KEGG   PATHWAY: ko00790Help
Entry
ko00790                     Pathway                                

Name
Folate biosynthesis
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Folate biosynthesis
ko00790

All organismsOrtholog table
Module
M00126  
Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00790]
M00840  
Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF [PATH:ko00790]
M00841  
Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF [PATH:ko00790]
M00842  
Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:ko00790]
M00843  
L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4 [PATH:ko00790]
Disease
H00167  
Phenylketonuria (PKU)
H00213  
Hypophosphatasia
H00831  
Primary dystonia
H01197  
Dihydrofolate reductase (DHFR) deficiency
Drug
D00145  
Trimethoprim (JAN/USP/INN)
D00433  
Sulfadiazine, silver (USP)
D00447  
Sulfamethoxazole (JP17/USP/INN)
D00450  
Sulfisoxazole (JP17/USP)
D00488  
Pyrimethamine (JAN/USP/INN)
D00580  
Sulfadoxine (JAN/USP/INN)
D00587  
Sulfadiazine (JAN/USP/INN)
D00592  
Dapsone (USP)
D00870  
Sulfamethizole (JP17/USP/INN)
D00871  
Sulfacetamide sodium (USP)
D01047  
Sulfathiazole (USP/INN)
D01142  
Sulfadimethoxine (JAN/USP)
D01526  
Sulfisomidine (JAN)
D01601  
Acetylsulfamethoxazole (JAN)
D01954  
Sulfaphenazole (JAN/INN)
D02434  
Sulfapyridine (USP/INN)
D02435  
Sulfamerazine (INN)
D02437  
Sulfaguanidine (INN)
D02439  
Sulfamethoxypyridazine (INN)
D02447  
Succinylsulfathiazole
D02487  
Proguanil hydrochloride (JAN)
D02516  
Sulfamoxole (USAN/INN)
D02520  
Glucosulfone (INN)
D03771  
Diaveridine (USAN/INN)
D05947  
Sulfacetamide (USP/INN)
D05948  
Sulfachlorpyridazine (USP/INN)
D05949  
Sulfadiazine sodium (USP)
D05952  
Sulfaquinoxaline (USP/INN)
D05956  
Sulfisoxazole acetyl (USP)
D05957  
Sulfisoxazole diolamine (USAN)
D06236  
Trimethoprim sulfate (USP)
D07060  
Succinylsulfathiazole (INN)
D07239  
Sulfathiourea (INN)
D08337  
Iclaprim (USAN/INN)
D08428  
Proguanil (INN)
D08538  
Sulfadimethoxine sodium (USP)
D08540  
Sulfamethoxypyridazine sodium salt
D08543  
Sulfanilamide (INN)
D08563  
Iclaprim mesylate (USAN)
D08644  
Trimethoprim lactate
Other DBs
BSID: 
GO: 
Orthology
K01495  
GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  
GTP cyclohydrolase IB [EC:3.5.4.16]
K01077  
alkaline phosphatase [EC:3.1.3.1]
K01113  
alkaline phosphatase D [EC:3.1.3.1]
K08310  
dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67]
K19965  
dihydroneopterin triphosphate pyrophosphohydrolase [EC:3.6.1.67]
K13939  
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.5.1.15 2.7.6.3 4.1.2.25]
K13940  
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3 4.1.2.25]
K01633  
7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:1.13.11.81 5.1.99.8 4.1.2.25]
K00950  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
K00796  
dihydropteroate synthase [EC:2.5.1.15]
K13941  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.5.1.15 2.7.6.3]
K18974  
dihydropteroate synthase type 1 [EC:2.5.1.15]
K18824  
dihydropteroate synthase type 2 [EC:2.5.1.15]
K18825  
dihydropteroate synthase type 3 [EC:2.5.1.15]
K00287  
dihydrofolate reductase [EC:1.5.1.3]
K18589  
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19645  
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K13998  
dihydrofolate reductase / thymidylate synthase [EC:2.1.1.45 1.5.1.3]
K01930  
folylpolyglutamate synthase [EC:6.3.2.17]
K11754  
dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.17 6.3.2.12]
K22099  
dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.17 6.3.2.12]
K20457  
dihydrofolate synthase [EC:6.3.2.12]
K01307  
gamma-glutamyl hydrolase [EC:3.4.19.9]
K01497  
GTP cyclohydrolase II [EC:3.5.4.25]
K14652  
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:3.5.4.25 4.1.99.12]
K22100  
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase [EC:4.2.1.160]
K22101  
dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase [EC:4.2.3.12 4.1.2.60]
K01664  
para-aminobenzoate synthetase component II [EC:2.6.1.85]
K01665  
para-aminobenzoate synthetase component I [EC:2.6.1.85]
K13950  
para-aminobenzoate synthetase [EC:2.6.1.85]
K03342  
para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:4.1.3.38 2.6.1.85]
K02619  
4-amino-4-deoxychorismate lyase [EC:4.1.3.38]
K18482  
4-amino-4-deoxychorismate lyase [EC:4.1.3.38]
K07589  
D-erythro-7,8-dihydroneopterin triphosphate epimerase [EC:5.1.99.7]
K13938  
dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.3 1.5.1.50]
K01737  
