3.5.4]
K00245  fumarate reductase iron-sulfur subunit [EC:1.3.5.4]
K00246  fumarate reductase subunit C
K00247  fumarate reductase subunit D
K01580  glutamate decarboxylase [EC:4.1.1.15]
K00823  4-aminobutyrate aminotransferase [EC:2.6.1.19]
K14268  5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.19 2.6.1.48]
K07250  4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.22 2.6.1.19]
K13524  4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.22 2.6.1.19]
K16871  4-aminobutyrate---pyruvate transaminase [EC:2.6.1.96]
K00135  succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.20 1.2.1.79 1.2.1.16]
K00139  succinate-semialdehyde dehydrogenase [EC:1.2.1.24]
K17761  succinate-semialdehyde dehydrogenase, mitochondrial [EC:1.2.1.24]
K08324  succinate-semialdehyde dehydrogenase [EC:1.2.1.24 1.2.1.16]
K18118  succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18]
K18119  succinate-semialdehyde dehydrogenase [EC:1.2.1.76]
K18120  4-hydroxybutyrate dehydrogenase [EC:1.1.1.61]
K00043  4-hydroxybutyrate dehydrogenase [EC:1.1.1.61]
K08318  4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase [EC:1.1.1.373 1.1.1.61]
K18121  glyoxylate/succinic semialdehyde reductase [EC:1.1.1.- 1.1.1.79]
K18122  4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]
K14534  4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:5.3.3.3 4.2.1.120]
K00656  formate C-acetyltransferase [EC:2.3.1.54]
K00169  pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
K00170  pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
K00172  pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
K00171  pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
K03737  pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.- 1.2.7.1]
K00174  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.11 1.2.7.3]
K00175  2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.11 1.2.7.3]
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
K01640  hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]
K01027  3-oxoacid CoA-transferase [EC:2.8.3.5]
K01028  3-oxoacid CoA-transferase subunit A [EC:2.8.3.5]
K01029  3-oxoacid CoA-transferase subunit B [EC:2.8.3.5]
K01907  acetoacetyl-CoA synthetase [EC:6.2.1.16]
K00019  3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]
K07518  hydroxybutyrate-dimer hydrolase [EC:3.1.1.22]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
K01575  acetolactate decarboxylase [EC:4.1.1.5]
K00004  (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.303 1.1.1.- 1.1.1.4]
K03366  meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.304 1.1.1.76 1.1.1.-]
K18009  meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.304 1.1.1.76 1.1.1.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00091  Succinyl-CoA
C00122  Fumarate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00246  Butanoic acid
C00332  Acetoacetyl-CoA
C00334  4-Aminobutanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00497  (R)-Malate
C00741  Diacetyl
C00810  (R)-Acetoin
C00877  Crotonoyl-CoA
C00989  4-Hydroxybutanoic acid
C01089  (R)-3-Hydroxybutanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01384  Maleic acid
C01412  Butanal
C01769  (S)-Acetoin
C02331  Vinylacetyl-CoA
C02411  Glutaconyl-1-CoA
C02527  Butanoylphosphate
C02630  2-Hydroxyglutarate
C03044  (R,R)-Butane-2,3-diol
C03046  (S,S)-Butane-2,3-diol
C03058  2-Hydroxyglutaryl-CoA
C03561  (R)-3-Hydroxybutanoyl-CoA
C04546  (R)-3-((R)-3-Hydroxybutanoyloxy)butanoate
C06010  (S)-2-Acetolactate
C06142  1-Butanol
C06143  Poly-beta-hydroxybutyrate
C06144  3-Butynoate
C06145  3-Butyn-1-al
C06146  3-Butyn-1-ol
C11062  4-Hydroxybutyryl-CoA
C20657  meso-2,3-Butanediol
C21390  Butane

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