KEGG PATHWAY: ko00670

PATHWAY: ko00670

Entry

ko00670 Pathway

Name

One carbon pool by folate

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

ko00670

One carbon pool by folate

Module

M00126	Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00670]
M00140	C1-unit interconversion, prokaryotes [PATH:ko00670]
M00141	C1-unit interconversion, eukaryotes [PATH:ko00670]

Disease

H00183	Homocystinuria
H00262	Spina bifida
H00966	AICA-ribosiduria
H01197	Dihydrofolate reductase (DHFR) deficiency
H01262	Formiminotransferase deficiency
H01285	Methylcobalamin deficiency type G (cblG)

Drug

D00145	Trimethoprim (JAN/USP/INN)
D00488	Pyrimethamine (JAN/USP/INN)
D02487	Proguanil hydrochloride (JAN)
D03771	Diaveridine (USAN/INN)
D06236	Trimethoprim sulfate (USP)
D08337	Iclaprim (USAN/INN)
D08428	Proguanil (INN)
D08563	Iclaprim mesylate (USAN)
D08644	Trimethoprim lactate

Orthology

K00287	dihydrofolate reductase [EC:1.5.1.3]
K13998	dihydrofolate reductase / thymidylate synthase [EC:2.1.1.45 1.5.1.3]
K13938	dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.3 1.5.1.-]
K01938	formate--tetrahydrofolate ligase [EC:6.3.4.3]
K13402	monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]
K00288	methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:6.3.4.3 3.5.4.9 1.5.1.5]
K01491	methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9 1.5.1.5]
K13403	methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9 1.5.1.15]
K00295	methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
K00600	glycine hydroxymethyltransferase [EC:2.1.2.1]
K11787	phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1 2.1.2.2 6.3.4.13]
K00601	phosphoribosylglycinamide formyltransferase [EC:2.1.2.2]
K11175	phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
K08289	phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2]
K00602	phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:3.5.4.10 2.1.2.3]
K00603	glutamate formiminotransferase [EC:2.1.2.5]
K13990	glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4 2.1.2.5]
K00604	methionyl-tRNA formyltransferase [EC:2.1.2.9]
K00605	aminomethyltransferase [EC:2.1.2.10]
K00548	5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
K00560	thymidylate synthase [EC:2.1.1.45]
K03465	thymidylate synthase (FAD) [EC:2.1.1.148]
K00289	formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]
K01433	formyltetrahydrofolate deformylase [EC:3.5.1.10]
K00297	methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]
K01746	formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]
K01934	5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]

Compound

C00101	Tetrahydrofolate
C00143	5,10-Methylenetetrahydrofolate
C00234	10-Formyltetrahydrofolate
C00415	Dihydrofolate
C00440	5-Methyltetrahydrofolate
C00445	5,10-Methenyltetrahydrofolate
C00504	Folate
C00664	5-Formiminotetrahydrofolate
C03479	Folinic acid

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (8)   
   KEGG PATHWAY (4)   
   KEGG MODULE (3)   
   BioSystems (1)   
Disease (6)   
   KEGG DISEASE (6)   
Drug (9)   
   KEGG DRUG (9)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (23)   
   KEGG ENZYME (23)   
Gene (27)   
   KEGG ORTHOLOGY (27)   
All databases (83)   

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