6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.1.2.50 4.2.3.12]
K00072  
sepiapterin reductase [EC:1.1.1.153]
K00011  
aldehyde reductase [EC:1.1.1.21]
K00079  
carbonyl reductase 1 [EC:1.1.1.197 1.1.1.189 1.1.1.184]
K04119  
aldo-keto reductase family 1 member C3 [EC:1.1.1.357 1.1.1.213 1.1.1.188 1.1.1.51]
K00357  
dihydropteridine reductase [EC:1.5.1.34]
K01724  
4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]
K00500  
phenylalanine-4-hydroxylase [EC:1.14.16.1]
K00501  
tyrosine 3-monooxygenase [EC:1.14.16.2]
K00502  
tryptophan 5-monooxygenase [EC:1.14.16.4]
K17745  
sepiapterin reductase [EC:1.1.1.325]
K00310  
pyrimidodiazepine synthase [EC:1.5.4.1]
K10026  
7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
K06920  
7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
K06879  
7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
K09457  
7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
K17488  
GTP cyclohydrolase IV [EC:3.5.4.39]
K17487  
7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase [EC:3.1.4.56]
K09739  
dihydroneopterin aldolase [EC:4.1.2.25]
K07142  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
K06984  
beta-ribofuranosylaminobenzene 5'-phosphate synthase [EC:2.4.2.54]
K06897  
7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase [EC:2.5.1.105]
K17364  
dihydromethanopterin reductase [EC:1.5.1.47]
K18853  
dihydromethanopterin reductase (acceptor) [EC:1.5.99.15]
K15740  
tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33]
K22102  
dihydroneopterin phosphate aldolase [EC:4.1.2.59]
K03639  
GTP 3',8-cyclase [EC:4.1.99.22]
K03637  
cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]
K20967  
GTP 3',8-cyclase / cyclic pyranopterin monophosphate synthase [EC:4.6.1.17 4.1.99.22]
K03635  
molybdopterin synthase catalytic subunit [EC:2.8.1.12]
K21142  
MoaE-MoaD fusion protein [EC:2.8.1.12]
K03831  
molybdopterin adenylyltransferase [EC:2.7.7.75]
K03750  
molybdopterin molybdotransferase [EC:2.10.1.1]
K15376  
gephyrin [EC:2.7.7.75 2.10.1.1]
K07141  
molybdenum cofactor cytidylyltransferase [EC:2.7.7.76]
K03752  
molybdenum cofactor guanylyltransferase [EC:2.7.7.77]
K13818  
molybdopterin-guanine dinucleotide biosynthesis protein [EC:2.7.7.77]
K15631  
molybdenum cofactor sulfurtransferase [EC:2.8.1.9]
Compound
C00044  
GTP
C00101  
Tetrahydrofolate
C00119  
5-Phospho-alpha-D-ribose 1-diphosphate
C00156  
4-Hydroxybenzoate
C00251  
Chorismate
C00266  
Glycolaldehyde
C00268  
Dihydrobiopterin
C00272  
Tetrahydrobiopterin
C00415  
Dihydrofolate
C00504  
Folate
C00568  
4-Aminobenzoate
C00835  
Sepiapterin
C00921  
Dihydropteroate
C01217  
5,6,7,8-Tetrahydromethanopterin
C01300  
6-(Hydroxymethyl)-7,8-dihydropterin
C01304  
2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  
Pyrimidodiazepine
C02953  
7,8-Dihydrobiopterin
C03541  
THF-polyglutamate
C03684  
6-Pyruvoyltetrahydropterin
C04244  
6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  
6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  
7,8-Dihydroneopterin
C04895  
7,8-Dihydroneopterin 3'-triphosphate
C05922  
Formamidopyrimidine nucleoside triphosphate
C05923  
2,5-Diaminopyrimidine nucleoside triphosphate
C05924  
Molybdopterin
C05925  
Dihydroneopterin phosphate
C05926  
Neopterin
C05927  
7,8-Dihydromethanopterin
C06148  
2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C09332  
THF-L-glutamate
C11355  
4-Amino-4-deoxychorismate
C15522  
4a-Hydroxytetrahydrobiopterin
C15996  
7-Cyano-7-carbaguanine
C16675  
7-Aminomethyl-7-carbaguanine
C18237  
Molybdoenzyme molybdenum cofactor
C18239  
Precursor Z
C18802  
Tetrahydrosarcinapterin
C19848  
Adenylated molybdopterin
C19871  
Guanylyl molybdenum cofactor
C20239  
6-Carboxy-5,6,7,8-tetrahydropterin
C20248  
7-Carboxy-7-carbaguanine
C20264  
L-threo-Tetrahydrobiopterin
C20559  
4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  
N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  
7,8-Dihydroneopterin 2'-phosphate
C20567  
7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  
5,6,7,8-Tetrahydromonapterin
C21008  
7,8-Dihydromonapterin
C21065  
7,8-Dihydroxanthopterin
C21094  
7,8-Dihydromonapterin 3'-triphosphate
C21107  
4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  
(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  
Cytidylyl molybdenum cofactor
C21486  
Thio-molybdenum cofactor
C21640  
6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P

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