| Entry |
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| Name |
Folate biosynthesis
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| Class |
Metabolism; Metabolism of cofactors and vitamins
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| Pathway map |
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| Module |
| Tetrahydrofolate biosynthesis, GTP => THF [PATH: ko00790] |
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| Disease |
| Phenylketonuria (PKU) | | Hypophosphatasia | | Primary dystonia | | Dihydrofolate reductase (DHFR) deficiency |
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| Drug |
| Trimethoprim (JAN/USP/INN) | | Sulfadiazine silver (JP16) | | Sulfamethoxazole (JP16/USP/INN) | | Sulfisoxazole (JP16/USP) | | Pyrimethamine (JAN/USP/INN) | | Sulfadoxine (JAN/USP/INN) | | Sulfadiazine (JAN/USP/INN) | | Diaphenylsulfone (JAN) | | Sulfamethizole (JP16/USP/INN) | | Sulfacetamide sodium (USP) | | Sulfathiazole (USP/INN) | | Sulfadimethoxine (JAN/USP) | | Sulfisomidine (JAN) | | Acetylsulfamethoxazole (JAN) | | Sulfaphenazole (JAN/INN) | | Sulfapyridine (USP/INN) | | Sulfamerazine (INN) | | Sulfaguanidine (INN) | | Sulfamethoxypyridazine (INN) | | Succinylsulfathiazole | | Proguanil hydrochloride (JAN) | | Sulfamoxole (USAN/INN) | | Glucosulfone (INN) | | Diaveridine (USAN/INN) | | Sulfacetamide (USP/INN) | | Sulfachlorpyridazine (USP/INN) | | Sulfadiazine sodium (USP) | | Sulfaquinoxaline (USP/INN) | | Acetylsulfisoxazole (JAN) | | Sulfisoxazole diolamine (USAN) | | Trimethoprim sulfate (USP) | | Succinylsulfathiazole (INN) | | Sulfathiourea (INN) | | Iclaprim (USAN/INN) | | Proguanil (INN) | | Sulfadimethoxine sodium (USP) | | Sulfamethoxypyridazine sodium salt | | Sulfanilamide (INN) | | Iclaprim mesylate (USAN) | | Trimethoprim lactate |
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| Other DBs |
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| Orthology |
| | | | | alkaline phosphatase D [EC: 3.1.3.1] | | dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC: 2.5.1.15 2.7.6.3 4.1.2.25] | | dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC: 2.7.6.3 4.1.2.25] | | | | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC: 2.7.6.3] | | | | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC: 2.5.1.15 2.7.6.3] | | dihydrofolate reductase [EC: 1.5.1.3] | | | | dihydromonapterin reductase / dihydrofolate reductase [EC: 1.5.1.3 1.5.1.-] | | folylpolyglutamate synthase [EC: 6.3.2.17] | | | | | | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC: 4.1.2.50 4.2.3.12] | | | | 6-pyruvoyltetrahydropterin 2'-reductase [EC: 1.1.1.220] | | dihydropteridine reductase [EC: 1.5.1.34] | | 7-carboxy-7-deazaguanine synthase [EC: 4.3.99.3] | | 7-cyano-7-deazaguanine synthase [EC: 6.3.4.20] | | 7-cyano-7-deazaguanine reductase [EC: 1.7.1.13] | | 7-cyano-7-deazaguanine reductase [EC: 1.7.1.13] | | molybdenum cofactor biosynthesis protein | | molybdenum cofactor biosynthesis protein C | | molybdopterin synthase catalytic subunit [EC:2.-.-.-] | | molybdopterin synthase sulfur carrier subunit | | para-aminobenzoate synthetase component I [EC: 2.6.1.85] | | para-aminobenzoate synthetase component II [EC: 2.6.1.85] | | para-aminobenzoate synthetase [EC: 2.6.1.85] | | 4-amino-4-deoxychorismate lyase [EC: 4.1.3.38] | | para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC: 4.1.3.38 2.6.1.85] |
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| Compound |
| GTP | | Tetrahydrofolate | | Chorismate | | Glycolaldehyde | | Dihydrobiopterin | | Tetrahydrobiopterin | | Dihydrofolate | | Folate | | 4-Aminobenzoate | | Dihydropteroate | | 5,6,7,8-Tetrahydromethanopterin | | 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine | | Tetrahydrofolyl-[Glu](n) | | 6-Pyruvoyltetrahydropterin | | 6-Lactoyl-5,6,7,8-tetrahydropterin | | 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine | | 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine | | 7,8-Dihydroneopterin 3'-triphosphate | | Formamidopyrimidine nucleoside triphosphate | | 2,5-Diaminopyrimidine nucleoside triphosphate | | Molybdopterin | | Dihydroneopterin phosphate | | Neopterin | | 7,8-Dihydromethanopterin | | 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine | | 6-(3'-Triphosphoryl-1'-methylglyceryl)-7-methyl-7,8-dihydrobiopterin | | Tetrahydrofolyl-[Glu](2) | | 4-Amino-4-deoxychorismate | | 7-Cyano-7-carbaguanine | | 7-Aminomethyl-7-carbaguanine | | Precursor Z | | 6-Carboxy-5,6,7,8-tetrahydropterin | | 7-Carboxy-7-carbaguanine |
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| Reference |
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| Authors |
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). |
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| Title |
[Cellular Functions and Metabolic Maps] (In Japanese) |
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| Journal |
Tokyo Kagaku Dojin (1997) |
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| Reference |
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| Authors |
Schwarz G, Mendel RR, Ribbe MW |
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| Title |
Molybdenum cofactors, enzymes and pathways. |
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| Journal |
Nature 460:839-47 (2009) |
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| Reference |
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| Authors |
Hanzelmann P, Schindelin H |
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| Title |
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism. |
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| Journal |
Proc Natl Acad Sci U S A 103:6829-34 (2006) |
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| Reference |
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| Authors |
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H |
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| Title |
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency. |
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| Journal |
Biochemistry 47:615-26 (2008) |
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| Reference |
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| Authors |
Wuebbens MM, Rajagopalan KV |
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| Title |
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis. |
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| Journal |
J Biol Chem 278:14523-32 (2003) |
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