KEGG   PATHWAY: ko00790Help
Entry
ko00790                     Pathway                                

Name
Folate biosynthesis
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Folate biosynthesis
ko00790

All organismsOrtholog table
Module
M00126  
Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00790]
Disease
H00167  
Phenylketonuria (PKU)
H00213  
Hypophosphatasia
H00831  
Primary dystonia
H01197  
Dihydrofolate reductase (DHFR) deficiency
Drug
D00145  
Trimethoprim (JAN/USP/INN)
D00433  
Sulfadiazine silver (JP16)
D00447  
Sulfamethoxazole (JP16/USP/INN)
D00450  
Sulfisoxazole (JP16/USP)
D00488  
Pyrimethamine (JAN/USP/INN)
D00580  
Sulfadoxine (JAN/USP/INN)
D00587  
Sulfadiazine (JAN/USP/INN)
D00592  
Diaphenylsulfone (JAN)
D00870  
Sulfamethizole (JP16/USP/INN)
D00871  
Sulfacetamide sodium (USP)
D01047  
Sulfathiazole (USP/INN)
D01142  
Sulfadimethoxine (JAN/USP)
D01526  
Sulfisomidine (JAN)
D01601  
Acetylsulfamethoxazole (JAN)
D01954  
Sulfaphenazole (JAN/INN)
D02434  
Sulfapyridine (USP/INN)
D02435  
Sulfamerazine (INN)
D02437  
Sulfaguanidine (INN)
D02439  
Sulfamethoxypyridazine (INN)
D02447  
Succinylsulfathiazole
D02487  
Proguanil hydrochloride (JAN)
D02516  
Sulfamoxole (USAN/INN)
D02520  
Glucosulfone (INN)
D03771  
Diaveridine (USAN/INN)
D05947  
Sulfacetamide (USP/INN)
D05948  
Sulfachlorpyridazine (USP/INN)
D05949  
Sulfadiazine sodium (USP)
D05952  
Sulfaquinoxaline (USP/INN)
D05956  
Acetylsulfisoxazole (JAN)
D05957  
Sulfisoxazole diolamine (USAN)
D06236  
Trimethoprim sulfate (USP)
D07060  
Succinylsulfathiazole (INN)
D07239  
Sulfathiourea (INN)
D08337  
Iclaprim (USAN/INN)
D08428  
Proguanil (INN)
D08538  
Sulfadimethoxine sodium (USP)
D08540  
Sulfamethoxypyridazine sodium salt
D08543  
Sulfanilamide (INN)
D08563  
Iclaprim mesylate (USAN)
D08644  
Trimethoprim lactate
Other DBs
BSID: 
GO: 
Orthology
K01495  
GTP cyclohydrolase I [EC:3.5.4.16]
K09007  
GTP cyclohydrolase I [EC:3.5.4.16]
K01077  
alkaline phosphatase [EC:3.1.3.1]
K01113  
alkaline phosphatase D [EC:3.1.3.1]
K13939  
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.5.1.15 2.7.6.3 4.1.2.25]
K13940  
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3 4.1.2.25]
K01633  
dihydroneopterin aldolase [EC:4.1.2.25]
K00950  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
K00796  
dihydropteroate synthase [EC:2.5.1.15]
K13941  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.5.1.15 2.7.6.3]
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:2.1.1.45 1.5.1.3]
K13938  
dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.3 1.5.1.-]
K01930  
folylpolyglutamate synthase [EC:6.3.2.17]
K11754  
dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.17 6.3.2.12]
K01307  
gamma-glutamyl hydrolase [EC:3.4.19.9]
K01737  
6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.1.2.50 4.2.3.12]
K00072  
sepiapterin reductase [EC:1.1.1.153]
K04071  
6-pyruvoyltetrahydropterin 2'-reductase [EC:1.1.1.220]
K00357  
dihydropteridine reductase [EC:1.5.1.34]
K10026  
7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
K06920  
7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
K06879  
7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
K09457  
7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
K03639  
molybdenum cofactor biosynthesis protein
K03637  
molybdenum cofactor biosynthesis protein C
K03635  
molybdopterin synthase catalytic subunit [EC:2.-.-.-]
K03636  
molybdopterin synthase sulfur carrier subunit
K01665  
para-aminobenzoate synthetase component I [EC:2.6.1.85]
K01664  
para-aminobenzoate synthetase component II [EC:2.6.1.85]
K13950  
para-aminobenzoate synthetase [EC:2.6.1.85]
K02619  
4-amino-4-deoxychorismate lyase [EC:4.1.3.38]
K03342  
para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:4.1.3.38 2.6.1.85]
K17364  
dihydromethanopterin reductase [EC:1.5.1.47]
K15740  
tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33]
Compound
C00044  
GTP
C00101  
Tetrahydrofolate
C00251  
Chorismate
C00266  
Glycolaldehyde
C00268  
Dihydrobiopterin
C00272  
Tetrahydrobiopterin
C00415  
Dihydrofolate
C00504  
Folate
C00568  
4-Aminobenzoate
C00921  
Dihydropteroate
C01217  
5,6,7,8-Tetrahydromethanopterin
C01300  
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
C03541  
THF-polyglutamate
C03684  
6-Pyruvoyltetrahydropterin
C04244  
6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  
2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine
C04874  
2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
C04895  
7,8-Dihydroneopterin 3'-triphosphate
C05922  
Formamidopyrimidine nucleoside triphosphate
C05923  
2,5-Diaminopyrimidine nucleoside triphosphate
C05924  
Molybdopterin
C05925  
Dihydroneopterin phosphate
C05926  
Neopterin
C05927  
7,8-Dihydromethanopterin
C06148  
2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06149  
6-(3'-Triphosphoryl-1'-methylglyceryl)-7-methyl-7,8-dihydrobiopterin
C09332  
THF-L-glutamate
C11355  
4-Amino-4-deoxychorismate
C15996  
7-Cyano-7-carbaguanine
C16675  
7-Aminomethyl-7-carbaguanine
C18239  
Precursor Z
C18802  
Tetrahydrosarcinapterin
C20239  
6-Carboxy-5,6,7,8-tetrahydropterin
C20248  
7-Carboxy-7-carbaguanine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)

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